Cited by 1,256Nanoparticle-Based Drug DeliverySurfactants and Colloidal SystemsAdvanced Drug Delivery Systems

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Polymeric micelles—A new generation of colloidal drug carriers

Jones, Marie-Christine, Leroux, Jean-Christophe·1999·European Journal of Pharmaceutics and Biopharmaceutics

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Abstract

Polymeric micelles have recently emerged as a novel promising colloidal carrier for the targeting of poorly water soluble and amphiphilic drugs. Polymeric micelles are considerably more stable than surfactant micelles and can solubilize substantial amounts of hydrophobic compounds in their inner core. Due to their hydrophilic shell and small size they sometimes exhibit prolonged circulation times in vivo and can accumulate in tumoral tissues. This review examines the chemical nature of polymeric micelles as well as the methods used to characterize them with regard to drug delivery. Special emphasis is put on the determination of critical micelle concentration and on drug loading procedures. Potential medical applications, especially in cancer chemotherapy, are described and discussed.

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Authors: Jones, M.-C., & Leroux, J.-C.
Affiliations: Université de Montréal (CA)
Corresponding author: Leroux, Jean-Christophe
ORCID: Jones, Marie-Christine
Leroux, Jean-Christophe
Venue: European Journal of Pharmaceutics and Biopharmaceutics
Publisher: Elsevier BV
Published: 1999-09
Volume: 48
Issue: 2
Pages: 101-111
ISSN: 0939-6411 (ISSN-L)
DOI: 10.1016/s0939-6411(99)00039-9
OpenAlex: W2120377744
Cited by: 1,256
References: 101
Citations by year: 2026: 13 · 2025: 25 · 2024: 35 · 2023: 40 · 2022: 45 · 2021: 51 · 2020: 66 · 2019: 58 · 2018: 59 · 2017: 70 · 2016: 68 · 2015: 57 · 2014: 72 · 2013: 70 · 2012: 71
FWCI: 2.07
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: European Journal of Pharmaceutics and Biopharmaceutics (publishedVersion)
PubMed (publishedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Surfactants and Colloidal Systems
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords: polymeric micelles, colloidal drug carriers, poorly water-soluble drugs, amphiphilic drugs, drug solubilization, critical micelle concentration, drug loading, tumor targeting, circulation time, cancer chemotherapy, micelle characterization
MeSH terms: Animals, Antineoplastic Agents, Chemistry, Pharmaceutical, Colloids, Drug Carriers, Humans, Micelles, Polymers

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Polymeric micelles—A new generation of colloidal drug carriers

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