Enzymology of retinoic acid biosynthesis and degradation
Open accessAbstract
All-trans-retinoic acid is a biologically active derivative of vitamin A that regulates numerous physiological processes. The concentration of retinoic acid in the cells is tightly regulated, but the exact mechanisms responsible for this regulation are not completely understood, largely because the enzymes involved in the biosynthesis of retinoic acid have not been fully defined. Recent studies using in vitro and in vivo models suggest that several members of the short-chain dehydrogenase/reductase superfamily of proteins are essential for retinoic acid biosynthesis and the maintenance of retinoic acid homeostasis. However, the exact roles of some of these recently identified enzymes are yet to be characterized. The properties of the known contributors to retinoid metabolism have now been better defined and allow for more detailed understanding of their interactions with retinoid-binding proteins and other retinoid enzymes. At the same time, further studies are needed to clarify the interactions between the cytoplasmic and membrane-bound proteins involved in the processing of hydrophobic retinoid metabolites. This review summarizes current knowledge about the roles of various biosynthetic and catabolic enzymes in the regulation of retinoic acid homeostasis and outlines the remaining questions in the field.
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With the exception of vision, the physiological actions of vitamin A are mediated by its bioactive metabolite, retinoic acid.
“With the exception of vision, the physiological actions of vitamin A are mediated by its bioactive metabolite, retinoic acid [8,9,10].”
From Molecular Basis for Vitamin A Uptake and Storage in Vertebrates (2016) · cites this paper as [9]
Cites
The retinoids—Biology, chemistry and medicine
(1996) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(97)80793-5 · Cited by 1,188 · see citing works
Embryonic retinoic acid synthesis is essential for early mouse post-implantation development
Niederreither, K., Subbarayan, V., Dollé, P., & Chambon, P. (1999) · Nature Genetics · doi:10.1038/7788 · Cited by 1,111 · see citing works
The Retinoids-Biology, Chemistry and Medicine
Wolf, G. (1994) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/60.5.796a · Cited by 1,005 · see citing works
Kavanagh, K. L., Jörnvall, H., Persson, B., & Oppermann, U. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8588-y · Cited by 908 · see citing works
Retinoic acid in the development, regeneration and maintenance of the nervous system
Maden, M. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2212 · Cited by 896 · see citing works
Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily
Marchitti, S. A., Brocker, C. N., Stagos, D., & Vasiliou, V. (2008) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.4.6.697 · Cited by 806 · see citing works
Schug, T. T., Berry, D. C., Shaw, N. S., Travis, S. N., & Noy, N. (2007) · Cell · doi:10.1016/j.cell.2007.02.050 · Cited by 680 · see citing works
PENNING, T. M., BURCZYNSKI, M. E., JEZ, J. M., HUNG, C.-F., LIN, H.-K., MA, H., MOORE, M., PALACKAL, N., & RATNAM, K. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3510067 · Cited by 649 · see citing works
PENNING, T. M., BURCZYNSKI, M. E., JEZ, J. M., HUNG, C.-F., LIN, H.-K., MA, H., MOORE, M., PALACKAL, N., & RATNAM, K. (2000) · Biochemical Journal · doi:10.1042/bj3510067 · Cited by 649 · see citing works
Vitamin A in Health and Disease
Blomhoff, R. (1994) · CRC Press eBooks · doi:10.1201/9781482277562 · Cited by 597 · see citing works
Mark, M. P., Ghyselinck, N. B., & Chambon, P. (2005) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.46.120604.141156 · Cited by 596 · see citing works
Abu–Abed, S., Dollé, P., METZGER, D., Beckett, B., Chambon, P., & Petkovich, M. P. (2001) · Genes & Development · doi:10.1101/gad.855001 · Cited by 572 · see citing works
The redox state of free nicotinamide-adenine dinucleotide phosphate in the cytoplasm of rat liver
Veech, R. L., Eggleston, L. V., & Krebs, H. A. (1969) · Biochemical Journal · doi:10.1042/bj1150609a · Cited by 563 · see citing works
Vitamin A metabolism: An update
D’Ambrosio, D. N., Clugston, R. D., & Blaner, W. S. (2011) · Nutrients · doi:10.3390/nu3010063 · Cited by 562 · see citing works
Kiefer, C., Hessel, S., Lampert, J. M., Vogt, K., Lederer, M. O., Breithaupt, D. E., & Lintig, J. V. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011510200 · Cited by 453 · see citing works
Vitamin A in Reproduction and Development
Clagett-Dame, M., & Knutson, D. (2011) · Nutrients · doi:10.3390/nu3040385 · Cited by 439 · see citing works
Retinoid-binding proteins: mediators of retinoid action
NOY, N. (2000) · Biochemical Journal · doi:10.1042/bj3480481 · Cited by 422 · see citing works
Retinoid-binding proteins: mediators of retinoid action
Noy, N. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3480481 · Cited by 420 · see citing works
The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative
Persson, B., Kallberg, Y., Bray, J. E., Bruford, E. A., Dellaporta, S. L., Favia, A. D., Duarte, R. G., Jörnvall, H., Kavanagh, K. L., Kedishvili, N. Y., et al. (2008) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2008.10.040 · Cited by 397 · see citing works
Self-citationRetinoids regulate stem cell differentiation
Gudas, L. J., & Wagner, J. A. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22417 · Cited by 395 · see citing works
Mechanisms involved in the intestinal absorption of dietary vitamin A and provitamin A carotenoids
Harrison, E. H. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.06.002 · Cited by 365 · see citing works
Function of retinoic acid receptors during embryonic development
Mark, M., Ghyselinck, N. B., & Chambon, P. (2009) · Nuclear Receptor Signaling · doi:10.1621/nrs.07002 · Cited by 363 · see citing works
Dong, D., Ruuska, S. E., Levinthal, D. J., & Noy, N. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.23695 · Cited by 362 · see citing works
Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony
Herman, M. A. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29027 · Cited by 349 · see citing works
Sandell, L. J., Sanderson, B. W., Moiseyev, G. P., Johnson, T. J., Mushegian, A. R., Young, K., Rey, J., Ma, J., Staehling‐Hampton, K., & Trainor, P. A. (2007) · Genes & Development · doi:10.1101/gad.1533407 · Cited by 341 · see citing works
Physiological insights into all-trans-retinoic acid biosynthesis
Napoli, J. L. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.05.004 · Cited by 326 · see citing works
Boylan, J. F., & Gudas, L. J. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.112.5.965 · Cited by 325 · see citing works
Cellular retinol‐binding protein I is essential for vitamin A homeostasis
Ghyselinck, N. B., Båvik, C., Sapin, V., Mark, M. P., Bonnier, D., Hindelang, C., Dierich, A., Nilsson, C. B., Håkansson, H., Sauvant, P., et al. (1999) · The EMBO Journal · doi:10.1093/emboj/18.18.4903 · Cited by 319 · see citing works
Dupé, V., Matt, N., Garnier, J., Chambon, P., Mark, M. P., & Ghyselinck, N. B. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2336223100 · Cited by 319 · see citing works
Yashiro, K., Zhao, X., Uehara, M., Yamashita, K., Nishijima, M., Nishino, J., Saijoh, Y., Sakai, Y., & Hamada, H. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00062-0 · Cited by 316 · see citing works
Cellular Retinoid-Binding Proteins
Ong, D. E. (1987) · Archives of Dermatology · doi:10.1001/archderm.1987.01660360140026 · Cited by 308 · see citing works
Yamamoto, H., Simon, A., Eriksson, U., Harris, E., Berson, E. L., & Dryja, T. P. (1999) · Nature Genetics · doi:10.1038/9707 · Cited by 298 · see citing works
Cytochrome P450s in the Regulation of Cellular Retinoic Acid Metabolism
Catharine Ross, A., & Zolfaghari, R. (2011) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-072610-145127 · Cited by 296 · see citing works
Fukumoto, S., Yamauchi, N., Moriguchi, H., Hippo, Y., Watanabe, A., Shibahara, J., Taniguchi, H., Ishikawa, S., Ito, H., Yamamoto, S., et al. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1238 · Cited by 290 · see citing works
Identification, Expression, and Substrate Specificity of a Mammalian β-Carotene 15,15′-Dioxygenase
Redmond, T. M., Gentleman, S., Duncan, T. E., Yu, S., Wiggert, B. O., Gantt, E., & Cunningham, F. X. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009030200 · Cited by 279 · see citing works
THE ROLES OF RETINOIDS IN VERTEBRATE DEVELOPMENT
Means, A. L., & Gudas, L. J. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.001221 · Cited by 277 · see citing works
Human aldo–keto reductases: Function, gene regulation, and single nucleotide polymorphisms
Penning, T. M., & Drury, J. E. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.04.024 · Cited by 266 · see citing works
Simon, A., Hellman, U., Wernstedt, C., & Eriksson, U. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.3.1107 · Cited by 254 · see citing works
Medium- and short-chain dehydrogenase/reductase gene and protein families
Persson, B., Hedlund, J., & Jörnvall, H. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8587-z · Cited by 249 · see citing works
Janecke, A. R., Thompson, D. A., Utermann, G., Becker, C., Hübner, C. A., Schmid, E., McHenry, C. L., Nair, A. R., Rüschendorf, F., Heckenlively, J., et al. (2004) · Nature Genetics · doi:10.1038/ng1394 · Cited by 246 · see citing works
Biochemistry of visual pigment regeneration: the Friedenwald lecture.
Saari, J. C. (2000) · PubMed · Cited by 243 · see citing works
Medium-chain and short-chain dehydrogenases/reductases in retinoid metabolism
Parés, X., Farrés, J., Kedishvili, N., & Duester, G. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8591-3 · Cited by 242 · see citing works
Self-citationFan, X., Molotkov, A., Manabe, S.-I., Donmoyer, C. M., Deltour, L., Foglio, M. H., Cuenca, A. E., Blaner, W. S., Lipton, S. A., & Duester, G. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.13.4637-4648.2003 · Cited by 230 · see citing works
Lampron, C., Rochette‐Egly, C., Gorry, P., Dollé, P., Mark, M. P., Lufkin, T., LeMeur, M., & Chambon, P. (1995) · Development · doi:10.1242/dev.121.2.539 · Cited by 226 · see citing works
Biswas, M. G., & Russell, D. W. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.25.15959 · Cited by 224 · see citing works
Cloning and Expression of β,β-Carotene 15,15′-Dioxygenase
Wyss, A., Wirtz, G., Woggon, W. ‐., Brugger, R., Wyss, M., Friedlein, A., Bachmann, H., & Hunziker, W. H. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2619 · Cited by 217 · see citing works
Bouillet, P., Sapin, V., Chazaud, C., Messaddeq, N., Décimo, D., Dollé, P., & Chambon, P. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00039-7 · Cited by 209 · see citing works
The role of CYP26 enzymes in retinoic acid clearance
Thatcher, J. E., & Isoherranen, N. (2009) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425250903032681 · Cited by 201 · see citing works
Marill, J., Cresteil, T., Lanotte, M., & Chabot, G. G. (2000) · Molecular Pharmacology · doi:10.1124/mol.58.6.1341 · Cited by 197 · see citing works
A Ligand-Activated Nuclear Localization Signal in Cellular Retinoic Acid Binding Protein-II
Sessler, R. J., & Noy, N. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.03.026 · Cited by 192 · see citing works
Between Death and Survival: Retinoic Acid in Regulation of Apoptosis
Noy, N. (2010) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.28.061807.155509 · Cited by 192 · see citing works
Retinal Dehydrogenase 12 (RDH12) Mutations in Leber Congenital Amaurosis
Perrault, I., Hanein, S., Gerber, S., Barbet, F., Ducroq, D., Dollfus, H., Hamel, C., Dufier, J., Münnich, A., Kaplan, J., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/424889 · Cited by 185 · see citing works
Haeseleer, F., Huang, J., Lebioda, L., Saari, J. C., & Palczewski, K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.34.21790 · Cited by 184 · see citing works
Multiple and Additive Functions of ALDH3A1 and ALDH1A1
Lassen, N., Bateman, J., Estey, T., Kuszak, J. R., Nees, D. W., Piatigorsky, J., Duester, G., Day, B. J., Huang, J., Hines, L. M., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702076200 · Cited by 175 · see citing works
Uehara, M., Yashiro, K., Mamiya, S., Nishino, J., Chambon, P., Dollé, P., & Sakai, Y. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.09.045 · Cited by 164 · see citing works
Retinoids and adipose tissues: metabolism, cell differentiation and gene expression
Villarroya, F., Giralt, M., & Iglesias, R. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0800799 · Cited by 161 · see citing works
Retinoic acid metabolism by a system reconstituted with cytochrome P-450
Leo, M. A., Iida, S., & Lieber, C. S. (1984) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(84)90353-9 · Cited by 154 · see citing works
Role of Retinoic Acid in the Differentiation of Embryonal Carcinoma and Embryonic Stem Cells
Soprano, D. R., Teets, B. W., & Soprano, K. J. (2007) · Vitamins and hormones · doi:10.1016/s0083-6729(06)75003-8 · Cited by 153 · see citing works
Yan, W., Jang, G.-F., Haeseleer, F., Esumi, N., Chang, J. T., Kerrigan, M., Campochiaro, M., Campochiaro, P. A., Palczewski, K., & Zack, D. J. (2001) · Genomics · doi:10.1006/geno.2000.6476 · Cited by 152 · see citing works
The structures of prostaglandin endoperoxide H synthases-1 and -2
Garavito, R. M., Malkowski, M. G., & DeWitt, D. L. (2002) · Prostaglandins & Other Lipid Mediators · doi:10.1016/s0090-6980(02)00026-6 · Cited by 150 · see citing works
Expression and Characterization of a Murine Enzyme Able to Cleave β-Carotene
Paik, J., During, A., Harrison, E. H., Mendelsohn, C. L., Lai, K., & Blaner, W. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010086200 · Cited by 150 · see citing works
Liver Retinol Transporter and Receptor for Serum Retinol-binding Protein (RBP4)
Alapatt, P., Guo, F., Komanetsky, S. M., Wang, S., Cai, J., Sargsyan, A., Rodríguez Díaz, E., Bacon, B. T., Aryal, P., & Graham, T. E. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.369132 · Cited by 150 · see citing works
The role of CYP26 enzymes in defining appropriate retinoic acid exposure during embryogenesis.
Pennimpede, T., Cameron, D., Maclean, G., Li, H., Abu-Abed, S., & Petkovich, M. (2010) · Birth defects research. Clinical and molecular teratology · doi:10.1002/bdra.20709 · Cited by 147 · see citing works
Smith, G. C., Wolf, C. R., Deeni, Y., Dawe, R. S., Evans, A. T., Comrie, M., Ferguson, J., & Ibbotson, S. H. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13081-4 · Cited by 147 · see citing works
Molotkov, A., & Duester, G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303709200 · Cited by 145 · see citing works
A paradoxical teratogenic mechanism for retinoic acid
Lee, L. M.-Y., Leung, C.-Y., Tang, W. W. C., Choi, H.-L., Leung, Y., McCaffery, P. J. A., Wang, C. C., Woolf, A. S., & Shum, A. S. W. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200872109 · Cited by 143 · see citing works
Lc, M., & Daly, A. K. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00356-7 · Cited by 141 · see citing works
Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX
Lobo, G. P., Amengual, J., Baus, D., Shivdasani, R. A., Taylor, D., & von Lintig, J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.444240 · Cited by 138 · see citing works
Provitamin A metabolism and functions in mammalian biology
von Lintig, J. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.034629 · Cited by 138 · see citing works
Liu, C., Russell, R. M., Seitz, H. K., & Wang, X. D. (2001) · Gastroenterology · doi:10.1053/gast.2001.20877 · Cited by 136 · see citing works
Gallego, O., Belyaeva, O., Porté, S., Ruiz, F., Stetsenko, A., Shabrova, E., Kostereva, N., Farrés, J., Parés, X., & Kedishvili, N. (2006) · Biochemical Journal · doi:10.1042/bj20051988 · Cited by 130 · see citing works
Self-citationDhrs3a Regulates Retinoic Acid Biosynthesis through a Feedback Inhibition Mechanism
Feng, L., Hernandez, R., Waxman, J., Yelon, D., & Moens, C. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.10.029 · Cited by 128 · see citing works
Lin, M., Zhang, M., Abraham, M., Smith, S. M., & Napoli, J. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211417200 · Cited by 127 · see citing works
Vogel, S., Mendelsohn, C. L., Mertz, J. R., Piantedosi, R., Waldburger, C. D., Gottesman, M. E., & Blaner, W. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m005118200 · Cited by 127 · see citing works
Regulation of Hepatic Retinol Metabolism: Perspectives from Studies on Vitamin A Status
Ross, A. C., & Zolfaghari, R. (2004) · Journal of Nutrition · doi:10.1093/jn/134.1.269s · Cited by 126 · see citing works
Cell Type-specific Expression of β-Carotene 9', 10'-Monooxygenase in Human Tissues
Lindqvist, A., He, Y.-G., & Andersson, S. (2005) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.5a6705.2005 · Cited by 124 · see citing works
MacDonald, P. N., & Ong, D. E. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)60997-4 · Cited by 123 · see citing works
Belyaeva, O. V., Korkina, O. V., Stetsenko, A. V., Kim, T., Nelson, P. S., & Kedishvili, N. Y. (2005) · Biochemistry · doi:10.1021/bi050226k · Cited by 122 · see citing works
Self-citationExpression pattern and localization of β,β-carotene 15,15′-dioxygenase in different tissues
Wyss, A., Wirtz, G., Woggon, W., BRUGGER, R., Wyss, M., Friedlein, A., Riss, G., Bachmann, H., & Hunziker, W. H. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3540521 · Cited by 122 · see citing works
Retinol Dehydrogenase (RDH12) Protects Photoreceptors from Light-induced Degeneration in Mice
Maeda, A., Maeda, T., Imanishi, Y., Sun, W., Jastrzębska, B., Hatala, D. A., Winkens, H. J., Hofmann, K. P., Janssen, J. J. M., Baehr, W., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m608375200 · Cited by 121 · see citing works
Bauman, D. R., Steckelbroeck, S., Williams, M. V., Peehl, D. M., & Penning, T. M. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0287 · Cited by 120 · see citing works
Fiorella, P. D., & Napoli, J. L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34093-0 · Cited by 114 · see citing works
Gough, W. H., VanOoteghem, S., Sint, T., & Kedishvili, N. Y. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.31.19778 · Cited by 114 · see citing works
Self-citationParticipation of CYP2C8 in retinoic acid 4-hydroxylation in human hepatic microsomes
Nadin, L., & Murray, M. T. (1999) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00192-6 · Cited by 113 · see citing works
Rhinn, M., Schuhbaur, B., Niederreither, K., & Dollé, P. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103877108 · Cited by 110 · see citing works
Comparison of the function and expression of CYP26A1 and CYP26B1, the two retinoic acid hydroxylases
Topletz, A. R., Thatcher, J. E., Zelter, A., Lutz, J. D., Tay, S., Nelson, W. L., & Isoherranen, N. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.10.007 · Cited by 109 · see citing works
Delayed Dark Adaptation in 11-cis-Retinol Dehydrogenase-deficient Mice
Kim, T. S., Maeda, A., Maeda, T., Heinlein, C. A., Kedishvili, N. Y., Palczewski, K., & Nelson, P. S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413172200 · Cited by 108 · see citing works
Self-citationRoss, A. C., & Gardner, E. M. (1994) · Advances in experimental medicine and biology · doi:10.1007/978-1-4899-2575-6_15 · Cited by 106 · see citing works
Napoli, J. L. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67061-9 · Cited by 104 · see citing works
Li, E., Qian, S. J., Winter, N. S., d'Avignon, A., Levin, M. S., & Gordon, J. I. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)67840-3 · Cited by 103 · see citing works
Fiorella, P. D., Giguère, V., & Napoli, J. L. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80576-6 · Cited by 102 · see citing works
Wu, Z., Sohl, C. D., Shimada, T., & Guengerich, F. P. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.023648 · Cited by 99 · see citing works
Zolfaghari, R., & Ross, A. C. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32364-6 · Cited by 96 · see citing works
Identification, retinoid binding, and x-ray analysis of a human retinol-binding protein
Folli, C., Calderone, V., Ottonello, S., Bolchi, A., Zanotti, G., Stoppini, M., & Berni, R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.061455898 · Cited by 95 · see citing works
Altered vitamin A homeostasis and increased size and adiposity in the rdhl‐null mouse
Zhang, M., Hu, P., Krois, C. R., Kane, M. A., & Napoli, J. L. (2007) · The FASEB Journal · doi:10.1096/fj.06-7964com · Cited by 91 · see citing works
The relative importance of CYP26A1 in hepatic clearance of all-trans retinoic acid
Thatcher, J. E., Zelter, A., & Isoherranen, N. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.05.023 · Cited by 91 · see citing works
Strate, I., Grahn, T. H. M., Iliev, D., & Pera, E. M. (2009) · Development · doi:10.1242/dev.024901 · Cited by 91 · see citing works
Levin, M. S., Locke, B., Yang, N. C., Li, E., & Gordon, J. I. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)77895-8 · Cited by 91 · see citing works
Wu, B. X., Chen, Y., Chen, Y., Fan, J., Rohrer, B., Crouch, R. K., & Ma, J.-X. (2002) · PubMed · Cited by 90 · see citing works
Jin, W. A. N. G., Chai, X., Eriksson, U., & Napoli, J. L. (1999) · Biochemical Journal · doi:10.1042/bj3380023 · Cited by 88 · see citing works
Biological Role of Aldo–Keto Reductases in Retinoic Acid Biosynthesis and Signaling
Ruiz, F. X., Porté, S., Parés, X., & Farrés, J. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00058 · Cited by 88 · see citing works
Williams, A. W., Boileau, T. W.-M., Zhou, J. R., Clinton, S. K., & Erdman, J. W. (2000) · Journal of Nutrition · doi:10.1093/jn/130.4.728 · Cited by 87 · see citing works
Farjo, K. M., Moiseyev, G. P., Nikolaeva, O., Sandell, L. J., Trainor, P. A., & Ma, J. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.07.011 · Cited by 86 · see citing works
Chen, C., Thompson, D. A., & Koutalos, Y. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.354514 · Cited by 85 · see citing works
Characterization of a Novel Type of Human Microsomal 3α-Hydroxysteroid Dehydrogenase
Chetyrkin, S. V., Belyaeva, O. V., Gough, W. H., & Kedishvili, N. Y. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102076200 · Cited by 78 · see citing works
Self-citationFogh, K., Voorhees, J. J., & Åström, A. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1104 · Cited by 77 · see citing works
Boerman, M. H. E. M., & Napoli, J. L. (1995) · Biochemistry · doi:10.1021/bi00021a014 · Cited by 75 · see citing works
p53-inducible DHRS3 Is an Endoplasmic Reticulum Protein Associated with Lipid Droplet Accumulation
Deisenroth, C., Itahana, Y., Tollini, L. A., Jin, A., & Zhang, Y. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.254227 · Cited by 74 · see citing works
Catalysis of the 4-Hydroxylation of Retinoic Acids by Cyp3a7 in Human Fetal Hepatic Tissues
Chen, H., Fantel, A. G., & Juchau, M. R. (2000) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(24)15185-9 · Cited by 72 · see citing works
Wang, C., Kane, M. A., & Napoli, J. L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.198382 · Cited by 72 · see citing works
β-Carotene Conversion into Vitamin A in Human Retinal Pigment Epithelial Cells
Chichili, G. R., Nöhr, D., ̈ffer, M. S., Lintig, J. V., & Biesalski, H. K. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-0089 · Cited by 72 · see citing works
Cerignoli, F., Guo, X., Cardinali, B., Rinaldi, C., Casaletto, J. B., Frati, L., Screpanti, I., Gudas, L. J., Gulino, A., Thiele, C. J., et al. (2002) · PubMed · Cited by 72 · see citing works
Ligand Binding and Structural Analysis of a Human Putative Cellular Retinol-binding Protein
Folli, C., Calderone, V., Ramazzina, I., Zanotti, G., & Berni, R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207124200 · Cited by 70 · see citing works
Dan, Z., Popov, Y. V., Patsenker, E., Preimel, D., Liu, C., Wang, X., Seitz, H. K., Schuppan, D., & Stickel, F. (2005) · The FASEB Journal · doi:10.1096/fj.04-2809fje · Cited by 70 · see citing works
Belyaeva, O. V., Johnson, M. P., & Kedishvili, N. Y. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800019200 · Cited by 69 · see citing works
Self-citationKedishvili, N. Y., Chumakova, O. V., Chetyrkin, S. V., Belyaeva, O. V., Lapshina, E. A., Lin, D. W., Matsumura, M., & Nelson, P. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202588200 · Cited by 68 · see citing works
Self-citationNuclear Detection of Cellular Retinoic Acid Binding Proteins I and II with New Antibodies
Gaub, M., Lutz, Y., Ghyselinck, N. B., Scheuer, I., Pfister, V., Chambon, P., & Rochette‐Egly, C. (1998) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215549804601002 · Cited by 68 · see citing works
Kurth, I., Thompson, D. A., Rüther, K., Feathers, K. L., Chrispell, J. D., Schroth, J., McHenry, C. L., Schweizer, M., Skosyrski, S., Gal, A., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01486-06 · Cited by 67 · see citing works
Belyaeva, O. V., Korkina, O. V., Stetsenko, A. V., & Kedishvili, N. Y. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.06184.x · Cited by 66 · see citing works
Self-citationYamamoto, M., Dräger, U. C., Ong, D. E., & McCaffery, P. J. A. (1998) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1998.2570344.x · Cited by 65 · see citing works
Wardlaw, S. A., Bucco, R. A., Zheng, W. L., & Ong, D. E. (1997) · Biology of Reproduction · doi:10.1095/biolreprod56.1.125 · Cited by 65 · see citing works
Mouse Liver CYP2C39 Is a Novel Retinoic Acid 4-Hydroxylase
Andreola, F., Hayhurst, G. P., Luo, G., Ferguson, S., Gonzalez, F. J., Goldstein, J. A., & Luca, L. M. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m305832200 · Cited by 65 · see citing works
Kinetic analysis of mouse retinal dehydrogenase type-2 (RALDH2) for retinal substrates
Gagnon, I., Duester, G., & Bhat, P. V. (2002) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/s0167-4838(02)00213-3 · Cited by 63 · see citing works
Fingert, J. H. (2008) · Archives of Ophthalmology · doi:10.1001/archopht.126.9.1301 · Cited by 63 · see citing works
Pan1b (17βHSD11)-enzymatic activity and distribution in the lung
Brereton, P. S., Suzuki, T., Sasano, H., Li, K., Duarte, C., Obeyesekere, V. R., Haeseleer, F., Palczewski, K., Smith, A. I., Komesaroff, P. A., et al. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(00)00417-2 · Cited by 63 · see citing works
Regulation of retinal dehydrogenases and retinoic acid synthesis by cholesterol metabolites
Huq, M. D. M., Tsai, N., Gupta, P. K., & Wei, L. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601181 · Cited by 63 · see citing works
Cai, A. Q., Radtke, K., Linville, A., Lander, A. D., Nie, Q. H., & Schilling, T. F. (2012) · Development · doi:10.1242/dev.077065 · Cited by 63 · see citing works
Lin, M., & Napoli, J. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m008027200 · Cited by 62 · see citing works
Chung, S. S. W., Wang, X., & Wolgemuth, D. J. (2009) · Development · doi:10.1242/dev.020040 · Cited by 62 · see citing works
Xi, J., & Yang, Z. (2008) · Gene Expression Patterns · doi:10.1016/j.gep.2008.04.003 · Cited by 61 · see citing works
Belyaeva, O. V., Stetsenko, A. V., Nelson, P. S., & Kedishvili, N. Y. (2003) · Biochemistry · doi:10.1021/bi035288u · Cited by 61 · see citing works
Self-citationKim, Y., Wassef, L., Chung, S., Jiang, H., Wyss, A., Blaner, W. S., & Quadro, L. (2011) · The FASEB Journal · doi:10.1096/fj.10-175448 · Cited by 60 · see citing works
Further characterization of human microsomal 3α-hydroxysteroid dehydrogenase
Chetyrkin, S. V., Hu, J., Gough, W. H., Dumaual, N., & Kedishvili, N. Y. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.2203 · Cited by 60 · see citing works
Self-citationDuring, A., Albaugh, G. P., & Smith, J. C. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9160 · Cited by 59 · see citing works
Zheng, W. L., & Ong, D. E. (1998) · Biology of Reproduction · doi:10.1095/biolreprod58.4.963 · Cited by 59 · see citing works
Soref, C. M., Di, Y. P., Hayden, L. J., Zhao, Y., Satre, M. A., & Wu, R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100332200 · Cited by 56 · see citing works
Wu, L., & Ross, A. C. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m001222 · Cited by 56 · see citing works
Napoli, J. L. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(00)00392-0 · Cited by 56 · see citing works
Molecular cloning and expression analysis of a new gene for short-chain dehydrogenase/reductase 9.
Liu, S., Huang, C., Li, D., Ren, W., Zhang, H., Qi, M., Li, X., & Yu, L. (2007) · Acta Biochimica Polonica · doi:10.18388/abp.2007_3289 · Cited by 52 · see citing works
Tomokazu, M., Gad, M. Z., Harrison, E., & Catharine, R. A. (1997) · Journal of Nutrition · doi:10.1093/jn/127.2.218 · Cited by 52 · see citing works
Ross, A. C. (2007) · Vitamins and hormones · doi:10.1016/s0083-6729(06)75008-7 · Cited by 52 · see citing works
Cloning of a rat cDNA encoding retinal dehydrogenase isozyme type I and its expression in E. coli
Penzes, P., Wang, X., Sperkova, Z., & Napoli, J. L. (1997) · Gene · doi:10.1016/s0378-1119(97)00054-1 · Cited by 52 · see citing works
Localization of cellular retinoic acid-binding protein (CRABP) II and CRABP in developing rat testis
Zheng, W. L., Bucco, R. A., Schmitt, M. C., Wardlaw, S. A., & Ong, D. E. (1996) · Endocrinology · doi:10.1210/en.137.11.5028 · Cited by 52 · see citing works
Zhang, M., Chen, W., Smith, S. M., & Napoli, J. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105748200 · Cited by 51 · see citing works
Sima, A., Parisotto, M., Mader, S., & Bhat, P. V. (2009) · Biochimica et Biophysica Acta · doi:10.1016/j.bbagen.2009.09.004 · Cited by 51 · see citing works
QUANTITATIVE HISTOCHEMISTRY OF NICOTINAMIDE ADENINE NUCLEOTIDES IN RETINA OF MONKEY AND RABBIT1
Matschinsky, F. M. (1968) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1968.tb08963.x · Cited by 50 · see citing works
Penning, T. M. (2011) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2011.01.009 · Cited by 50 · see citing works
Díez-Dacal, B., Gayarre, J., Gharbi, S., Timms, J. F., Coderch, C., Gago, F., & Pérez‐Sala, D. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3816 · Cited by 50 · see citing works
Kasus‐Jacobi, A., Ou, J., Bashmakov, Y. K., Shelton, J. M., Richardson, J. A., Goldstein, J. L., & Brown, M. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304969200 · Cited by 47 · see citing works
The 11β hydroxysteroid dehydrogenase 2 exists as an inactive dimer
Gómez-Sánchez, E. P., Ganjam, V. K., Chen, Y. J., Liu, Y., Clark, S. A., & Gómez-Sánchez, C. E. (2001) · Steroids · doi:10.1016/s0039-128x(01)00119-2 · Cited by 47 · see citing works
Focal facial dermal dysplasia, type IV, is caused by mutations in CYP26C1
Slavotinek, A. M., Mehrotra, P., Nazarenko, I. A., Tang, P. L.-F., Lao, R., Cameron, D. A., Li, B., Chu, C., Chou, C., Marqueling, A. L., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds477 · Cited by 46 · see citing works
The Retinol Dehydrogenase Rdh10 Localizes to Lipid Droplets during Acyl Ester Biosynthesis
Jiang, W., & Napoli, J. L. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.402883 · Cited by 45 · see citing works
Role of Retinoids in Embryonic Development
INTRODUCTION, E. D. M. M. I. (1994) · CRC Press eBooks · doi:10.1201/9781482277562-52 · Cited by 44 · see citing works
Belyaeva, O. V., & Kedishvili, N. Y. (2006) · Genomics · doi:10.1016/j.ygeno.2006.06.004 · Cited by 42 · see citing works
Self-citationLapshina, E. A., Belyaeva, O. V., Chumakova, O. V., & Kedishvili, N. Y. (2002) · Biochemistry · doi:10.1021/bi026836r · Cited by 41 · see citing works
Self-citationZolfaghari, R., Chen, Q., & Ross, A. C. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00234.2012 · Cited by 41 · see citing works
Thermodynamic parameters of the binding of retinol to binding proteins and to membranes
Noy, N., & Xu, Z. J. (1990) · Biochemistry · doi:10.1021/bi00468a014 · Cited by 41 · see citing works
Lee, S., Belyaeva, O. V., Popov, I. A., & Kedishvili, N. Y. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706372200 · Cited by 39 · see citing works
Self-citationBelyaeva, O. V., & Kedishvili, N. Y. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03588-3 · Cited by 39 · see citing works
Self-citationAshique, A. M., May, S., Kane, M. A., Folias, A. E., Phamluong, K., Choe, Y., Napoli, J. L., & Peterson, A. S. (2011) · genesis · doi:10.1002/dvg.22002 · Cited by 38 · see citing works
Kirschner, R. D., Rother, K., Müller, G. A., & Engeland, K. (2010) · Cell Cycle · doi:10.4161/cc.9.11.11844 · Cited by 38 · see citing works
Role of aldo-keto reductases in development of prostate and breast cancer
Jin, J. (2006) · Frontiers in bioscience · doi:10.2741/2006 · Cited by 37 · see citing works
Bucco, R. A., Zheng, W. L., Wardlaw, S. A., Davis, J. T., Sierra‐Rivera, E., Osteen, K. G., Melner, M. H., Kakkad, B., & Ong, D. E. (1996) · Endocrinology · doi:10.1210/endo.137.7.8770937 · Cited by 36 · see citing works
Biochemical characterization of human epidermal retinol dehydrogenase 2
Lee, S., Belyaeva, O. V., & Kedishvili, N. Y. (2008) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2008.09.019 · Cited by 36 · see citing works
Self-citationBelyaeva, O. V., Lee, S., Adams, M. K., Chang, C., & Kedishvili, N. Y. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.336727 · Cited by 36 · see citing works
Self-citationHerr, F. M., Li, E., Weinberg, R. B., Cook, V. R., & Storch, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.14.9556 · Cited by 35 · see citing works
Belyaeva, O. V., Chetyrkin, S. V., Clark, A. L., Kostereva, N. V., SantaCruz, K. S., Chronwall, B. M., & Kedishvili, N. Y. (2007) · Endocrinology · doi:10.1210/en.2006-1491 · Cited by 34 · see citing works
Self-citationQian, L., Zolfaghari, R., & Ross, A. C. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m002840 · Cited by 34 · see citing works
Hardy, D. O., Ge, R., Catterall, J. F., Hou, Y., Penning, T. M., & Hardy, M. P. (2000) · Endocrinology · doi:10.1210/endo.141.5.7445 · Cited by 34 · see citing works
β‐carotene uptake and effects on intracellular levels of retinolin vitro
Wei, R., Warner, W. G., Lambert, L. A., & Kornhauser, A. (1998) · Nutrition and Cancer · doi:10.1080/01635589809514640 · Cited by 34 · see citing works
CYP2C7 expression in rat liver and hepatocytes: regulation by retinoids
Westin, S. K., Sonneveld, E., van der Leede, B. M., van der Saag, P. T., Gustafsson, J.-Α., & Mode, A. (1997) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(97)04055-0 · Cited by 33 · see citing works
Ross, A. C., Cifelli, C. J., Zolfaghari, R., & Li, N. (2010) · Physiological Genomics · doi:10.1152/physiolgenomics.00182.2010 · Cited by 32 · see citing works
Lee, S.-A., Belyaeva, O. V., Wu, L., & Kedishvili, N. Y. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.181065 · Cited by 31 · see citing works
Self-citationCellular retinoic acid binding protein is associated with mitochondria
Ruff-Jamison, S., & Ong, D. E. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)02366-8 · Cited by 28 · see citing works
Bucco, R. A., Melner, M. H., Gordon, D. S., Leers‐Sucheta, S., & Ong, D. E. (1995) · Endocrinology · doi:10.1210/endo.136.6.7750498 · Cited by 28 · see citing works
Boerman, M. H. E. M., & Napoli, J. L. (1995) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1995.1415 · Cited by 26 · see citing works
Reijntjes, S., Zile, M. H., & Maden, M. (2010) · The International Journal of Developmental Biology · doi:10.1387/ijdb.093009sr · Cited by 26 · see citing works
Enzymatic characterization of recombinant mouse retinal dehydrogenase type 1
Gagnon, I., Duester, G., & Bhat, P. V. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(03)00150-3 · Cited by 26 · see citing works
Jiang, W., & Napoli, J. L. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.03.016 · Cited by 24 · see citing works
Retinol dehydrogenase 13 protects the mouse retina from acute light damage.
Wang, H., Cui, X., Gu, Q., Chen, Y., Zhou, J., Kuang, Y., Wang, Z., & Xu, X. (2012) · Europe PMC (PubMed Central) · Cited by 21 · see citing works
Keller, B., & Adamski, J. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2007.03.015 · Cited by 21 · see citing works
PPARα activators down-regulate CYP2C7, a retinoic acid and testosterone hydroxylase
Fan, L.-Q., Brown‐Borg, H. M., Brown, S. S., Westin, S. K., Mode, A., & Corton, J. C. (2004) · Toxicology · doi:10.1016/j.tox.2004.05.013 · Cited by 21 · see citing works
Koenig, U., Amatschek, S., Mildner, M., Eckhart, L., & Tschachler, E. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.08.035 · Cited by 19 · see citing works
Belyaeva, O. V., Lee, S., Kolupaev, O., & Kedishvili, N. Y. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.06.002 · Cited by 19 · see citing works
Self-citationForced expression of RDH10 gene retards growth of HepG2 cells
Rossi, E. G., Picozzi, P., Bodega, B., Lavazza, C., Carlo‐Stella, C., Marozzi, A., & Ginelli, E. (2007) · Cancer Biology & Therapy · doi:10.4161/cbt.6.2.3625 · Cited by 17 · see citing works
Scita, G., Aponte, G. W., & Wolf, G. (1993) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(93)14050-s · Cited by 13 · see citing works
Fink, S. M., Mömke, S., & Distl, O. (2012) · Europe PMC (PubMed Central) · Cited by 6 · see citing works
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Retinoic acid receptors: From molecular mechanisms to cancer therapy
di Masi, A., Leboffe, L., De Marinis, E., Pagano, F., Cicconi, L., Rochette-Egly, C., Lo-Coco, F., Ascenzi, P., & Nervi, C. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2014.12.003 · Cited by 403 · see citing works
Retinol and retinyl esters: biochemistry and physiology
O'Byrne, S. M., & Blaner, W. S. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r037648 · Cited by 378 · see citing works
Vitamin A signaling and homeostasis in obesity, diabetes, and metabolic disorders
Blaner, W. S. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.01.006 · Cited by 287 · see citing works
Napoli, J. L. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.01.004 · Cited by 256 · see citing works
Scientific Opinion on Dietary Reference Values for vitamin A
EFSA Panel on Dietetic Products, N. (2015) · EFSA Journal · doi:10.2903/j.efsa.2015.4028 · Cited by 240 · see citing works
Eroglu, A., & Harrison, E. H. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r039537 · Cited by 192 · see citing works
Bhattacharya, N., Yuan, R. T., Prestwood, T. R., Penny, H. L., DiMaio, M. A., Reticker-Flynn, N. E., Krois, C. R., Kenkel, J. A., Pham, T. D., Carmi, Y., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.08.008 · Cited by 165 · see citing works
Carotenoid Metabolism at the Intestinal Barrier
von Lintig, J., Moon, J., Lee, J., & Ramkumar, S. (2019) · Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2019.158580 · Cited by 139 · see citing works
Biochemical and physiological importance of the CYP26 retinoic acid hydroxylases
Isoherranen, N., & Zhong, G. G. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107400 · Cited by 139 · see citing works
Vitamin A and Retinoic Acid in Cognition and Cognitive Disease
Wołoszynowska-Fraser, M. U., Kouchmeshky, A., & McCaffery, P. J. A. (2020) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-122319-034227 · Cited by 136 · see citing works
Billings, S. E., Pierzchalski, K., Tjaden, N. E. B., Pang, X.-Y., Trainor, P., Kane, M. A., & Moise, A. (2013) · The FASEB Journal · doi:10.1096/fj.13-227967 · Cited by 120 · see citing works
Retinoic Acid Synthesis and Degradation
Kedishvili, N. Y. (2016) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-024-0945-1_5 · Cited by 111 · see citing works
Self-citationAdams, M. K., Belyaeva, O., Wu, L., & Kedishvili, N. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.552257 · Cited by 98 · see citing works
Self-citationRole of Retinoic Acid-Metabolizing Cytochrome P450s, CYP26, in Inflammation and Cancer
Stevison, F., Jing, J., Tripathy, S., & Isoherranen, N. (2015) · Advances in pharmacology · doi:10.1016/bs.apha.2015.04.006 · Cited by 94 · see citing works
Functions of Intracellular Retinoid Binding-Proteins
Napoli, J. L. (2016) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-024-0945-1_2 · Cited by 91 · see citing works
Retinoids in health and disease: A role for hepatic stellate cells in affecting retinoid levels
Haaker, M. W., Vaandrager, A. B., & Helms, J. B. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2020.158674 · Cited by 84 · see citing works
Importance of ALDH1A enzymes in determining human testicular retinoic acid concentrations
Arnold, S. L. M., Kent, T., Hogarth, C., Schlatt, S., Prasad, B., Haenisch, M., Walsh, T., Muller, C., Griswold, M., Amory, J., et al. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m054718 · Cited by 72 · see citing works
TRP-channels as key integrators of lipid pathways in nociceptive neurons
Sisignano, M., Bennett, D., Geißlinger, G., & Scholich, K. (2013) · Progress in Lipid Research · doi:10.1016/j.plipres.2013.11.002 · Cited by 74 · see citing works
Molecular Basis for Vitamin A Uptake and Storage in Vertebrates
Chelstowska, S., Widjaja-Adhi, M., Silvaroli, J., & Golczak, M. (2016) · Nutrients · doi:10.3390/nu8110676 · Cited by 69 · see citing works
STRA6: role in cellular retinol uptake and efflux.
Kelly, M., & Lintig, J. V. (2015) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2304-3881.2015.01.12 · Cited by 67 · see citing works
New insights and changing paradigms in the regulation of vitamin A metabolism in development
Shannon, S. R., Moise, A. R., & Trainor, P. A. (2017) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.264 · Cited by 63 · see citing works
The molecular aspects of absorption and metabolism of carotenoids and retinoids in vertebrates
Widjaja‐Adhi, M. A. K., & Golczak, M. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2019.158571 · Cited by 65 · see citing works
Enzymatic Metabolism of Vitamin A in Developing Vertebrate Embryos
Metzler, M. A., & Sandell, L. J. (2016) · Nutrients · doi:10.3390/nu8120812 · Cited by 62 · see citing works
Generation of Retinaldehyde for Retinoic Acid Biosynthesis
Belyaeva, O. V., Adams, M. K., Popov, K. M., & Kedishvili, N. Y. (2019) · Biomolecules · doi:10.3390/biom10010005 · Cited by 58 · see citing works
Self-citationPetrelli, B., Bendelac-Kapon, L., Hicks, G. G., & Fainsod, A. (2019) · genesis · doi:10.1002/dvg.23278 · Cited by 51 · see citing works
Abdelnour, S. A., El-Hack, M. E. A., Swelum, A. A., Saadeldin, I. M., Noreldin, A. E., Khafaga, A. F., Al-Mutary, M. G., Arif, M. A., & Hussein, E. O. (2019) · Animals · doi:10.3390/ani9080561 · Cited by 50 · see citing works
Molecular components affecting ocular carotenoid and retinoid homeostasis
von Lintig, J., Moon, J., & Babino, D. (2021) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100864 · Cited by 50 · see citing works
Retinoic Acid Mediates Visceral-Specific Adipogenic Defects of Human Adipose-Derived Stem Cells
Takeda, K., Sriram, S., Chan, X. H. D., Ong, W. K., Yeo, C. R., Tan, B., Lee, S., Kong, K. V., Hoon, S. S., Jiang, H., et al. (2016) · Diabetes · doi:10.2337/db15-1315 · Cited by 49 · see citing works
Moreb, J. S., Uçar, D. A., & Khan, A. (2016) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-016-3213-5 · Cited by 49 · see citing works
Cycles, waves, and pulses: Retinoic acid and the organization of spermatogenesis
Gewiss, R. L., Topping, T., & Griswold, M. D. (2019) · Andrology · doi:10.1111/andr.12722 · Cited by 47 · see citing works
Zhu, L., Kamalathevan, P., Koneva, L. A., Zarebska, J. M., Chanalaris, A., Ismail, H. M., Wiberg, A., Ng, M., Muhammad, H., Walsby-Tickle, J., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abm4054 · Cited by 47 · see citing works
Retinoic acid maintains human skeletal muscle progenitor cells in an immature state
Haddad, M. E., Notarnicola, C., Evano, B., Khatib, N. E., Blaquière, M., Bonnieu, A., Tajbakhsh, S., Hugon, G., Vernus, B., Mercier, J. G., et al. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2445-1 · Cited by 47 · see citing works
Reprogramming of the retinoic acid pathway in decidualizing human endometrial stromal cells
Ozaki, R., Kuroda, K., Ikemoto, Y., Ochiai, A., Matsumoto, A., Kumakiri, J., Kitade, M., Itakura, A., Muter, J., Brosens, J. J., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173035 · Cited by 47 · see citing works
Nuclear and extranuclear effects of vitamin A
Iskakova, M., Karbyshev, M. S., Piskunov, A., & Rochette‐Egly, C. (2015) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2014-0522 · Cited by 44 · see citing works
Guo, Z., Liu, Y., & Luo, Y. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2119204 · Cited by 43 · see citing works
D'Aniello, E., & Waxman, J. (2015) · Developmental Dynamics · doi:10.1002/dvdy.24232 · Cited by 43 · see citing works
Cardiac retinoic acid levels decline in heart failure
Yang, N., Parker, L. E., Yu, J., Jones, J. W., Liu, T., Papanicolaou, K. N., Talbot, C. C., Margulies, K. B., O'Rourke, B. P., Kane, M. A., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.137593 · Cited by 42 · see citing works
Chen, F., Jiang, Z., Jiang, S., Li, L., Lin, X., Gou, Z., & Fan, Q. (2015) · Poultry Science · doi:10.3382/ps/pev305 · Cited by 40 · see citing works
Dubey, A., Rose, R. E., Jones, D. R., & Saint‐Jeannet, J. (2018) · genesis · doi:10.1002/dvg.23091 · Cited by 39 · see citing works
Coyle, K. M., Maxwell, S. P., Thomas, M. L., & Marcato, P. (2017) · Scientific Reports · doi:10.1038/s41598-017-16687-6 · Cited by 38 · see citing works
Vitamin A and retinoid signaling in the kidneys
DiKun, K. M., & Gudas, L. J. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108481 · Cited by 38 · see citing works
Reiterative Mechanisms of Retinoic Acid Signaling during Vertebrate Heart Development
Perl, E., & Waxman, J. S. (2019) · Journal of Developmental Biology · doi:10.3390/jdb7020011 · Cited by 36 · see citing works
A specific inhibitor of ALDH1A3 regulates retinoic acid biosynthesis in glioma stem cells
Li, J., Garavaglia, S., Ye, Z., Moretti, A., Belyaeva, O. V., Beiser, A., Ibrahim, M., Wilk, A. M., McClellan, S., Klyuyeva, A. V., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02949-7 · Cited by 39 · see citing works
Self-citationChen, H.-H., Sun, A., Ojcius, D. M., Hu, W., Ge, Y., Lin, X., Li, L., Pan, J., & Yan, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142881 · Cited by 34 · see citing works
Zhong, G. G., Hogarth, C. A., Snyder, J. M., Palau, L., Topping, T., Huang, W., Czuba, L. C., LaFrance, J., Ghiaur, G., & Isoherranen, N. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.009023 · Cited by 33 · see citing works
Monteiro, J. P., Wise, C., Morine, M. J., Teitel, C. H., Pence, L. M., Williams, A., McCabe‐Sellers, B., Champagne, C. M., Turner, J., Shelby, B., et al. (2014) · Genes & Nutrition · doi:10.1007/s12263-014-0403-9 · Cited by 33 · see citing works
Synthetic Retinoids Beyond Cancer Therapy
Gudas, L. J. (2021) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-052120-104428 · Cited by 32 · see citing works
Lerner, U. H. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1298851 · Cited by 36 · see citing works
All-trans retinoic acid in hematologic disorders: not just acute promyelocytic leukemia
Chen, Y., Tong, X., Lu, R., Zhang, Z., & Ma, T. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1404092 · Cited by 30 · see citing works
Giménez-Dejoz, J., Kolář, M. H., Ruiz, F. X., Crespo, I., Cousido-Siah, A., PODJARNY, A. D., Barski, O. A., Fanfrlík, J., Parés, X., Farrés, J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134506 · Cited by 29 · see citing works
Aldehyde Oxidase Contributes to All-Trans-Retinoic Acid Biosynthesis in Human Liver
Zhong, G. G., Seaman, C. J., Paragas, E. M., Xi, H., Herpoldt, K., King, N. P., Jones, J. P., & Isoherranen, N. (2020) · Drug Metabolism and Disposition · doi:10.1124/dmd.120.000296 · Cited by 29 · see citing works
Coronel, J., Yu, J., Pilli, N. R., Kane, M. A., & Amengual, J. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101640 · Cited by 29 · see citing works
Conformationally Defined Rexinoids and Their Efficacy in the Prevention of Mammary Cancers
Atigadda, V. R., Xia, G., Deshpande, A. M., Wu, L., Kedishvili, N. Y., Smith, C. D. L., Krontiras, H., Bland, K. I., Grubbs, C. J., Brouillette, W. J., et al. (2015) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b00829 · Cited by 29 · see citing works
Self-citationRetinoid-xenobiotic interactions: the Ying and the Yang.
Shmarakov, I. O. (2015) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2304-3881.2015.05.05 · Cited by 29 · see citing works
Human DHRS7, promising enzyme in metabolism of steroids and retinoids?
Navrátilová, H., Zemanová, L., Lundová, T., Malčeková, B., Skarka, A., Šafr, M., & Wsól, V. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.09.041 · Cited by 28 · see citing works
Molecular Mechanisms of Retinoid Receptors in Diabetes-Induced Cardiac Remodeling
Pan, J., Guleria, R. S., Zhu, S., & Baker, K. M. (2014) · Journal of Clinical Medicine · doi:10.3390/jcm3020566 · Cited by 28 · see citing works
Snyder, J. M., Zhong, G. G., Hogarth, C. A., Huang, W., Topping, T., LaFrance, J., Palau, L., Czuba, L. C., Griswold, M. D., Ghiaur, G., et al. (2020) · The FASEB Journal · doi:10.1096/fj.202001734r · Cited by 27 · see citing works
The Structural and Biochemical Basis of Apocarotenoid Processing by β-Carotene Oxygenase-2
Bandara, S., Thomas, L. D., Ramkumar, S., Khadka, N., Kiser, P. D., Golczak, M., & Lintig, J. V. (2021) · ACS Chemical Biology · doi:10.1021/acschembio.0c00832 · Cited by 27 · see citing works
Vitamin A and Its Multi-Effects on Pancreas: Recent Advances and Prospects
Zhou, Y., Wang, H., Zhou, J., Qiu, S., Cai, T., Li, H., Shen, Z., Hu, Y., Ding, B., Luo, M.-H., et al. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.620941 · Cited by 27 · see citing works
Belyaeva, O., Adams, M. K., Wu, L., & Kedishvili, N. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.776914 · Cited by 29 · see citing works
Self-citationNutrición animal: Texto de formación universitaria
Huanca, B. R. (2023) · Instituto Universitario de Innovación Ciencia y Tecnología Inudi Perú eBooks · doi:10.35622/inudi.b.090 · Cited by 25 · see citing works
MRP5 and MRP9 play a concerted role in male reproduction and mitochondrial function
Chambers, I. G., Kumar, P., Lichtenberg, J., Wang, P., Yu, J., Phillips, J. D., Kane, M. A., Bodine, D. M., & Hamza, I. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2111617119 · Cited by 25 · see citing works
Adams, M. K., Lee, S., Belyaeva, O. V., Wu, L., & Kedishvili, N. Y. (2016) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2016.10.019 · Cited by 25 · see citing works
Self-citationLundová, T., Zemanová, L., Malčeková, B., Skarka, A., Navrátilová, H., Havránková, J., Šafr, M., & Wsól, V. (2014) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2014.10.018 · Cited by 24 · see citing works
Pregnancy and maternal iron deficiency stimulate hepatic CRBPII expression in rats
Cottin, S. C., Gambling, L., Hayes, H. E., Stevens, V. J., & McArdle, H. J. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.02.005 · Cited by 24 · see citing works
Sahoyama, Y., Hamazato, F., Shiozawa, M., Nakagawa, T., Suda, W., Ogata, Y., Hachiya, T., Kawakami, E., & Hattori, M. (2022) · Scientific Reports · doi:10.1038/s41598-022-07398-8 · Cited by 24 · see citing works
Wu, L., Chaudhary, S., Atigadda, V., Belyaeva, O., Harville, S., Elmets, C., Muccio, D., Athar, M., & Kedishvili, N. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153556 · Cited by 21 · see citing works
Self-citationBeedle, M., Stevison, F., Zhong, G. G., Topping, T., Hogarth, C. A., Isoherranen, N., & Griswold, M. D. (2018) · Biology of Reproduction · doi:10.1093/biolre/ioy200 · Cited by 25 · see citing works
Ma, J., & Lwigale, P. Y. (2019) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.18-26018 · Cited by 23 · see citing works
17β-hydroxysteroid dehydrogenases in the progression of nonalcoholic fatty liver disease
Wang, M., & Peng, Z. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108428 · Cited by 23 · see citing works
Wu, L., Belyaeva, O. V., Adams, M. K., Klyuyeva, A. V., Lee, S., Goggans, K. R., Kesterson, R. A., Popov, K. M., & Kedishvili, N. Y. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010835 · Cited by 22 · see citing works
Self-citationRetinoids Modulate Thioacetamide-Induced Acute Hepatotoxicity
Shmarakov, I. O., Borschovetska, V. L., Marchenko, M. M., & Blaner, W. S. (2014) · Toxicological Sciences · doi:10.1093/toxsci/kfu045 · Cited by 21 · see citing works
Advanced progress on the relationship between RA and its receptors and malignant tumors
Li, M., Sun, Y., Guan, X., Shu, X. H., & Li, C. (2014) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2014.04.001 · Cited by 21 · see citing works
Loss of Serpina1 in Mice Leads to Altered Gene Expression in Inflammatory and Metabolic Pathways
Meghadri, S. H., Martínez–Delgado, B., Ostermann, L., Gómez‐Mariano, G., Pérez-Luz, S., Tumpara, S., Wrenger, S., DeLuca, D. S., Maus, U. A., Welte, T., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810425 · Cited by 20 · see citing works
Retinol dehydrogenases: Membrane-bound enzymes for the visual function
Lhor, M., & Salesse, C. (2014) · Biochemistry and Cell Biology · doi:10.1139/bcb-2014-0082 · Cited by 20 · see citing works
Fetal Alcohol Spectrum Disorder: Embryogenesis Under Reduced Retinoic Acid Signaling Conditions
Fainsod, A., Bendelac-Kapon, L., & Shabtai, Y. (2020) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-030-42282-0_8 · Cited by 21 · see citing works
Evolutionary origins of retinoid active short-chain dehydrogenases/reductases of SDR16C family
Belyaeva, O., Chang, C.-B., Berlett, M., & Kedishvili, N. (2014) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2014.10.026 · Cited by 20 · see citing works
Self-citationRXR Ligands Modulate Thyroid Hormone Signaling Competence in Young Xenopus laevis Tadpoles
Mengeling, B. J., Goodson, M. L., & Furlow, J. D. (2018) · Endocrinology · doi:10.1210/en.2018-00172 · Cited by 20 · see citing works
Therapeutic Uses of Retinol and Retinoid-Related Antioxidants
Vašková, J., Stupák, M., Uğurbaş, M. V., Židzik, J., & Mičková, H. (2025) · Molecules · doi:10.3390/molecules30102191 · Cited by 19 · see citing works
Retinoid Agonists in the Targeting of Heterotopic Ossification
Pignolo, R. J., & Pacifici, M. (2021) · Cells · doi:10.3390/cells10113245 · Cited by 19 · see citing works
Thangavelu, G., Lee, Y., Loschi, M. L., Schaechter, K. M., Feser, C. J., Koehn, B. H., Nowak, E. C., Zeiser, R., Serody, J. S., Murphy, W. J., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1800899 · Cited by 18 · see citing works
Nutraceuticals for Diabetic Retinopathy: Recent Advances and Novel Delivery Systems
Ye, X., Fung, N. S. K., Lam, W., & Lo, A. (2024) · Nutrients · doi:10.3390/nu16111715 · Cited by 18 · see citing works
Paracardial fat remodeling affects systemic metabolism through alcohol dehydrogenase 1
Petrosino, J. M., Longenecker, J. Z., Ramkumar, S., Xu, X., Dorn, L. E., Bratasz, A., Yu, L., Maurya, S. K., Tolstikov, V., Bussberg, V., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci141799 · Cited by 18 · see citing works
Wan, S., Li, Q., Yu, H., Liu, S., & Kong, L. (2022) · Gene · doi:10.1016/j.gene.2022.146226 · Cited by 17 · see citing works
Shmarakov, I. O., Gusarova, G. A., Islam, M. N., Marhuenda‐Muñoz, M., Bhattacharya, J., & Blaner, W. S. (2023) · Nature Communications · doi:10.1038/s41467-023-36475-3 · Cited by 17 · see citing works
Kim, Y., Zuccaro, M. V., Costabile, B. K., Rodas, R., & Quadro, L. (2015) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.01.002 · Cited by 17 · see citing works
Retinoic acid signaling reduction recapitulates the effects of alcohol on embryo size
Shukrun, N., Shabtai, Y., Pillemer, G., & Fainsod, A. (2019) · genesis · doi:10.1002/dvg.23284 · Cited by 17 · see citing works
Giménez-Dejoz, J., Weber, S., Fernández‐Pardo, Á., Möller, G., Adamski, J., Porté, S., Parés, X., & Farrés, J. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2019.04.030 · Cited by 16 · see citing works
Dutta, D., Nayak, A., & Dutta, D. (2022) · Food and Bioprocess Technology · doi:10.1007/s11947-022-02888-z · Cited by 16 · see citing works
Wassef, L., Shete, V., Costabile, B. K., Rodas, R., & Quadro, L. (2015) · Journal of NutriLife · doi:10.3945/jn.114.207043 · Cited by 16 · see citing works
Ito, K., Zolfaghari, R., Hao, L., & Ross, A. C. (2014) · Nutrition & Metabolism · doi:10.1186/1743-7075-11-54 · Cited by 17 · see citing works
Retinoic acid signaling and metabolism in heart failure
Parker, L. E., Papanicolaou, K. N., Zalesak‐Kravec, S., Weinberger, E. M., Kane, M. A., & Foster, D. B. (2025) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00871.2024 · Cited by 15 · see citing works
Retinoids in Cutaneous Squamous Cell Carcinoma
Everts, H. B., & Akuailou, E.-N. (2021) · Nutrients · doi:10.3390/nu13010153 · Cited by 15 · see citing works
Kalaskar, V. K., Alur, R. P., Li, L. K., Thomas, J. W., Sergeev, Y. V., Blain, D., Hufnagel, R. B., Cogliati, T., & Brooks, B. P. (2019) · Human Mutation · doi:10.1002/humu.23954 · Cited by 15 · see citing works
Morgenstern, J., Fleming, T. H., Kliemank, E., Brune, M., Nawroth, P. P., & Fischer, A. (2021) · Metabolites · doi:10.3390/metabo11010060 · Cited by 15 · see citing works
Galbán-Velázquez, S., Esteban, J., Cakmak, G. D., Artacho‐Cordón, F., León, J., Barril, J., Vela-Soria, F., Martín‐Olmedo, P., Fernández, M. F., Pellin, M. C., et al. (2021) · Environmental Research · doi:10.1016/j.envres.2021.110764 · Cited by 15 · see citing works
The Absorption, Storage, and Transport of Ocular Carotenoids and Retinoids
Lintig, J. V., & Bandara, S. (2024) · Annual Review of Vision Science · doi:10.1146/annurev-vision-102122-101846 · Cited by 15 · see citing works
Pet Wellness and Vitamin A: A Narrative Overview
Shastak, Y., & Pelletier, W. (2024) · Animals · doi:10.3390/ani14071000 · Cited by 18 · see citing works
Translation of a Tissue-Selective Rexinoid, UAB30, to the Clinic for Breast Cancer Prevention
Muccio, D. D., Atigadda, V. R., Brouillette, W. J., Bland, K. I., Krontiras, H., & Grubbs, C. J. (2016) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026616666160617093604 · Cited by 14 · see citing works
- Authors
- Kedishvili, N. Y.
- Affiliations
- University of Alabama at Birmingham (US)
- Corresponding author
- Kedishvili, Natalia Y.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 54
- Issue
- 7
- Pages
- 1744-1760
- ISSN
- 0022-2275 (ISSN-L)
- PMC
- PMC3679379
- OpenAlex
- W2327834369
- Cited by
- 196
- References
- 191
- Citations by year
- 2026: 10 · 2025: 16 · 2024: 11 · 2023: 14 · 2022: 12 · 2021: 15 · 2020: 10 · 2019: 29 · 2018: 6 · 2017: 12 · 2016: 19 · 2015: 22 · 2014: 14 · 2013: 5 · 2012: 1
- FWCI
- 1.91
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01 AA-12153, R01AA012153)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (P30AR050948)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- retinoic acid synthesis, vitamin A metabolism, short-chain dehydrogenase/reductase superfamily, retinoid-binding proteins, vitamin A
- MeSH terms
- Enzymes, Tretinoin
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