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Cited by 407Microtubule and mitosis dynamicsCancer Treatment and PharmacologyProtein Kinase Regulation and GTPase Signaling

Microtubules and signal transduction

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Gundersen, Gregg G, Cook, Tiffani A·1999·Current Opinion in Cell Biology
DOI 10.1016/s0955-0674(99)80010-6
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Abstract

Although molecular components of signal transduction pathways are rapidly being identified, how elements of these pathways are positioned spatially and how signals traverse the intracellular environment from the cell surface to the nucleus or to other cytoplasmic targets are not well understood. The discovery of signaling molecules that interact with microtubules (MTs), as well as the multiple effects on signaling pathways of drugs that destabilize or hyperstabilize MTs, indicate that MTs are likely to be critical to the spatial organization of signal transduction. MTs themselves are also affected by signaling pathways and this may contribute to the transmission of signals to downstream targets.

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  • Dynamic microtubules serve as upstream mediators in signaling pathways such as Rho, hedgehog, Wnt, Jnk, and G-protein.

    “However, it has been known for a long time that dynamic microtubules also serve as upstream mediators in signaling pathways, such as Ras homology (Rho), hedgehog, Wingless-related integration site (Wnt), c-Jun N-terminal kinase (Jnk), and G-protein.”

    From Structural basis of microtubule-mediated signal transduction (2026) · cites this paper as [3]

    The Conclusion says microtubules play important roles in Hedgehog, Wnt, and JNK signaling, and the G-proteins section describes microtubule interactions that can modulate receptor signaling. But the Wnt section says their role in localizing signaling is only suggested, while the actin-and-signaling section also describes Rho acting upstream to stabilize microtubules. The paper therefore does not establish that dynamic microtubules serve as upstream mediators in all five named pathways. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • The findings provide a structural framework for understanding how microtubules modulate signaling proteins via a C1 domain-dependent mechanism and support a microtubule sequestration-and-release (MSR) model.

    “Our findings provide a structural framework for understanding how microtubules modulate signaling proteins via a C1 domain-dependent mechanism.”

    From Structural basis of microtubule-mediated signal transduction (2026) · cites this paper as [3]

    The section “Mechanisms for microtubule ‘signal transduction’” proposes sequestration and release of microtubule-bound signaling factors, supporting the model in broad terms. It does not describe a C1 domain-dependent mechanism or provide structural findings; the citing sentence calls those findings its own. The indexed passage has no page number. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • The mechanisms by which microtubules regulate signaling proteins and their diverse pathways remain poorly understood.

    “However, the mechanisms by which microtubules regulate them and their diverse pathways remain poorly understood.”

    From Structural basis of microtubule-mediated signal transduction (2026) · cites this paper as [3]

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Research works printed but not linked: 50

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Cited by

Sorted by citations

Authors
Gundersen, G. G., & Cook, T. A.
Affiliations
Columbia University (US)
Corresponding author
Gundersen, Gregg G
ORCID
Gundersen, Gregg G
Venue
Current Opinion in Cell Biology
Publisher
Elsevier BV
Published
1999-02
Volume
11
Issue
1
Pages
81-94
ISSN
0955-0674 (ISSN-L)
DOI
10.1016/s0955-0674(99)80010-6
OpenAlex
W2135723950
Cited by
407
References
3
Citations by year
2026: 1 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 9 · 2020: 4 · 2019: 8 · 2018: 5 · 2017: 10 · 2016: 7 · 2015: 13 · 2014: 8 · 2013: 14 · 2012: 16
FWCI
2.95
Type
journal article
Language
en
Open access
Licence
Locations
  • Current Opinion in Cell Biology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
  • Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords
microtubules, signal transduction, microtubule stabilizers, microtubule destabilizers, cytoskeleton signaling
MeSH terms
Animals, Cytoskeleton, Drosophila melanogaster, Microtubule-Associated Proteins, Microtubules, Proto-Oncogene Proteins, Signal Transduction, Calcium-Calmodulin-Dependent Protein Kinases, Centrosome, GTP-Binding Proteins, Insect Proteins, Drosophila Proteins, Zebrafish Proteins, Wnt Proteins, Hedgehog Proteins

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