The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology
Open accessAbstract
This review documents the changing perspectives on the function of fatty-acid synthase and fatty-acid synthesis in human tumor biology. With the recent discovery that human cancer cells express high levels of fatty-acid synthase and undergo significant endogenous fatty-acid synthesis, our understanding of the role of fatty acids in tumor biology is expanding. Once considered largely an anabolic-energy-storage pathway, fatty-acid synthesis is now associated with clinically aggressive tumor behavior and tumor-cell growth and survival and has become a novel target pathway for chemotherapy development. These findings will ultimately enhance our understanding of fatty acids in tumor biology and may provide new diagnostic and therapeutic moieties for patient care.
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Cites
Fatty acid synthase, a proficient multifunctional enzyme
Wakil, S. J. (1989) · Biochemistry · doi:10.1021/bi00437a001 · Cited by 820
Tumor Mitochondria and the Bioenergetics of Cancer Cells
Pedersen, P. L. (2015) · Progress in Tumor Research · doi:10.1159/000401202 · Cited by 711
Fatty acid synthesis: a potential selective target for antineoplastic therapy
Kuhajda, F. P., Jenner, K., Wood, F. D., Hennigar, R. A., Jacobs, L. B., Dick, J. D., & Pasternack, G. R. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.14.6379 · Cited by 705
Self-citationMOLECULAR GENETICS OF POLYKETIDES AND ITS COMPARISON TO FATTY ACID BIOSYNTHESIS
Hopwood, D. A., & Sherman, D. H. (1990) · Annual Review of Genetics · doi:10.1146/annurev.ge.24.120190.000345 · Cited by 684
Regulation of fatty acid biosynthesis in Escherichia coli
Magnuson, K. S., Jackowski, S., Rock, C. O., & Cronan, J. E. (1993) · Microbiological Reviews · doi:10.1128/mmbr.57.3.522-542.1993 · Cited by 654
�ber den Stoffwechsel der Carcinomzelle
Warburg, O. (1924) · Die Naturwissenschaften · doi:10.1007/bf01504608 · Cited by 631
The animal fatty acid synthase: one gene, one polypeptide, seven enzymes
Smith, S. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.15.8001737 · Cited by 598
The antibiotic cerulenin, a novel tool for biochemistry as an inhibitor of fatty acid synthesis
Omura, S. (1976) · Bacteriological Reviews · doi:10.1128/br.40.3.681-697.1976 · Cited by 493
Medes, G., Thomas, A. J., & Weinhouse, S. (1953) · PubMed · Cited by 405
Uber den Stoffwechsel der Karzinomezellen
Warburg, O. (1924) · Medical Entomology and Zoology · Cited by 402
Cited by
Aerobic glycolysis: Meeting the metabolic requirements of cell proliferation
Lunt, S. Y., & Vander Heiden, M. G. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154237 · Cited by 3,057
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Menendez, J. A., & Lupu, R. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2222 · Cited by 2,941
ATP citrate lyase inhibition can suppress tumor cell growth
Hatzivassiliou, G., Zhao, F., Bauer, D. E., Andreadis, C., Shaw, A. N., Dhanak, D., Hingorani, S. R., Tuveson, D. A., & Thompson, C. B. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.09.008 · Cited by 1,086
Factors affecting odd- and branched-chain fatty acids in milk: A review
Vlaeminck, B., Fievez, V., Cabrita, A. R. J., Fonseca, A. J. M., & Dewhurst, R. J. (2006) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2006.06.017 · Cited by 750
Kurhanewicz, J., Vigneron, D. B., Brindle, K., Chekmenev, E. Y., Comment, A., Cunningham, C. H., DeBerardinis, R. J., Green, G. G., Leach, M. O., Rajan, S. S., et al. (2011) · Neoplasia · doi:10.1593/neo.101102 · Cited by 681
Metadata
- Authors
- Kuhajda, F. P.
- Venue
- Nutrition
- Publisher
- Elsevier BV
- Published
- 2000-03
- Volume
- 16
- Issue
- 3
- Pages
- 202-208
- ISSN
- 0899-9007 (ISSN-L)
- OpenAlex
- W2093265805
- Cited by
- 788
- References
- 63
- FWCI
- 4.71
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
