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TNF receptor subtype signalling: Differences and cellular consequences
Abstract
Tumour necrosis factor-alpha (TNF alpha) is a multifunctional cytokine belonging to a family of ligands with an associated family of receptor proteins. The pleiotropic actions of TNF range from proliferative responses such as cell growth and differentiation, to inflammatory effects and the mediation of immune responses, to destructive cellular outcomes such as apoptotic and necrotic cell death mechanisms. Activated TNF receptors mediate the association of distinct adaptor proteins that regulate a variety of signalling processes including kinase or phosphatase activation, lipase stimulation, and protease induction. Moreover, the cytokine regulates the activities of transcription factors, heterotrimeric or monomeric G-proteins and calcium ion homeostasis in order to orchestrate its cellular functions. This review addresses the structural basis of TNF signalling, the pathways employed with their cellular consequences, and focuses on the specific role played by each of the two TNF receptor isotypes, TNFR1 and TNFR2.
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“TNF-α has been reported to bind to tumor necrosis factor (TNFR1), leading to neuronal apoptosis [155,156].”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [156]
Citations
Cites
Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics
Kerr, J. F. R., Wyllie, A. H., & Currie, A. R. (1972) · British Journal of Cancer · doi:10.1038/bjc.1972.33 · Cited by 15,673
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., & Greenberg, M. E. (1995) · Science · doi:10.1126/science.270.5240.1326 · Cited by 5,273
Caspases: the executioners of apoptosis
Cohen, G. M. (1997) · Biochemical Journal · doi:10.1042/bj3260001 · Cited by 4,737
Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C
Nishizuka, Y. (1992) · Science · doi:10.1126/science.1411571 · Cited by 4,472
The TNF and TNF Receptor Superfamilies
Locksley, R. M., Killeen, N., & Lenardo, M. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00237-9 · Cited by 3,650
Muzio, M., Chinnaiyan, A. M., Kischkel, F. C., O'Rourke, K., Shevchenko, A., Ni, J., Scaffidi, C., Bretz, J. D., Zhang, M., Gentz, R., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81266-0 · Cited by 3,046
Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F., & Spiegelman, B. M. (1996) · Science · doi:10.1126/science.271.5249.665 · Cited by 2,630
Inhibition of death receptor signals by cellular FLIP
Irmler, M., Thome, M., Hahne, M., Schneider, P., Hofmann, K., Steiner, V., Bodmer, J.-L., Schröter, M., Burns, K., Mattmann, C., et al. (1997) · Nature · doi:10.1038/40657 · Cited by 2,548
Chinnaiyan, A. M., O'Rourke, K., Tewari, M., & Dixit, V. M. (1995) · Cell · doi:10.1016/0092-8674(95)90071-3 · Cited by 2,431
Tewari, M., Quan, L. T., O’Rourke, K. M., Desnoyers, S., Zeng, Z., Beidler, D. R., Poirier, G. G., Salvesen, G. S., & Dixit, V. M. (1995) · Cell · doi:10.1016/0092-8674(95)90541-3 · Cited by 2,367
Raingeaud, J., Gupta, S., Rogers, J. S., Dickens, M., Han, J., Ulevitch, R. J., & Davis, R. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7420 · Cited by 2,244
Protection from obesity-induced insulin resistance in mice lacking TNF-α function
Uysal, K. T., Wiesbrock, S. M., Marino, M. W., & Hotamisligil, G. S. (1997) · Nature · doi:10.1038/39335 · Cited by 2,234
The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation
Hsu, H., Xiong, J., & Goeddel, D. V. (1995) · Cell · doi:10.1016/0092-8674(95)90070-5 · Cited by 2,024
Hsu, H., Shu, H., Pan, M., & Goeddel, D. V. (1996) · Cell · doi:10.1016/s0092-8674(00)80984-8 · Cited by 1,998
Holler, N., Zaru, R., Micheau, O., Thome, M., Attinger, A., Valitutti, S., Bodmer, J.-L., Schneider, P., Seed, B., & Tschopp, J. (2000) · Nature Immunology · doi:10.1038/82732 · Cited by 1,987
Liu, Z.-G., Hsu, H., Goeddel, D. V., & Karin, M. (1996) · Cell · doi:10.1016/s0092-8674(00)81375-6 · Cited by 1,937
Old, L. J. (1985) · Science · doi:10.1126/science.2413547 · Cited by 1,885
Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
Kuida, K., Zheng, T. S., Na, S., Kuan, C.-Y., Yang, D., Karasuyama, H., RAKIC, P. T., & Flavell, R. A. (1996) · Nature · doi:10.1038/384368a0 · Cited by 1,881
cPLA2 is phosphorylated and activated by MAP kinase
Lin, L., Wartmann, M., Lin, A. Y., Knopf, J. L., Seth, A., & Davis, R. J. (1993) · Cell · doi:10.1016/0092-8674(93)90666-e · Cited by 1,851
NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase
Nidai Ozes, O., Mayo, L. D., Gustin, J. A., Pfeffer, S. R., Pfeffer, L. M., & Donner, D. B. (1999) · Nature · doi:10.1038/43466 · Cited by 1,832
Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
Verheij, M., Bose, R., Lin, X. H., Yao, B., Jarvis, W. D., Grant, S., Birrer, M. J., Szabo, E. M., Zon, L. I., Kyriakis, J. M., et al. (1996) · Nature · doi:10.1038/380075a0 · Cited by 1,767
Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway
Tournier, C., Hess, P., Yang, D. D., Xu, J., Turner, T. K., Nimnual, A., Bar-Sagi, D., Jones, S. N., Flavell, R. A., & Davis, R. J. (2000) · Science · doi:10.1126/science.288.5467.870 · Cited by 1,728
Clark, J. D., Lin, L.-L., Kriz, R. W., Ramesha, C. S., Sultzman, L. A., Lin, A. Y., Milona, N., & Knopf, J. L. (1991) · Cell · doi:10.1016/0092-8674(91)90556-e · Cited by 1,688
BCL-2 FAMILY: Regulators of Cell Death
Chao, D. T., & Korsmeyer, S. J. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.395 · Cited by 1,686
Pfeffer, K., Matsuyama, T., Kündig, T. M., Wakeham, A., Kishihara, K., Shahinian, A., Wiegmann, K., Ohashi, P. S., Krönke, M., & Mak, T. W. (1993) · Cell · doi:10.1016/0092-8674(93)90134-c · Cited by 1,677
The PI3K‒PDK1 connection: more than just a road to PKB
Vanhaesebroeck, B., & Alessi, D. R. (2000) · Biochemical Journal · doi:10.1042/bj3460561 · Cited by 1,649
Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9
Kuida, K., Haydar, T. F., Kuan, C.-Y., Gu, Y., Taya, C., Karasuyama, H., Su, M. S.-S., Rakic, P., & Flavell, R. A. (1998) · Cell · doi:10.1016/s0092-8674(00)81476-2 · Cited by 1,643
Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme
Kuida, K., Lippke, J. A., Ku, G., Harding, M. W., Livingston, D. J., Su, M. S. S., & Flavell, R. A. (1995) · Science · doi:10.1126/science.7535475 · Cited by 1,631
Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate
Cuvillier, O., Pirianov, G., Kleuser, B., Vanek, P. G., Coso, O. A., Gutkind, J. S., & Spiegel, S. (1996) · Nature · doi:10.1038/381800a0 · Cited by 1,532
Grell, M., Douni, E. K., Wajant, H., Löhden, M., Clauss, M. A., Maxeiner, B., Georgopoulos, S., Lesslauer, W., Kollias, G. A., Pfizenmaier, K., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90192-2 · Cited by 1,328
Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors
Thome, M., Schneider, P., Hofmann, K., Fickenscher, H., Meinl, E., Neipel, F., Mattmann, C., Burns, K., Bodmer, J.-L., Schröter, M., et al. (1997) · Nature · doi:10.1038/386517a0 · Cited by 1,316
Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo
Hakem, R., Hakem, A., Duncan, G. S., Henderson, J. T., Woo, M., Soengas, M. S., Elia, A., de la Pompa, J. L., Kägi, D., Khoo, W., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81477-4 · Cited by 1,296
A novel domain within the 55 kd TNF receptor signals cell death
Tartaglia, L. A., Ayres, T. M., Wong, G. H., & Goeddel, D. V. (1993) · Cell · doi:10.1016/0092-8674(93)90464-2 · Cited by 1,290
MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1
Malinin, N. L., Boldin, M., Kovalenko, A. V., & Wallach, D. (1997) · Nature · doi:10.1038/385540a0 · Cited by 1,279
Rothe, M., Pan, M.-G., Henzel, W. J., Ayres, T. M., & V. Goeddel, D. (1995) · Cell · doi:10.1016/0092-8674(95)90149-3 · Cited by 1,253
Anti-TNFα Therapy of Rheumatoid Arthritis: What Have We Learned?
Feldmann, M., & Maini, R. N. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.163 · Cited by 1,252
Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation
Hannun, Y. A., & Bell, R. M. (1989) · Science · doi:10.1126/science.2643164 · Cited by 1,251
Rothe, J., Lesslauer, W., Loetscher, H., Lang, Y., Koebel, P., Köntgen, F., Althage, A., Zinkernagel, R. M., Steinmetz, M., & Bluethmann, H. (1993) · Nature · doi:10.1038/364798a0 · Cited by 1,246
The sphingomyelin cycle and the second messenger function of ceramide.
Hannun, Y. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41834-5 · Cited by 1,229
Tumor necrosis factor alpha inhibits signaling from the insulin receptor.
Hotamışlıgil, G. S., Murray, D. L., Choy, L., & Spiegelman, B. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.4854 · Cited by 1,220
Dayer, J., Beutler, B., & Cerami, A. (1985) · The Journal of Experimental Medicine · doi:10.1084/jem.162.6.2163 · Cited by 1,208
TNF-Dependent Recruitment of the Protein Kinase RIP to the TNF Receptor-1 Signaling Complex
Hsu, H., Huang, J., Shu, H.-B., Baichwal, V., & Goeddel, D. V. (1996) · Immunity · doi:10.1016/s1074-7613(00)80252-6 · Cited by 1,182
Identity of tumour necrosis factor and the macrophage-secreted factor cachectin
Beutler, B., Greenwald, D., Hulmes, J. D., Chang, M., Pan, Y.-C. E., Mathison, J. C., Ulevitch, R. J., & Cerami, A. (1985) · Nature · doi:10.1038/316552a0 · Cited by 1,132
The Death Domain Kinase RIP Mediates the TNF-Induced NF-κB Signal
Kelliher, M. A., Grimm, S., Ishida, Y., Kuo, F., Stanger, B. Z., & Leder, P. (1998) · Immunity · doi:10.1016/s1074-7613(00)80535-x · Cited by 1,102
Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK
Minden, A., Lin, A., McMahon, M., Lange, C. A., Dérijard, B., Davis, R. J., Johnson, G. L., & Karin, M. (1994) · Science · doi:10.1126/science.7992057 · Cited by 1,069
Rothe, M., Wong, S. C., Henzel, W. J., & Goeddel, D. V. (1994) · Cell · doi:10.1016/0092-8674(94)90532-0 · Cited by 1,054
TRAF2-Mediated Activation of NF-κB by TNF Receptor 2 and CD40
Rothe, M., Sarma, V. J., Dixit, V. M., & Goeddel, D. V. (1995) · Science · doi:10.1126/science.7544915 · Cited by 1,050
Schütze, S., Potthoff, K., Machleidt, T., Berkovic, D., Wiegmann, K., & Krönke, M. (1992) · Cell · doi:10.1016/0092-8674(92)90553-o · Cited by 1,046
Stanger, B. Z., Leder, P., Lee, T.-H., Kim, E., & Seed, B. (1995) · Cell · doi:10.1016/0092-8674(95)90072-1 · Cited by 969
Molecular cloning and expression of a receptor for human tumor necrosis factor
Schall, T. J., Lewis, M., Koller, K. J., Lee, A. L., Rice, G. C., Wong, G. H., Gatanaga, T., Granger, G. A., Lentz, R., Raab, H. E., et al. (1990) · Cell · doi:10.1016/0092-8674(90)90816-w · Cited by 958
Vercammen, D., Beyaert, R., Denecker, G., Goossens, V., Loo, G., Declercq, W., Grooten, J., Fiers, W., & Vandenabeele, P. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.9.1477 · Cited by 925
Induction of manganous superoxide dismutase by tumor necrosis factor: possible protective mechanism
Wong, G. H. W., & Goeddel, D. V. (1988) · Science · doi:10.1126/science.3263703 · Cited by 914
Molecular cloning and expression of the human 55 kd tumor necrosis factor receptor
Loetscher, H., Pan, Y. E., Lahm, H., Gentz, R., Brockhaus, M., Tabuchi, H., & Lesslauer, W. (1990) · Cell · doi:10.1016/0092-8674(90)90815-v · Cited by 897
Colquhoun, D. M. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702164 · Cited by 893
Characterization of receptors for human tumour necrosis factor and their regulation by γ-interferon
Aggarwal, B. B., Eessalu, T. E., & Hass, P. E. (1985) · Nature · doi:10.1038/318665a0 · Cited by 876
A Domain in TNF Receptors That Mediates Ligand-Independent Receptor Assembly and Signaling
Chan, F. K.-M., Chun, H. J., Zheng, L., Siegel, R. M., Bui, K. L., & Lenardo, M. J. (2000) · Science · doi:10.1126/science.288.5475.2351 · Cited by 856
Cleavage of the death domain kinase RIP by Caspase-8 prompts TNF-induced apoptosisPreprint
Lin, Y., Devin, A., Rodriguez, Y., & Liu, Z.-G. (1999) · Genes & Development · doi:10.1101/gad.13.19.2514 · Cited by 849
Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changesPreprint
Woo, M., Hakem, R., Soengas, M. S., Duncan, G. S., Shahinian, A., Kägi, D., Hakem, A., McCurrach, M. E., Khoo, W., Kaufman, S. A., et al. (1998) · Genes & Development · doi:10.1101/gad.12.6.806 · Cited by 835
Hotamisligil, G. S., Budavari, A., Murray, D., & Spiegelman, B. M. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117495 · Cited by 819
REGULATION OF CERAMIDE PRODUCTION AND APOPTOSIS
Kolesnick, R., & Krönke, M. (1998) · Annual Review of Physiology · doi:10.1146/annurev.physiol.60.1.643 · Cited by 803
Wong, G. H. W., Elwell, J. H., Oberley, L. W., & Goeddel, D. V. (1989) · Cell · doi:10.1016/0092-8674(89)90944-6 · Cited by 802
Two tumour necrosis factor receptors: structure and function
Vandenabeele, P., Declercq, W., Beyaert, R., & Fiers, W. (1995) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)89088-1 · Cited by 799
Yeh, W., Shahinian, A., Speiser, D. E., Kraunus, J., Billia, F., Wakeham, A. C., de la Pompa, J. L., Ferrick, D. A., Hum, B., Iscove, N. N., et al. (1997) · Immunity · doi:10.1016/s1074-7613(00)80391-x · Cited by 798
The two different receptors for tumor necrosis factor mediate distinct cellular responses.
Tartaglia, L. A., Weber, R. F., Figari, I. S., Reynolds, C. P., Palladino, M. A., & Goeddel, D. V. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.20.9292 · Cited by 792
Sphingosine 1-phosphate signalling in mammalian cells
Pyne, S., & Pyne, N. J. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3490385 · Cited by 737
Potential Role of TNF-α in the Pathogenesis of Insulin Resistance and Type 2 Diabetes
Moller, D. E. (2000) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(00)00272-1 · Cited by 730
Defying death after DNA damage
Rich, T., Allen, R. L., & Wyllie, A. H. (2000) · Nature · doi:10.1038/35037717 · Cited by 724
Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling
Wiegmann, K., Schütze, S., Machleidt, T., Witte, D., & Krönke, M. (1994) · Cell · doi:10.1016/0092-8674(94)90275-5 · Cited by 714
Serine/Threonine Protein Kinases and Apoptosis
Cross, T. G., Scheel‐Toellner, D., Henriquez, N. V., Deacon, E. M., Salmon, M., & Lord, J. M. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4836 · Cited by 693
New Perspectives into the Molecular Pathogenesis and Treatment of Type 2 Diabetes
Saltiel, A. R. (2001) · Cell · doi:10.1016/s0092-8674(01)00239-2 · Cited by 688
Berghe, W. V., Plaisance, S., Boone, E., Bosscher, K. D., Schmitz, M. L., Fiers, W., & Haegeman, G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.6.3285 · Cited by 679
Signal transduction of stress via ceramide
Mathias, S., Peña, L. A., & Kolesnick, R. (1998) · Biochemical Journal · doi:10.1042/bj3350465 · Cited by 673
Proteolytic activation of protein kinase C delta by an ICE‐like protease in apoptotic cells.
Emoto, Y., Manome, Y., Meinhardt, G., Kisaki, H., Kharbanda, S. M., Robertson, M. J., Ghayur, T., Wong, W. W., Kamen, R., & Weichselbaum, R. R. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00305.x · Cited by 671
Ceramide activates heterotrimeric protein phosphatase 2A
Dobrowsky, R. T., Kamibayashi, C., Mumby, M. C., & Hannun, Y. A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82288-8 · Cited by 666
Beyaert, R., Cuenda, A., Berghe, W. V., Plaisance, S., Lee, J. C., Haegeman, G., Cohen, P., & Fiers, W. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00542.x · Cited by 650
ASK1 Is Essential for JNK/SAPK Activation by TRAF2
Nishitoh, H., Saitoh, M., Mochida, Y., Takeda, K., Nakano, H., Rothe, M., Miyazono, K., & Ichijo, H. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80283-x · Cited by 647
The Beginning of the End: IκB Kinase (IKK) and NF-κB Activation
Karin, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.39.27339 · Cited by 640
Kim, M. Y., Linardic, C. M., Obeid, L. M., & Hannun, Y. A. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52461-3 · Cited by 628
Sphingomyelin turnover induced by vitamin D3 in HL-60 cells
Okazaki, T., Bell, R. M., & Hannun, Y. A. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)47268-2 · Cited by 623
Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins.Preprint
Perona, R., Montaner, S., Saniger, L., Sánchez‐Pérez, I., Bravo, R., & Lacal, J. C. (1997) · Genes & Development · doi:10.1101/gad.11.4.463 · Cited by 620
Erickson, S. L., de Sauvage, F. J., Kikly, K. K., Carver-Moore, K., Pitts-Meek, S., Gillett, N. A., Sheehan, K. C. F., Schreiber, R. D., Goeddel, D. V., & Moore, M. W. (1994) · Nature · doi:10.1038/372560a0 · Cited by 587
Tartaglia, L. A., Pennica, D., & Goeddel, D. V. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)46661-0 · Cited by 570
Lewis, M., Tartaglia, L. A., Lee, A. L., Bennett, G. L., Rice, G. C., Wong, G. H., Chen, E. Y., & Goeddel, D. V. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.7.2830 · Cited by 561
Dual Signaling of the Fas Receptor: Initiation of Both Apoptotic and Necrotic Cell Death Pathways
Vercammen, D., Brouckaert, G., Denecker, G., Van de Craen, M., Declercq, W., Fiers, W., & Vandenabeele, P. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.5.919 · Cited by 556
Song, H. Y., Régnier, C. H., Kirschning, C. J., Goeddel, D. V., & Rothe, M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9792 · Cited by 554
The caspase-8 inhibitor FLIP promotes activation of NF-κB and Erk signaling pathways
Kataoka, T., Budd, R. C., Holler, N., Thome, M., Martinon, F., Irmler, M., Burns, K. A., Hahne, M., Kennedy, N. J., Kovacsovics, M., et al. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00512-1 · Cited by 549
NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176
Lei, L., Cao, Z., & Goeddel, D. V. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3792 · Cited by 536
Enslen, H., Raingeaud, J., & Davis, R. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.3.1741 · Cited by 534
Nemenoff, R. A., Winitz, S., Qian, N. X., Putten, V. V., Johnson, G. L., & Heasley, L. E. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53948-x · Cited by 522
The Regulation of Anoikis: MEKK-1 Activation Requires Cleavage by Caspases
Cardone, M. H., Salvesen, G. S., Widmann, C., Johnson, G. L., & Frisch, S. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80339-6 · Cited by 508
Enzymes of Sphingolipid Metabolism: From Modular to Integrative Signaling
Hannun, Y. A., Luberto, C., & Argraves, K. M. (2001) · Biochemistry · doi:10.1021/bi002836k · Cited by 502
Müller, G., Ayoub, M., Störz, P., Rennecke, J., Fabbro, D., & Pfizenmaier, K. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07188.x · Cited by 494
Kramer, R. M., Roberts, E. F., Um, S. L., BÖRSCH-HAUBOLD, A. G., Watson, S. P., Fisher, M. J., & Jakubowski, J. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.44.27723 · Cited by 481
The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor
Grell, M., Wajant, H., Zimmermann, G., & Scheurich, P. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.2.570 · Cited by 478
Lozano, J., Berra, E., Municio, M. M., Díaz-Meco, M. T., Dominguez, I. M., Sanz, L., & Moscat, J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32152-x · Cited by 465
Baud, V., Liu, Z.-G., Bennett, B. L., Suzuki, N., Xia, Y., & Karin, M. (1999) · Genes & Development · doi:10.1101/gad.13.10.1297 · Cited by 464
Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-κb-inducing kinase
Shinkura, R., Kitada, K., Matsuda, F., Tashiro, K., Ikuta, K., Suzuki, M., Kogishi, K., Serikawa, T., & Honjo, T. (1999) · Nature Genetics · doi:10.1038/8780 · Cited by 451
Inoue, J., Ishida, T., Tsukamoto, N., Kobayashi, N., Naito, A., Azuma, S., & Yamamoto, T. S. (2000) · Experimental Cell Research · doi:10.1006/excr.1999.4733 · Cited by 449
Lee, S. Y., Reichlin, A., Santana, A., Sokol, K. A., Nussenzweig, M. C., & Choi, Y. (1997) · Immunity · doi:10.1016/s1074-7613(00)80390-8 · Cited by 445
Dressler, K. A., Mathias, S., & Kolesnick, R. (1992) · Science · doi:10.1126/science.1313189 · Cited by 442
RIP2 Is a Novel NF-κB-activating and Cell Death-inducing Kinase
McCarthy, J. V., Ni, J., & Dixit, V. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.27.16968 · Cited by 437
Kinase Suppressor of Ras Is Ceramide-Activated Protein Kinase
Zhang, Y., Yao, B., Delikat, S. E., Bayoumy, S. S., Lin, X., Basu, S., McGinley, M., Chan-Hui, P.-Y., Lichenstein, H. S., & Kolesnick, R. (1997) · Cell · doi:10.1016/s0092-8674(00)80183-x · Cited by 437
Cunningham, A. J., Murray, C. A., O'Neill, L. A. J., Lynch, M. A., & O'Connor, J. J. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(95)12252-4 · Cited by 433
The Distinct Roles of TRAF2 and RIP in IKK Activation by TNF-R1
Devin, A., Cook, A., Lin, Y., Rodriguez, Y., Kelliher, M. A., & Liu, Z.-G. (2000) · Immunity · doi:10.1016/s1074-7613(00)80194-6 · Cited by 433
Caspase-dependent Cleavage of Signaling Proteins during Apoptosis
Widmann, C., Gibson, S. B., & Johnson, G. L. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.12.7141 · Cited by 423
Tumor necrosis factor: specific binding and internalization in sensitive and resistant cells.
Tsujimoto, M., Yip, Y. K., & Vilček, J. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.22.7626 · Cited by 422
Prevention of Constitutive TNF Receptor 1 Signaling by Silencer of Death Domains
Jiang, Y., Woronicz, J. D., Liu, W., & Goeddel, D. V. (1999) · Science · doi:10.1126/science.283.5401.543 · Cited by 415
Song, H. Y., Rothe, M., & Goeddel, D. V. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6721 · Cited by 414
The interaction of p62 with RIP links the atypical PKCs to NF‐κB activation
Sanz, L., Sánchez‐Gómez, P., Lallena, M., Díaz-Meco, M. T., & Moscat, J. (1999) · The EMBO Journal · doi:10.1093/emboj/18.11.3044 · Cited by 410
Defective Lymphotoxin-β Receptor-Induced NF-κB Transcriptional Activity in NIK-Deficient Mice
Li, Y., Wu, L., Wesche, H., Arthur, C. D., White, J. M., Goeddel, D. V., & Schreiber, R. D. (2001) · Science · doi:10.1126/science.1058453 · Cited by 408
Inverse, protean, and ligand‐selective agonism: matters of receptor conformation
Kenakin, T. (2001) · The FASEB Journal · doi:10.1096/fj.00-0438rev · Cited by 408
Tumor necrosis factor receptor-mediated signaling pathways.
Heller, R. A., & Krönke, M. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.126.1.5 · Cited by 392
Ceramide stimulates a cytosolic protein phosphatase.
Dobrowsky, R., & Hannun, Y. A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42727-5 · Cited by 376
MAP kinase activation in macrophages
Rao, K. M. K. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.69.1.3 · Cited by 371
Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha.
Mathias, S., Dressler, K. A., & Kolesnick, R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.22.10009 · Cited by 362
Thomas, P. S., Yates, D., & Barnes, P. J. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.152.1.7599866 · Cited by 360
The TNF-receptor-associated factor family
Wajant, H., Henkler, F., & Scheurich, P. (2001) · Cellular Signalling · doi:10.1016/s0898-6568(01)00160-7 · Cited by 359
Zhou, H., Summers, S. A., Birnbaum, M. J., & Pittman, R. N. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.26.16568 · Cited by 356
Eliopoulos, A. G., Gallagher, N. J., Blake, S. M. S., Dawson, W. O., & Young, L. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.23.16085 · Cited by 354
Tumor necrosis factor's cytotoxic activity is signaled by the p55 TNF receptor
Tartaglia, L. A., Rothe, M., Hu, Y.-F., & Goeddel, D. V. (1993) · Cell · doi:10.1016/0092-8674(93)90222-c · Cited by 339
Phosphorylation of Raf by ceramide-activated protein kinase
Yao, B., Zhang, Y., Delikat, S. E., Mathias, S., Basu, S., & Kolesnick, R. (1995) · Nature · doi:10.1038/378307a0 · Cited by 327
Stress-activated Protein Kinases: Activation, Regulation and Function
Paul, A., Wilson, S., BELHAM, C. M., ROBINSON, C. J. M., Scott, P., Gould, G. W., & Plevin, R. J. (1997) · Cellular Signalling · doi:10.1016/s0898-6568(97)00042-9 · Cited by 321
Identification of CARDIAK, a RIP-like kinase that associates with caspase-1
Thome, M., Hofmann, K., Burns, K., Martinon, F., Bodmer, J.-L., Mattmann, C., & Tschopp, J. (1998) · Current Biology · doi:10.1016/s0960-9822(07)00352-1 · Cited by 319
Tumour necrosis factor‐α: The role of this multifunctional cytokine in asthma
Thomas, P. S. (2001) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.2001.00980.x · Cited by 315
Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation
Zheng, T. S., Hunot, S., Kuida, K., Momoi, T., Srinivasan, A. N., Nicholson, D. W., Lazebnik, Y. A., & Flavell, R. A. (2000) · Nature Medicine · doi:10.1038/81343 · Cited by 309
Scheid, M. P., & Duronio, V. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7439 · Cited by 305
Non‐specific effects of methyl ketone peptide inhibitors of caspases
Schotte, P., Declercq, W., Huffel, S. V., Vandenabeele, P., & Beyaert, R. (1999) · FEBS Letters · doi:10.1016/s0014-5793(98)01640-8 · Cited by 302
Takeuchi, M., Rothe, M., & Goeddel, D. V. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.33.19935 · Cited by 301
Heyninck, K., VALCK, D. D., Berghe, W. V., Criekinge, W. V., Contreras, R., Fiers, W., Haegeman, G., & Beyaert, R. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.7.1471 · Cited by 295
Murray, J., Barbara, J. A. J., Dunkley, S. A., Lopez, A. F., Ostade, X. V., Condliffe, A. M., Dransfield, I., Haslett, C., & Chilvers, E. R. (1997) · Blood · doi:10.1182/blood.v90.7.2772 · Cited by 294
Tartaglia, L. A., Goeddel, D. V., Reynolds, C. P., Figari, I. S., Weber, R. F., FENDLY, B. M., & Palladino, M. A. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.9.4637 · Cited by 289
Grell, M., Zimmermann, G., Gottfried, E., Chen, C., Grünwald, U., Huang, D. C. S., Lee, Y. W., Dürkop, H., Engelmann, H., Scheurich, P., et al. (1999) · The EMBO Journal · doi:10.1093/emboj/18.11.3034 · Cited by 284
Regulated Commitment of TNF Receptor Signaling
Pimentel‐Muiños, F. X., & Seed, B. (1999) · Immunity · doi:10.1016/s1074-7613(00)80152-1 · Cited by 282
Kull, F. C., Jacobs, S., & Cuatrecasas, P. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.17.5756 · Cited by 281
Apoptotic and necrotic cell death induced by death domain receptors
Denecker, G., Vercammen, D., Declercq, W., & Vandenabeele, P. (2001) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000863 · Cited by 279
Caspase knockouts: matters of life and death
Zheng, T. S., Hunot, S., Kuida, K., & Flavell, R. (1999) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400593 · Cited by 279
Ceramide Inhibits Protein Kinase B/Akt by Promoting Dephosphorylation of Serine 473
Schubert, K. M., Scheid, M. P., & Duronio, V. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.18.13330 · Cited by 277
Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction.
Wolff, R. A., Dobrowsky, R., Bielawska, A., Obeid, L., & Hannun, Y. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32212-3 · Cited by 277
Yuasa, T., Ohno, S., Kehrl, J. H., & Kyriakis, J. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.35.22681 · Cited by 268
Ceramide Inactivates Cellular Protein Kinase Cα
Lee, J. Y., Hannun, Y. A., & Obeid, L. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.22.13169 · Cited by 268
The p70 tumor necrosis factor receptor mediates cytotoxicity
Holler, R. A., Song, K. B., Fan, N. C., & Chang, D. J. (1992) · Cell · doi:10.1016/0092-8674(92)90532-h · Cited by 266
Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta.
Berra, E., Díaz-Meco, M. T., Lozano, J., Frutos, S., Municio, M. M., Sánchez‐Gómez, P., Sanz, L., & Moscat, J. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00306.x · Cited by 263
Sphingomyelinase and ceramide activate mitogen-activated protein kinase in myeloid HL-60 cells
Raines, M. A., Kolesnick, R., & Golde, D. W. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82367-5 · Cited by 255
Hayakawa, M., Ishida, N., Takeuchi, K., Shibamoto, S., Hori, T., Oku, N., Ito, F., & Tsujimoto, M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82123-8 · Cited by 253
Noncaspase proteases in apoptosis
Johnson, D. (2000) · Leukemia · doi:10.1038/sj.leu.2401879 · Cited by 251
Tumor Necrosis Factor-α-inducible IκBα Proteolysis Mediated by Cytosolic m-Calpain
Han, Y., Weinman, S. A., Boldogh, I. R., Walker, R. K., & Brasier, A. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.2.787 · Cited by 241
RIP3, a Novel Apoptosis-inducing Kinase
Sun, X., Lee, J., Navas, T. A., Baldwin, D. T., Stewart, T. A., & Dixit, V. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.24.16871 · Cited by 240
MEK Kinase 1, a Substrate for DEVD-Directed Caspases, Is Involved in Genotoxin-Induced Apoptosis
Widmann, C., Gerwins, P., Johnson, N. L., Jarpe, M. B., & Johnson, G. L. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.4.2416 · Cited by 236
Li, G. C., Ouyang, H., Li, X., Nagasawa, H., Little, J. B., Chen, D. J., Ling, C., FUKS, Z. Y., & Cordon-Cardo, C. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80108-2 · Cited by 235
Atsumi, G., Tajima, M., Hadano, A., Nakatani, Y., Murakami, M., & Kudo, I. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.22.13870 · Cited by 235
Aggarwal, B. B. (2000) · Annals of the Rheumatic Diseases · doi:10.1136/ard.59.suppl_1.i6 · Cited by 234
Crowe, P. D., Walter, B. N., Mohler, K. M., Otten-Evans, C., Black, R. A., & Ware, C. F. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.3.1205 · Cited by 231
Wyllie, A. (1997) · PubMed · Cited by 224
Evidence for the in vitro and in vivo interaction of Ras with protein kinase C zeta.
Díaz-Meco, M. T., Lozano, J., Municio, M. M., Berra, E., Frutos, S., Sanz, L., & Moscat, J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)31753-8 · Cited by 218
Ravichandran, L. V., Esposito, D. L., Chen, J. Y. ‐., & Quon, M. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007231200 · Cited by 217
Through thick and thin: Wasting, obesity, and TNFα
Spiegelman, B. M., & Hotamışlıgil, G. S. (1993) · Cell · doi:10.1016/0092-8674(93)90243-j · Cited by 217
Receptor Binding and Activation of Polymorphonuclear Neutrophils by Tumor Necrosis Factor-Alpha
Shalaby, M. R., Palladino, M. A., Hirabayashi, S. E., Eessalu, T. E., Lewis, G. D., Shepard, H. M., & Aggarwal, B. B. (1987) · Journal of Leukocyte Biology · doi:10.1002/jlb.41.3.196 · Cited by 216
Hoeck, W. G., Ramesha, C. S., Chang, D. J., Fan, N. C., & Heller, R. A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.10.4475 · Cited by 208
Wissing, D., Mouritzen, H., Egeblad, M., Poirier, G. G., & Jäättelä, M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5073 · Cited by 207
Cleavage of the calpain inhibitor, calpastatin, during apoptosis
Pörn-Ares, M. I., Samali, A., & Orrenius, S. (1998) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400424 · Cited by 207
Madge, L. A., & Pober, J. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001237200 · Cited by 205
Clark, M. A., Chen, M. J., Crooke, S. T., & Bomalaski, J. S. (1988) · Biochemical Journal · doi:10.1042/bj2500125 · Cited by 203
Loetscher, H., Stueber, D., Banner, D. W., Mackay, F., & Lesslauer, W. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74322-1 · Cited by 202
Hohmann, H., Brockhaus, M., Baeuerle, P. A., Remy, R., Kolbeck, R., & van Loon, A. P. G. M. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45720-1 · Cited by 201
Matsushima, A., Kaisho, T., Rennert, P. D., Nakano, H., Kurosawa, K., Uchida, D., Takeda, K., Akira, S., & Matsumoto, M. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.5.631 · Cited by 200
Salinas, M., López‐Valdaliso, R., Martı́n, D., Alvarez, A. M., & Cuadrado, A. (2000) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1999.0813 · Cited by 199
Schwenger, P., Alpert, D. R., Skolnik, E. Y., & Vilček, J. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.1.78 · Cited by 196
Watts, A. D., Hunt, N. H., Wanigasekara, Y., Bloomfield, G., Wallach, D., Roufogalis, B. D., & Chaudhri, G. (1999) · The EMBO Journal · doi:10.1093/emboj/18.8.2119 · Cited by 195
Human 55-kDa receptor for tumor necrosis factor coupled to signal transduction cascades.
Wiegmann, K., Schütze, S., Kampen, E., Himmler, A., Machleidt, T., & Krönke, M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)37142-x · Cited by 194
Weiss, T., Grell, M., Hessabi, B., Bourteele, S., Müller, G., Scheurich, P., & Wajant, H. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.5.2398 · Cited by 184
Schütze, S., Berkovic, D., Tomsing, O., Unger, C., & Krönke, M. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.174.5.975 · Cited by 183
Wajant, H., Haas, E., Schwenzer, R., Mühlenbeck, F., Kreuz, S., Schubert, G., Grell, M., Smith, C. A., & Scheurich, P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000811200 · Cited by 182
BAD Enables Ceramide to Signal Apoptosis via Ras and Raf-1
Basu, S., Bayoumy, S. S., Zhang, Y., Lozano, J., & Kolesnick, R. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.46.30419 · Cited by 182
Lucas, R., Juillard, P., Decoster, E., Redard, M., Burger, D., Donati, Y. R. A., Giroud, C., Monso‐Hinard, C., Kesel, T. D., Buurman, W. A., et al. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270719 · Cited by 177
Küsters, S., Tiegs, G., Alexopoulou, L., Pasparakis, M., Douni, E. K., Künstle, G., Bluethmann, H., Wendel, A., Pfizenmaier, K., Kollias, G. A., et al. (1997) · European Journal of Immunology · doi:10.1002/eji.1830271119 · Cited by 176
Human TNF mutants with selective activity on the p55 receptor
Ostade, X. V., Vandenabeele, P., Everaerdt, B., Loetscher, H., Gentz, R., Brockhaus, M., Lesslauer, W., Tavernier, J. H., Brouckaert, P., & Fiers, W. (1993) · Nature · doi:10.1038/361266a0 · Cited by 176
TNF induces internalization of the p60 receptor and shedding of the p80 receptor.
Higuchi, M., & Aggarwal, B. B. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.7.3550 · Cited by 173
Ceramide-induced Translocation of Protein Kinase C-δ and -ϵ to the Cytosol
Sawai, H., Okazaki, T., Takeda, Y., Tashima, M., Sawada, H., Okuma, M., Kishi, S., Umehara, H., & Domae, N. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.4.2452 · Cited by 172
Schievella, A. R., Chen, J. H., Graham, J. R., & Lin, L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.18.12069 · Cited by 170
Both TNF receptors are required for TNF-mediated induction of apoptosis in PC60 cells.
Vandenabeele, P., Declercq, W., Vanhaesebroeck, B., Grooten, J., & Fiers, W. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.6.2904 · Cited by 169
Dressler, K. A., & Kolesnick, R. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77204-9 · Cited by 166
Pollock, J., McFarlane, S. M., Connell, M. C., Zehavi, U., Vandenabeele, P., MacEwan, D. J., & Scott, R. H. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(01)00163-0 · Cited by 163
Nasuhara, Y., Adcock, I. M., Catley, M. C., Barnes, P. J., & Newton, R. C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.28.19965 · Cited by 162
Jones, S. J., Ledgerwood, E. C., Prins, J. B., Galbraith, J., Johnson, D. R., Pober, J. S., & Bradley, J. R. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.2.1042 · Cited by 160
Haridas, V., Darnay, B. G., Natarajan, K., Heller, R. A., & Aggarwal, B. B. (1998) · PubMed · Cited by 159
Phospholipase A2 Is Necessary for Tumor Necrosis Factor α-induced Ceramide Generation in L929 Cells
Jayadev, S., Hayter, H., Andrieu‐Abadie, N., Gamard, C. J., Liu, B., Balu, R., Hayakawa, M., Ito, F., & Hannun, Y. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.27.17196 · Cited by 159
BÖRSCH-HAUBOLD, A. G., Bártoli, F., Asselin, J., Dudler, T., Kramer, R. M., Apitz-Castro, R. J., Watson, S. P., & Gelb, M. H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.8.4449 · Cited by 158
Control of apoptosis by IP3and ryanodine receptor driven calcium signals
Hajnóczky, G., Csordás, G., Madesh, M., & Pacher, P. (2000) · Cell Calcium · doi:10.1054/ceca.2000.0169 · Cited by 157
Molecular Cloning and Expression of the Type 1 and Type 2 Murine Receptors for Tumor Necrosis Factor
Goodwin, R. G., Anderson, D. M., Jerzy, R., Davis, T., Brannan, C. I., Copeland, N. G., Jenkins, N. A., & Smith, C. A. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.6.3020 · Cited by 155
Life and death decisions: regulation of apoptosis by proteolysis of signaling molecules
Utz, P. J., & Anderson, P. (2000) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400696 · Cited by 155
BÖRSCH-HAUBOLD, A. G., Kramer, R. M., & Watson, S. P. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.t01-1-00751.x · Cited by 154
Xu, H., Sethi, J. K., & Hotamışlıgil, G. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.37.26287 · Cited by 154
Min, W., & Pober, J. S. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.7.3508 · Cited by 151
Declercq, W., Denecker, G., Fiers, W. C., & Vandenabeele, P. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.1.390 · Cited by 145
Barbara, J. A., Smith, W., Gamble, J. R., Ostade, X. V., Vandenabeele, P., Tavernier, J. H., Fiers, W., Vadas, M. A., & Lopez, A. F. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06327.x · Cited by 143
Puls, A., Eliopoulos, A. G., Nobes, C. D., Bridges, T., Young, L. S., & Hall, A. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.17.2983 · Cited by 143
Gehr, G., Gentz, R., Brockhaus, M., Loetscher, H., & Lesslauer, W. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.3.911 · Cited by 142
Mühlenbeck, F., Haas, E., Schwenzer, R., Schubert, G., Grell, M., Smith, C. W., Scheurich, P., & Wajant, H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.49.33091 · Cited by 141
Gray, P. W., Barrett, K., Chantry, D., Turner, M., & Feldmann, M. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.19.7380 · Cited by 141
Research works printed but not linked: 39
- Hass, 1985, Fed Proc, 44, 1686
- Vitt, 1987, Fed Proc, 46, 2117
- Adam, 1996, J Inflammation, 47, 61
- Kreder, 1998, J Interferon Cytokine Res, 18, A-54
- Wyllie, 1997, Eur J Cell Biol, 73, 189
- Kinloch, 1999, TIPS, 20, 35
- Squier, 1996, Cell Death Differ, 3, 275
- Marquet, 1987, Immunobiology, 175, 54
- Beyaert, 1987, Immunobiology, 175, 3
- Clark, 1987, Fed Proc, 46, 1946
- Kronke, 1990, Lymphokine Res, 9, 549
- Pyne, 2000, Biochem J, 349, 385, 10.1042/bj3490385 · DOI
- Wu, 1998, Cancer Res, 58, 633
- Fiers, 1996, J Inflammation, 47, 67
- Bermudez, 1987, J Leukocyte Biol, 42, 598
- Matsubara, 1991, Immunology, 73, 457
- Davis, 1999, Cell Resp Stress, 1
- Nakada, 2001, Anticancer Res, 21, 167
- Kunz, 2001, Cell Growth Differ, 12, 137
- Wang, 2000, Arthritis Rheum, 43, 1989
- Hiraoka, 2001, Am J Physiol: Heart Circ Physiol, 280, H1861
- Totpal, 1992, Cancer Res, 52, 2557
- Mishra, 1994, Lymphokine Cytokine Res, 13, 77
- Peraldi, 1996, Diabetes, 45, 161
- Ermakova, 1999, Diabetologia, 42, 529
- Klein, 1994, Clin Res, 42, A331
- Scherzer, 1993, Clin Res, 41, A241
- Klein, 1992, Clin Res, 40, A745
- Yan, 2001, Cancer Res, 61, 963
- Hunter, 2001, FASEB J, 15, A163
- Bick, 1997, Am J Physiol: Heart Circ Physiol, 41, H1937
- Amrani, 1993, C R Acad Sci, Ser III, 316, 1489
- Amrani, 1996, Rev Mal Respir, 13, 539
- Grell, 1993, Lymphokine Cytokine Res, 12, 143
- Moosmayer, 1994, Lymphokine Cytokine Res, 13, 295
- Ledgerwood, 1999, Lab Invest, 79, 1041
- Vanderpoll, 1996, Blood, 88, 922
- Rothe, 1994, Circ Shock, 44, 51
- Aggarwal, 1993, Lymphokine Cytokine Res, 12, 149
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Metadata
- Authors
- MacEwan, D. J.
- Affiliations
- University of Aberdeen (GB)
- Corresponding author
- MacEwan, David J.
- ORCID
- MacEwan, David J.
- Venue
- Cellular Signalling
- Publisher
- Elsevier BV
- Published
- 2002-06
- Volume
- 14
- Issue
- 6
- Pages
- 477-492
- ISSN
- 0898-6568 (ISSN-L)
- OpenAlex
- W2069681479
- Cited by
- 610
- References
- 394
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 8 · 2023: 11 · 2022: 18 · 2021: 14 · 2020: 17 · 2019: 20 · 2018: 24 · 2017: 18 · 2016: 13 · 2015: 21 · 2014: 20 · 2013: 29 · 2012: 37
- FWCI
- 2.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cellular Signalling (publishedVersion)
- PubMed (publishedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- TNF-α, TNFR1, TNFR2, adaptor proteins, apoptosis, necrosis, transcription factors, G proteins, calcium homeostasis
- MeSH terms
- Animals, Models, Biological, Phospholipases, Phosphoprotein Phosphatases, Protein Kinases, Sphingomyelin Phosphodiesterase, Tumor Necrosis Factor-alpha, Signal Transduction, Antigens, CD, Receptors, Tumor Necrosis Factor, Caspases, Receptors, Tumor Necrosis Factor, Type I, Receptors, Tumor Necrosis Factor, Type II, Mice
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