Hypothalamic control of energy expenditure and thermogenesis

Tran, Le Trung; Park, Sohee; Kim, Seul Ki; Lee, Jin Sun; Kim, Ki Woo; Kwon, Obin

doi:10.1038/s12276-022-00741-z

Cited by 211Regulation of Appetite and ObesityAdipose Tissue and MetabolismHypothalamic control of reproductive hormones

Hypothalamic control of energy expenditure and thermogenesis

Open access

Tran, Le Trung, Park, Sohee, Kim, Seul Ki, Lee, Jin Sun, Kim, Ki Woo, Kwon, Obin·2022·Experimental & Molecular Medicine

DOI 10.1038/s12276-022-00741-zPMC PMC9076616

Open this paper in CoChat — free account Open PDF

Abstract

Energy expenditure and energy intake need to be balanced to maintain proper energy homeostasis. Energy homeostasis is tightly regulated by the central nervous system, and the hypothalamus is the primary center for the regulation of energy balance. The hypothalamus exerts its effect through both humoral and neuronal mechanisms, and each hypothalamic area has a distinct role in the regulation of energy expenditure. Recent studies have advanced the understanding of the molecular regulation of energy expenditure and thermogenesis in the hypothalamus with targeted manipulation techniques of the mouse genome and neuronal function. In this review, we elucidate recent progress in understanding the mechanism of how the hypothalamus affects basal metabolism, modulates physical activity, and adapts to environmental temperature and food intake changes.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/s12276-022-00741-z

Cites

216 of 216 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The hypothalamus has a critical role in maintaining body temperature via circulating humoral signals (eg, thyroid hormone) and regulation of nervous system inputs (eg, sympathetic tone).
“The hypothalamus has a critical role in maintaining body temperature via circulating humoral signals (eg, thyroid hormone) and regulation of nervous system inputs (eg, sympathetic tone) (78).”
From Approach to the patient with acquired hypothalamic syndrome (2026) · cites this paper as [78]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice
Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017 · see citing works
Cellular energy utilization and molecular origin of standard metabolic rate in mammals
Rolfe, D. F., & Brown, G. C. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.3.731 · Cited by 2,021 · see citing works
A biometric study of human basal metabolism
Harris, J. A., & Benedict, F. G. (1918) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.4.12.370 · Cited by 1,980 · see citing works
Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
Ollmann, M. M., Wilson, B. D., Yang, Y.-K., Kerns, J. A., Chen, Y., Gantz, I., & Barsh, G. S. (1997) · Science · doi:10.1126/science.278.5335.135 · Cited by 1,881 · see citing works
UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality
Feldmann, H. M., Golozoubova, V., Cannon, B., & Nedergaard, J. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.12.014 · Cited by 1,318 · see citing works
Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin
Yaswen, L. R., Diehl, N. L., Brennan, M. B., & Hochgeschwender, U. (1999) · Nature Medicine · doi:10.1038/12506 · Cited by 1,010 · see citing works
Skeletal muscle metabolism is a major determinant of resting energy expenditure.
Zurlo, F., Larson, K., Bogardus, C., & Ravussin, E. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114857 · Cited by 959 · see citing works
Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity
Timper, K., & Brüning, J. C. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.026609 · Cited by 802 · see citing works
Regulation of Body Temperature by the Nervous System
Tan, C. L., & Knight, Z. A. (2018) · Neuron · doi:10.1016/j.neuron.2018.02.022 · Cited by 798 · see citing works
Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis
Dhillon, H., Zigman, J. M., Ye, C., Lee, C. E., McGovern, R. A., Tang, V., Kenny, C. D., Christiansen, L. M., White, R. D., Edelstein, E. A., et al. (2006) · Neuron · doi:10.1016/j.neuron.2005.12.021 · Cited by 791 · see citing works
Glossary of terms for thermal physiology.
Bligh, J., & Johnson, K. (1973) · Journal of Applied Physiology · doi:10.1152/jappl.1973.35.6.941 · Cited by 740 · see citing works
Thermogenic Mechanisms and Their Hormonal Regulation
Silva, J. E. (2006) · Physiological Reviews · doi:10.1152/physrev.00009.2005 · Cited by 687 · see citing works
Nonshivering thermogenesis and its adequate measurement in metabolic studies
Cannon, B., & Nedergaard, J. (2011) · Journal of Experimental Biology · doi:10.1242/jeb.050989 · Cited by 677 · see citing works
Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance
López, M., Varela, L., Vazquez, M. J., Rodríguez‐Cuenca, S., González, C. R., Velagapudi, V., Morgan, D. A., Schoenmakers, E., Agassandian, K., Lage, R., et al. (2010) · Nature Medicine · doi:10.1038/nm.2207 · Cited by 674 · see citing works
Cafeteria Diet Is a Robust Model of Human Metabolic Syndrome With Liver and Adipose Inflammation: Comparison to High‐Fat Diet
Sampey, B. P., Vanhoose, A. M., Winfield, H. M., Freemerman, A. J., Muehlbauer, M. J., Fueger, P. T., Newgard, C. B., & Makowski, L. (2011) · Obesity · doi:10.1038/oby.2011.18 · Cited by 618 · see citing works
GLP-1 agonism stimulates brown adipose tissue thermogenesis and browning through hypothalamic AMPK
Beiroa, D., Imbernon, M., Gallego, R., Senra, A., Herranz, D., Villarroya, F., Serrano, M., Fernø, J., Salvador, J., Escalada, J., et al. (2014) · Diabetes · doi:10.2337/db14-0302 · Cited by 602 · see citing works
The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis
Cone, R. D., Cowley, M. A., Butler, A. A., Fan, W., Dl, M., & Low, M. J. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801913 · Cited by 591 · see citing works
Cellular bioenergetics as a target for obesity therapy
Tseng, Y.-H., Cypess, A. M., & Kahn, C. R. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3138 · Cited by 591 · see citing works
Central Mechanisms for Thermoregulation
Morrison, S. F., & Nakamura, K. (2018) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020518-114546 · Cited by 586 · see citing works
THE POSSIBLE MECHANISMS OF CONTRACTING AND PAYING THE OXYGEN DEBT AND THE RÔLE OF LACTIC ACID IN MUSCULAR CONTRACTION
Margaria, R., Edwards, H. T., & Dill, D. B. (1933) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1933.106.3.689 · Cited by 573 · see citing works
Central circuitries for body temperature regulation and fever
Nakamura, K. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00109.2011 · Cited by 543 · see citing works
Mapping of human brown adipose tissue in lean and obese young men
Leitner, B. P., Huang, S., Brychta, R. J., Duckworth, C. J., Baskin, A. S., McGehee, S., Tal, I., Dieckmann, W., Gupta, G., Kolodny, G. M., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705287114 · Cited by 530 · see citing works
Factors influencing variation in basal metabolic rate include fat-free mass, fat mass, age, and circulating thyroxine but not sex, circulating leptin, or triiodothyronine
Johnstone, A. M., Murison, S. D., Duncan, J. S., Rance, K. A., & Speakman, J. R. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.5.941 · Cited by 514 · see citing works
The Browning of White Adipose Tissue: Some Burning Issues
Nedergaard, J., & Cannon, B. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.07.005 · Cited by 500 · see citing works
The melanocortin system
Gantz, I., & Fong, T. M. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00434.2002 · Cited by 466 · see citing works
The hypothalamic arcuate nucleus: A key site for mediating leptin’s effects on glucose homeostasis and locomotor activity
Coppari, R., Ichinose, M., Lee, C. E., Pullen, A. E., Kenny, C. D., McGovern, R. A., Tang, V., Liu, S. M., Ludwig, T., Chua, S. C., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.004 · Cited by 457 · see citing works
The ventromedial hypothalamic syndrome, satiety, and a cephalic phase hypothesis.
Powley, T. L. (1977) · Psychological Review · doi:10.1037/0033-295x.84.1.89 · Cited by 452 · see citing works
Estradiol Regulates Brown Adipose Tissue Thermogenesis via Hypothalamic AMPK
de Morentin, P. B. M., González‐García, I., Martins, L., Lage, R., Fernández-Mallo, D., Martínez‐Sánchez, N., Ruíz-Pino, F., Liu, J. T., Morgan, D. A., Pinilla, L., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.031 · Cited by 452 · see citing works
Self-starvation of rats living in activity wheels on a restricted feeding schedule.
Routtenberg, A., & Kuznesof, A. W. (1967) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0025205 · Cited by 450 · see citing works
Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake
Kitamura, T., Feng, Y., Kitamura, Y., Chua, S. C., Xu, A. W., Barsh, G. S., Rossetti, L., & Accili, D. (2006) · Nature Medicine · doi:10.1038/nm1392 · Cited by 449 · see citing works
Regulation of muscle mass by growth hormone and IGF‐I
Velloso, C. P. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.153 · Cited by 444 · see citing works
The hypothalamus
Saper, C. B., & Lowell, B. B. (2014) · Current Biology · doi:10.1016/j.cub.2014.10.023 · Cited by 423 · see citing works
Central nervous system control of metabolism
Myers, M. G., & Olson, D. P. (2012) · Nature · doi:10.1038/nature11705 · Cited by 399 · see citing works
Thyroid Hormone as a Determinant of Energy Expenditure and the Basal Metabolic Rate
Kim, B. W. (2008) · Thyroid · doi:10.1089/thy.2007.0266 · Cited by 383 · see citing works
Diagnosis, Genetics, and Therapy of Short Stature in Children: A Growth Hormone Research Society International Perspective
Collett‐Solberg, P. F., Ambler, G. R., Backeljauw, P. F., Bidlingmaier, M., Biller, B. M. K., Boguszewski, M. C. D. S., Cheung, P. T., Choong, C. S., Cohen, L. E., Cohen, P., et al. (2019) · Hormone Research in Paediatrics · doi:10.1159/000502231 · Cited by 370 · see citing works
A hypothalamic circuit that controls body temperature
Zhao, Z., Yang, W. Z., Gao, C., Fu, X., Zhang, W., Zhou, Q., Chen, W., Ni, X., Lin, J.-K., Yang, J., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1616255114 · Cited by 352 · see citing works
The Central Melanocortin System and Energy Homeostasis
Cone, R. D. (1999) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(99)00153-8 · Cited by 351 · see citing works
Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis
Kim, M.-S., Pak, Y. K., Jang, P., NamKoong, C., Choi, Y.-S., Won, J. C., Kim, K., Kim, S., Kim, H.-S., Park, J., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1731 · Cited by 330 · see citing works
Self-citation
Increased energy requirements and changes in body composition with resistance training in older adults
Campbell, W. W., Crim, M. C., Young, V. R., & Evans, W. (1994) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/60.2.167 · Cited by 330 · see citing works
Activation of brown adipose tissue thermogenesis by the ventromedial hypothalamus
Perkins, M., Rothwell, N. J., Stock, M. J., & Stone, T. W. (1981) · Nature · doi:10.1038/289401a0 · Cited by 326 · see citing works
The effects of aging on gene expression in the hypothalamus and cortex of mice
Jiang, C. H., Tsien, J. Z., Schultz, P. G., & Hu, Y. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1930 · Cited by 318 · see citing works
The design of barriers in the hypothalamus allows the median eminence and the arcuate nucleus to enjoy private milieus: The former opens to the portal blood and the latter to the cerebrospinal fluid
Rodríguez, E. M., Blázquez, J. L., & Guerra, M. (2010) · Peptides · doi:10.1016/j.peptides.2010.01.003 · Cited by 308 · see citing works
Thermal physiology of laboratory mice: Defining thermoneutrality
Gordon, C. J. (2012) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2012.08.004 · Cited by 305 · see citing works
Whole-brain mapping of the direct inputs and axonal projections of POMC and AgRP neurons
Wang, D., He, X., Zhao, Z., Feng, Q., Lin, R., Sun, Y., Ding, T., Xu, F., Luo, M., & Zhan, C. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2015.00040 · Cited by 298 · see citing works
Microinjection of leptin into the ventromedial hypothalamus increases glucose uptake in peripheral tissues in rats.
Minokoshi, Y., Haque, M. S., & Shimazu, T. (1999) · Diabetes · doi:10.2337/diabetes.48.2.287 · Cited by 296 · see citing works
Oxytocin receptor-deficient mice developed late-onset obesity
Takayanagi, Y., Kasahara, Y., Onaka, T., Takahashi, N., Kawada, T., & Nishimori, K. (2008) · Neuroreport · doi:10.1097/wnr.0b013e3283021ca9 · Cited by 294 · see citing works
Hypothalamic Obesity: The Myth of the Ventromedial Nucleus
Gold, R. M. (1973) · Science · doi:10.1126/science.182.4111.488 · Cited by 290 · see citing works
Knockout Mice Lacking Steroidogenic Factor 1 Are a Novel Genetic Model of Hypothalamic Obesity
Majdič, G., Young, M. J., Gómez-Sánchez, E. P., Anderson, P., Szczepaniak, L. S., Dobbins, R. L., McGarry, J., & Parker, K. L. (2002) · Endocrinology · doi:10.1210/endo.143.2.8652 · Cited by 289 · see citing works
O-GlcNAc Transferase Enables AgRP Neurons to Suppress Browning of White Fat
Ruan, H.-B., Dietrich, M. O., Liu, Z.-W., Zimmer, M. R., Li, M.-D., Singh, J. P., Zhang, K., Yin, R., Wu, J., Horvath, T. L., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.010 · Cited by 281 · see citing works
UCP1 Dependent and Independent Thermogenesis in Brown and Beige Adipocytes
Ikeda, K., & Yamada, T. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00498 · Cited by 276 · see citing works
The Versatile Tanycyte: A Hypothalamic Integrator of Reproduction and Energy Metabolism
Prévot, V., Dehouck, B., Sharif, A., Ciofi, P., Giacobini, P., & Clasadonte, J. (2018) · Endocrine Reviews · doi:10.1210/er.2017-00235 · Cited by 271 · see citing works
Androgen Receptor Null Male Mice Develop Late-Onset Obesity Caused by Decreased Energy Expenditure and Lipolytic Activity but Show Normal Insulin Sensitivity With High Adiponectin Secretion
Fan, W., Yanase, T., Nomura, M., Okabe, T., Goto, K., Sato, T., Kawano, H., Kato, S., & Nawata, H. (2005) · Diabetes · doi:10.2337/diabetes.54.4.1000 · Cited by 269 · see citing works
Acute Hyperinsulinemia and Its Reversal by Vagotomy after Lesions of the Ventromedial Hypothalamus in Anesthetized Rats*
BERTHOUD, H. R., & JEANRENAUD, B. (1979) · Endocrinology · doi:10.1210/endo-105-1-146 · Cited by 266 · see citing works
Arcuate NPY Controls Sympathetic Output and BAT Function via a Relay of Tyrosine Hydroxylase Neurons in the PVN
Shi, Y.-C., Lau, J., Lin, Z., Zhang, H., Zhai, L., Sperk, G., Heilbronn, R., Mietzsch, M., Weger, S., Huang, X.-F., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.006 · Cited by 266 · see citing works
Effect of age on body composition and resting metabolic rate
Fukagawa, N. K., Bandini, L. G., & Young, J. B. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.259.2.e233 · Cited by 262 · see citing works
The MC4 receptor and control of appetite
Adan, R. A. H., Tiesjema, B., Hillebrand, J. J., la Fleur, S. E., Kas, M. J., & de Krom, M. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706929 · Cited by 260 · see citing works
Basal Metabolic Rate: History, Composition, Regulation, and Usefulness
Hulbert, A. J., & Else, P. L. (2004) · Physiological and Biochemical Zoology · doi:10.1086/422768 · Cited by 242 · see citing works
Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons
Yang, S.-B., Tien, A.-C., Boddupalli, G., Xu, A. W., Jan, Y. N., & Jan, L. Y. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.043 · Cited by 242 · see citing works
Brown Adipose Tissue, Diet-Induced Thermogenesis, and Thermogenic Food Ingredients: From Mice to Men
Saito, M., Matsushita, M., Yoneshiro, T., & Okamatsu‐Ogura, Y. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00222 · Cited by 241 · see citing works
Leptin-Receptor-Expressing Neurons in the Dorsomedial Hypothalamus and Median Preoptic Area Regulate Sympathetic Brown Adipose Tissue Circuits
Zhang, Y., Kerman, I. A., Laque, A., Nguyen, P., Faouzi, M., Louis, G. W., Jones, J. C., Rhodes, C. J., & Münzberg, H. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3223-10.2011 · Cited by 240 · see citing works
Central efferent pathways for cold-defensive and febrile shivering
Nakamura, K., & Morrison, S. F. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.210047 · Cited by 238 · see citing works
Health Care–Associated Bloodstream Infections
Kaye, K. S., Friedman, N. D., & Sexton, D. J. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-3-200308050-00018 · Cited by 232 · see citing works
Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance
Martínez‐Sánchez, N., Seoane‐Collazo, P., Contreras, C., Varela, L., Villarroya, J., Rial‐Pensado, E., Buqué, X., Aurrekoetxea, I., Delgado, T. C., Vázquez‐Martínez, R., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.06.014 · Cited by 231 · see citing works
Central Administration of Ghrelin and Agouti-Related Protein (83–132) Increases Food Intake and Decreases Spontaneous Locomotor Activity in Rats
Tang-Christensen, M., Vrang, N., Ortmann, S., Bidlingmaier, M., Horvath, T. L., & Tschöp, M. (2004) · Endocrinology · doi:10.1210/en.2004-0529 · Cited by 226 · see citing works
Non-Exercise Activity Thermogenesis
Levine, J. A., Weg, M. W. V., Hill, J. O., & Klesges, R. C. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000205848.83210.73 · Cited by 225 · see citing works
Total energy expenditure in the elderly
Elia, M., Ritz, P., & Stubbs, R. J. (2000) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601030 · Cited by 223 · see citing works
Integration of body temperature into the analysis of energy expenditure in the mouse
Abreu-Vieira, G., Xiao, C., Gavrilova, O., & Reitman, M. L. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.03.001 · Cited by 221 · see citing works
Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus
Kim, K. W., Zhao, L., Donato, J., Kohno, D., Xu, Y., Elias, C. F., Lee, C., Parker, K. L., & Elmquist, J. K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102364108 · Cited by 219 · see citing works
Self-citation
Thermoregulatory responses to hypothalamic cooling in unanesthetized dogs
Hammel, H. T., Hardy, J. D., & Fusco, M. M. (1960) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1960.198.3.481 · Cited by 218 · see citing works
GABAergic RIP-Cre Neurons in the Arcuate Nucleus Selectively Regulate Energy Expenditure
Kong, D., Tong, Q., Ye, C., Koda, S., Fuller, P. M., Krashes, M. J., Vong, L., Ray, R. S., Olson, D. P., & Lowell, B. B. (2012) · Cell · doi:10.1016/j.cell.2012.09.020 · Cited by 215 · see citing works
Selective Loss of Leptin Receptors in the Ventromedial Hypothalamic Nucleus Results in Increased Adiposity and a Metabolic Syndrome
Bingham, N. C., Anderson, K. K., Reuter, A. L., Stallings, N. R., & Parker, K. L. (2008) · Endocrinology · doi:10.1210/en.2007-1200 · Cited by 213 · see citing works
Torpor in mice is induced by both leptin-dependent and -independent mechanisms
Gavrilova, O., Leon, L. R., Marcus‐Samuels, B., Mason, M. M., Castle, A. L., Refetoff, S., Vinson, C., & Reitman, M. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.25.14623 · Cited by 210 · see citing works
Knockdown of NPY Expression in the Dorsomedial Hypothalamus Promotes Development of Brown Adipocytes and Prevents Diet-Induced Obesity
Chao, P.-T., Yang, L., Aja, S. M., Moran, T. H., & Bi, S. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.02.019 · Cited by 206 · see citing works
Evidence for a Continuum of Genetic, Phenotypic, and Biochemical Abnormalities in Children with Growth Hormone Insensitivity
David, A., Hwa, V., Metherell, L., Netchine, I., Camacho‐Hübner, C., Clark, A., Rosenfeld, R. G., & Savage, M. O. (2011) · Endocrine Reviews · doi:10.1210/er.2010-0023 · Cited by 203 · see citing works
FoxO1 Target Gpr17 Activates AgRP Neurons to Regulate Food Intake
Ren, H., Orozco, I. J., Su, Y., Suyama, S., Juárez, R. G., Horváth, T. L., Wardlaw, S. L., Plum, L., Arancio, O., & Accili, D. (2012) · Cell · doi:10.1016/j.cell.2012.04.032 · Cited by 201 · see citing works
Leptin receptor neurons in the dorsomedial hypothalamus are key regulators of energy expenditure and body weight, but not food intake
Rezai-Zadeh, K. P., Yu, S., Jiang, Y., Laque, A., Schwartzenburg, C., Morrison, C. D., Derbenev, A. V., Zsombok, A., & Münzberg, H. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.07.008 · Cited by 193 · see citing works
Hypothalamic Arcuate Nucleus Mediates the Sympathetic and Arterial Pressure Responses to Leptin
Rahmouni, K., & Morgan, D. A. (2006) · Hypertension · doi:10.1161/01.hyp.0000254827.59792.b2 · Cited by 180 · see citing works
The thermogenic effect of thyroid hormone and its clinical implications
Silva, J. E. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-3-200308050-00010 · Cited by 173 · see citing works
Development of a steroidogenic factor 1/Cre transgenic mouse line
Bingham, N. C., Verma‐Kurvari, S., Parada, L. F., & Parker, K. L. (2006) · genesis · doi:10.1002/dvg.20231 · Cited by 167 · see citing works
Translating Animal Model Research: Does It Matter That Our Rodents Are Cold?
Maloney, S. K., Fuller, A., Mitchell, D., Gordon, C. J., & Overton, J. M. (2014) · Physiology · doi:10.1152/physiol.00029.2014 · Cited by 166 · see citing works
Thyroid hormones induce browning of white fat
Martínez‐Sánchez, N., Moreno‐Navarrete, J. M., Contreras, C., Rial‐Pensado, E., Fernø, J., Nogueiras, R., Diéguez, C., Fernández‐Real, J. M., & López, M. (2016) · Journal of Endocrinology · doi:10.1530/joe-16-0425 · Cited by 166 · see citing works
Discrete BDNF Neurons in the Paraventricular Hypothalamus Control Feeding and Energy Expenditure
An, J. J., Liao, G., Kinney, C. E., Sahibzada, N., & Xu, B. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.008 · Cited by 164 · see citing works
Feeding and activity induced by orexin A in the lateral hypothalamus in rats
Kotz, C. M., Teske, J. A., Levine, J. A., & Wang, C. (2002) · Regulatory Peptides · doi:10.1016/s0167-0115(01)00346-9 · Cited by 163 · see citing works
Identification of Body Fat Mass as a Major Determinant of Metabolic Rate in Mice
Kaiyala, K. J., Morton, G. J., Leroux, B. G., Ogimoto, K., Wisse, B. E., & Schwartz, M. W. (2010) · Diabetes · doi:10.2337/db09-1582 · Cited by 163 · see citing works
Genetic rescue of nonclassical ERα signaling normalizes energy balance in obese Erα-null mutant mice
Park, C. J., Zhao, Z., Glidewell-Kenney, C., Lazic, M., Chambon, P., Krust, A., Weiss, J., Clegg, D. J., Dunaif, A., Jameson, J. L., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci41702 · Cited by 162 · see citing works
Plasma insulin and triglyceride levels after hypothalamic lesions in weanling rats
Frohman, L. A., Bernardis, L. L., Schnatz, J. D., & BUREK, L. (1969) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1969.216.6.1496 · Cited by 160 · see citing works
Glutamatergic Preoptic Area Neurons That Express Leptin Receptors Drive Temperature-Dependent Body Weight Homeostasis
Yu, S., Qualls‐Creekmore, E., Rezai-Zadeh, K. P., Jiang, Y., Berthoud, H., Morrison, C. D., Derbenev, A. V., Zsombok, A., & Münzberg, H. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0213-16.2016 · Cited by 159 · see citing works
An Estrogen-Responsive Module in the Ventromedial Hypothalamus Selectively Drives Sex-Specific Activity in Females
Correa, S. M., Newstrom, D. W., Warne, J. P., Flandin, P., Cheung, C. C., Lin-Moore, A. T., Pierce, A. A., Xu, A. W., Rubenstein, J. L. R., & Ingraham, H. A. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.12.011 · Cited by 155 · see citing works
Coordination of hypothalamic and pituitary T3 production regulates TSH expression
Fonseca, T. L., Correa-Medina, M., Campos, M. P. O., Wittmann, G., Werneck-de-Castro, J. P., Arrojo e Drigo, R., Mora-Garzon, M., Ueta, C. B., Caicedo, A., Fekete, C., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci61231 · Cited by 155 · see citing works
Low levels of physical activity are associated with dysregulation of energy intake and fat mass gain over 1 year
Shook, R. P., Hand, G. A., Drenowatz, C. J., Hébert, J. R., Paluch, A. E., Blundell, J. E., Hill, J. O., Katzmarzyk, P. T., Church, T. S., & Blair, S. N. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.115360 · Cited by 149 · see citing works
A role for insulin in the diet-induced thermogenesis of cafeteria-fed rats
Rothwell, N. J., & Stock, M. J. (1981) · Metabolism · doi:10.1016/0026-0495(81)90082-2 · Cited by 148 · see citing works
Ablation of the Leptin Receptor in the Hypothalamic Arcuate Nucleus Abrogates Leptin-Induced Sympathetic Activation
Harlan, S. M., Morgan, D. A., Agassandian, K., Guo, D.-F., Cassell, M. D., Sigmund, C. D., Mark, A. L., & Rahmouni, K. (2011) · Circulation Research · doi:10.1161/circresaha.111.240226 · Cited by 144 · see citing works
Disruption of Thyroid Hormone Activation in Type 2 Deiodinase Knockout Mice Causes Obesity With Glucose Intolerance and Liver Steatosis Only at Thermoneutrality
Castillo, M., Hall, J. A., Correa-Medina, M., Ueta, C. B., Kang, H. W., Cohen, D. E., & Bianco, A. C. (2011) · Diabetes · doi:10.2337/db10-0758 · Cited by 138 · see citing works
Hypothalamic regulation of energy homeostasis
Sainsbury, A., Cooney, G. J., & Herzog, H. (2002) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1053/beem.2002.0230 · Cited by 138 · see citing works
Negative feedback regulation of hypophysiotropic thyrotropin-releasing hormone (TRH) synthesizing neurons: role of neuronal afferents and type 2 deiodinase
Fekete, C., & Lechan, R. M. (2007) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.04.002 · Cited by 137 · see citing works
FOXO1 in the ventromedial hypothalamus regulates energy balance
Kim, K. W., Donato, J., Berglund, E. D., Choi, Y., Kohno, D., Elias, C. F., DePinho, R. A., & Elmquist, J. K. (2012) · Journal of Clinical Investigation · doi:10.1172/jci62848 · Cited by 137 · see citing works
Self-citation
Cardiovascular Responses Evoked by Leptin Acting on Neurons in the Ventromedial and Dorsomedial Hypothalamus
Marsh, A. J., Fontes, M. A. P., Killinger, S., Pawlak, D. B., Polson, J. W., & Dampney, R. A. L. (2003) · Hypertension · doi:10.1161/01.hyp.0000090097.22678.0a · Cited by 136 · see citing works
Adipose tissue browning in mice and humans
Herz, C. T., & Kiefer, F. W. (2019) · Journal of Endocrinology · doi:10.1530/joe-18-0598 · Cited by 135 · see citing works
Preoptic mechanism for cold‐defensive responses to skin cooling
Nakamura, K., & Morrison, S. F. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.152686 · Cited by 133 · see citing works
Whole-body energy metabolism and skeletal muscle biochemical characteristics
ZURLO, F., Nemeth, P. M., Choksi, R. M., Sesodia, S., & Ravussin, É. (1994) · Metabolism · doi:10.1016/0026-0495(94)90081-7 · Cited by 130 · see citing works
Revisiting the Ventral Medial Nucleus of the Hypothalamus: The Roles of SF-1 Neurons in Energy Homeostasis
Choi, Y., Fujikawa, T., Lee, J., Reuter, A. L., & Kim, K. W. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00071 · Cited by 130 · see citing works
Self-citation
Activation of brain areas in rat following warm and cold ambient exposure
Bratincsák, A., & Palkovits, M. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.05.016 · Cited by 128 · see citing works
Activation of Stat3 Signaling in AgRP Neurons Promotes Locomotor Activity
Mesaros, A., Koralov, S. B., Rother, E., Wunderlich, F. T., Ernst, M. B., Barsh, G. S., Rajewsky, K., & Brüning, J. C. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.01.007 · Cited by 128 · see citing works
Mechanisms of changes in basal metabolism during ageing
Henry, C. (2000) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601029 · Cited by 125 · see citing works
Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis
Müller‐Fielitz, H., Stahr, M., Bernau, M., Richter, M., Abele, S., Krajka, V., Benzin, A. E., Wenzel, J., Kalies, K., Mittag, J., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00604-6 · Cited by 124 · see citing works
Galanin-Expressing GABA Neurons in the Lateral Hypothalamus Modulate Food Reward and Noncompulsive Locomotion
Qualls‐Creekmore, E., Yu, S., Francois, M., Hoang, J. G., Huesing, C., Bruce‐Keller, A. J., Burk, D. H., Berthoud, H., Morrison, C. D., & Münzberg, H. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0155-17.2017 · Cited by 121 · see citing works
Role of hypothalamus in aging and its underlying cellular mechanisms
Kim, K., & Choe, H. K. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.04.008 · Cited by 113 · see citing works
Self-citation
Identification of thyroid hormone receptor isoforms in thyrotropin-releasing hormone neurons of the hypothalamic paraventricular nucleus
Lechan, R. M., Qi, Y., Jackson, I. M., & Mahdavi, V (1994) · Endocrinology · doi:10.1210/endo.135.1.7516871 · Cited by 113 · see citing works
Hypothalamic leptin regulation of energy homeostasis and glucose metabolism
Morton, G. J. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.135590 · Cited by 112 · see citing works
Tanycyte pyroglutamyl peptidase II contributes to regulation of the hypothalamic-pituitary-thyroid axis through glial-axonal associations in the median eminence
Sánchez, E., Vargas, M. A., Singru, P. S., Pascual, I., Romero, F., Fekete, C., Charli, J.-L., & Lechan, R. M. (2009) · Endocrinology · doi:10.1210/en.2008-1643 · Cited by 110 · see citing works
Integration of feeding and spontaneous physical activity: Role for orexin
Kotz, C. M. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.05.031 · Cited by 110 · see citing works
Orexin A mediation of time spent moving in rats: Neural mechanisms
Kotz, C. M., Wang, C., Teske, J. A., Thorpe, A. J., Novak, C. M., Kiwaki, K., & Levine, J. A. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.05.028 · Cited by 109 · see citing works
Hypothalamic control of brown adipose tissue thermogenesis
Labbé, S. M., Caron, A., Lanfray, D., Monge-Roffarello, B., Bartness, T. J., & Richard, D. (2015) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2015.00150 · Cited by 108 · see citing works
Rho-kinase regulates energy balance by targeting hypothalamic leptin receptor signaling
Hu, H., Kong, D., Byun, K. H., Ye, C., Koda, S., Lee, D. H., Oh, B., Lee, S. W., Lee, B., Zabolotny, J. M., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3207 · Cited by 106 · see citing works
Short stature and failure of pubertal development in thalassaemia major: evidence for hypothalamic neurosecretory dysfunction of growth hormone secretion and defective pituitary gonadotropin secretion
Roth, C., Pekrun, A., Bartz, M., Jarry, H., Eber, S., Lakomek, M., & Schröter, W. (1997) · European Journal of Pediatrics · doi:10.1007/s004310050711 · Cited by 105 · see citing works
The hypothalamus for whole-body physiology: from metabolism to aging
Liu, T., Xu, Y., Yi, C., Tong, Q., & Cai, D. (2021) · Protein & Cell · doi:10.1007/s13238-021-00834-x · Cited by 103 · see citing works
Adaptive thermogenesis and uncoupling proteins: a reappraisal of their roles in fat metabolism and energy balance
Dulloo, A. G., Seydoux, J., & Jacquet, J. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.07.028 · Cited by 100 · see citing works
Full Expression of Uncoupling Protein Gene Requires the Concurrence of Norepinephrine and Triiodothyronine
Silva, J. E., & Matthews, P. S. (1988) · Molecular Endocrinology · doi:10.1210/mend-2-8-706 · Cited by 100 · see citing works
Neuroregulation of nonexercise activity thermogenesis and obesity resistance
Kotz, C. M., Teske, J. A., & Billington, C. J. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00095.2007 · Cited by 99 · see citing works
Modulation of SF1 Neuron Activity Coordinately Regulates Both Feeding Behavior and Associated Emotional States
Viskaitis, P., Irvine, E. E., Smith, M. A., Choudhury, A. I., Alvarez‐Curto, E., Glegola, J. A., Hardy, D. G., Pedroni, S. M. A., Pessoa, M. R. P., Fernando, A. B. P., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.11.089 · Cited by 99 · see citing works
An excitatory ventromedial hypothalamus to paraventricular thalamus circuit that suppresses food intake
Zhang, J., Chen, D., Sweeney, P. R., & Yang, Y. (2020) · Nature Communications · doi:10.1038/s41467-020-20093-4 · Cited by 97 · see citing works
Oxytocin Receptor in the Hypothalamus Is Sufficient to Rescue Normal Thermoregulatory Function in Male Oxytocin Receptor Knockout Mice
Kasahara, Y., Sato, K., Takayanagi, Y., Mizukami, H., Ozawa, K., Hidema, S., So, K.-H., Kawada, T., Inoue, N., Ikeda, I., et al. (2013) · Endocrinology · doi:10.1210/en.2012-2206 · Cited by 96 · see citing works
Fos activation in hypothalamic neurons during cold or warm exposure: Projections to periaqueductal gray matter
Yoshida-Court, K., Konishi, M., Nagashima, K., Saper, C. B., & Kanosue, K. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.03.044 · Cited by 93 · see citing works
Activation of SF1 Neurons in the Ventromedial Hypothalamus by DREADD Technology Increases Insulin Sensitivity in Peripheral Tissues
Coutinho, E. A., Okamoto, S., Ishikawa, A. W., Yokota, S., Wada, N., Hirabayashi, T., Saito, K., Sato, T., Takagi, K., Wang, C.-C., et al. (2017) · Diabetes · doi:10.2337/db16-1344 · Cited by 93 · see citing works
Hypothalamic oestrogen receptor alpha establishes a sexually dimorphic regulatory node of energy expenditure
van Veen, J. E., Kammel, L. G., Bunda, P., Shum, M., Reid, M., Massa, M. G., Arneson, D. V., Park, J. W., Zhang, Z., Joseph, A., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0189-6 · Cited by 93 · see citing works
Impaired thermoregulatory ability of oxytocin-deficient mice during cold-exposure
KASAHARA, Y., TAKAYANAGI, Y., KAWADA, T., ITOI, K., & NISHIMORI, K. (2007) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.70498 · Cited by 89 · see citing works
Involvement of Hypothalamic AMP-Activated Protein Kinase in Leptin-Induced Sympathetic Nerve Activation
Tanida, M., Yamamoto, N., Shibamoto, T., & Rahmouni, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056660 · Cited by 88 · see citing works
PI3K signaling effects in hypothalamic neurons mediated by estrogen
Malyala, A., Zhang, C., Bryant, D. N., Kelly, M. J., & Rønnekleiv, O. K. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21584 · Cited by 87 · see citing works
Orexin-driven GAD65 network of the lateral hypothalamus sets physical activity in mice
Kosse, C., Schöne, C., Bracey, E. F., & Burdakov, D. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1619700114 · Cited by 87 · see citing works
Genetic labeling of steroidogenic factor‐1 (SF‐1) neurons in mice reveals ventromedial nucleus of the hypothalamus (VMH) circuitry beginning at neurogenesis and development of a separate non‐SF‐1 neuronal cluster in the ventrolateral VMH
Cheung, C. C., Kurrasch, D. M., Liang, J. K., & Ingraham, H. A. (2012) · The Journal of Comparative Neurology · doi:10.1002/cne.23226 · Cited by 84 · see citing works
Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons
Burke, L. K., Doslikova, B., D’Agostino, G., Greenwald-Yarnell, M. L., Georgescu, T. R., Chianese, R., de Morentin, P. B. M., Ogunnowo-Bada, E., Cansell, C., Valencia-Torres, L., et al. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.01.005 · Cited by 84 · see citing works
Cellular and synaptic reorganization of arcuate NPY/AgRP and POMC neurons after exercise
He, Z., Gao, Y., Alhadeff, A. L., Castorena, C. M., Huang, Y., Lieu, L., Afrin, S., Sun, J. M., Betley, J. N., Guo, H., et al. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.08.011 · Cited by 84 · see citing works
Neuropeptidergic Mediators of Spontaneous Physical Activity and Non-Exercise Activity Thermogenesis
Teske, J. A., Billington, C. J., & Kotz, C. M. (2007) · Neuroendocrinology · doi:10.1159/000110802 · Cited by 79 · see citing works
Leptin: Is It Thermogenic?
Fischer, A. W., Cannon, B., & Nedergaard, J. (2019) · Endocrine Reviews · doi:10.1210/endrev/bnz016 · Cited by 79 · see citing works
AgRP neurons control compulsive exercise and survival in an activity-based anorexia model
Miletta, M. C., İyilikci, O., Shanabrough, M., Šestan-Peša, M., Cammisa, A., Zeiss, C. J., Dietrich, M. O., & Horváth, T. L. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00300-8 · Cited by 79 · see citing works
SF1-Specific AMPKα1 Deletion Protects Against Diet-Induced Obesity
Seoane‐Collazo, P., Roa, J., Rial‐Pensado, E., Liñares‐Pose, L., Beiroa, D., Ruíz-Pino, F., López-González, T., Morgan, D. A., Pardavila, J. Á., Sanchez-Tapia, M. J., et al. (2018) · Diabetes · doi:10.2337/db17-1538 · Cited by 76 · see citing works
Leptin Stimulates Neuropeptide Y and Cocaine Amphetamine-Regulated Transcript Coexpressing Neuronal Activity in the Dorsomedial Hypothalamus in Diet-Induced Obese Mice
Lee, S. J., Verma, S., Simonds, S. E., Kirigiti, M. A., Kievit, P., Lindsley, S. R., Loche, A., Smith, M. S., Cowley, M. A., & Grove, K. L. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0837-13.2013 · Cited by 74 · see citing works
Mice as experimental models for human physiology: when several degrees in housing temperature matter
Seeley, R. J., & MacDougald, O. A. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00372-0 · Cited by 74 · see citing works
Voluntary exercise improves hypothalamic and metabolic function in obese mice
Laing, B. T., Do, K., Matsubara, T., Wert, D., Avery, M. J., Langdon, E. M., Zheng, D., & Hu, H. (2016) · Journal of Endocrinology · doi:10.1530/joe-15-0510 · Cited by 73 · see citing works
Intragastric pair feeding fails to prevent VMH obesity or hyperinsulinemia
Cox, J. E., & Powley, T. L. (1981) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1981.240.5.e566 · Cited by 73 · see citing works
Effects of hyothalamic lesions at different loci on development of hyperinsulinemia and obesity in the weanling rat
Bernardis, L. L., & Frohman, L. A. (1971) · The Journal of Comparative Neurology · doi:10.1002/cne.901410109 · Cited by 72 · see citing works
Identification of temperature-sensitive neural circuits in mice using c-Fos expression mapping
Bachtell, R. K., Tsivkovskaia, N. O., & Ryabinin, A. E. (2003) · Brain Research · doi:10.1016/s0006-8993(02)03807-6 · Cited by 70 · see citing works
Neuromodulation of orexin neurons reduces diet-induced adiposity
Zink, A. N., Bunney, P. E., Holm, A. A., Billington, C. J., & Kotz, C. M. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.276 · Cited by 69 · see citing works
Diet-induced adaptive thermogenesis requires neuropeptide FF receptor-2 signalling
Zhang, L., Ip, C. K., Lee, I.-C. J., Qi, Y., Reed, F. M., Karl, T., Low, J. K., Enriquez, R. F., Lee, N. J., Baldock, P. A. J., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06462-0 · Cited by 66 · see citing works
Ventromedial hypothalamic primary cilia control energy and skeletal homeostasis
Sun, J. S., Yang, D. J., Kinyua, A. W., Yoon, S. G., Seong, J. K., Kim, J.-W., Moon, S. J., Shin, D. M., Choi, Y., & Kim, K. W. (2020) · Journal of Clinical Investigation · doi:10.1172/jci138107 · Cited by 65 · see citing works
Self-citation
TRH Neurons and Thyroid Hormone Coordinate the Hypothalamic Response to Cold
Zhang, Z., Boelen, A., Kalsbeek, A., & Fliers, E. (2018) · European Thyroid Journal · doi:10.1159/000493976 · Cited by 61 · see citing works
Pregnancy Induces Resistance to the Anorectic Effect of Hypothalamic Malonyl-CoA and the Thermogenic Effect of Hypothalamic AMPK Inhibition in Female Rats
de Morentin, P. B. M., Lage, R., González‐García, I., Ruíz-Pino, F., Martins, L., Fernández-Mallo, D., Gallego, R., Fernø, J., Señarís, R. M., Saha, A. K., et al. (2014) · Endocrinology · doi:10.1210/en.2014-1611 · Cited by 60 · see citing works
Dlx1/2 and Otp coordinate the production of hypothalamic GHRH- and AgRP-neurons
Lee, B., Kim, J., An, T., Kim, S., Patel, E. M., Raber, J., Lee, S., Lee, J. W., & Lee, J. W. (2018) · Nature Communications · doi:10.1038/s41467-018-04377-4 · Cited by 58 · see citing works
Self-citation
TrkB-expressing paraventricular hypothalamic neurons suppress appetite through multiple neurocircuits
An, J. J., Kinney, C. E., Tan, J., Liao, G., Kremer, E. J., & Xu, B. (2020) · Nature Communications · doi:10.1038/s41467-020-15537-w · Cited by 58 · see citing works
Paraventricular hypothalamus mediates diurnal rhythm of metabolism
Kim, E. R., Xu, Y., Cassidy, R. M., Lu, Y., Yang, Y., Tian, J., Li, D., Drunen, R. V., Ribas‐Latre, A., Cai, Z., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17578-7 · Cited by 58 · see citing works
[Basal metabolism standard and its determination with the "metabocalculator"].
Fleisch, A. (1951) · PubMed · Cited by 57 · see citing works
Spontaneous physical activity protects against fat mass gain
Teske, J. A., Billington, C. J., Kuskowski, M. A., & Kotz, C. M. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.108 · Cited by 56 · see citing works
Spontaneous Physical Activity Defends Against Obesity
Kotz, C. M., Perez‐Leighton, C. E., Teske, J. A., & Billington, C. J. (2017) · Current Obesity Reports · doi:10.1007/s13679-017-0288-1 · Cited by 56 · see citing works
Hypothalamic gene transfer of BDNF promotes healthy aging in mice
McMurphy, T. B., Huang, W., Liu, X., Siu, J. J., Queen, N. J., Xiao, R., & Cao, L. (2018) · Aging Cell · doi:10.1111/acel.12846 · Cited by 56 · see citing works
Leptin receptor neurons in the dorsomedial hypothalamus regulate diurnal patterns of feeding, locomotion, and metabolism
Faber, C. L., Deem, J. D., Phan, B. A., Doan, T. P., Ogimoto, K., Mirzadeh, Z., Schwartz, M. W., & Morton, G. J. (2021) · eLife · doi:10.7554/elife.63671 · Cited by 56 · see citing works
Hypothalamic Thyroid Hormone in Energy Balance Regulation
Herwig, A., Ross, A., Nilaweera, K. N., Morgan, P. J., & Barrett, P. (2008) · Obesity Facts · doi:10.1159/000123428 · Cited by 54 · see citing works
Hypothalamic pro-opiomelanocortin gene delivery ameliorates obesity and glucose intolerance in aged rats
Li, G., Zhang, Y., Wilsey, J. T., & Scarpace, P. J. (2005) · Diabetologia · doi:10.1007/s00125-005-1943-8 · Cited by 54 · see citing works
FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase
Doan, K. V., Kinyua, A. W., Yang, D. J., Ko, C. M., Moh, S. H., Shong, K. E., Kim, H., Park, S.-K., Kim, D. H., Kim, I., et al. (2016) · Nature Communications · doi:10.1038/ncomms12733 · Cited by 54 · see citing works
Self-citation
The ventromedial hypothalamus mediates predator fear memory
Silva, B. A., Mattucci, C., Krzywkowski, P., Cuozzo, R., Carbonari, L., & Gross, C. T. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13239 · Cited by 53 · see citing works
Brown adipose tissue and the regulation of nonshivering thermogenesis
Lichtenbelt, W. D. V. M. (2012) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3283599184 · Cited by 53 · see citing works
Critical Temperature in Lapps
Scholander, P. F., Andersen, K. L., Krog, J. O., Lorentzen, F. V., & van der Steen, J. A. (1957) · Journal of Applied Physiology · doi:10.1152/jappl.1957.10.2.231 · Cited by 52 · see citing works
Hypothalamic network for thermoregulatory shivering
Kanosue, K., Zhang, Y. H., Yanase‐Fujiwara, M., & Hosono, T. (1994) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1994.267.1.r275 · Cited by 52 · see citing works
Distinct regulation of hypothalamic and brown/beige adipose tissue activities in human obesity
Rachid, B., van de Sande‐Lee, S., Rodovalho, S., Folli, F. B., Beltramini, G. C., Morari, J., Amorim, B. J., Pedro, T., Ramalho, A. F. S., Bombassaro, B., et al. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.94 · Cited by 51 · see citing works
Tanycytes and the Control of Thyrotropin-Releasing Hormone Flux Into Portal Capillaries
Rodríguez-Rodríguez, A., Lazcano, I., Sánchez‐Jaramillo, E., Uribe, R. M., Jaimes-Hoy, L., Joseph‐Bravo, P., & Charli, J. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00401 · Cited by 51 · see citing works
Structural and functional evidence supporting a role for leptin in central neural pathways influencing blood pressure in rats
Montanaro, M. S., Allen, A. M., & Oldfield, B. J. (2005) · Experimental Physiology · doi:10.1113/expphysiol.2005.030775 · Cited by 49 · see citing works
Mapping of thyrotropin-releasing hormone (TRH) neuronal systems of rat forebrain projecting to the median eminence and the OVLT. Immunocytochemistry combined with retrograde labeling at the light and electron microscopic levels.
Merchenthaler, I., & Liposits, Z. (1994) · PubMed · Cited by 49 · see citing works
Energy metabolism of tube-fed hypophysectomized rats bearing hypothalamic lesions
Han, P. (1968) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1968.215.6.1343 · Cited by 48 · see citing works
Preoptic leptin signaling modulates energy balance independent of body temperature regulation
Yu, S., Cheng, H., François, M., Qualls‐Creekmore, E., Huesing, C., He, Y., Jiang, Y., Gao, H., Xu, Y., Zsombok, A., et al. (2018) · eLife · doi:10.7554/elife.33505 · Cited by 48 · see citing works
SHIVERING SUPPRESSION BY HYPOTHALAMIC STIMULATION
Hemingway, A., Forgrave, P., & Birzis, L. (1954) · Journal of Neurophysiology · doi:10.1152/jn.1954.17.4.375 · Cited by 47 · see citing works
Sustained NPY Overexpression in the PVN Results in Obesity via Temporarily Increasing Food Intake
Tiesjema, B., la Fleur, S. E., Luijendijk, M. C. M., & Adan, R. A. H. (2009) · Obesity · doi:10.1038/oby.2008.670 · Cited by 46 · see citing works
Ire1α in Pomc Neurons Is Required for Thermogenesis and Glycemia
Yao, T. S., Deng, Z., Gao, Y., Sun, J. M., Kong, X., Huang, Y., He, Z., Xu, Y., Chang, Y., Yu, K.-J., et al. (2016) · Diabetes · doi:10.2337/db16-0533 · Cited by 45 · see citing works
Spontaneous physical activity: relationship between fidgeting and body weight control
Johannsen, D. L., & Ravussin, É. (2008) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e32830b10bb · Cited by 44 · see citing works
PI3K in the ventromedial hypothalamic nucleus mediates estrogenic actions on energy expenditure in female mice
Saito, K., He, Y., Yang, Y., Zhu, L., Wang, C., Xu, P., Hinton, A. O., Jr., Yan, X., Zhao, J. J., Fukuda, M., et al. (2016) · Scientific Reports · doi:10.1038/srep23459 · Cited by 44 · see citing works
Voluntary Exercise Adapts the Hypothalamus-Pituitary-Thyroid Axis in Male Rats
Uribe, R. M., Jaimes-Hoy, L., Ramírez-Martínez, C. E., García-Vázquez, A., Romero, F., Cisneros, M., Cote-Vélez, A., Charli, J., & Joseph‐Bravo, P. (2014) · Endocrinology · doi:10.1210/en.2013-1724 · Cited by 43 · see citing works
DNA methylation in AgRP neurons regulates voluntary exercise behavior in mice
MacKay, H., Scott, C. A., Duryea, J., Baker, M. S., Laritsky, E., Elson, A. E. T., Garland, T., Fiorotto, M. L., Chen, R., Li, Y., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13339-3 · Cited by 43 · see citing works
ROCK1 in AgRP Neurons Regulates Energy Expenditure and Locomotor Activity in Male Mice
Hu, H., Lee, S., Ye, C., Sousa‐Lima, I., Oh, B., Lowell, B. B., Zabolotny, J. M., & Kim, Y. (2013) · Endocrinology · doi:10.1210/en.2013-1343 · Cited by 41 · see citing works
Diet-induced thermogenesis: fake friend or foe?
Ho, K. K. Y. (2018) · Journal of Endocrinology · doi:10.1530/joe-18-0240 · Cited by 41 · see citing works
CPT1C in the ventromedial nucleus of the hypothalamus is necessary for brown fat thermogenesis activation in obesity
Rodríguez‐Rodríguez, R., Miralpeix, C., Fosch, A., Pozo, M., Calderón‐Domínguez, M., Perpiñà, X., Vellvehi, M., López, M., Herrero, L., Serra, D., et al. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.10.010 · Cited by 38 · see citing works
Lesions of the Ventromedial Hypothalamus Reduce Postingestional Thermogenesis
Monda, M., Sullo, A., & Luca, B. D. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(96)00520-3 · Cited by 37 · see citing works
Appetitive and consummatory ingestive behaviors stimulated by PVH and perifornical area NPY injections
Dailey, M. J., & Bartness, T. J. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90568.2008 · Cited by 37 · see citing works
α/β-Hydrolase Domain 6 in the Ventromedial Hypothalamus Controls Energy Metabolism Flexibility
Fisette, A., Tobin, S. W., Décarie-Spain, L., Bouyakdan, K., Peyot, M., Madiraju, S. R. M., Prentki, M., Fulton, S. E., & Alquier, T. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.10.004 · Cited by 35 · see citing works
Exercise and the hypothalamic–pituitary–adrenal axis: a special focus on acute cortisol and growth hormone responses
Anderson, T., Berry, N. T., & Wideman, L. (2019) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2019.08.002 · Cited by 34 · see citing works
Hypothalamic primary cilium: A hub for metabolic homeostasis
Yang, D. J., Hong, J., & Kim, K. W. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00644-5 · Cited by 34 · see citing works
Self-citation
Insulin synthesized in the paraventricular nucleus of the hypothalamus regulates pituitary growth hormone production
Lee, J., Kim, K., Cho, J. H., Bae, J. Y., O’Leary, T. P., Johnson, J. D., Bae, Y. C., & Kim, E. (2020) · JCI Insight · doi:10.1172/jci.insight.135412 · Cited by 33 · see citing works
Self-citation
Thermoregulation in hibernating mammals: The role of the “thyroid hormones system”
Frare, C., Williams, C. T., & Drew, K. L. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.111054 · Cited by 33 · see citing works
Median preoptic area neurons are required for the cooling and febrile activations of brown adipose tissue thermogenesis in rat
da Conceição, E. P. S., Morrison, S. F., Cano, G., Chiavetta, P., & Tupone, D. (2020) · Scientific Reports · doi:10.1038/s41598-020-74272-w · Cited by 33 · see citing works
CNGA3 acts as a cold sensor in hypothalamic neurons
Feketa, V. V., Nikolaev, Y. A., Merriman, D. K., Bagriantsev, S. N., & Gracheva, E. O. (2020) · eLife · doi:10.7554/elife.55370 · Cited by 31 · see citing works
City-Scale Expansion of Human Thermoregulatory Costs
Hill, R. W., Muhich, T. E., & Humphries, M. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076238 · Cited by 30 · see citing works
Long-Acting PASylated Leptin Ameliorates Obesity by Promoting Satiety and Preventing Hypometabolism in Leptin-Deficient Lepob/ob Mice
Bolze, F., Morath, V., Bast‐Habersbrunner, A., Rink, N., Schlapschy, M., Mocek, S., Skerra, A., & Klingenspor, M. (2015) · Endocrinology · doi:10.1210/en.2015-1519 · Cited by 30 · see citing works
Brown adipose tissue thermogenesis is activated by electrical and chemical (l-glutamate) stimulation of the ventromedial hypothalamic nucleus in cold-acclimated rats
Halvorson, I., Gregor, L., & Thornhill, J. A. (1990) · Brain Research · doi:10.1016/0006-8993(90)91579-6 · Cited by 29 · see citing works
The hypothalamic regulation of metabolic adaptations to exercise
Fujikawa, T., Castorena, C. M., Lee, S., & Elmquist, J. K. (2017) · Journal of Neuroendocrinology · doi:10.1111/jne.12533 · Cited by 28 · see citing works
Colchicine lesions of ventromedial hypothalamus: Effects on regulatory thermogenesis in the rat
Preston, E., Triandafillou, J., & Haas, N. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90247-5 · Cited by 27 · see citing works
Hypothalamic rAAV-mediated GDNF gene delivery ameliorates age-related obesity
Tümer, N., Scarpace, P. J., Doğan, M. D., Broxson, C. S., Matheny, M. E., Yurek, D. M., Peden, C. S., Bürger, C., Muzyczka, N., & Mandel, R. J. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.03.018 · Cited by 27 · see citing works
Stimulation of the hypothalamic arcuate nucleus increases brown adipose tissue nerve activity via hypothalamic paraventricular and dorsomedial nuclei
Chitravanshi, V. C., Kawabe, K., & Sapru, H. N. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00176.2016 · Cited by 27 · see citing works
Stimulation of ventromedial hypothalamus induces cold defense responses in conscious rabbits
Morimoto, A., Murakami, N., Ono, T., Watanabe, T., & Sakata, Y. (1986) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1986.250.4.r560 · Cited by 27 · see citing works
Coupling of signals to brown fat: alpha- and beta-adrenergic responses in intact rats
Flaim, K. E., Horwitz, B. A., & Horowitz, J. M. (1977) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1977.232.3.r101 · Cited by 27 · see citing works
Contribution of adaptive thermogenesis to the hypothalamic regulation of energy balance
Lage, R., Fernø, J., Nogueiras, R., Diéguez, C., & López, M. (2016) · Biochemical Journal · doi:10.1042/bcj20160012 · Cited by 26 · see citing works
Time-dependent effects of neuropeptide Y infusion in the paraventricular hypothalamus on ingestive and associated behaviors in rats
van Dijk, G., & Strubbe, J. H. (2003) · Physiology & Behavior · doi:10.1016/s0031-9384(03)00125-2 · Cited by 25 · see citing works
Endocannabinoid and nitric oxide systems of the hypothalamic paraventricular nucleus mediate effects of NPY on energy expenditure
Péterfi, Z., Farkas, I., Denis, R., Farkas, E., Uchigashima, M., Füzesi, T., Watanabe, M., Lechan, R. M., Liposits, Z., Luquet, S. H., et al. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.08.007 · Cited by 24 · see citing works
Ghrelin infused into the dorsomedial hypothalamus of male mice increases food intake and adiposity.
Hyland, L., Park, S., Abdelaziz, Y., & Abizaid, A. B. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.112882 · Cited by 24 · see citing works
Self-citation

Flagged first, then by citations

1 of the 217 references couldn’t be matched to a known paper.

Sorted by citations

Obesity: A Review of Pathophysiology and Classification
Busebee, B. T., Ghusn, W., Cifuentes, L., & Acosta, A. J. (2023) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2023.05.026 · Cited by 182 · see citing works
Chrononutrition and Energy Balance: How Meal Timing and Circadian Rhythms Shape Weight Regulation and Metabolic Health
Reytor-González, C., Simancas-Racines, D., Román-Galeano, N. M., Annunziata, G., Galasso, M., Zambrano-Villacres, R., Verde, L., Muscogiuri, G., Frias-Toral, E., & Barrea, L. (2025) · Nutrients · doi:10.3390/nu17132135 · Cited by 88 · see citing works
Diagnostic criteria for the hypothalamic syndrome in childhood
van Santen, H. M., van Schaik, J., van Roessel, I. M. A. A., Beckhaus, J., Boekhoff, S., & Müller, H. L. (2023) · European Journal of Endocrinology · doi:10.1093/ejendo/lvad009 · Cited by 67 · see citing works
An Expanding Role for Nonvisual Opsins in Extraocular Light Sensing Physiology
Andrabi, M., Upton, B. A., Lang, R. A., & Vemaraju, S. (2023) · Annual Review of Vision Science · doi:10.1146/annurev-vision-100820-094018 · Cited by 69 · see citing works
Obesity: A Global Health Challenge Demanding Urgent Action
Abad‐Jiménez, Z., & Vezza, T. (2025) · Biomedicines · doi:10.3390/biomedicines13020502 · Cited by 67 · see citing works
Molecular Mechanisms of Western Diet-Induced Obesity and Obesity-Related Carcinogenesis—A Narrative Review
Lathigara, D., Kaushal, D., & Wilson, R. B. (2023) · Metabolites · doi:10.3390/metabo13050675 · Cited by 62 · see citing works
The Critical Role of the Bile Acid Receptor TGR5 in Energy Homeostasis: Insights into Physiology and Therapeutic Potential
Zangerolamo, L., Carvalho, M. U. W. B. D., & Barbosa, H. C. L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26146547 · Cited by 54 · see citing works
Obesity‐induced tissue alterations resist weight loss: A mechanistic review
Guardia, L. D., & Shin, A. C. (2024) · Diabetes Obesity and Metabolism · doi:10.1111/dom.15637 · Cited by 40 · see citing works
Central and peripheral actions of nicotine that influence blood glucose homeostasis and the development of diabetes
Chen, Z., Liu, X.-A., & Kenny, P. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106860 · Cited by 37 · see citing works
A brainstem–hypothalamus neuronal circuit reduces feeding upon heat exposure
Benevento, M., Alpár, A., Gundacker, A., Afjehi, L., Balueva, K., Hevesi, Z., Hanics, J., Rehman, S., Pollak, D. D., Lübec, G., et al. (2024) · Nature · doi:10.1038/s41586-024-07232-3 · Cited by 35 · see citing works
Carbohydrate and sleep: An evaluation of putative mechanisms
Benton, D., Bloxham, A., Gaylor, C., Brennan, A., & Young, H. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.933898 · Cited by 30 · see citing works
Fine particulate matter induces adipose tissue expansion and weight gain: Pathophysiology
Guardia, L. D., & Wang, L. (2023) · Obesity Reviews · doi:10.1111/obr.13552 · Cited by 34 · see citing works
mTORC1 in energy expenditure: consequences for obesity
Allard, C., Miralpeix, C., López-Gambero, A. J., & Cota, D. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00934-0 · Cited by 29 · see citing works
Exploring the Therapeutic Potential of Targeting GH and IGF-1 in the Management of Obesity: Insights from the Interplay between These Hormones and Metabolism
Al-Samerria, S., & Radovick, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119556 · Cited by 32 · see citing works
Mitochondria-derived peptide SHLP2 regulates energy homeostasis through the activation of hypothalamic neurons
Kim, S. K., Tran, T. L., NamKoong, C., Choi, H. J., Chun, H. J., Lee, Y., Cheon, M., Chung, C., Hwang, J., Lim, H., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40082-7 · Cited by 31 · see citing works
Self-citation
A subset of dopamine receptor-expressing neurons in the nucleus accumbens controls feeding and energy homeostasis
Liu, Y., Wang, Y., Zhao, Z., Xie, G., Zhang, C., Chen, R., & Zhang, Y. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01100-0 · Cited by 28 · see citing works
GPR45 modulates Gα s at primary cilia of the paraventricular hypothalamus to control food intake
Xun, Y., Jiang, Y., Xu, B., Tang, M., Ludwig, S. M., Nakamura, K., Mukhopadhyay, S., Liu, C., Beutler, B., & Zhang, Z. (2025) · Science · doi:10.1126/science.adp3989 · Cited by 26 · see citing works
Paternal High-Fat Diet Affects Weight and DNA Methylation of Their Offspring
Haberman, M., Menashe, T., Cohen, N., Kisliouk, T., Yadid, T., Marco, A., Meiri, N., & Weller, A. (2024) · Scientific Reports · doi:10.1038/s41598-024-70438-y · Cited by 23 · see citing works
The role of hypothalamic endoplasmic reticulum stress in schizophrenia and antipsychotic-induced weight gain: A narrative review
Zhou, R., He, M. X., Fan, J., Li, R., Zuo, Y.-F., Li, B., Gao, G., & Sun, T. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.947295 · Cited by 23 · see citing works
Management of Acquired Hypothalamic Dysfunction and the Hypothalamic Syndrome; It Is More Than Obesity
van Santen, H. M., & Müller, H. L. (2025) · Endocrine Reviews · doi:10.1210/endrev/bnaf025 · Cited by 21 · see citing works
Effects of endocrine disruptors on the electrical activity of leptin receptor neurons in the dorsomedial hypothalamus and anxiety-like behavior in male mice
Yavuz, Y., Ozen, D. O., Erol, Z. Y., Goren, H., & Yilmaz, B. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.121366 · Cited by 20 · see citing works
Adipocyte-derived extracellular vesicles are key regulators of central leptin sensitivity and energy homeostasis
Wang, J., Zhang, X., Zhu, Y., Sun, H., Chen, X., Zhao, Z., Zhang, N., Zhang, C., Li, L., & Bi, Y. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.10.005 · Cited by 19 · see citing works
Exercise Restores Hypothalamic Health in Obesity by Reshaping the Inflammatory Network
Guardia, L. D., & Codella, R. (2023) · Antioxidants · doi:10.3390/antiox12020297 · Cited by 21 · see citing works
Progression to Obesity: Variations in Patterns of Metabolic Fluxes, Fat Accumulation, and Gastrointestinal Responses
Milhem, F., & Komarnytsky, S. (2023) · Metabolites · doi:10.3390/metabo13091016 · Cited by 19 · see citing works
Gut microbiota intervention attenuates thermogenesis in broilers exposed to high temperature through modulation of the hypothalamic 5-HT pathway
Li, S., Li, X., Wang, K., Li, Y., Nagaoka, K., & Li, C. (2023) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-023-00950-0 · Cited by 19 · see citing works
Obesity-Resistant Mice on a High-Fat Diet Display a Distinct Phenotype Linked to Enhanced Lipid Metabolism
Milhem, F., Skates, E., Wilson, M., & Komarnytsky, S. (2024) · Nutrients · doi:10.3390/nu16010171 · Cited by 19 · see citing works
Growth hormone receptor (GHR) in AgRP neurons regulates thermogenesis in a sex-specific manner
Stilgenbauer, L., de Lima, J. B. M., Debarba, L. K., Khan, M. M., Koshko, L., Kopchick, J. J., Bartke, A., Schneider, A., & Sadagurski, M. (2023) · GeroScience · doi:10.1007/s11357-023-00726-4 · Cited by 18 · see citing works
Platelet-derived growth factor signaling in pericytes promotes hypothalamic inflammation and obesity
Okekawa, A., Wada, T., Onogi, Y., Takeda, Y., Miyazawa, Y., Sasahara, M., Tsuneki, H., & Sasaoka, T. (2024) · Molecular Medicine · doi:10.1186/s10020-024-00793-z · Cited by 18 · see citing works
Precision calories: A promising strategy for personalized health interventions in the precision nutrition framework
Wang, Z., Wang, L., Hou, Y., Zhang, X., Wang, H., Zhang, S., Du, C., & Huang, J. (2024) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2024.104727 · Cited by 18 · see citing works
Anti-Pyretic, Analgesic, and Anti-Inflammatory Activities of Meloxicam and Curcumin Co-Encapsulated PLGA Nanoparticles in Acute Experimental Models
Aslam, B., Hussain, A., Bari, M. U., Faisal, M. N., Sindhu, Z. U. D., Alonaizan, R., Al-Akeel, R. K., Naz, S., & Khan, R. U. (2023) · Metabolites · doi:10.3390/metabo13080935 · Cited by 18 · see citing works
Sleep and global warming: How will we sleep when the Earth is hotter?
Buguet, A., Reis, J. J., & Radomski, M. W. (2023) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2023.120859 · Cited by 16 · see citing works
Secretin-dependent signals in the ventromedial hypothalamus regulate energy metabolism and bone homeostasis in mice
Zhang, F., Qiao, W., Wei, J., Tao, Z., Chen, C., Wu, Y., Lin, M., Ng, K. M. C., Zhang, L., Yeung, K., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45436-3 · Cited by 18 · see citing works
miRNA and leptin signaling in metabolic diseases and at extreme environments
Mondal, S., Rathor, R., Singh, S. N., & Suryakumar, G. (2024) · Pharmacology Research & Perspectives · doi:10.1002/prp2.1248 · Cited by 18 · see citing works
Ultra-Processed Foods and Metabolic Dysfunction: A Narrative Review of Dietary Processing, Behavioral Drivers and Chronic Disease Risk
Godsey, T. J., Eden, T., & Emerson, S. R. (2025) · Metabolites · doi:10.3390/metabo15120784 · Cited by 18 · see citing works
Glutamatergic neurons in lateral hypothalamus play a vital role in acupuncture preconditioning to alleviate MIRI
Shu, Q., Wang, S.-Y., Chen, P.-P., Zhang, F., Wang, Q., Wei, X., Zhou, J., Zhou, X., Yu, Q., & Cai, R.-L. (2022) · Journal of Neurophysiology · doi:10.1152/jn.00424.2022 · Cited by 15 · see citing works
The widely used Ucp1-Cre transgene elicits complex developmental and metabolic phenotypes
Halurkar, M. S., Inoue, O., Singh, A., Mukherjee, R., Ginugu, M., Ahn, C., Paese, C. L. B., Duszynski, M., Brugmann, S. A., Lim, H., et al. (2025) · Nature Communications · doi:10.1038/s41467-024-54763-4 · Cited by 14 · see citing works
Hydroxytyrosol Alleviates Obesity-Induced Cognitive Decline by Modulating the Expression Levels of Brain-Derived Neurotrophic Factors and Inflammatory Factors in Mice
Liu, S., Lu, Y., Tian, D., Zhang, T., Zhang, C., Hu, C. Y., Chen, P., & Meng, Y. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c08319 · Cited by 13 · see citing works
Volume loss in the left anterior‐superior subunit of the hypothalamus in amyotrophic lateral sclerosis
Ghaderi, S., Fatehi, F., Kalra, S., Mohammadi, S., Zemorshidi, F., Ramezani, M., Hesami, O., Pezeshgi, S., & Batouli, S. A. H. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14801 · Cited by 13 · see citing works
Ventromedial hypothalamic nucleus subset stimulates tissue thermogenesis via preoptic area outputs
Basu, R., Elmendorf, A. J., Lorentz, B., Mahler, C. A., Lazzaro, O., App, B., Zhou, S., Yamamoto, Y., Suber, M., Wann, J., et al. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.101951 · Cited by 12 · see citing works
Deciphering hypothalamic pathology in ALS: insights into non-motor symptoms and disease progression
Chang, J., Teo, A. H., Shaw, T. B., Dupuis, L., Ngo, S. T., & Steyn, F. J. (2025) · EBioMedicine · doi:10.1016/j.ebiom.2025.105845 · Cited by 12 · see citing works
Hyperexcitation of the glutamatergic neurons in lateral hypothalamus induced by chronic pain contributes to depression-like behavior and learning and memory impairment in male mice
Meng, L., Zheng, X., Xie, K., Li, Y., Liu, D., Xu, Y., Zhang, J., Wu, F., & Guo, G. (2024) · Neurobiology of Stress · doi:10.1016/j.ynstr.2024.100654 · Cited by 11 · see citing works
Sex-specific role of high-fat diet and stress on behavior, energy metabolism, and the ventromedial hypothalamus
Shetty, S., Duesman, S. J., Patel, S., Huynh, P., Toh, P., Shroff, S., Das, A., Chowhan, D., Keller, B., Alvarez, J., et al. (2024) · Biology of Sex Differences · doi:10.1186/s13293-024-00628-w · Cited by 11 · see citing works
Cardamom (Elettaria cardamomum (L.) Maton) Seeds Intake Increases Energy Expenditure and Reduces Fat Mass in Mice by Modulating Neural Circuits That Regulate Adipose Tissue Lipolysis and Mitochondrial Oxidative Metabolism in Liver and Skeletal Muscle
Delgadillo-Puga, C., Torre-Villalvazo, I., Cariño-Cervantes, Y. Y., García-Luna, C., Soberanes-Chávez, P., de Gortari, P., Noriega, L. G., Bautista, C. J., & Cisneros‐Zevallos, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043909 · Cited by 11 · see citing works
Young human alpha synuclein transgenic (BAC-SNCA) mice display sex- and gene-dose-dependent phenotypic disturbances
Moceri, S., Bäuerle, N., Habermeyer, J., Ratz, V., Harrer, J., Distler, J. H. W., Schulze-Krebs, A., Timotius, I. K., Bluhm, A., Hartlage‐Rübsamen, M., et al. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114781 · Cited by 10 · see citing works
UV Irradiation Increases Appetite and Prevents Body Weight Gain through the Upregulation of Norepinephrine in Mice
Quan, Q., Kim, E. J., Kim, S., Kim, Y. K., Chung, M. H., Tian, Y.-D., Shin, C.-Y., Lee, D. H., & Chung, J. H. (2024) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2024.03.012 · Cited by 10 · see citing works
Self-citation
A Mixture of Lactobacillus HY7601 and KY1032 Regulates Energy Metabolism in Adipose Tissue and Improves Cholesterol Disposal in High-Fat-Diet-Fed Mice
Lee, K., Kim, H., Kim, J.-Y., Shim, J.-J., & Lee, J. (2024) · Nutrients · doi:10.3390/nu16152570 · Cited by 10 · see citing works
Self-citation
Molecular and functional mapping of the neuroendocrine hypothalamus: a new era begins
Lee, T. H., Nicolas, J.-C., & Quarta, C. (2024) · Journal of Endocrinological Investigation · doi:10.1007/s40618-024-02411-5 · Cited by 11 · see citing works
Total energy expenditure measured using doubly labeled water in adults with major chronic diseases: a systematic review
Purcell, S. A., Craven, S. A., Limón‐Miró, A. T., Elliott, S. A., Melanson, E. L., Tandon, P., & Prado, C. M. M. (2024) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2024.08.023 · Cited by 10 · see citing works
Management of Acquired Hypothalamic Obesity After Childhood-Onset Craniopharyngioma—A Narrative Review
Muller, H. L. (2025) · Biomedicines · doi:10.3390/biomedicines13051016 · Cited by 9 · see citing works
Berberine-induced browning and energy metabolism: mechanisms and implications
Ağaçdiken, A., & Göktaş, Z. (2025) · PeerJ · doi:10.7717/peerj.18924 · Cited by 8 · see citing works
The complexity of the relationship between thyroid disease and body weight
Jonklaas, J. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-025-01190-0 · Cited by 9 · see citing works
Whole Transcriptome Analysis of Hypothalamus in Mice during Short-Term Starvation
Oh, E.-Y., Park, B. S., Yang, H. R., Lee, H. G., Tu, T. H., Yang, S., Han, M.-R., & Kim, J. G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043204 · Cited by 8 · see citing works
Early-life exposure to acephate inhibits sexual development and induces testicular and ovarian toxicity in mice
Sasaki, T., Hara, K., & Tanemura, K. (2023) · Reproductive Toxicology · doi:10.1016/j.reprotox.2023.108472 · Cited by 8 · see citing works
Ahdc1 is a potent regulator of obesity and energy metabolism
Li, L., Shao, S., Wang, Y., Du, Z., Yu, H., Li, F., & Qin, Y. (2023) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00048.2023 · Cited by 7 · see citing works
Brain endocannabinoid control of metabolic and non-metabolic feeding behaviors
Zhang, M., Wang, Q., & Wang, Y. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105921 · Cited by 7 · see citing works
The role of ovarian hormone dynamics in metabolic phenotype and gene expression in female mice
Ouldibbat, L., Rocks, D., Sampson, B., & Kundaković, M. (2025) · Hormones and Behavior · doi:10.1016/j.yhbeh.2025.105693 · Cited by 7 · see citing works
Identification of a neural basis for energy expenditure in the mouse arcuate hypothalamus
Wang, T., Han, S., Wang, Y., Li, Y., Li, Y., Xing, Z., Zhang, S., Xia, Y., Zhu, F., Chen, Z., et al. (2025) · Neuron · doi:10.1016/j.neuron.2025.08.021 · Cited by 8 · see citing works
Reanalysis of primate brain circadian transcriptomics reveals connectivity-related oscillations
Lee, J., Chen, S., Monfared, R. V., Derdeyn, P., Leong, K., Chang, T. Y., Beier, K. T., Baldi, P., & Alachkar, A. (2023) · iScience · doi:10.1016/j.isci.2023.107810 · Cited by 7 · see citing works
Self-citation
Sex-specific effects of Cre expression in Syn1Cre mice
Baghdadi, M., Mesaros, A., Purrio, M., & Partridge, L. (2023) · Scientific Reports · doi:10.1038/s41598-023-37029-9 · Cited by 9 · see citing works
Cold Exposure Alleviates T2DM Through Plasma-Derived Extracellular Vesicles
Li, F., Xu, F., Li, C., Lei, L.-M., Shan, S., Zheng, M.-H., Lin, X., Guo, B., Tang, K.-X., Duan, J.-Y., et al. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s441847 · Cited by 6 · see citing works
Cold induces increased ad libitum energy intake independent of changes in energy expenditure: a controlled crossover trial in adults
Ünlü, Y., Piaggi, P., Stinson, E. J., de Baca, T. C., Rodzevik, T. L., Walter, M. F., Fry, H., Krakoff, J. A., & Chang, D. C. (2024) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2024.12.013 · Cited by 6 · see citing works
Regulation of BAT thermogenesis via TRPA1-expressing hypothalamic POMC neurons
Halanobis, A. B. B. I., Yang, J. H., Byeon, E.-H., Park, S. W., Kim, H. J., Kang, D., Kim, D. R., Yang, J., Kim, W., Kim, D.-H., et al. (2025) · Animal Cells and Systems · doi:10.1080/19768354.2025.2559611 · Cited by 6 · see citing works
Self-citation
Targeting CD44-Hyaluronic Acid Signalling in Obesity Treatment: Insights from Small Molecules and Nanobioconjugates
Uti, D. E., Omang, W. A., Alum, E. U., Ugwu, O. P.-C., Wokoma, M. A., Oplekwu, I. R., Atangwho, I. J., & Egbung, G. E. (2026) · Nutrition and Metabolic Insights · doi:10.1177/11786388251408961 · Cited by 6 · see citing works
Mitofusin 2 controls mitochondrial and synaptic dynamics of suprachiasmatic VIP neurons and related circadian rhythms
Stoiljković, M., Song, J. E., Hong, H., Endle, H., Varela, L., Catarino, J. D. S., Gao, X., Liu, Z.-W., Sótonyi, P., Diano, S., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci185000 · Cited by 6 · see citing works
Long-term dietary exposure to 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) reduced feeding in common carp (Cyprinus carpio): Via the JAK-STAT signaling pathway
Zhang, X., Liu, Y., Sun, H., Chen, S., Tang, P., He, M., He, M., Tang, N., Li, Z., & Chen, D. (2024) · Environmental Pollution · doi:10.1016/j.envpol.2024.123966 · Cited by 6 · see citing works
Phytoactives for Obesity Management: Integrating Nanomedicine for Its Effective Delivery
Mandal, A. K., Sahoo, A., Almalki, W. H., Almujri, S. S., Alhamyani, A., Aodah, A. H., Alruwaili, N. K., Kadir, S. Z. B. S. A., Mandal, R. K., Almalki, R. A., et al. (2024) · Nutrition Reviews · doi:10.1093/nutrit/nuae136 · Cited by 5 · see citing works
Goat Milk Supplementation Modulates the Mitochondrial Metabolic Flexibility and Orexin-A Levels Influencing the Inflammatory Pattern in Rats
Petrella, L., Polito, R., Catapano, A., Santillo, A., Ciliberti, M. G., Sevi, A., Messina, A., Cavaliere, G., Marino, F., Polverino, M. G., et al. (2024) · Antioxidants · doi:10.3390/antiox13091054 · Cited by 5 · see citing works
Intermittent cold stimulation acclimates broilers to acute cold stress by affecting cardiac lipid metabolism
Zhang, Y., Chang, M., Xue, Q., Wang, H., Liu, Y., Wei, H., & Li, J. (2024) · Animal Bioscience · doi:10.5713/ab.24.0389 · Cited by 6 · see citing works
Ontogenetic Changes in the Expression of the Lin28 Protein in the Rat Hypothalamic Tuberal Nuclei
Anfimova, P. A., Pankrasheva, L. G., Moiseev, K. Y., Shirina, E. S., Порсева, В. В., & Masliukov, P. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113468 · Cited by 5 · see citing works
TRPγ regulates lipid metabolism through Dh44 neuroendocrine cellsPreprint
Nath, D. K., Dhakal, S., & Lee, Y. (2024) · eLife · doi:10.7554/elife.99258 · Cited by 5 · see citing works
The potential role of hypothalamic POMCTRPM2 in interscapular BAT thermogenesis
Yang, J. H., Halanobis, A. B. B. I., Byeon, E.-H., Park, N. H., Park, S. W., Kim, H. J., Kang, D., Kim, D. R., Yang, J., Choe, E. S., et al. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01538-6 · Cited by 4 · see citing works
Self-citation
Constitutive Serotonin Tone as a Modulator of Brown Adipose Tissue Thermogenesis: A Rat Study
Kesić, M., Baković, P., Farkaš, V., Bagarić, R., Kolarić, D., Štefulj, J., & Čičin‐Šain, L. (2023) · Life · doi:10.3390/life13071436 · Cited by 4 · see citing works
The evolution of obesity and the origin of adipose tissue
Karaoğlan, M., & Karaoglan, M. (2024) · Obesity Medicine · doi:10.1016/j.obmed.2024.100561 · Cited by 4 · see citing works
Increased Leptin Levels in Plasma and Serum in Patients with Metabolic Disorders: A Systematic Review and Meta-Analysis
Hernández‐Díaz, Y., Ovando-Almeida, M. D. L. Á., Fresán, A., Juárez‐Rojop, I. E., Mendoza, A. D. G., Nicolini, H., González‐Castro, T. B., Tovilla‐Zárate, C. A., & López‐Narváez, M. L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312668 · Cited by 4 · see citing works
Pro-Opiomelanocortin and Melanocortin Receptor 3 and 4 Mutations in Genetic Obesity
Yanık, T., & Durhan, S. T. (2025) · Biomolecules · doi:10.3390/biom15020209 · Cited by 4 · see citing works
Lateral Habenula Neurons Signal Cold Aversion and Participate in Cold Aversion
Liu, R., Xiang, H., Liu, C., Jiang, Q., Liang, Y., Wang, G., Wang, L., Sun, Y., & Yang, G. (2023) · Neurochemical Research · doi:10.1007/s11064-023-04076-7 · Cited by 4 · see citing works
Proteomic landscape of astrocytes and pericytes infected with HIV/SARS-CoV-2 mono/co-infection, impacting on neurological complicationsPreprint
Acharya, A., Ambikan, A. T., Thurman, M., Malik, M. R., Dyavar, S. R., Végvári, Á., Neogi, U., & Byrareddy, S. N. (2023) · Research Square · doi:10.21203/rs.3.rs-3031591/v1 · Cited by 4 · see citing works
Reviewer #3 (Public Review): TRPγ regulates lipid metabolism through Dh44 neuroendocrine cells
(2024) · eLife · doi:10.7554/elife.99258.1.sa0 · Cited by 4 · see citing works
Genomic and transcriptomic analyses of Heteropoda venatoria reveal the expansion of P450 family for starvation resistance in spiders
Zhang, G., Wang, Y., Jiang, H., & Wang, Y. (2025) · GigaScience · doi:10.1093/gigascience/giaf019 · Cited by 3 · see citing works
Inhibition of sulfotransferase SULT2B1 prevents obesity and insulin resistance by regulating energy expenditure and intestinal lipid absorption
Wang, J., Young, G., Zhang, M., Salvatore, S. R., Qin, F., Cai, X., Xu, M., Ke, M., Liu, L., Kim, J., et al. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110327 · Cited by 3 · see citing works
Biomolecular Basis of Life
Błaszczyk, J. W. (2025) · Metabolites · doi:10.3390/metabo15060404 · Cited by 3 · see citing works
Dax1 in AgRP neurons regulates thermogenesis via GR-HDAC3-mediated CRFR1 suppression
Wei, Z., Cha, J., & Lee, S. (2025) · Molecular Metabolism · doi:10.1016/j.molmet.2025.102258 · Cited by 3 · see citing works
Improving incretin-mediated body weight loss via energy expenditure
Elmendorf, A. J., Douros, J. D., Knerr, P. J., & Flak, J. N. (2026) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2025.12.004 · Cited by 3 · see citing works
PI3K/Akt/mTOR-immunoreactive neurons in the rat mediobasal hypothalamus during aging
Pankrasheva, L. G., Anfimova, P. A., Moiseev, K. Y., Shirina, E. S., & Masliukov, P. M. (2023) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-023-01504-7 · Cited by 3 · see citing works
Molecular Imprints of Clinical Comorbidities in Hypothalamic Extracellular Vesicles at the Onset of Obesity
Fernández‐Rhodes, M., Suárez, M., Molet, I., Suárez‐Garcia, S., Arola, L., Sze, S. K., Gallart‐Palau, X., & Serra, A. (2025) · ACS Omega · doi:10.1021/acsomega.5c02274 · Cited by 3 · see citing works
Sustained effect of habitual feeding time on daily rhythm of core body temperature in mice
Ando, H., Nagata, N., Hosono, T., Hasan, N., Morishige, J., Daikoku, T., Maida, Y., Ono, M., Fujiwara, T., & Fujiwara, H. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.966788 · Cited by 3 · see citing works
A Synergistic Botanical Composition Increases Resting Energy Expenditure and Reduces Adiposity in High-Fat Diet-Fed Rats
Kundimi, S., Chinta, G., Alluri, K. V., Golakoti, T., Veeramachaneni, S., Ramanathan, G., & Sengupta, K. (2023) · Journal of the American Nutrition Association · doi:10.1080/27697061.2023.2280777 · Cited by 3 · see citing works
The multi-tissue gene expression and physiological responses of water deprived Peromyscus eremicus
Blumstein, D. M., & MacManes, M. D. (2024) · BMC Genomics · doi:10.1186/s12864-024-10629-z · Cited by 3 · see citing works
Thyroid Hormone Clearance in the Paraventricular Nucleus of Male Mice Regulates Lean Mass and Physical Activity
Wu, Z., & Hernández, A. (2024) · Neuroendocrinology · doi:10.1159/000541525 · Cited by 3 · see citing works
Population-Based Study of Rare Coding Variants in NR5A1/SF-1
Kouri, C., Jia, R., Kentistou, K. A., Gardner, E. J., Perry, J. R. B., Flueck, C. E., & Ong, K. K. (2024) · Journal of the Endocrine Society · doi:10.1210/jendso/bvae178 · Cited by 3 · see citing works
Sex-specific effects of chronic unpredictable stress on mitochondrial function in the HPA axis in micePreprint
Crockett, A. M., Frambes, N. I., Mullaly, A., Churillo, A. M., dos Passos, R. R., Folk, C., Freeburg, L., Cavalli, E., Gardiner, J., Harrington, E. N., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.28.667247 · Cited by 3 · see citing works
Diagnosis, physiological mechanisms, risk factors, treatment and prevention of obesity: A brief commentary
Chaves, S. F. N., Araújo, D. P. D. S., Guilherme, L. Q., & Agostinho, P. A. G. (2024) · Obesity Medicine · doi:10.1016/j.obmed.2024.100572 · Cited by 2 · see citing works
Hunger Games: A Modern Battle Between Stress and Appetite
Smith, W., & Azevedo, E. P. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70006 · Cited by 3 · see citing works
Impact of obesity on human brain metabolites: a systematic review on magnetic resonance spectroscopy studies
Majumder, S., Menon, K. C., & Borotikar, B. S. (2025) · Nutritional Neuroscience · doi:10.1080/1028415x.2025.2559874 · Cited by 2 · see citing works
Inhibition of the lateral hypothalamus emboldens adult female spiny mice to huddle with an established group of novel peers
Roshko, V. C., Gose, N. A., & Kelly, A. M. (2025) · Scientific Reports · doi:10.1038/s41598-025-20283-4 · Cited by 2 · see citing works
Effects of sappan cider on post-menopause obese model rat
Vichitphan, K., Phalanisong, P., Nurhidayah, A., & Bahtiar, A. (2025) · Cogent Food & Agriculture · doi:10.1080/23311932.2025.2587354 · Cited by 2 · see citing works
Interorgan crosstalk in metabolic dysfunction-associated steatotic liver disease
Yang, R., Fang, Z., He, F., & Wang, L. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003927 · Cited by 2 · see citing works
Hypothalamic obesity following craniopharyngioma surgery: What is the role of hypothalamic T2 signal changes in brain MRI?
Yurddas, D., Nievelstein, R. A. J., Bison, B., Fiocco, M. F., Tissing, W. J. E., Hulsmann, S. C., Beckhaus, J., Friedrich, C., Hoving, E. W., Muller, H. L., et al. (2026) · Neuro-Oncology Advances · doi:10.1093/noajnl/vdag050 · Cited by 2 · see citing works
Methionine restriction provides sex-specific protection against high-fat diet-induced adiposity, peripheral insulin resistance, and neuroinflammation in FGF21-dependent and independent manners in mice
Lail, H. L., Lawrence, R. C., Pinheiro, F., Price, E., & Wanders, D. (2026) · PLoS ONE · doi:10.1371/journal.pone.0343503 · Cited by 2 · see citing works
Python metabolomics uncovers a conserved postprandial metabolite and gut–brain feeding pathway
Xiao, S., Wang, M., Martin, T. G., Scott, B., Fang, X., Liu, X., Yang, Y., Fu, S., Truong, S. D., Gugel, J. F., et al. (2026) · Nature Metabolism · doi:10.1038/s42255-026-01485-0 · Cited by 2 · see citing works

Authors: Tran, L. T., Park, S., Kim, S. K., Lee, J. S., Kim, K. W., & Kwon, O.
Affiliations: Seoul National University (KR)
Yonsei University (KR)
Corresponding author: Kim, Seul Ki
Kim, Ki Woo
Kwon, Obin
ORCID: Tran, Le Trung
Park, Sohee
Kim, Seul Ki
Lee, Jin Sun
Kim, Ki Woo
Kwon, Obin
Venue: Experimental & Molecular Medicine
Publisher: Springer Science and Business Media LLC
Published: 2022-03-17
Volume: 54
Issue: 4
Pages: 358-369
ISSN: 1226-3613 (ISSN-L)
2092-6413
DOI: 10.1038/s12276-022-00741-z
PMC: PMC9076616
OpenAlex: W4220699785
Cited by: 208
References: 217
Citations by year: 2026: 47 · 2025: 60 · 2024: 58 · 2023: 35 · 2022: 6 · 2021: 1
FWCI: 5.84
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (tdm)
creativecommons.org/licenses/by/4.0 (vor)
Locations: Experimental & Molecular Medicine (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
Funders: National Research Foundation of Korea (2018R1C1B5086453, 2020R1C1C1008033, 2016R1A5A2008630, 2021R1A2C4002011)
Creative-Pioneering Researchers Program through Seoul National University
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: hypothalamus, energy expenditure, thermogenesis, energy homeostasis, basal metabolic rate, physical activity, dietary intake, neuronal regulation, molecular regulation
MeSH terms: Animals, Energy Metabolism, Homeostasis, Hypothalamus, Neurons, Thermogenesis, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Hypothalamic control of energy expenditure and thermogenesis

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks