The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
A gradient of cytoplasmic Cactus degradation establishes the nuclear localization gradient of the dorsal morphogen in Drosophila
Open accessAbstract
Dorsoventral axis formation in the Drosophila embryo is established by a signal transduction pathway that comprises the products of at least 12 maternal genes. Two of these genes, dorsal and cactus, show homology to the mammalian transcription factor NF-kappa B and its inhibitor I kappa B, respectively. As in the case for I kappa B and NF-kappa B, Cactus inhibits Dorsal by retaining it in the cytoplasm. In response to the signal produced and transmitted by the products of the other genes, Dorsal translocates to the nucleus preferentially on the ventral side of the embryo. Here, we show that Cactus forms a cytoplasmic concentration gradient inversely correlated to the nuclear translocation gradient of Dorsal. Deletions of the N-terminus and C-terminus of Cactus reveal that two modes of degradation control cactus activity: signal-induced degradation and signal-independent degradation, respectively. Genetic evidence indicates that degradation of Cactus is required, but not sufficient to translocates Dorsal completely into the nucleus.
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“Toll signaling likely potentiates Dorsal nuclear translocation in a Cactus-independent manner, as even in cactus mutants, Dorsal is not fully nuclear on the dorsal side of the embryo”
From Graded dorsal and differential gene regulation in the Drosophila embryo. (2009) · cites this paper as Bergmann et al. 1996
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Toll receptors in innate immunity.
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Metadata
- Authors
- Bergmann, A., Stein, D., Geisler, R., Hagenmaier, S., Schmid, B., Fernandez, N., Schnell, B., & Nüsslein-Volhard, C.
- Affiliations
- Max Planck Institute for Developmental Biology (DE)
- Albert Einstein College of Medicine (US)
- Corresponding author
- Bergmann, Andreas
- Venue
- Mechanisms of Development
- Publisher
- Elsevier BV
- Published
- 1996-11
- Volume
- 60
- Issue
- 1
- Pages
- 109-123
- ISSN
- 0925-4773 (ISSN-L)
- OpenAlex
- W2057381460
- Cited by
- 119
- References
- 53
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2022: 3 · 2021: 6 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 2 · 2015: 4 · 2014: 4 · 2013: 3 · 2012: 3
- FWCI
- 2.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Mechanisms of Development (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- cactus, Dorsal, cytoplasmic degradation, NF-κB, IκB, maternal genes, Drosophila embryo, protein degradation
- MeSH terms
- Animals, Cell Nucleus, Cytoplasm, DNA-Binding Proteins, Drosophila, Immunohistochemistry, Membrane Glycoproteins, Mutation, Nuclear Proteins, Phosphoproteins, Receptors, Cell Surface, Transcription Factors, Genes, Insect, Sequence Deletion, In Situ Hybridization, Gene Expression Regulation, Developmental, Insect Proteins, Body Patterning, Drosophila Proteins, Toll-Like Receptors
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