Developmental expression pattern of Stra6, a retinoic acid-responsive gene encoding a new type of membrane protein
Open accessAbstract
Retinoic acid plays important roles in development, growth and differentiation by regulating the expression of target genes. A new retinoic acid-inducible gene, Stra6, has been identified in P19 embryonal carcinoma cells using a subtractive hybridization cDNA cloning technique. Stra6 codes for a very hydrophobic membrane protein of a new type, which does not display similarities with previously characterized integral membrane proteins. Stra6, which exhibits a specific pattern of expression during development and in the adult, is strongly expressed at the level of blood-organ barriers. Interestingly, in testis Sertoli cells, Stra6 has a spermatogenic cycle-dependent expression which is lost in testes of RAR alpha null mutants where Stra6 is expressed in all tubules. We suggest that the Stra6 protein may be a component of an as yet unidentified transport machinery.
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STRA6 is expressed in numerous tissues involved in or dependent on retinoid metabolism, with the exception of liver and adipocytes.
“This integral membrane protein is expressed in numerous tissues known to be involved or dependent on retinoid metabolism with the exception of liver and adipocytes [69,72].”
From Molecular Basis for Vitamin A Uptake and Storage in Vertebrates (2016) · cites this paper as [72]
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“This integral membrane protein is expressed in numerous tissues known to be involved or dependent on retinoid metabolism with the exception of liver and adipocytes [69,72].”
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“Again, STRA6 and RBPR2 share expression within the kidney, with mutually exclusive expression in all other organ systems [27,32,36,37].”
BackgroundInfluential
- Authors
- Bouillet, P., Sapin, V., Chazaud, C., Messaddeq, N., Décimo, D., Dollé, P., & Chambon, P.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Chambon, Pierre
- ORCID
- Venue
- Mechanisms of Development
- Publisher
- Elsevier BV
- Published
- 1997-05
- Volume
- 63
- Issue
- 2
- Pages
- 173-186
- ISSN
- 0925-4773 (ISSN-L)
- OpenAlex
- W2070421130
- Cited by
- 209
- References
- 1
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 7 · 2023: 5 · 2022: 7 · 2021: 16 · 2020: 14 · 2019: 12 · 2018: 3 · 2017: 7 · 2016: 13 · 2015: 11 · 2014: 10 · 2013: 14 · 2012: 11
- FWCI
- 0.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Mechanisms of Development (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Bristol-Myers Squibb
- Association pour la Recherche sur le Cancer
- Institut National de la Santé et de la Recherche Médicale
- Fondation pour la Recherche Médicale
- Centre National de la Recherche Scientifique
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- STRA6, retinoic acid, retinoic acid receptor alpha, membrane proteins, developmental gene expression, Sertoli cells, spermatogenesis, transport equipment, P19 embryonal carcinoma cells
- MeSH terms
- Retinoic Acid Receptor alpha, Amino Acid Sequence, Animals, Base Sequence, Choroid Plexus, Cloning, Molecular, Male, Membrane Proteins, Molecular Sequence Data, Pigment Epithelium of Eye, Placenta, Sertoli Cells, Time Factors, Tissue Distribution, Transcription Factors, Tretinoin, Tumor Cells, Cultured, Yolk Sac, In Situ Hybridization, Receptors, Retinoic Acid, Carcinoma, Embryonal, Mice, Knockout, Gene Expression Regulation, Developmental, Retinoid X Receptors, Mice
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