ATP citrate lyase inhibition can suppress tumor cell growth
Open accessAbstract
Many tumors display a high rate of glucose utilization, as evidenced by 18-F-2-deoxyglucose PET imaging. One potential advantage of catabolizing glucose through glycolysis at a rate that exceeds bioenergetic need is that the growing cell can redirect the excess glycolytic end product pyruvate toward lipid synthesis. Such de novo lipid synthesis is necessary for membrane production and lipid-based posttranslational modification of proteins. A key enzyme linking glucose metabolism to lipid synthesis is ATP citrate lyase (ACL), which catalyzes the conversion of citrate to cytosolic acetyl-CoA. ACL inhibition by RNAi or the chemical inhibitor SB-204990 limits in vitro proliferation and survival of tumor cells displaying aerobic glycolysis. The same treatments also reduce in vivo tumor growth and induce differentiation.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Targeting ACLY genetically or chemically prevents xenograft tumor formation and proliferation.
“ACLY activity is elevated in cancers (Migita et al., 2008), and targeting ACLY genetically or chemically prevents xenograft tumor formation and proliferation (Adam et al., 2013; Bauer et al., 2005; Hatzivassiliou et al., 2005; Migita et al., 2008).”
From Targeting Metabolism for Cancer Therapy (2017) · cites this paper as Hatzivassiliou et al., 2005
Mitochondrial citrate controls anabolic reactions by directly acting as the carbon source for fatty acids, cholesterol and ketone bodies through ATP citrate lyase, and by allosteric modulation.
“Mitochondrial citrate controls anabolic reactions by directly acting as the carbon source for FAs, cholesterol and ketone bodies through ATP citrate lyase (ACLY),78 and by allosteric modulation.”
From The multifaceted contributions of mitochondria to cellular metabolism (2018) · cites this paper as [78]
In this model, mitochondrial citrate is formed from oxaloacetate and acetyl-CoA, exported to cytosol, and converted back to acetyl-CoA by ATP citrate lyase (ACL).
“In this model, mitochondrial citrate is formed from condensation of oxaloacetate and acetyl-CoA, after which citrate is exported from the mitochondrion to the cytosol and converted back to acetyl-CoA by ATP citrate lyase (ACL) (47).”
From Fueling Immunity: Insights into Metabolism and Lymphocyte Function (2013) · cites this paper as [47]
Cites
A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION
Bligh, E. G., & Dyer, W. J. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o59-099 · Cited by 54,751 · see citing works
(1975) · Journal of AOAC INTERNATIONAL · doi:10.1093/jaoac/58.5.1085 · Cited by 20,078 · see citing works
Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425 · see citing works
(1966) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(66)80573-4 · Cited by 4,287 · see citing works
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells
Druker, B. J., Tamura, S., Buchdunger, E., Ohno-Jones, S., Segal, G. M., Fanning, S., Zimmermann, J., & Lydon, N. (1996) · Nature Medicine · doi:10.1038/nm0596-561 · Cited by 3,618 · see citing works
Hingorani, S. R., Wang, L., Multani, A. S., Combs, C., Deramaudt, T. B., Hruban, R. H., Rustgi, A. K., Chang, S., & Tuveson, D. A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.04.023 · Cited by 2,609 · see citing works
Self-citationPreinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
Hingorani, S. R., Petricoin, E. F., Maitra, A., Rajapakse, V., King, C., Jacobetz, M. A., Ross, S., Conrads, T. P., Veenstra, T. D., Hitt, B. A., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00309-x · Cited by 2,471 · see citing works
Self-citationMolecular imaging of cancer with positron emission tomography
Gambhir, S. S. (2002) · Nature reviews. Cancer · doi:10.1038/nrc882 · Cited by 1,658 · see citing works
Growth factor regulation of autophagy and cell survival in the absence of apoptosis
Lum, J. J., Bauer, D. E., Kong, M., Harris, M. H., Li, C., Lindsten, T., & Thompson, C. B. (2005) · Cell · doi:10.1016/j.cell.2004.11.046 · Cited by 1,487 · see citing works
Self-citationAkt Stimulates Aerobic Glycolysis in Cancer Cells
Elstrom, R. L., Bauer, D. E., Buzzai, M., Karnauskas, R., Harris, M. H., Plas, D. R., Zhuang, H., Cinalli, R. M., Alavi, A., Rudin, C. M., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2904 · Cited by 1,454 · see citing works
Self-citationOncogenic alterations of metabolism
Dang, C. V., & Semenza, G. L. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01344-9 · Cited by 1,106 · see citing works
Observations on the carbohydrate metabolism of tumours
Crabtree, H. G. (1929) · Biochemical Journal · doi:10.1042/bj0230536 · Cited by 864 · see citing works
Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology
Kuhajda, F. P. (2000) · Nutrition · doi:10.1016/s0899-9007(99)00266-x · Cited by 789 · see citing works
Mansfield, K. D., Guzy, R. D., Pan, Y., Young, R. M., Cash, T. P., Schumacker, P. T., & Simon, M. C. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.003 · Cited by 606 · see citing works
Medes, G., Thomas, A. J., & Weinhouse, S. (1953) · PubMed · Cited by 405 · see citing works
Srere, P. A. (1959) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69735-2 · Cited by 394 · see citing works
The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes
Berwick, D. C., Hers, I., Heesom, K. J., Moule, S. K., & Tavareá, J. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204681200 · Cited by 383 · see citing works
Buzzai, M., Bauer, D. E., Jones, R. G., DeBerardinis, R. J., Hatzivassiliou, G., Elstrom, R. L., & Thompson, C. B. (2005) · Oncogene · doi:10.1038/sj.onc.1208622 · Cited by 357 · see citing works
Self-citationPlas, D. R., Talapatra, S., Edinger, A. L., Rathmell, J. C., & Thompson, C. B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010551200 · Cited by 308 · see citing works
Self-citationREGULATION OF THE EXPRESSION OF LIPOGENIC ENZYME GENES BY CARBOHYDRATE
Towle, H. C., Kaytor, E. N., & Shih, H. (1997) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.17.1.405 · Cited by 302 · see citing works
Deviant energetic metabolism of glycolytic cancer cells
Baggetto, L. G. (1992) · Biochimie · doi:10.1016/0300-9084(92)90016-8 · Cited by 268 · see citing works
Liver and adipose tissue contributions to newly formed fatty acids in an ascites tumor
Ookhtens, M., Kannan, R., Lyon, I., & Baker, N. (1984) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1984.247.1.r146 · Cited by 199 · see citing works
Nakashima, R. A., Paggi, M. G., & Pedersen, P. L. (1984) · PubMed · Cited by 190 · see citing works
Blum, R., Jacob‐Hirsch, J., Amariglio, N., Rechavi, G., & Kloog, Y. (2005) · Cancer Research · doi:10.1158/0008-5472.999.65.3 · Cited by 189 · see citing works
Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand
Bauer, D. E., Harris, M. H., Plas, D. R., Lum, J. J., Hammerman, P. S., Rathmell, J. C., Riley, J. L., & Thompson, C. B. (2004) · The FASEB Journal · doi:10.1096/fj.03-1001fje · Cited by 188 · see citing works
Self-citationBoren, J., Cascante, M., Marín, S., Comı́n-Anduix, B., Centelles, J. J., Lim, S. K., Bassilian, S., Ahmed, S. M., Lee, W. P., & Boros, L. G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105796200 · Cited by 182 · see citing works
Blum, R., Jacob‐Hirsch, J., Amariglio, N., Rechavi, G., & Kloog, Y. (2005) · PubMed · Cited by 178 · see citing works
Kaplan, R. S., Mayor, J. A., & Wood, D. O. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38701-0 · Cited by 167 · see citing works
Zambell, K. L., Fitch, M. D., & Fleming, S. E. (2003) · Journal of Nutrition · doi:10.1093/jn/133.11.3509 · Cited by 164 · see citing works
The role of ATP citrate-lyase in the metabolic regulation of plasma lipids
PEARCE, N. J., Yates, J. W., Berkhout, T. A., Jackson, B., Tew, D. G., Boyd, H., Camilleri, P., Sweeney, P. J., Gribble, A. D., Shaw, A. N., et al. (1998) · Biochemical Journal · doi:10.1042/bj3340113 · Cited by 144 · see citing works
Self-citationWang, H., Cai, Q., Zeng, X., Yu, D. S., Agrawal, S., & Zhang, R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.13989 · Cited by 133 · see citing works
Edinger, A. L., Cinalli, R. M., & Thompson, C. B. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00291-0 · Cited by 127 · see citing works
Self-citationTYROSINE KINASE INHIBITORS AND THE DAWN OF MOLECULAR CANCER THERAPEUTICS
Tibes, R., Trent, J. C., & Kurzrock, R. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.45.120403.100124 · Cited by 117 · see citing works
Sabine, J. R., Abraham, S., & Chaikoff, I. L. (1967) · PubMed · Cited by 116 · see citing works
Jackowski, S., Wang, J., & Baburina, I. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(99)00203-6 · Cited by 108 · see citing works
Szutowicz, A., Kwiatkowski, J., & Angielski, S. (1979) · British Journal of Cancer · doi:10.1038/bjc.1979.120 · Cited by 103 · see citing works
Shiotsu, Y., Neckers, L. Μ., Wortman, I. A., An, W. G., Schulte, T. W., Soga, S., Murakata, C., Tamaoki, T., & Akinaga, S. (2000) · Blood · doi:10.1182/blood.v96.6.2284 · Cited by 102 · see citing works
Involvement of p38 kinase in hydroxyurea-induced differentiation of K562 cells.
Park, J. I., Choi, H.-K., Jeong, J., Han, J. Y., & Kim, I. H. (2001) · PubMed · Cited by 99 · see citing works
Turyn, J., Schlichtholz, B., Dettlaff‐Pokora, A., Presler, M., Goyke, E., Matuszewski, M., Kmieć, Z., Krajka, K., & Świerczyński, J. (2003) · Hormone and Metabolic Research · doi:10.1055/s-2003-43500 · Cited by 92 · see citing works
Acetyl-coenzyme A synthetase is a lipogenic enzyme controlled by SREBP-1 and energy status
Sone, H., Shimano, H., Sakakura, Y., Inoue, N., Amemiya-Kudo, M., Yahagi, N., Osawa, M., Suzuki, H., Yokoo, T., Takahashi, A., et al. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00189.2001 · Cited by 80 · see citing works
Srere, P. A., & Bhaduri, A. (1964) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)51645-8 · Cited by 79 · see citing works
The Stable Isotope-based Dynamic Metabolic Profile of Butyrate-induced HT29 Cell Differentiation
Boren, J., Lee, W.-N. P., Bassilian, S., Centelles, J. J., Lim, S., Ahmed, S., Boros, L. G., & Cascante, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302932200 · Cited by 78 · see citing works
CoA cycling: An enzymatic amplification method for determination of CoASH and acetyl CoA
Kato, T. (1975) · Analytical Biochemistry · doi:10.1016/0003-2697(75)90605-3 · Cited by 56 · see citing works
Shara, M., Ohia, S. E., Yasmin, T., et al. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/a:1027358106407 · Cited by 55 · see citing works
Jiang, Y., Rom, W. N., Yie, T.-A., X, C., & Tchou-Wong, K.-M. (1999) · Oncogene · doi:10.1038/sj.onc.1202984 · Cited by 49 · see citing works
Different roles of p38 MAPK and ERK in STI571‐induced multi‐lineage differentiation of K562 cells
Kohmura, K., Miyakawa, Y., Kawai, Y., Ikeda, Y., & Kizaki, M. (2003) · Journal of Cellular Physiology · doi:10.1002/jcp.10426 · Cited by 47 · see citing works
Mitchell, C. E., Belinsky, S. A., & Lechner, J. F. (1995) · Analytical Biochemistry · doi:10.1006/abio.1995.1020 · Cited by 42 · see citing works
Seeking a Home for a PET, Part 3
Detterbeck, F. C., Vansteenkiste, J., Morris, D. E., et al. (2004) · CHEST Journal · doi:10.1378/chest.126.5.1656 · Cited by 33 · see citing works
Katz, N., & Giffhorn, S. (1983) · Biochemical Journal · doi:10.1042/bj2120065 · Cited by 21 · see citing works
Hydroxycitrate causes altered pyruvate metabolism by tumorigenic cells
Mary Board, & Newsholme, E. A. (1996) · IUBMB Life · doi:10.1080/15216549600201683 · Cited by 16 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197 · see citing works
Self-citationThe Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.002 · Cited by 4,088 · see citing works
Self-citationMetabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
Ward, P. S., & Thompson, C. B. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.014 · Cited by 3,233 · see citing works
Self-citationAerobic glycolysis: Meeting the metabolic requirements of cell proliferation
Lunt, S. Y., & Vander Heiden, M. G. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154237 · Cited by 3,057 · see citing works
Mitochondrial TCA cycle metabolites control physiology and disease
Martínez-Reyes, I., & Chandel, N. S. (2020) · Nature Communications · doi:10.1038/s41467-019-13668-3 · Cited by 2,813 · see citing works
DeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709747104 · Cited by 2,622 · see citing works
Self-citationCancer cell metabolism: warburg and beyond
Hsu, P. P., & Sabatini, D. M. (2008) · Cell · doi:10.1016/j.cell.2008.08.021 · Cited by 2,452 · see citing works
ATP-citrate lyase links cellular metabolism to histone acetylation
Wellen, K. E., Hatzivassiliou, G., Sachdeva, U. M., Bui, T. V., Cross, J. R., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1164097 · Cited by 2,298 · see citing works
Self-citationCellular Fatty Acid Metabolism and Cancer
Currie, E., Schulze, A., Zechner, R., Walther, T. C., & Farese, R. V. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.05.017 · Cited by 2,123 · see citing works
The multifaceted contributions of mitochondria to cellular metabolism
Spinelli, J. B., & Haigis, M. C. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0124-1 · Cited by 1,935 · see citing works
Glutamine addiction: a new therapeutic target in cancer
Wise, D. R., & Thompson, C. B. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.05.003 · Cited by 1,770 · see citing works
Self-citationReductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
Metallo, C. M., Gameiro, P. A., Bell, E. L., Mattaini, K. R., Yang, J., Hiller, K., Jewell, C. M., Johnson, Z. R., Irvine, D. J., Guarente, L., et al. (2012) · Nature · doi:10.1038/nature10602 · Cited by 1,791 · see citing works
Hypoxia, HIF1 and glucose metabolism in the solid tumour
Denko, N. C. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2468 · Cited by 1,707 · see citing works
The multifaceted roles of fatty acid synthesis in cancer
Röhrig, F., & Schulze, A. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.89 · Cited by 1,651 · see citing works
Cancer metabolism: a therapeutic perspective
Martinez-Outschoorn, U. E., Peiris-Pagés, M., Pestell, R. G., Sotgia, F., & Lisanti, M. P. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.60 · Cited by 1,505 · see citing works
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
Porstmann, T., Santos, C. R., Griffiths, B., Cully, M., Wu, M., Leevers, S., Griffiths, J. R., Chung, Y.-L., & Schulze, A. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.07.007 · Cited by 1,413 · see citing works
Fueling Immunity: Insights into Metabolism and Lymphocyte Function
Pearce, E. L., Poffenberger, M. C., Chang, C.-H., & Jones, R. G. (2013) · Science · doi:10.1126/science.1242454 · Cited by 1,363 · see citing works
AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress
Jeon, S.-M., Chandel, N. S., & Hay, N. (2012) · Nature · doi:10.1038/nature11066 · Cited by 1,132 · see citing works
Tumor suppressors and cell metabolism: a recipe for cancer growth
Jones, R. G., & Thompson, C. B. (2009) · Genes & Development · doi:10.1101/gad.1756509 · Cited by 1,085 · see citing works
Self-citationEverts, B., Amiel, E., Huang, S. C.-C., Smith, A. M., Chang, C.-H., Lam, W. Y., Redmann, V., Freitas, T. C., Blagih, J., van der Windt, G. J. W., et al. (2014) · Nature Immunology · doi:10.1038/ni.2833 · Cited by 1,064 · see citing works
Brick by brick: metabolism and tumor cell growth
DeBerardinis, R. J., Sayed, N., Ditsworth, D., & Thompson, C. B. (2008) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2008.02.003 · Cited by 1,018 · see citing works
Self-citationTargeting Metabolism for Cancer Therapy
Luengo, A., Gui, D. Y., & Vander Heiden, M. G. (2017) · Cell Chemical Biology · doi:10.1016/j.chembiol.2017.08.028 · Cited by 971 · see citing works
Pyruvate kinase M2 is a phosphotyrosine-binding protein
Christofk, H. R., Vander Heiden, M. G., Wu, N., Asara, J. M., & Cantley, L. C. (2008) · Nature · doi:10.1038/nature06667 · Cited by 995 · see citing works
Wise, D. R., Ward, P. S., Shay, J. E. S., Cross, J. R., Gruber, J. J., Sachdeva, U. M., Platt, J. M., DeMatteo, R. G., Simon, M. C., & Thompson, C. B. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117773108 · Cited by 975 · see citing works
Self-citationSchug, Z. T., Peck, B., Jones, D. T., Zhang, Q., Grosskurth, S., Alam, I. S., Goodwin, L. M., Smethurst, E., Mason, S., Blyth, K., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2014.12.002 · Cited by 820 · see citing works
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
Anastasiou, D., Yu, Y., Israelsen, W. J., Jiang, J.-K., Boxer, M. B., Hong, B. S., Tempel, W., Dimov, S., Shen, M., Jha, A., et al. (2012) · Nature Chemical Biology · doi:10.1038/nchembio.1060 · Cited by 816 · see citing works
O’Sullivan, D., van der Windt, G. J. W., Huang, S. C.-C., Curtis, J. D., Chang, C.-H., Buck, M. D., Qiu, J., Smith, A. M., Lam, W. Y., DiPlato, L. M., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.005 · Cited by 790 · see citing works
Kurhanewicz, J., Vigneron, D. B., Brindle, K., Chekmenev, E. Y., Comment, A., Cunningham, C. H., DeBerardinis, R. J., Green, G. G., Leach, M. O., Rajan, S. S., et al. (2011) · Neoplasia · doi:10.1593/neo.101102 · Cited by 681 · see citing works
Serine is an essential metabolite for effector T cell expansion
Ma, E. H., Bantug, G., Griss, T., Condotta, S., Johnson, R. M., Samborska, B., Mainolfi, N., Suri, V., Guak, H., Balmer, M. L., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2016.12.011 · Cited by 657 · see citing works
Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation
Lee, J. V., Carrer, A., Shah, S., Snyder, N. W., Wei, S., Venneti, S., Worth, A. J., Yuan, Z.-F., Lim, H.-W., Liu, S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.06.004 · Cited by 563 · see citing works
Xie, H., Hanai, J.-I., Ren, J.-G., Kats, L., Burgess, K., Bhargava, P., Signoretti, S., Billiard, J., Duffy, K. J., Grant, A., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.003 · Cited by 516 · see citing works
A two-way street: reciprocal regulation of metabolism and signalling
Wellen, K. E., & Thompson, C. B. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3305 · Cited by 528 · see citing works
Self-citationRegulation and function of the mammalian tricarboxylic acid cycle
Arnold, P. K., & Finley, L. W. S. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102838 · Cited by 535 · see citing works
“Citrate efflux from mitochondria has since been found to be a major process in some cancers, for example, cholesterol-rich rat hepatomas and and immune cells (38, 119, 120).”
BackgroundCellular Metabolic Stress: Considering How Cells Respond to Nutrient Excess
Wellen, K. E., & Thompson, C. B. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.10.004 · Cited by 486 · see citing works
Self-citationGuo, D., Reinitz, F., Youssef, M., Hong, C., Nathanson, D., Akhavan, D., Kuga, D., Amzajerdi, A. N., Soto, H., Zhu, S., et al. (2011) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0102 · Cited by 452 · see citing works
Lum, J. J., Bui, T., Gruber, M., Gordan, J. D., DeBerardinis, R. J., Covello, K. L., Simon, M. C., & Thompson, C. B. (2007) · Genes & Development · doi:10.1101/gad.1529107 · Cited by 429 · see citing works
Self-citationATP citrate lyase: activation and therapeutic implications in non-small cell lung cancer
Migita, T., Narita, T., Nomura, K., Miyagi, E., Inazuka, F., Matsuura, M., Ushijima, M., Mashima, T., Seimiya, H., Satoh, Y., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1235 · Cited by 403 · see citing works
Mitochondria as biosynthetic factories for cancer proliferation
Ahn, C. S., & Metallo, C. M. (2015) · Cancer & Metabolism · doi:10.1186/s40170-015-0128-2 · Cited by 399 · see citing works
ATP-citrate lyase controls a glucose-to-acetate metabolic switch
Zhao, S., Torres, A., Henry, R. A., Trefely, S., Wallace, M., Lee, J. V., Carrer, A., Sengupta, A., Campbell, S. L., Kuo, Y.-M., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.09.069 · Cited by 394 · see citing works
Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth
Lin, R., Tao, R., Gao, X., Li, T., Zhou, X., Guan, K.-L., Xiong, Y., & Lei, Q.-Y. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.07.002 · Cited by 384 · see citing works
Cancer metabolism: current perspectives and future directions
Muñoz-Pinedo, C., El Mjiyad, N., & Ricci, J.-E. (2012) · Cell Death & Disease · doi:10.1038/cddis.2011.123 · Cited by 385 · see citing works
Pan, M., Reid, M. A., Lowman, X. H., Kulkarni, R. P., Tran, T. Q., Liu, X., Yang, Y., Hernandez-Davies, J. E., Rosales, K. K., Li, H., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3410 · Cited by 368 · see citing works
The molecular determinants of de novo nucleotide biosynthesis in cancer cells
Tong, X., Zhao, F., & Thompson, C. B. (2009) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2009.01.002 · Cited by 351 · see citing works
Self-citationAcetyl-CoA Carboxylase α Is Essential to Breast Cancer Cell Survival
Chajès, V., Cambot, M., Moreau, K., Lenoir, G. M., & Joulin, V. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1489 · Cited by 347 · see citing works
Revving the Engine: Signal Transduction Fuels T Cell Activation
Jones, R. G., & Thompson, C. B. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.008 · Cited by 349 · see citing works
Self-citationThe metabolic fate of acetate in cancer
Schug, Z. T., Vande Voorde, J., & Gottlieb, E. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.87 · Cited by 331 · see citing works
Acetyl-CoA metabolism in cancer
Guertin, D. A., & Wellen, K. E. (2023) · Nature Reviews Cancer · doi:10.1038/s41568-022-00543-5 · Cited by 303 · see citing works
A non-canonical tricarboxylic acid cycle underlies cellular identity
Arnold, P. K., Jackson, B. T., Paras, K. I., Brunner, J. S., Hart, M. L., Newsom, O. J., Alibeckoff, S. P., Endress, J., Drill, E., Sullivan, L. B., et al. (2022) · Nature · doi:10.1038/s41586-022-04475-w · Cited by 304 · see citing works
Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination
Sivanand, S., Rhoades, S., Jiang, Q., Lee, J. V., Benci, J., Zhang, J., Yuan, S., Viney, I., Zhao, S., Carrer, A., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.06.008 · Cited by 295 · see citing works
Grassian, A. R., Parker, S. J., Davidson, S. M., Divakaruni, A. S., Green, C. R., Zhang, X., Slocum, K. L., Pu, M., Lin, F., Vickers, C., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0772-t · Cited by 280 · see citing works
Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells
Metallo, C. M., Walther, J. L., & Stephanopoulos, G. (2009) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2009.07.010 · Cited by 280 · see citing works
Loss of the Tumor Suppressor LKB1 Promotes Metabolic Reprogramming of Cancer Cells via HIF-1α
Faubert, B., Vincent, E. E., Griss, T., Samborska, B., Izreig, S., Svensson, R. U., Mamer, O. A., Avizonis, D., Shackelford, D. B., Shaw, R. J., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312570111 · Cited by 278 · see citing works
UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis
Moon, J.-S., Lee, S., Park, M.-A., Siempos, I. I., Haslip, M., Lee, P. J., Yun, M., Kim, C. K., Howrylak, J., Ryter, S. W., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78253 · Cited by 238 · see citing works
RetractedMetabolic catastrophe as a means to cancer cell death
Jin, S., DiPaola, R. S., Mathew, R., & White, E. (2007) · Journal of Cell Science · doi:10.1242/jcs.03349 · Cited by 229 · see citing works
Zhao, F., Mancuso, A., Bui, T. V., Tong, X., Gruber, J. J., Swider, C. R., Sanchez, P. V., Lum, J. J., Sayed, N., Melo, J. V., et al. (2010) · Oncogene · doi:10.1038/onc.2010.67 · Cited by 179 · see citing works
Self-citationOncogene-Directed Alterations in Cancer Cell Metabolism
Nagarajan, A., Malvi, P., & Wajapeyee, N. (2016) · Trends in Cancer · doi:10.1016/j.trecan.2016.06.002 · Cited by 169 · see citing works
Glucose-dependent de Novo Lipogenesis in B Lymphocytes
Dufort, F. J., Gumina, M. R., Ta, N. L., Tao, Y., Heyse, S. A., Scott, D. A., Richardson, A. D., Seyfried, T. N., & Chiles, T. C. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.551051 · Cited by 160 · see citing works
Williams, J. B., Pang, D., Delgado, B., Kocherginsky, M., Tretiakova, M., Krausz, T., Pan, D., He, J., McClintock, M. K., & Conzen, S. D. (2009) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-08-0238 · Cited by 137 · see citing works
Obre, E., & Rossignol, R. (2015) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2014.12.008 · Cited by 137 · see citing works
Altered energy metabolism in cancer: A unique opportunity for therapeutic intervention
Zhang, Y., & Yang, J.-M. (2013) · Cancer Biology & Therapy · doi:10.4161/cbt.22958 · Cited by 132 · see citing works
ATP Citrate Lyase Improves Mitochondrial Function in Skeletal Muscle
Das, S., Morvan, F., Jourde, B., Meier, V., Kahle, P., Brebbia, P., Toussaint, G., Glass, D. J., & Fornaro, M. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.006 · Cited by 91 · see citing works
ATP-citrate lyase: genetics, molecular biology and therapeutic target for dyslipidemia
Burke, A. C., & Huff, M. W. (2017) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000390 · Cited by 91 · see citing works
Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited
Li, Z., Ji, B. W., Dixit, P. D., Tchourine, K., Lien, E. C., Hosios, A. M., Abbott, K. L., Rutter, J. C., Westermark, A. M., Gorodetsky, E. F., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00588-8 · Cited by 81 · see citing works
Acetyl-CoA metabolism as a therapeutic target for cancer
Chen, G., Bao, B., Cheng, Y., Tian, M., Song, J., Zheng, L., & Tong, Q. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115741 · Cited by 54 · see citing works
Tumor metabolic reprogramming in lung cancer progression (Review)
Li, X., Liu, M., Liu, H., & Chen, J. (2022) · Oncology Letters · doi:10.3892/ol.2022.13407 · Cited by 52 · see citing works
Osinalde, N., Mitxelena, J., Sánchez-Quiles, V., Akimov, V., Aloria, K., Arizmendi, J. M., Zubiaga, A. M., Blagoev, B., & Kratchmarova, I. (2016) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m115.057158 · Cited by 48 · see citing works
Glucose-sensitive acetylation of Seryl tRNA synthetase regulates lipid synthesis in breast cancer
Zhao, J., Bai, H., Li, X., Yan, J., Zou, G., Wang, L., Li, X., Liu, Z., Xiang, R., Yang, X.-L., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00714-0 · Cited by 27 · see citing works
Acetyl-CoA: an interplay between metabolism and epigenetics in cancer
Hao, Y., Yi, Q., XiaoWu, X., WeiBo, C., GuangChen, Z., & XueMin, C. (2022) · Frontiers in Molecular Medicine · doi:10.3389/fmmed.2022.1044585 · Cited by 26 · see citing works
Solomon, L. A., Podder, S., He, J., Jackson-Chornenki, N. L., Gibson, K., Ziliotto, R. G., Rhee, J., & DeKoter, R. P. (2017) · Molecular and Cellular Biology · doi:10.1128/mcb.00013-17 · Cited by 22 · see citing works
- Authors
- Hatzivassiliou, G., Zhao, F., Bauer, D. E., Andreadis, C., Shaw, A. N., Dhanak, D., Hingorani, S. R., Tuveson, D. A., & Thompson, C. B.
- Affiliations
- University of Pennsylvania (US)
- Abramson Cancer Center (US)
- GlaxoSmithKline (United States) (US)
- Corresponding author
- Thompson, Craig B.
- ORCID
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2005-10
- Volume
- 8
- Issue
- 4
- Pages
- 311-321
- ISSN
- 1535-6108 (ISSN-L)
- OpenAlex
- W2086546138
- Cited by
- 1,086
- References
- 50
- Citations by year
- 2026: 34 · 2025: 35 · 2024: 76 · 2023: 59 · 2022: 93 · 2021: 79 · 2020: 55 · 2019: 60 · 2018: 59 · 2017: 49 · 2016: 54 · 2015: 60 · 2014: 65 · 2013: 52 · 2012: 63
- FWCI
- 7.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Damon Runyon Cancer Research Foundation
- National Institutes of Health (DRG-1714-02)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- ATP citrate lyase, tumor cell proliferation, aerobic glycolysis, glucose metabolism, lipogenesis, acetyl-CoA, tumor differentiation, tumor growth inhibition
- MeSH terms
- ATP Citrate (pro-S)-Lyase, Base Sequence, Cell Differentiation, Cell Division, Enzyme Inhibitors, Homeostasis, Humans, Lactones, Mitochondria, Neoplasms, DNA Primers, RNA, Small Interfering, Cell Line, Tumor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
