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Negative Regulation and Gain Control of Sensory Neurons by the C. elegans Calcineurin TAX-6

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Kuhara, Atsushi, Inada, Hitoshi, Katsura, Isao, Mori, Ikue·2002·Neuron

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Abstract

Animals sense and adapt to variable environments by regulating appropriate sensory signal transduction pathways. Here, we show that calcineurin plays a key role in regulating the gain of sensory neuron responsiveness across multiple modalities. C. elegans animals bearing a loss-of-function mutation in TAX-6, a calcineurin A subunit, exhibit pleiotropic abnormalities, including many aberrant sensory behaviors. The tax-6 mutant defect in thermosensation is consistent with hyperactivation of the AFD thermosensory neurons. Conversely, constitutive activation of TAX-6 causes a behavioral phenotype consistent with inactivation of AFD neurons. In olfactory neurons, the impaired olfactory response of tax-6 mutants to an AWC-sensed odorant is caused by hyperadaptation, which is suppressible by a mutation causing defective olfactory adaptation. Taken together, our results suggest that stimulus-evoked calcium entry activates calcineurin, which in turn negatively regulates multiple aspects of sensory signaling.

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Authors: Kuhara, A., Inada, H., Katsura, I., & Mori, I.
Affiliations: Nagoya University (JP)
National Institute of Genetics (JP)
Corresponding author: Mori, Ikue
ORCID: Kuhara, Atsushi
Inada, Hitoshi
Mori, Ikue
Venue: Neuron
Publisher: Elsevier BV
Published: 2002-02
Volume: 33
Issue: 5
Pages: 751-763
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/s0896-6273(02)00607-4
OpenAlex: W2019816797
Cited by: 153
References: 57
Citations by year: 2026: 2 · 2025: 7 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 4 · 2020: 10 · 2019: 4 · 2018: 2 · 2017: 6 · 2016: 4 · 2015: 5 · 2014: 5 · 2013: 9 · 2012: 8
FWCI: 2.56
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4184 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Funders: Ministerio de Economía y Competitividad
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords: calcineurin, sensory neurons, gain control, negative regulation, thermosensation, AFD neurons, olfactory adaptation, olfactory sensory neurons, AWC neurons, sensory transduction, calcium influx, Caenorhabditis elegans
MeSH terms: Pentanols, Amino Acid Sequence, Animals, Humans, Ion Channels, Locomotion, Models, Biological, Molecular Sequence Data, Nerve Tissue Proteins, Neurons, Afferent, Osmolar Concentration, Phenotype, Recombinant Fusion Proteins, Smell, Thermosensing, Signal Transduction, Sequence Alignment, Caenorhabditis elegans, Calcineurin, Protein Subunits, Caenorhabditis elegans Proteins, Animals, Genetically Modified, Transient Receptor Potential Channels, TRPV Cation Channels

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Negative Regulation and Gain Control of Sensory Neurons by the C. elegans Calcineurin TAX-6

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