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Cited by 23Regulation of Appetite and ObesityThermal Regulation in MedicineAdipose Tissue and Metabolism

Acute lesions of the ventromedial hypothalamus reduce sympathetic activation and thermogenic changes induced by PGE1

Monda, M, Sullo, A, De Luca, V, Viggiano, A, Pellicano, MP·1997·Journal of Physiology-Paris
DOI 10.1016/s0928-4257(97)82408-4
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Abstract

The aim of this experiment was to evaluate the effects of an intracerebroventricular (icv) injection of prostaglandin E1 (PGE1) on the sympathetic activation and the thermogenic changes in rats with acute lesions of the ventromedial hypothalamus (VMH). Four groups of six Sprague-Dawley male rats were anesthetized with ethyl-urethane. The firing rate of the sympathetic nerves innervating the interscapular brown adipose tissue (IBAT) and the colonic and IBAT temperatures were monitored both before and after one of the following treatments: 1) VMH lesion plus icv injection of PGE1 (500 ng); 2) VMH lesion plus icv injection of saline: 3) sham lesion plus icv injection of PGE1; and 4) sham lesion plus icv injection of saline. PGE1 induced an increase in the firing rate of IBAT nerves and the colonic and IBAT temperatures. These effects were reduced by VMH lesion. The findings indicate that acute lesions of the VMH reduce the effects of PGE1 and seem to suggest a possible role played by the VMH in the control of the sympathetic activation and the thermogenic changes during PGE1 hyperthermia.

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  • The hypothalamus, particularly the ventromedial and dorsomedial nuclei, integrates signals from the autonomic nervous system that govern heart rate, blood pressure, respiratory rate, body temperature, and digestion.

    “First, the hypothalamus, in particular the ventromedial and dorsomedial hypothalamic nuclei, integrates signals from the autonomic nervous system that govern physiologic processes including heart rate, blood pressure, respiratory rate, body temperature, and digestion (53-56).”

    From Approach to the patient with acquired hypothalamic syndrome (2026) · cites this paper as [53]

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Authors
Monda, M., Sullo, A., De Luca, V, Viggiano, A., & Pellicano, M.
Affiliations
  • University of Campania "Luigi Vanvitelli" (IT)
  • Institute of Food Science (IT)
ORCID
Venue
Journal of Physiology-Paris
Publisher
Elsevier BV
Published
1997-12
Volume
91
Issue
6
Pages
285-290
ISSN
0928-4257 (ISSN-L)
DOI
10.1016/s0928-4257(97)82408-4
OpenAlex
W1975587758
Cited by
23
References
0
Citations by year
2026: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2018: 1 · 2017: 2 · 2015: 2 · 2014: 1 · 2013: 2
FWCI
0.44
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Physiology-Paris (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
ventromedial hypothalamus, hypothalamic lesions, prostaglandin E1, thermogenesis, sympathetic activation, interscapular brown adipose tissue, colonic temperature, thermoregulation, hyperthermia, intracerebroventricular administration
MeSH terms
Alprostadil, Animals, Body Temperature Regulation, Adipose Tissue, Brown, Colon, Electrophysiology, Injections, Intraventricular, Male, Sympathetic Nervous System, Ventromedial Hypothalamic Nucleus, Rats, Sprague-Dawley, Rats

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