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24-Hour motor activity after treatment with imipramine or fluvoxamine in major depressive disorder
Abstract
Psychomotor dysfunction in depression is related to alterations in the 24-h pattern of motor activity. After antidepressant treatment the diurnal pattern may be changed due to improvement of clinical state or pharmacological actions. The purpose of this study was to evaluate in 52 depressed in-patients the effects of imipramine (tricyclic antidepressant) and fluvoxamine (SSRI) on the 24-h motor activity. Motor activity was monitored by wrist-actigraphy during a medication-free period and after 4 weeks of treatment. Clinical improvement was not different after imipramine or fluvoxamine treatment. The Hamilton depression score decreased in patients treated with imipramine, as well as in patients treated with fluvoxamine. The clinical retardation score was also reduced in both treatment groups. However, patients treated with imipramine showed higher motor activity levels during the wake period in comparison to the medication-free period, and more fragmentation of motor activity during sleep. Treatment with fluvoxamine did not result in alterations in the 24-h pattern of motor activity. The improvement of depressive mood and retardation seems to play a minor role in the change of the pattern of motor activity after imipramine.
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In depressed patients, imipramine caused more fragmentation of motor activity during sleep than fluvoxamine.
“IMI more fragmentation of motor activity during sleep (p<.05) than FLUV”
From Antidepressants and their effect on sleep (2005) · cites this paper as Volkers, 2002
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Metadata
- Authors
- Volkers, A.
- Affiliations
- Erasmus MC (NL)
- Corresponding author
- Volkers, A
- Venue
- European Neuropsychopharmacology
- Publisher
- Elsevier BV
- Published
- 2002-08
- Volume
- 12
- Issue
- 4
- Pages
- 273-278
- ISSN
- 0924-977X (ISSN-L)
- OpenAlex
- W2044926299
- Cited by
- 56
- References
- 0
- Citations by year
- 2026: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 4 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 3 · 2012: 4
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- major depressive disorder, motor activity, 24-hour activity patterns, imipramine, fluvoxamine, antidepressant effects, psychomotor retardation, actigraphy, diurnal cycle, tricyclic antidepressants, selective serotonin reuptake inhibitors
- MeSH terms
- Adult, Antidepressive Agents, Major Depressive Disorder, Female, Humans, Imipramine, Male, Middle Aged, Motor Activity, Time Factors, Fluvoxamine
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