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Cited by 5Stress Responses and CortisolEstrogen and related hormone effectsTreatment of Major Depression

P.1.155 Steroid-independent translocation of the glucocorticoid receptor by the antidepressant, desipramine

Pariante, C.M., Pearce, B.D., Pisell, T.L., Owens, M.J., Miller, A.H.·1997·European Neuropsychopharmacology
DOI 10.1016/s0924-977x(97)88604-x
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  • Antidepressants like desipramine stimulate glucocorticoid receptor translocation from the cytoplasm to the nucleus and increase GR-mediated gene transcription, which promotes feedback inhibition mediated by glucocorticoids in the HPA axis.

    “Moreover, antidepressants like desipramine stimulate GR translocation from the cytoplasm to the nucleus and increase GR-mediated gene transcription, which eventually promotes the feedback inhibition that is mediated by glucocorticoids in the HPA axis[40].”

    From Neuroinflammation and cytokine abnormality in major depression: cause or consequence in that illness? (2016) · cites this paper as [40]

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Authors
Pariante, C. M., Pearce, B. D., Pisell, T. L., Owens, M. J., & Miller, A. H.
ORCID
Venue
European Neuropsychopharmacology
Publisher
Elsevier BV
Published
1997-09
Volume
7
Pages
S184
ISSN
0924-977X (ISSN-L)
DOI
10.1016/s0924-977x(97)88604-x
OpenAlex
W2147906713
Cited by
5
References
0
Citations by year
2025: 1 · 2016: 1 · 2015: 1
FWCI
0.20
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
European Neuropsychopharmacology (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
glucocorticoid receptor, desipramine, antidepressants, receptor translocation, antidepressant mechanism

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