Cited by 197Retinoids in leukemia and cellular processesCholesterol and Lipid MetabolismPeroxisome Proliferator-Activated Receptors

Enzymology of retinoic acid biosynthesis and degradation

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Kedishvili, Natalia Y.·2013·Journal of Lipid Research

Abstract

All-trans-retinoic acid is a biologically active derivative of vitamin A that regulates numerous physiological processes. The concentration of retinoic acid in the cells is tightly regulated, but the exact mechanisms responsible for this regulation are not completely understood, largely because the enzymes involved in the biosynthesis of retinoic acid have not been fully defined. Recent studies using in vitro and in vivo models suggest that several members of the short-chain dehydrogenase/reductase superfamily of proteins are essential for retinoic acid biosynthesis and the maintenance of retinoic acid homeostasis. However, the exact roles of some of these recently identified enzymes are yet to be characterized. The properties of the known contributors to retinoid metabolism have now been better defined and allow for more detailed understanding of their interactions with retinoid-binding proteins and other retinoid enzymes. At the same time, further studies are needed to clarify the interactions between the cytoplasmic and membrane-bound proteins involved in the processing of hydrophobic retinoid metabolites. This review summarizes current knowledge about the roles of various biosynthetic and catabolic enzymes in the regulation of retinoic acid homeostasis and outlines the remaining questions in the field.

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Crossref · 10.1194/jlr.r037028

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  • With the exception of vision, the physiological actions of vitamin A are mediated by its bioactive metabolite, retinoic acid.

    “With the exception of vision, the physiological actions of vitamin A are mediated by its bioactive metabolite, retinoic acid [8,9,10].”

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Authors
Kedishvili, N. Y.
Affiliations
University of Alabama at Birmingham (US)
Corresponding author
Kedishvili, Natalia Y.
Venue
Journal of Lipid Research
Publisher
Elsevier BV
Published
2013-07
Volume
54
Issue
7
Pages
1744-1760
ISSN
0022-2275 (ISSN-L)
OpenAlex
W2327834369
Cited by
196
References
191
Citations by year
2026: 10 · 2025: 16 · 2024: 11 · 2023: 14 · 2022: 12 · 2021: 15 · 2020: 10 · 2019: 29 · 2018: 6 · 2017: 12 · 2016: 19 · 2015: 22 · 2014: 14 · 2013: 5 · 2012: 1
FWCI
1.91
Type
journal article
Language
en
Open access
Locations
  • Journal of Lipid Research (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Institute on Alcohol Abuse and Alcoholism (R01 AA-12153, R01AA012153)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (P30AR050948)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords
retinoic acid synthesis, vitamin A metabolism, short-chain dehydrogenase/reductase superfamily, retinoid-binding proteins, vitamin A
MeSH terms
Enzymes, Tretinoin

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