Outcomes of continuous process improvement of a nutritional care program incorporating serum prealbumin measurements
Abstract
It has been reported that the risk of protein-calorie malnutrition (PCM) for hospitalized patient populations can be as high as 50%. Left undiagnosed. PCM can lead to serious consequences, including increased morbidity and mortality. Visceral protein albumin is the traditional laboratory indicator of PCM. In the past few years, however, several other visceral proteins have been lauded as superior markers. We undertook several studies to test the effectiveness of using one of these, prealbumin, as an aid in nutritional assessment. We found prealbumin to be a sensitive measure of nutritional status, allowing for earlier assessment and intervention, and thus reducing length of stay. Based on these findings, our hospital has generated and implemented a multidisciplinary nutrition care program that meets the 1995 Joint Commission on Accreditation of Healthcare Organizations Nutrition Care Standards. Prealbumin testing is an integral portion of this program; levels are determined on admission and repeated semi-weekly until discharge. Use of this program has led to improved patient care and financial benefit to the hospital.
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Renewed focus on the use of suitable biochemical markers of malnutrition resulted in the recommendation of serum transthyretin (prealbumin) as a more sensitive nutrition marker than albumin and transferrin due to its shorter half-life.
“Renewed focus on the use of suitable biochemical markers of malnutrition resulted in the recommendation of serum transthyretin, otherwise known as prealbumin, as a more sensitive nutrition marker than albumin and transferrin due to its shorter half-life (46).”
From Evolution of the diagnosis of malnutrition in adults: a primer for clinicians (2024) · cites this paper as [46]
Cites
Protein Status of General Surgical Patients
Bistrian, B. R. (1974) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1974.03240060028025 · Cited by 822 · see citing works
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The use of visceral proteins as nutrition markers: an ASPEN position paper
Evans, D. C., Corkins, M. R., Malone, A., Miller, S., Mogensen, K. M., Guenter, P., Jensen, G. L., & the ASPEN Malnutrition Committee (2021) · Nutrition in Clinical Practice · doi:10.1002/ncp.10588 · Cited by 589 · see citing works
Evolution of the diagnosis of malnutrition in adults: a primer for clinicians
Hegazi, R., Miller, A., & Sauer, A. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1169538 · Cited by 26 · see citing works
- Authors
- Mears, E.
- Affiliations
- Leonard J. Chabert Medical Center (US)
- Corresponding author
- Mears, Elia
- Venue
- Nutrition
- Publisher
- Elsevier BV
- Published
- 1996-07
- Volume
- 12
- Issue
- 7-8
- Pages
- 479-484
- ISSN
- 0899-9007 (ISSN-L)
- OpenAlex
- W2022000808
- Cited by
- 110
- References
- 1
- Citations by year
- 2025: 2 · 2024: 6 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 8 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 5 · 2013: 3 · 2012: 5
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Health Professions › Health Information Management › Dietetics, Nutrition, and Education
- Keywords
- prealbumin, protein-energy malnutrition, nutritional assessment, hospitalized patients, length of hospital stay, nutritional monitoring, process improvement, hospital nutrition services
- MeSH terms
- Adult, Hospitalization, Humans, Prealbumin, Protein-Energy Malnutrition, Risk Factors, Nutrition Assessment, Nutritional Support
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