The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Correlation between virulence of Candida albicans mutants in mice and Galleria mellonella larvae
Open accessAbstract
Candida albicans is a dimorphic human pathogen in which the yeast to hyphal switch may be an important factor in virulence in mammals. This pathogen has recently been shown to also kill insects such as the Greater Wax Moth Galleria mellonella when injected into the haemocoel of the insect larvae. We have investigated the effect of previously characterised C. albicans mutations that influence the yeast to hyphal transition on virulence in G. mellonella larvae. There is a good correlation between the virulence of these mutants in the insect host and the virulence measured through systemic infection of mice. Although the predominant cellular species detected in G. mellonella infections is the yeast form of C. albicans, mutations that influence the hyphal transition also reduce pathogenicity in the insect. The correlation with virulence measured in the mouse infection system suggests that Galleria may provide a convenient and inexpensive model for the in vivo screening of mutants of C. albicans.
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Cites
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Cited by
Cowen, L. E., Singh, S. D., Köhler, J. R., Collins, C., Zaas, A. K., Schell, W. A., Aziz, H., Mylonakis, E., Perfect, J. R., Whitesell, L., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813394106 · Cited by 413
Transcriptional regulation of carbohydrate metabolism in the human pathogen Candida albicans
Askew, C., Sellam, A., Epp, E., Hogues, H., Mullick, A., Nantel, A., & Whiteway, M. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000612 · Cited by 260
Self-citationPathogenicity of Aspergillus fumigatus mutants assessed in Galleria mellonella matches that in mice
Slater, J. L., Gregson, L., Denning, D. W., & Warn, P. A. (2011) · Medical Mycology · doi:10.3109/13693786.2010.523852 · Cited by 136
Immune Response of Galleria mellonella against Human Fungal Pathogens
Trevijano-Contador, N., & Zaragoza, O. (2018) · Journal of Fungi · doi:10.3390/jof5010003 · Cited by 134
Hall, R. A., Bates, S., Lenardon, M. D., MacCallum, D. M., Wagener, J., Lowman, D. W., Kruppa, M. D., Williams, D. L., Odds, F. C., Brown, A. J. P., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003276 · Cited by 128
Metadata
- Authors
- Brennan, M.
- Venue
- FEMS Immunology and Medical Microbiology
- Publisher
- Wiley
- Published
- 2002-10-11
- Volume
- 34
- Issue
- 2
- Pages
- 153-157
- ISSN
- 0928-8244 (ISSN-L)
- OpenAlex
- W2156960740
- Cited by
- 357
- References
- 26
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- bronze
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