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Cited by 610NF-κB Signaling PathwaysCytokine Signaling Pathways and InteractionsCell death mechanisms and regulation

The DOI matches its Crossref record; 394 of the 394 references it cites were found in a registry or an index.

TNF receptor subtype signalling: Differences and cellular consequences

MacEwan, David J.·2002·Cellular Signalling
DOI 10.1016/s0898-6568(01)00262-5
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Abstract

Tumour necrosis factor-alpha (TNF alpha) is a multifunctional cytokine belonging to a family of ligands with an associated family of receptor proteins. The pleiotropic actions of TNF range from proliferative responses such as cell growth and differentiation, to inflammatory effects and the mediation of immune responses, to destructive cellular outcomes such as apoptotic and necrotic cell death mechanisms. Activated TNF receptors mediate the association of distinct adaptor proteins that regulate a variety of signalling processes including kinase or phosphatase activation, lipase stimulation, and protease induction. Moreover, the cytokine regulates the activities of transcription factors, heterotrimeric or monomeric G-proteins and calcium ion homeostasis in order to orchestrate its cellular functions. This review addresses the structural basis of TNF signalling, the pathways employed with their cellular consequences, and focuses on the specific role played by each of the two TNF receptor isotypes, TNFR1 and TNFR2.

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Citations

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Items 201–394 of 394

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Metadata

Authors
MacEwan, D. J.
Affiliations
University of Aberdeen (GB)
Corresponding author
MacEwan, David J.
ORCID
MacEwan, David J.
Venue
Cellular Signalling
Publisher
Elsevier BV
Published
2002-06
Volume
14
Issue
6
Pages
477-492
ISSN
0898-6568 (ISSN-L)
DOI
10.1016/s0898-6568(01)00262-5
OpenAlex
W2069681479
Cited by
610
References
394
Citations by year
2026: 1 · 2025: 6 · 2024: 8 · 2023: 11 · 2022: 18 · 2021: 14 · 2020: 17 · 2019: 20 · 2018: 24 · 2017: 18 · 2016: 13 · 2015: 21 · 2014: 20 · 2013: 29 · 2012: 37
FWCI
2.95
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Cellular Signalling (publishedVersion)
  • PubMed (publishedVersion)
  • UEA Digital Repository (University of East Anglia) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
  • Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords
TNF-α, TNFR1, TNFR2, adaptor proteins, apoptosis, necrosis, transcription factors, G proteins, calcium homeostasis
MeSH terms
Animals, Models, Biological, Phospholipases, Phosphoprotein Phosphatases, Protein Kinases, Sphingomyelin Phosphodiesterase, Tumor Necrosis Factor-alpha, Signal Transduction, Antigens, CD, Receptors, Tumor Necrosis Factor, Caspases, Receptors, Tumor Necrosis Factor, Type I, Receptors, Tumor Necrosis Factor, Type II, Mice

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