Cited by 1,256Nanoparticle-Based Drug DeliverySurfactants and Colloidal SystemsAdvanced Drug Delivery Systems

The DOI matches its Crossref record; 99 of the 101 references it cites were found in a registry or an index.

Polymeric micelles—A new generation of colloidal drug carriers

Jones, Marie-Christine, Leroux, Jean-Christophe·1999·European Journal of Pharmaceutics and Biopharmaceutics

Abstract

Polymeric micelles have recently emerged as a novel promising colloidal carrier for the targeting of poorly water soluble and amphiphilic drugs. Polymeric micelles are considerably more stable than surfactant micelles and can solubilize substantial amounts of hydrophobic compounds in their inner core. Due to their hydrophilic shell and small size they sometimes exhibit prolonged circulation times in vivo and can accumulate in tumoral tissues. This review examines the chemical nature of polymeric micelles as well as the methods used to characterize them with regard to drug delivery. Special emphasis is put on the determination of critical micelle concentration and on drug loading procedures. Potential medical applications, especially in cancer chemotherapy, are described and discussed.

Overview

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Crossref · 10.1016/s0939-6411(99)00039-9

Cites

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Citations

Cites

Show all 101 references

Research works printed but not linked: 4

  1. Weissig, 1998, micellar delivery system for dequalinium, Proceed. Intern. Symp. Control. Rel. Bioact. Mater., 25, 415
  2. Hagan, 1996, Polylactide-poly(ethylene glycol) copolymers as drug delivery systems, 1. Characterization of water dispersible micelle-forming systems, Langmuir, 12, 2153
  3. Chung, 1998, Thermo-responsive drug delivery of polymeric micelles incorporating adriamycin, Proceed. Intern. Symp. Control. Rel. Bioact. Mater., 25, 380
  4. Cho, 1998, Release of dehydroepiandrosterone from nanoparticles composed of poly(L-lactic acid) and poly(ethylene oxide) diblock copolymer endcapped with sugar moiety, Proceed. Intern. Symp. Control. Rel. Bioact. Mater., 25, 721

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Metadata

Authors
Jones, M.-C., & Leroux, J.-C.
Affiliations
Université de Montréal (CA)
Corresponding author
Leroux, Jean-Christophe
Venue
European Journal of Pharmaceutics and Biopharmaceutics
Publisher
Elsevier BV
Published
1999-09
Volume
48
Issue
2
Pages
101-111
ISSN
0939-6411 (ISSN-L)
OpenAlex
W2120377744
Cited by
1,256
References
101
Citations by year
2026: 13 · 2025: 25 · 2024: 35 · 2023: 40 · 2022: 45 · 2021: 51 · 2020: 66 · 2019: 58 · 2018: 59 · 2017: 70 · 2016: 68 · 2015: 57 · 2014: 72 · 2013: 70 · 2012: 71
FWCI
2.07
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Pharmaceutics and Biopharmaceutics (publishedVersion)
  • PubMed (publishedVersion)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Surfactants and Colloidal Systems
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords
polymeric micelles, colloidal drug carriers, poorly water-soluble drugs, amphiphilic drugs, drug solubilization, critical micelle concentration, drug loading, tumor targeting, circulation time, cancer chemotherapy, micelle characterization
MeSH terms
Animals, Antineoplastic Agents, Chemistry, Pharmaceutical, Colloids, Drug Carriers, Humans, Micelles, Polymers

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