Autophagy and microtubules - new story, old players

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227 · see citing works

Autophagy: Renovation of Cells and Tissues

Mizushima, N., & Komatsu, M. (2011) · Cell · doi:10.1016/j.cell.2011.10.026 · Cited by 6,467 · see citing works

Microtubules as a target for anticancer drugs

Jordan, M. A., & Wilson, L. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1317 · Cited by 4,534 · see citing works

Development by Self-Digestion

Levine, B., & Klionsky, D. J. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00099-1 · Cited by 3,671 · see citing works

Autophagy and the Integrated Stress Response

Kroemer, G., Mariño, G., & Levine, B. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.023 · Cited by 3,506 · see citing works

Dynamic instability of microtubule growth

Mitchison, T., & Kirschner, M. (1984) · Nature · doi:10.1038/312237a0 · Cited by 3,337 · see citing works

The Role of Atg Proteins in Autophagosome Formation

Mizushima, N., Yoshimori, T., & Ohsumi, Y. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154005 · Cited by 2,978 · see citing works

MICROTUBULE POLYMERIZATION DYNAMICS

Desai, A. B., & Mitchison, T. J. (1997) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.13.1.83 · Cited by 2,570 · see citing works

The Beclin 1 network regulates autophagy and apoptosis

Kang, R., Zeh, H. J., Lotze, M. T., & Tang, D. (2011) · Cell Death & Differentiation · doi:10.1038/cdd.2010.191 · Cited by 2,485 · see citing works

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

Sancak, Y., Bar-Peled, L., Zoncu, R., Markhard, A. L., Nada, S., & Sabatini, D. M. (2010) · Cell · doi:10.1016/j.cell.2010.02.024 · Cited by 2,464 · see citing works

HDAC6 is a microtubule-associated deacetylase

Hubbert, C., Guardiola, A., Shao, R., Kawaguchi, Y., Ito, A., Nixon, A., Yoshida, M., Wang, X.-F., & Yao, T.-P. (2002) · Nature · doi:10.1038/417455a · Cited by 2,403 · see citing works

Autophagosome formation: core machinery and adaptations

Xie, Z., & Klionsky, D. J. (2007) · Nature Cell Biology · doi:10.1038/ncb1007-1102 · Cited by 2,165 · see citing works

Autophagy and Aging

Rubinsztein, D. C., Mariño, G., & Kroemer, G. (2011) · Cell · doi:10.1016/j.cell.2011.07.030 · Cited by 2,107 · see citing works

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

Jung, C. H., Jun, C. B., Ro, S.-H., Kim, Y.-M., Otto, N. M., Cao, J., Kundu, M., & Kim, D.-H. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-12-1249 · Cited by 2,025 · see citing works

Mammalian autophagy: core molecular machinery and signaling regulation

Yang, Z., & Klionsky, D. J. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.11.014 · Cited by 1,956 · see citing works

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

Axe, E. L., Walker, S. A., Manifava, M., Chandra, P., Roderick, H. L., Habermann, A., Griffiths, G., & Ktistakis, N. T. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200803137 · Cited by 1,885 · see citing works

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

Ravikumar, B., Sarkar, S., Davies, J. E., Futter, M., Garcı́a-Arencibia, M., Green-Thompson, Z. W., Jiménez-Sánchez, M., Korolchuk, V. I., Lichtenberg, M., Luo, S., et al. (2010) · Physiological Reviews · doi:10.1152/physrev.00030.2009 · Cited by 1,726 · see citing works

Microtubule nucleation by γ-tubulin complexes

Kollman, J. M., Merdes, A., Mourey, L., & Agard, D. A. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3209 · Cited by 1,583 · see citing works

The Human Sir2 Ortholog, SIRT2, Is an NAD+-Dependent Tubulin Deacetylase

North, B. J., Marshall, B. L., Borra, M. T., Denu, J. M., & Verdin, E. M. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00038-8 · Cited by 1,542 · see citing works

The Deacetylase HDAC6 Regulates Aggresome Formation and Cell Viability in Response to Misfolded Protein Stress

Kawaguchi, Y., Kovacs, J. J., McLaurin, A. C., Vance, J. M., Ito, A., & Yao, T. (2003) · Cell · doi:10.1016/s0092-8674(03)00939-5 · Cited by 1,529 · see citing works

Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks

Alers, S., Löffler, A. S., Wesselborg, S., & Stork, B. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06159-11 · Cited by 1,483 · see citing works

Autophagy modulation as a potential therapeutic target for diverse diseases

Rubinsztein, D. C., Codogno, P., & Levine, B. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3802 · Cited by 1,429 · see citing works

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

Wei, Y., Pattingre, S., Sinha, S., Bassik, M., & Levine, B. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.06.001 · Cited by 1,329 · see citing works

HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS.

Pandey, U. B., Nie, Z., Batlevi, Y., McCray, B. A., Ritson, G. P., Nedelsky, N. B., Schwartz, S. L., DiProspero, N. A., Knight, M. A., Schuldiner, O., et al. (2007) · Nature · doi:10.1038/nature05853 · Cited by 1,234 · see citing works

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

Sengupta, S., Peterson, T. R., & Sabatini, D. M. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.026 · Cited by 1,234 · see citing works

The Atg12-Atg5 Conjugate Has a Novel E3-like Activity for Protein Lipidation in Autophagy

Hanada, T., Noda, N. N., Satomi, Y., Ichimura, Y., Fujioka, Y., Takao, T., Inagaki, F., & Ohsumi, Y. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.c700195200 · Cited by 1,123 · cited 2× · see citing works

The Atg16L Complex Specifies the Site of LC3 Lipidation for Membrane Biogenesis in Autophagy

Fujita, N., Itoh, T., Omori, H., Fukuda, M., Noda, T., & Yoshimori, T. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-12-1257 · Cited by 1,083 · see citing works

The role of the Atg1/ULK1 complex in autophagy regulation

Mizushima, N. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.12.004 · Cited by 1,062 · see citing works

A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

Hayashi, M., Fujita, N., Noda, T., Yamaguchi, A., Yoshimori, T., & Yamamoto, A. (2009) · Nature Cell Biology · doi:10.1038/ncb1991 · Cited by 1,050 · see citing works

Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice

Tanaka, Y., Guhde, G., Suter, A., Eskelinen, E.-L., Hartmann, D., Lüllmann-Rauch, R., Janssen, P. M. L., Blanz, J., von Figura, K., & Saftig, P. (2000) · Nature · doi:10.1038/35022595 · Cited by 925 · see citing works

Microtubule Acetylation Promotes Kinesin-1 Binding and Transport

Reed, N. A., Cai, D., Blasius, T. L., Jih, G. T., Meyhofer, E., Gaertig, J., & Verhey, K. J. (2006) · Current Biology · doi:10.1016/j.cub.2006.09.014 · Cited by 919 · see citing works

Role for Rab7 in maturation of late autophagic vacuoles

Jäger, S., Bucci, C., Tanida, I., Ueno, T., Kominami, E., Säftig, P., & Eskelinen, E. (2004) · Journal of Cell Science · doi:10.1242/jcs.01370 · Cited by 907 · see citing works

Lysosomal positioning coordinates cellular nutrient responses

Korolchuk, V. I., Saiki, S., Lichtenberg, M., Siddiqi, F. H., Roberts, E. A., Imarisio, S., Jahreiss, L., Sarkar, S., Futter, M., Menzies, F. M., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2204 · Cited by 891 · see citing works

Autophagy, Immunity, and Microbial Adaptations

Deretic, V. P., & Levine, B. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.05.016 · Cited by 865 · see citing works

Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions

Janke, C., & Bulinski, J. C. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3227 · Cited by 838 · see citing works

Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation

Dompierre, J. P., Godin, J. D., Charrin, B. C., Cordelières, F. P., King, S. J., Humbert, S., & Saudou, F. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0037-07.2007 · Cited by 792 · see citing works

Autophagy in the Cellular Energetic Balance

Singh, R., & Cuervo, A. M. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.04.004 · Cited by 788 · see citing works

The Beclin 1–VPS34 complex – at the crossroads of autophagy and beyond

Funderburk, S. F., Wang, Q. J., & Yue, Z. (2010) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.03.002 · Cited by 778 · see citing works

HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo

Zhang, Y., Li, N., Caron, C., Matthias, G., Hess, D., Khochbin, S., & Matthias, P. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg115 · Cited by 740 · see citing works

Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation

Polson, H. E. J., de Lartigue, J., Rigden, D. J., Reedijk, M., Urbé, S., Clague, M. J., & Tooze, S. A. (2010) · Autophagy · doi:10.4161/auto.6.4.11863 · Cited by 712 · see citing works

Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells

Chen, Y., McMillan‐Ward, E., Kong, J., Israels, S. J., & Gibson, S. B. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402233 · Cited by 689 · see citing works

Rab7 is required for the normal progression of the autophagic pathway in mammalian cells

Gutierrez, M. G., Munafó, D. B., Berón, W., & Colombo, M. I. (2004) · Journal of Cell Science · doi:10.1242/jcs.01114 · Cited by 680 · see citing works

3D tomography reveals connections between the phagophore and endoplasmic reticulum

Ylä‐Anttila, P., Vihinen, H., Jokitalo, E., & Eskelinen, E. (2009) · Autophagy · doi:10.4161/auto.5.8.10274 · Cited by 670 · see citing works

FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end–directed vesicle transport

Pankiv, S., Alemu, E. A., Brech, A., Bruun, J., Lamark, T., Øvervatn, A., Bjørkøy, G., & Johansen, T. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200907015 · Cited by 645 · see citing works

Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules

Verhey, K. J., Meyer, D., Deehan, R., Blenis, J., Schnapp, B. J., Rapoport, T. A., & Margolis, B. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.5.959 · Cited by 609 · see citing works

Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity

Zhao, Y., Yang, J. H., Liao, W., Liu, X., Zhang, H., Wang, S., Wang, D., Feng, J., Yu, L., & Zhu, W. (2010) · Nature Cell Biology · doi:10.1038/ncb2069 · Cited by 607 · see citing works

DAP‐kinase‐mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl‐XL and induction of autophagy

Zalckvar, E., Berissi, H., Mizrachy, L., Idelchuk, Y., Koren, I., Eisenstein, M., Sabanay, H., Pinkas‐Kramarski, R., & Kimchi, A. (2009) · The EMBO Reports · doi:10.1038/embor.2008.246 · Cited by 592 · see citing works

mDia mediates Rho-regulated formation and orientation of stable microtubules

Palazzo, A. F., Cook, T. A., Alberts, A. S., & Gundersen, G. G. (2001) · Nature Cell Biology · doi:10.1038/35087035 · Cited by 582 · see citing works

Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy

Orsi, A., Razi, M., Dooley, H. C., Robinson, D. J., Weston, A., Collinson, L., & Tooze, S. A. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-09-0746 · Cited by 570 · see citing works

The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy

Bartolomeo, S. D., Corazzari, M., Nazio, F., Oliverio, S., Lisi, G., Antonioli, M., Pagliarini, V., Matteoni, S., Fuoco, C., Giunta, L., et al. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201002100 · Cited by 519 · see citing works

Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

Lee, J., Nagano, Y., Taylor, J. P., Lim, K. L., & Yao, T. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201001039 · Cited by 517 · see citing works

Activation of endosomal dynein motors by stepwise assembly of Rab7–RILP–p150Glued, ORP1L, and the receptor βlll spectrin

Johansson, M., Rocha, N., Zwart, W., Jordens, I., Janssen, L., Kuijl, C., Olkkonen, V. M., & Neefjes, J. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200606077 · Cited by 505 · see citing works

Asymmetric CLASP-Dependent Nucleation of Noncentrosomal Microtubules at the trans-Golgi Network

Efimov, A., Kharitonov, A., Efimova, N., Lončarek, J., Miller, P. M., Andreyeva, N., Gleeson, P. A., Galjart, N., Maia, A. R. R., McLeod, I. X., et al. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.04.002 · Cited by 498 · see citing works

Atg101, a novel mammalian autophagy protein interacting with Atg13

Hosokawa, N., Sasaki, T., Iemura, S.-I., Natsume, T., Hara, T., & Mizushima, N. (2009) · Autophagy · doi:10.4161/auto.5.7.9296 · Cited by 488 · see citing works

Overview of macroautophagy regulation in mammalian cells

Mehrpour, M., Esclatine, A., Beau, I., & Codogno, P. (2010) · Cell Research · doi:10.1038/cr.2010.82 · Cited by 488 · see citing works

Dynein mutations impair autophagic clearance of aggregate-prone proteins

Ravikumar, B., Acevedo‐Arozena, A., Imarisio, S., Berger, Z., Vacher, C., O’Kane, C. J., Brown, S. D. M., & Rubinsztein, D. C. (2005) · Nature Genetics · doi:10.1038/ng1591 · Cited by 458 · see citing works

The Itinerary of Autophagosomes: From Peripheral Formation to Kiss‐and‐Run Fusion with Lysosomes

Jahreiss, L., Menzies, F. M., & Rubinsztein, D. C. (2008) · Traffic · doi:10.1111/j.1600-0854.2008.00701.x · Cited by 453 · see citing works

Microtubules Facilitate Autophagosome Formation and Fusion of Autophagosomes with Endosomes

Köchl, R., Hu, X. W., Chan, E. Y. W., & Tooze, S. A. (2005) · Traffic · doi:10.1111/j.1600-0854.2005.00368.x · Cited by 436 · see citing works

Dynein-dependent Movement of Autophagosomes Mediates Efficient Encounters with Lysosomes

Kimura, S., Noda, T., & Yoshimori, T. (2008) · Cell Structure and Function · doi:10.1247/csf.08005 · Cited by 434 · see citing works

Microtubules and signal transduction

Gundersen, G. G., & Cook, T. A. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)80010-6 · Cited by 407 · see citing works

Autophagosome Precursor Maturation Requires Homotypic Fusion

Moreau, K., Ravikumar, B., Renna, M., Puri, C., & Rubinsztein, D. C. (2011) · Cell · doi:10.1016/j.cell.2011.06.023 · Cited by 382 · see citing works

Organization of organelles and membrane traffic by microtubules

Cole, N. B., & Lippincott‐Schwartz, J. (1995) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(95)80045-x · Cited by 323 · see citing works

The Golgi Complex Is a Microtubule-organizing Organelle

Chabin-Brion, K., Marceiller, J., Perez, F., Settegrana, C., Drechou, A., Durand, G., & Poüs, C. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.7.2047 · Cited by 319 · see citing works

Mitosis is not a key target of microtubule agents in patient tumors

Komlodi-Pasztor, E., Sackett, D., Wilkerson, J., & Fojo, T. (2011) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2010.228 · Cited by 312 · cited 1× · see citing works

Single molecule imaging reveals differences in microtubule track selection between Kinesin motors

Cai, D., McEwen, D. P., Martens, J. R., Meyhofer, E., & Verhey, K. J. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000216 · Cited by 300 · see citing works

Golgi-derived CLASP-dependent microtubules control Golgi organization and polarized trafficking in motile cells

Miller, P. M., Folkmann, A. W., Maia, A. R. R., Efimova, N., Efimov, A., & Kaverina, I. (2009) · Nature Cell Biology · doi:10.1038/ncb1920 · Cited by 294 · see citing works

Microtubules Support Production of Starvation-induced Autophagosomes but Not Their Targeting and Fusion with Lysosomes

Fass, E., Shvets, E., Degani, I., Hirschberg, K., & Elazar, Z. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607031200 · Cited by 286 · see citing works

Molecular characterization of light chain 3. A microtubule binding subunit of MAP1A and MAP1B

Mann, S. S., & Hammarback, J. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)78150-2 · Cited by 284 · see citing works

Posttranslational modifications of tubulin and the polarized transport of kinesin-1 in neurons

Hammond, J. W., Huang, C.-F., Kaech, S., Jacobson, C., Banker, G., & Verhey, K. J. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-01-0044 · Cited by 281 · see citing works

Detection of GTP-Tubulin Conformation in Vivo Reveals a Role for GTP Remnants in Microtubule Rescues

Dimitrov, A., Quesnoit, M., Moutel, S., Cantaloube, I., Poüs, C., & Perez, F. (2008) · Science · doi:10.1126/science.1165401 · Cited by 273 · see citing works

Differential turnover of tyrosinated and detyrosinated microtubules

Webster, D. R., Gundersen, G. G., Bulinski, J. C., & Borisy, G. G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9040 · Cited by 261 · see citing works

The formin mDia2 stabilizes microtubules independently of its actin nucleation activity

Bartolini, F., Moseley, J. B., Schmoranzer, J., Cassimeris, L., Goode, B. L., & Gundersen, G. G. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200709029 · Cited by 237 · see citing works

Multiple roles of the cytoskeleton in autophagy

Monastyrska, I., Rieter, E., Klionsky, D. J., & Reggiori, F. (2009) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.2009.00082.x · Cited by 223 · see citing works

Starvation-induced Hyperacetylation of Tubulin Is Required for the Stimulation of Autophagy by Nutrient Deprivation

Geeraert, C., Ratier, A., Pfisterer, S. G., Perdiz, D., Cantaloube, I., Rouault, A., Pattingre, S., Proikas‐Cezanne, T., Codogno, P., & Poüs, C. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.091553 · Cited by 204 · see citing works

Bim Inhibits Autophagy by Recruiting Beclin 1 to Microtubules

Luo, S., Garcı́a-Arencibia, M., Zhao, R., Puri, C., Toh, P. P. C., Sadiq, O., & Rubinsztein, D. C. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.05.040 · Cited by 203 · see citing works

Acetylated microtubules are required for fusion of autophagosomes with lysosomes

Xie, R., Nguyen, S., McKeehan, W. L., & Liu, L. (2010) · BMC Cell Biology · doi:10.1186/1471-2121-11-89 · Cited by 203 · see citing works

Cytoskeletal elements are required for the formation and maturation of autophagic vacuoles

Aplin, A. E., Jasionowski, T., Tuttle, D. L., Lenk, S. E., & Dunn, W. A. (1992) · Journal of Cellular Physiology · doi:10.1002/jcp.1041520304 · Cited by 192 · see citing works

Guanosinetriphosphatase activity of tubulin associated with microtubule assembly.

David-Pfeuty, T., Erickson, H., & Pantaloni, D. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.12.5372 · Cited by 182 · see citing works

Involvement of microtubule motors in basolateral and apical transport in kidney cells

Lafont, F., Burkhardt, J. K., & Simons, K. (1994) · Nature · doi:10.1038/372801a0 · Cited by 181 · see citing works

Cortical control of microtubule stability and polarization

Gundersen, G. G., Gomes, E. R., & Wen, Y. (2003) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2003.11.010 · Cited by 179 · see citing works

Posttranslational Acetylation of α-Tubulin Constrains Protofilament Number in Native Microtubules

Cueva, J. G., Hsin, J., Huang, K. C., & Goodman, M. B. (2012) · Current Biology · doi:10.1016/j.cub.2012.05.012 · Cited by 178 · see citing works

Microtubule disruption inhibits autophagosome-lysosome fusion: implications for studying the roles of aggresomes in polyglutamine diseases

Webb, J. L., Ravikumar, B., & Rubinsztein, D. C. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.02.003 · Cited by 167 · see citing works

From signaling pathways to microtubule dynamics: the key players

Etienne‐Manneville, S. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.11.008 · Cited by 163 · see citing works

Differential microtubule requirements for transcytosis in MDCK cells.

Hunziker, W., Mâle, P., & Mellman, I. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07560.x · Cited by 160 · see citing works

Genetically Separable Functions of the MEC-17 Tubulin Acetyltransferase Affect Microtubule Organization

Topalidou, I., Keller, C., Kalebic, N., Nguyen, K. C. Q., Somhegyi, H., Politi, K. A., Heppenstall, P. A., Hall, D. H., & Chalfie, M. (2012) · Current Biology · doi:10.1016/j.cub.2012.03.066 · Cited by 159 · see citing works

UNC-51/ATG1 kinase regulates axonal transport by mediating motor–cargo assemblyPreprint

Toda, H., Mochizuki, H., Flores, R., Josowitz, R., Krasieva, T. B., LaMorte, V. J., Suzuki, E., Gindhart, J. G., Furukubo-Tokunaga, K., & Tomoda, T. (2008) · Genes & Development · doi:10.1101/gad.1734608 · Cited by 141 · see citing works

Export from Pericentriolar Endocytic Recycling Compartment to Cell Surface Depends on Stable, Detyrosinated (Glu) Microtubules and Kinesin

Lin, S. X. H., Gundersen, G. G., & Maxfield, F. R. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-05-0224 · Cited by 133 · see citing works

Detyrosinated (Glu) microtubules are stabilized by an ATP-sensitive plus-end cap

Infante, A. S., Stein, M. S., Zhai, Y., Borisy, G. G., & Gundersen, G. G. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.22.3907 · Cited by 127 · see citing works

Depletion of Kinesin 5B Affects Lysosomal Distribution and Stability and Induces Peri-Nuclear Accumulation of Autophagosomes in Cancer Cells

Cardoso, C. M. P., Groth‐Pedersen, L., Høyer-Hansen, M. H., Kirkegaard, T., Corcelle, E., Andersen, J., Jäättelä, M., & Nylandsted, J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004424 · Cited by 125 · see citing works

Microtubule-associated Protein 1S (MAP1S) Bridges Autophagic Components with Microtubules and Mitochondria to Affect Autophagosomal Biogenesis and Degradation

Xie, R., Nguyen, S., McKeehan, K. A., Wang, F., McKeehan, W. L., & Leyuan, L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.206532 · Cited by 123 · see citing works

Luminal Localization of α-tubulin K40 Acetylation by Cryo-EM Analysis of Fab-Labeled Microtubules

Soppina, V., Herbstman, J. F., Skiniotis, G., & Verhey, K. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048204 · Cited by 116 · see citing works

The chemotherapeutic agent paclitaxel inhibits autophagy through two distinct mechanisms that regulate apoptosis

Veldhoen, R. A., Banman, S. L., Hemmerling, D., Odsen, R., Simmen, T., Simmonds, A. J., Underhill, D. A., & Goping, I. S. (2012) · Oncogene · doi:10.1038/onc.2012.92 · Cited by 114 · see citing works

Effect of microtubular or translational inhibitors on general cell protein degradation. Evidence for a dual catabolic pathway

Amenta, J. S., Sargus, M. J., & Baccino, F. M. (1977) · Biochemical Journal · doi:10.1042/bj1680223 · Cited by 109 · see citing works

Solution Structure of Microtubule-associated Protein Light Chain 3 and Identification of Its Functional Subdomains

Kouno, T., Mizuguchi, M., Tanida, I., Ueno, T., Kanematsu, T., Mori, Y., Shinoda, H., Hirata, M., Kominami, E., & Kawano, K. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413565200 · Cited by 103 · see citing works

Tubulin Acetylation Alone Does Not Affect Kinesin-1 Velocity and Run Length In Vitro

Walter, W. J., Beránek, V., Fischermeier, E., & Diez, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042218 · Cited by 97 · see citing works

Push-me-pull-you: how microtubules organize the cell interior

Tolić, I. M. (2008) · European Biophysics Journal · doi:10.1007/s00249-008-0321-0 · Cited by 92 · see citing works

Elastic and damping forces generated by confined arrays of dynamic microtubules

Howard, J. (2006) · Physical Biology · doi:10.1088/1478-3975/3/1/006 · Cited by 90 · see citing works

2-Methoxyestradiol suppresses microtubule dynamics and arrests mitosis without depolymerizing microtubules

Kamath, K., Okouneva, T., Larson, G., Panda, D., Wilson, L., & Jordan, M. A. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0113 · Cited by 88 · see citing works

c-Jun NH2-Terminal Kinase Activation Is Essential for DRAM-Dependent Induction of Autophagy and Apoptosis in 2-Methoxyestradiol–Treated Ewing Sarcoma Cells

Lorin, S., Borges, A., Santos, L. R. D., Souquère, S., Pierron, G., Ryan, K. M., Codogno, P., & Djavaheri‐Mergny, M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1270 · Cited by 82 · see citing works

Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic

Arduíno, D. M., Esteves, A. R., Cortes, L., Silva, D. F., Patel, B., Grazina, M. M., Swerdlow, R. H., Oliveira, C. R., & Cardoso, S. M. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds309 · Cited by 82 · see citing works

Polarized Entry of Uropathogenic Afa/Dr Diffusely AdheringEscherichia coliStrain IH11128 into Human Epithelial Cells: Evidence for α5β1Integrin Recognition and Subsequent Internalization through a Pathway Involving Caveolae and Dynamic Unstable Microtubules

Guignot, J., Bernet‐Camard, M., Poüs, C., Plançon, L., Bouguénec, C. L., & Servin, A. L. (2001) · Infection and Immunity · doi:10.1128/iai.69.3.1856-1868.2001 · Cited by 78 · see citing works

A possible role for stable microtubules in intracellular transport from the endoplasmic reticulum to the Golgi apparatus

Mizuno, M., & Singer, S. J. (1994) · Journal of Cell Science · doi:10.1242/jcs.107.5.1321 · Cited by 65 · see citing works

Lysosome positioning coordinates mTORC1 activity and autophagy

Poüs, C., & Codogno, P. (2011) · Nature Cell Biology · doi:10.1038/ncb0411-342 · Cited by 63 · see citing works

Functional Specialization of Stable and Dynamic Microtubules in Protein Traffic in WIF-B Cells

Poüs, C., Chabin-Brion, K., Drechou, A., Barbot, L., Phung-Koskas, T., Settegrana, C., Bourguet‐Kondracki, M., Maurice, M., Cassio, D., Guyot, M., et al. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.1.153 · Cited by 51 · see citing works

Microtubule depolymerization inhibits transport of cathepsin D from the Golgi apparatus to lysosomes

Scheel, J., Matteoni, R., Ludwig, T., Hoflack, B., & Kreis, T. E. (1990) · Journal of Cell Science · doi:10.1242/jcs.96.4.711 · Cited by 46 · see citing works

Microtubule acetylation and stability may explain alcohol-induced alterations in hepatic protein trafficking

Joseph, R. A., Shepard, B. D., Kannarkat, G. T., Rutledge, T. W., Tuma, D. J., & Tuma, P. L. (2007) · Hepatology · doi:10.1002/hep.22014 · Cited by 40 · see citing works

New Targets for Acetylation in Autophagy

Hamaï, A., & Codogno, P. (2012) · Science Signaling · doi:10.1126/scisignal.2003187 · Cited by 36 · see citing works

Effects of griseofulvin and nocodazole on the accumulation of autophagic vacuoles in ehrlich ascites tumor cells

Reunanen, H., Marttinen, M. T., & Hirsimäki, P. (1988) · Experimental and Molecular Pathology · doi:10.1016/0014-4800(88)90048-2 · Cited by 32 · see citing works

What is the advantage of a transient precursor in autophagosome biogenesis?

Ktistakis, N. T., Andrews, S., & Long, J. (2011) · Autophagy · doi:10.4161/auto.7.1.13697 · Cited by 18 · see citing works

The cell biology of the retinal pigment epithelium

Lakkaraju, A., Umapathy, A., Tan, L. X., Daniele, L., Philp, N. J., Boesze-Battaglia, K., & Williams, D. S. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100846 · Cited by 422 · see citing works

The Cytoskeleton-Autophagy Connection

Kast, D. J., & Dominguez, R. (2017) · Current Biology · doi:10.1016/j.cub.2017.02.061 · Cited by 267 · see citing works

Mitophagy in Cancer: A Tale of Adaptation

Vara‐Pérez, M., Felipe‐Abrio, B., & Agostinis, P. (2019) · Cells · doi:10.3390/cells8050493 · Cited by 256 · see citing works

Autophagy regulation and its role in cancer

Lorin, S., Hamaï, A., Mehrpour, M., & Codogno, P. (2013) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2013.06.007 · Cited by 247 · see citing works

Pharmacologic agents targeting autophagy

Vakifahmetoglu-Norberg, H., Xia, H., & Yuan, J. (2015) · Journal of Clinical Investigation · doi:10.1172/jci73937 · Cited by 240 · see citing works

Targeting autophagy in disease: established and new strategies

Koçak, M., Erdi, S. E., Jorba, G., Maestro, I., Farrés, J., Kirkin, V., Martı́nez, A., & Pleß, O. (2021) · Autophagy · doi:10.1080/15548627.2021.1936359 · Cited by 229 · see citing works

Impairment of the autophagy–lysosomal pathway in Alzheimer's diseases: Pathogenic mechanisms and therapeutic potential

Zhang, W., Xu, C., Sun, J., Shen, H., Wang, J., & Yang, C. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.01.008 · Cited by 214 · see citing works

Dual roles for autophagy: Degradation and secretion of Alzheimer's disease Aβ peptide

Nilsson, P., & Saido, T. C. (2014) · BioEssays · doi:10.1002/bies.201400002 · Cited by 202 · see citing works

The cytoskeleton in cell-autonomous immunity: structural determinants of host defence

Mostowy, S., & Shenoy, A. R. (2015) · Nature reviews. Immunology · doi:10.1038/nri3877 · Cited by 175 · see citing works

Autophagy: A Druggable Process

Morel, É., Mehrpour, M., Botti, J., Dupont, N., Hamaï, A., Nascimbeni, A. C., & Codogno, P. (2017) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010716-104936 · Cited by 168 · see citing works

Autophagy is required for ectoplasmic specialization assembly in sertoli cells

Liu, C., Wang, H., Shang, Y., Liu, W., Song, Z., Zhao, H., Wang, L., Jia, P., Gao, F., Xu, Z., et al. (2016) · Autophagy · doi:10.1080/15548627.2016.1159377 · Cited by 154 · see citing works

Futsch/MAP1B mRNA Is a Translational Target of TDP-43 and Is Neuroprotective in aDrosophilaModel of Amyotrophic Lateral Sclerosis

Coyne, A. N., Siddegowda, B. B., Estes, P. S., Johannesmeyer, J., Kovalik, T., Daniel, S. G., Pearson, A., Bowser, R. P., & Zarnescu, D. C. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2526-14.2014 · Cited by 153 · see citing works

Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential

Chauhan, S., Ahmed, Z., Bradfute, S. B., Arko‐Mensah, J., Mandell, M. A., Choi, S. W., Kimura, T., Blanchet, F. P., Waller, A., Mudd, M. H., et al. (2015) · Nature Communications · doi:10.1038/ncomms9620 · Cited by 138 · see citing works

Autophagy in Age-Associated Neurodegeneration

Metaxakis, A., Ploumi, C., & Tavernarakis, N. (2018) · Cells · doi:10.3390/cells7050037 · Cited by 121 · see citing works

p27 controls autophagic vesicle trafficking in glucose-deprived cells via the regulation of ATAT1-mediated microtubule acetylation

Nowosad, A., Creff, J., Jeannot, P., Culerrier, R. M., Codogno, P., Manenti, S., Nguyen, L., & Besson, A. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03759-9 · Cited by 125 · see citing works

Tubulin hyperacetylation is adaptive in cardiac proteotoxicity by promoting autophagy

McLendon, P. M., Ferguson, B. S., Osińska, H. E., Bhuiyan, M. S., James, J. F., McKinsey, T. A., & Robbins, J. M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415589111 · Cited by 121 · see citing works

Crosstalk between Apoptosis and Autophagy: Molecular Mechanisms and Therapeutic Strategies in Cancer

El‐Khattouti, A., Selimović, D., Haïkel, Y., & Hassan, M. (2013) · Journal of Cell Death · doi:10.4137/jcd.s11034 · Cited by 121 · see citing works

An mTORC1-to-CDK1 Switch Maintains Autophagy Suppression during Mitosis

Odle, R., Walker, S. A., Oxley, D., Kidger, A. M., Balmanno, K., Gilley, R., Okkenhaug, H., Florey, O., Ktistakis, N. T., & Cook, S. J. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.10.016 · Cited by 113 · see citing works

Autophagy in adhesion and migration

Kenific, C. M., Wittmann, T., & Debnath, J. (2016) · Journal of Cell Science · doi:10.1242/jcs.188490 · Cited by 108 · see citing works

Microtubules: Evolving roles and critical cellular interactions

Logan, C. M., & Menko, A. S. (2019) · Experimental Biology and Medicine · doi:10.1177/1535370219867296 · Cited by 110 · see citing works

Cardiac microtubules in health and heart disease

Caporizzo, M. A., Chen, C. Y., & Prosser, B. L. (2019) · Experimental Biology and Medicine · doi:10.1177/1535370219868960 · Cited by 109 · see citing works

Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium

Toops, K. A., Tan, L. X., Jiang, Z., Radu, R. A., & Lakkaraju, A. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-05-1028 · Cited by 105 · see citing works

Reactive Oxygen Species, AMP-activated Protein Kinase, and the Transcription Cofactor p300 Regulate α-Tubulin Acetyltransferase-1 (αTAT-1/MEC-17)-dependent Microtubule Hyperacetylation during Cell Stress

Mackeh, R., Lorin, S., Ratier, A., Mejdoubi‐Charef, N., Baillet, A., Bruneel, A., Hamaï, A., Codogno, P., Poüs, C., & Perdiz, D. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.507400 · Cited by 99 · see citing works

Centriolar Satellites Control GABARAP Ubiquitination and GABARAP-Mediated Autophagy

Joachim, J., Razi, M., Judith, D., Wirth, M., Calamita, E., Encheva, V., Dynlacht, B. D., Snijders, A. P., O’Reilly, N., Jefferies, H. B. J., et al. (2017) · Current Biology · doi:10.1016/j.cub.2017.06.021 · Cited by 101 · see citing works

Activation of mitophagy leads to decline in Mfn2 and loss of mitochondrial mass in Fuchs endothelial corneal dystrophy

Benischke, A., Vasanth, S., Miyai, T., Katikireddy, K. R., White, T. L., Chen, Y., Halilovic, A., Price, M. O., Price, F. W., Liton, P. B., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-06523-2 · Cited by 99 · see citing works

WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy

Kannan, M., Bayam, E., Wagner, C., Rinaldi, B., Kretz, P. F., Tilly, P., Roos, M., McGillewie, L., Bär, S., Minocha, S., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1713625114 · Cited by 99 · see citing works

The Role of HDAC6 in Autophagy and NLRP3 Inflammasome

Chang, P., Li, H., Hu, H., Li, Y., & Wang, T. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.763831 · Cited by 101 · see citing works

Emerging roles for the autophagy machinery in extracellular vesicle biogenesis and secretion

Leidal, A. M., & Debnath, J. (2021) · FASEB BioAdvances · doi:10.1096/fba.2020-00138 · Cited by 90 · see citing works

RASSF1A, puppeteer of cellular homeostasis, fights tumorigenesis, and metastasis—an updated review

Dubois, F., Bergot, E., Zalcman, G., & Levallet, G. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-2169-x · Cited by 93 · see citing works

Enhancing autophagy in Alzheimer's disease through drug repositioning

Eshraghi, M., Ahmadi, M., Afshar, S., Lorzadeh, S., Adlimoghaddam, A., Rezvani Jalal, N., West, R., Dastghaib, S., Igder, S., Torshizi, S. R. N., et al. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108171 · Cited by 89 · see citing works

Actin nucleation by WH2 domains at the autophagosome

Coutts, A. S., & Thangue, N. B. L. (2015) · Nature Communications · doi:10.1038/ncomms8888 · Cited by 83 · see citing works

The detyrosination/re-tyrosination cycle of tubulin and its role and dysfunction in neurons and cardiomyocytes

Sanyal, C., Pietsch, N., Ramírez‐Ríos, S., Peris, L., Carrier, L., & Moutin, M. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.12.006 · Cited by 80 · see citing works

Targeting autophagy in breast cancer

Maycotte, P. (2014) · World Journal of Clinical Oncology · doi:10.5306/wjco.v5.i3.224 · Cited by 80 · see citing works

Host cell autophagy contributes to Plasmodium liver development

Thieleke‐Matos, C., Lopes‐da‐Silva, M., Cabrita‐Santos, L., Portal, M. D., Rodrigues, I. P., Zuzarte‐Luís, V., Ramalho, J. S., Futter, C. E., Mota, M. M., Barral, D. C., et al. (2015) · Cellular Microbiology · doi:10.1111/cmi.12524 · Cited by 78 · see citing works

Blockage of autophagosome-lysosome fusion through SNAP29 O-GlcNAcylation promotes apoptosis via ROS production

Pellegrini, F. R., Martino, S. D., Fianco, G., Ventura, I., Valente, D., Fiore, M., Trisciuoglio, D., & Degrassi, F. (2023) · Autophagy · doi:10.1080/15548627.2023.2170962 · Cited by 75 · see citing works

Glutathione transferase mu 2 protects glioblastoma cells against aminochrome toxicity by preventing autophagy and lysosome dysfunction

Huenchuguala, S., Muñoz, P., Zavala, P., Villa, M., Cuevas, C., Ahumada, U., Graumann, R., Nore, B., Couve, E., Mannervik, B., et al. (2014) · Autophagy · doi:10.4161/auto.27720 · Cited by 69 · see citing works

Vac8 spatially confines autophagosome formation at the vacuole in S. cerevisiae

Hollenstein, D. M., Gómez‐Sánchez, R., Ciftci, A., Kriegenburg, F., Mari, M. C., Torggler, R., Licheva, M., Reggiori, F., & Kraft, C. (2019) · Journal of Cell Science · doi:10.1242/jcs.235002 · Cited by 67 · see citing works

Carbon nanotubes, but not spherical nanoparticles, block autophagy by a shape-related targeting of lysosomes in murine macrophages

Cohignac, V., Landry, M., Ridoux, A., Pinault, M., Annangi, B., Gerdil, A., Herlin‐Boime, N., Mayne–L'Hermite, M., Haruta, M., Codogno, P., et al. (2018) · Autophagy · doi:10.1080/15548627.2018.1474993 · Cited by 66 · see citing works

Key Role of Microtubule and Its Acetylation in a Zinc Oxide Nanoparticle–Mediated Lysosome–Autophagy System

Liu, J., Kang, Y., Yin, S., Chen, A., Wu, J., Liang, H., & Shao, L. (2019) · Small · doi:10.1002/smll.201901073 · Cited by 65 · see citing works

Selective autophagy: Lysophagy

Hasegawa, J., Maejima, I., Iwamoto, R., & Yoshimori, T. (2014) · Methods · doi:10.1016/j.ymeth.2014.12.014 · Cited by 64 · see citing works

Structural basis of FYCO1 and MAP1LC3A interaction reveals a novel binding mode for Atg8-family proteins

Cheng, X., Wang, Y., Gong, Y., Li, F., Guo, Y., Hu, S., Liu, J., & Pan, L. (2016) · Autophagy · doi:10.1080/15548627.2016.1185590 · Cited by 62 · see citing works

Autophagy and Mitochondrial Dysfunction in Tenon Fibroblasts from Exfoliation Glaucoma Patients

Want, A., Gillespie, S. R., Wang, Z., Gordon, R., Iomini, C., Ritch, R. H., Wolosin, J. M., & Bernstein, A. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157404 · Cited by 61 · see citing works

Suppression of autophagy during mitosis via CUL4-RING ubiquitin ligases-mediated WIPI2 polyubiquitination and proteasomal degradation

Lu, G. X., Yi, J., Gubaš, A., Wang, Y., Wu, Y., Ren, Y., Wu, M., Shi, Y. P., Ouyang, C., Tan, H. W. S., et al. (2019) · Autophagy · doi:10.1080/15548627.2019.1596484 · Cited by 60 · see citing works

Tubulin Post-Translational Modifications: The Elusive Roles of Acetylation

Carmona, B., Marinho, H. S., Matos, C. L., Nolasco, S., & Soares, H. (2023) · Biology · doi:10.3390/biology12040561 · Cited by 58 · see citing works

Disruption of microtubules in plants suppresses macroautophagy and triggers starch excess-associated chloroplast autophagy

Wang, Y., Zheng, X., Yu, B., Han, S., Guo, J., Tang, H., Yu, A. Y. L., Deng, H., Hong, Y., & Liu, Y. (2015) · Autophagy · doi:10.1080/15548627.2015.1113365 · Cited by 58 · see citing works

The role of APC-mediated actin assembly in microtubule capture and focal adhesion turnover

Juanes, M. A., Isnardon, D., Badache, A., Brasselet, S., Mavrakis, M., & Goode, B. L. (2019) · The Journal of Cell Biology · doi:10.1083/jcb.201904165 · Cited by 53 · see citing works

Histone deacetylase 6 inhibition restores autophagic flux to promote functional recovery after spinal cord injury

Zheng, Z., Zhou, Y., Ye, L., Lu, Q., Zhang, K., Zhang, J., Xie, L., Wu, Y., Xu, K., Zhang, H., et al. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.113138 · Cited by 53 · see citing works

The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy

Biskou, O., Casanova, V., Hooper, K. M., Kemp, S. E., Wright, G. P., Satsangi, J. J., Barlow, P. G., & Stevens, C. (2019) · PLoS ONE · doi:10.1371/journal.pone.0209665 · Cited by 52 · see citing works

The Microtubule-associated Protein EB1 Links AIM2 Inflammasomes with Autophagy-dependent Secretion

Wang, L., Huang, H., Huang, M.-P., Liou, W., Chang, Y., Wu, C., Ojcius, D. M., & Chang, Y. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.559153 · Cited by 52 · see citing works

PTEN/FOXO3/AKT pathway regulates cell death and mediates morphogenetic differentiation of Colorectal Cancer Cells under Simulated Microgravity

Arun, R. P., Sivanesan, D., Vidyasekar, P., & Verma, R. S. (2017) · Scientific Reports · doi:10.1038/s41598-017-06416-4 · Cited by 52 · see citing works

Stress-induced hyperacetylation of microtubule enhances mitochondrial fission and modulates the phosphorylation of Drp1 at 616Ser

Perdiz, D., Lorin, S., Leroy-Gori, I., & Poüs, C. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.07.020 · Cited by 51 · see citing works

Role of Autophagy in Proteostasis: Friend and Foe in Cardiac Diseases

Li, J., Zhang, D., Wiersma, M., & Brundel, B. J. J. M. (2018) · Cells · doi:10.3390/cells7120279 · Cited by 54 · see citing works

LC3B phosphorylation regulates FYCO1 binding and directional transport of autophagosomes

Nieto-Torres, J. L., Shanahan, S.-L., Chassefeyre, R., Chaiamarit, T., Zaretski, S., Landeras-Bueno, S., Verhelle, A., Encalada, S. E., & Hansen, M. (2021) · Current Biology · doi:10.1016/j.cub.2021.05.052 · Cited by 52 · see citing works

Protein complexes and neighborhoods driving autophagy

Sankar, D. S., & Dengjel, J. (2020) · Autophagy · doi:10.1080/15548627.2020.1847461 · Cited by 51 · see citing works

Shear stress induces noncanonical autophagy in intestinal epithelial monolayers

Kim, S. W., Ehrman, J. D., Ahn, M., Kondo, J., Lopez, A. A., Oh, Y. S., Kim, X. H., Crawley, S. W., Goldenring, J. R., Tyska, M. J., et al. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e17-01-0021 · Cited by 49 · see citing works

Connecting autophagy: AMBRA1 and its network of regulation

Cianfanelli, V., Nazio, F., & Cecconi, F. (2015) · Molecular & Cellular Oncology · doi:10.4161/23723548.2014.970059 · Cited by 43 · see citing works

Alzheimer's disease genes and autophagy

Yoon, S., & Kim, D. (2016) · Brain Research · doi:10.1016/j.brainres.2016.03.018 · Cited by 47 · see citing works

Regulation of actin nucleation and autophagosome formation

Coutts, A. S., & Thangue, N. B. L. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2224-z · Cited by 47 · see citing works

Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents

Brindisi, M., Ulivieri, C., Alfano, G., Gemma, S., Balaguer, F. D. A., Khan, T., Grillo, A., Chemi, G., Menchon, G., Prota, A. E., et al. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.11.004 · Cited by 47 · see citing works

Rotenone Induces the Formation of 4-Hydroxynonenal Aggresomes. Role of ROS-Mediated Tubulin Hyperacetylation and Autophagic Flux Disruption

Bonet‐Ponce, L., Sáez-Atiénzar, S., da Casa, C., Sancho-Pellúz, J., Barcia, J. M., Martínez‐Gil, N., Nava, E., Jordán, J., Romero, F. J., & Galindo, M. F. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9509-3 · Cited by 45 · see citing works

Defective recruitment of motor proteins to autophagic compartments contributes to autophagic failure in aging

Bejarano, E., Murray, J. W., Wang, X., Pampliega, O., Yin, D., Patel, B., Yuste, A., Wolkoff, A. W., & Cuervo, A. M. (2018) · Aging Cell · doi:10.1111/acel.12777 · Cited by 45 · see citing works

LAMP2 Cardiomyopathy: Consequences of Impaired Autophagy in the Heart

Alcalai, R., Arad, M., Wakimoto, H., Yadin, D., Gorham, J., Wang, L., Burns, E., Maron, B. J., Roberts, W. C., Konno, T., et al. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.120.018829 · Cited by 42 · see citing works

The role of Runx2 in facilitating autophagy in metastatic breast cancer cells

Tandon, M., Othman, A. H., Ashok, V., Stein, G. S., & Pratap, J. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25916 · Cited by 41 · see citing works

FSIP1 regulates autophagy in breast cancer

Liu, C., Sun, L., Yang, J., Liu, T., Yang, Y., Kim, S., Ou, X., Wang, Y., Sun, L., Zaidi, M., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1809681115 · Cited by 41 · see citing works

AGBL2 promotes cancer cell growth through IRGM-regulated autophagy and enhanced Aurora A activity in hepatocellular carcinoma

Wang, L.-L., Jin, X.-H., Cai, M.-Y., Li, H.-G., Chen, J.-W., Wang, F., Wang, C.-Y., Hu, W.-W., Liu, F., & Xie, D. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.11.003 · Cited by 40 · see citing works

A current view of molecular dissection in autophagy machinery

Al‐Bari, M. A. A. (2020) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-020-00746-0 · Cited by 38 · see citing works

Autophagy protects cardiomyocytes from the myocardial ischaemia-reperfusion injury through the clearance of CLP36

Li, S., Liu, C., Gu, L., Wang, L., Shang, Y., Liu, Q., Wan, J., Shi, J. Y., Wang, F., Xu, Z., et al. (2016) · Open Biology · doi:10.1098/rsob.160177 · Cited by 36 · see citing works

Phenotypic Drug Screening for Dysferlinopathy Using Patient-Derived Induced Pluripotent Stem Cells

Kokubu, Y., Nagino, T., Sasa, K., Oikawa, T., Miyake, K., Kume, A., Fukuda, M., Fuse, H., Tozawa, R., & Sakurai, H. (2019) · Stem Cells Translational Medicine · doi:10.1002/sctm.18-0280 · Cited by 34 · see citing works

Molecular mechanisms of mammalian autophagy

Trelford, C. B., & Guglielmo, G. M. D. (2021) · Biochemical Journal · doi:10.1042/bcj20210314 · Cited by 34 · see citing works

Ablation of C/EBP homologous protein attenuates renal fibrosis after ureteral obstruction by reducing autophagy and microtubule disruption

Noh, M. R., Woo, C.-H., Park, M.-J., In Kim, J., & Park, K. M. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.02.001 · Cited by 33 · see citing works

Autophagic degradation of KAT2A/GCN5 promotes directional migration of vascular smooth muscle cells by reducing TUBA/α-tubulin acetylation

Ouyang, C., Mu, J., Lu, Q., Li, J., Zhu, H., Wang, Q., Zou, M., & Xie, Z. (2019) · Autophagy · doi:10.1080/15548627.2019.1707488 · Cited by 33 · see citing works

Viriditoxin regulates apoptosis and autophagy via mitotic catastrophe and microtubule formation in human prostate cancer cells

Kundu, S., Kim, T. H., Yoon, J. H., Shin, H.-S., Lee, J., Jung, J. H., & Kim, H. S. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2659 · Cited by 32 · see citing works

The Tubulin Code and Tubulin-Modifying Enzymes in Autophagy and Cancer

Trisciuoglio, D., & Degrassi, F. (2021) · Cancers · doi:10.3390/cancers14010006 · Cited by 30 · see citing works

The role of autophagic cell death in cardiac disease

Nah, J., Zablocki, D., & Sadoshima, J. (2022) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2022.08.362 · Cited by 30 · see citing works

The SFTSV Nonstructural Proteins Induce Autophagy to Promote Viral Replication via Interaction with Vimentin

Liu, S., Su, Y., Lu, Z., Zou, X., Xu, L., Teng, Y., Wang, Z., & Wang, T. (2023) · Journal of Virology · doi:10.1128/jvi.00302-23 · Cited by 29 · see citing works

GABARAPL1 tumor suppressive function is independent of its conjugation to autophagosomes in MCF-7 breast cancer cells

Poillet-Perez, L., Jacquet, M., Hervouet, É., Gauthier, T., Fraîchard, A., Borg, C., Pallandre, J., Gonzalez, B. J., Ramdani, Y., Boyer‐Guittaut, M., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.19639 · Cited by 29 · see citing works

Alcohol-induced microtubule acetylation leads to the accumulation of large, immobile lipid droplets

Groebner, J. L., Bravo, M. G., Rothberg, M. L., Adhikari, R., Tuma, D. J., & Tuma, P. L. (2019) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00026.2019 · Cited by 29 · see citing works

Broad-spectrum antitumor properties of Withaferin A: a proteomic perspective

Dom, M. P., Berghe, W. V., & Ostade, X. V. (2019) · RSC Medicinal Chemistry · doi:10.1039/c9md00296k · Cited by 29 · see citing works

Probing Protein–Protein Interactions with Label-Free Mass Spectrometry Quantification in Combination with Affinity Purification by Spin-Tip Affinity Columns

Liu, G., Fu, T., Han, Y., Hu, S., Zhang, X., Zheng, M., Hao, P., Pan, L., & Kang, J. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.9b05355 · Cited by 29 · see citing works

Azithromycin, a potent autophagy inhibitor for cancer therapy, perturbs cytoskeletal protein dynamics

Takano, N., Hiramoto, M., Yamada, Y., Kokuba, H., Tokuhisa, M., Hino, H., & Miyazawa, K. (2023) · British Journal of Cancer · doi:10.1038/s41416-023-02210-4 · Cited by 29 · see citing works

Kisspeptin inhibits cancer growth and metastasis via activation of EIF2AK2

Kim, T., & Cho, S. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7578 · Cited by 27 · see citing works

Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress

Chambraud, B., Daguinot, C., Guillemeau, K., Genet, M., Dounane, O., Méduri, G., Poüs, C., Baulieu, E. E., & Giustiniani, J. (2021) · Autophagy · doi:10.1080/15548627.2021.1875611 · Cited by 27 · see citing works

The crystal structure of mouse LC3B in complex with the FYCO1 LIR reveals the importance of the flanking region of the LIR motif

Sakurai, S., Tomita, T., Shimizu, T., & Ohto, U. (2017) · Acta Crystallographica Section F Structural Biology Communications · doi:10.1107/s2053230x17001911 · Cited by 25 · see citing works

Lidocaine induces protective autophagy in rat C6 glioma cell line

Izdebska, M., Hałas‐Wiśniewska, M., Zielińska, W., Klimaszewska‐Wiśniewska, A., Grzanka, D., & Gagat, M. (2018) · International Journal of Oncology · doi:10.3892/ijo.2018.4668 · Cited by 26 · see citing works

Canonical and Non-canonical TGFβ Signaling Activate Autophagy in an ULK1-Dependent Manner

Trelford, C. B., & Guglielmo, G. M. D. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.712124 · Cited by 25 · see citing works

Tubulin-binding anticancer polysulfides induce cell death via mitotic arrest and autophagic interference in colorectal cancer

Efe, E. Y., Mazumder, A., Lee, J., Gaigneaux, A., Radogna, F., Nasim, M. J., Christov, C., Jacob, C., Kim, K., Dicato, M. A., et al. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.09.011 · Cited by 25 · see citing works

Tubulin acetylation accompanies autophagy development induced by different abiotic stimuli in Arabidopsis thaliana

Olenieva, V. D., Lytvyn, D. I., Yemets, A. I., Catherine Bergounioux, A., & Blume, Y. B. (2017) · Cell Biology International · doi:10.1002/cbin.10843 · Cited by 24 · see citing works

Control of GABARAP‐mediated autophagy by the Golgi complex, centrosome and centriolar satellites

Joachim, J., & Tooze, S. A. (2017) · Biology of the Cell · doi:10.1111/boc.201700046 · Cited by 24 · see citing works

Berberine, a natural alkaloid sensitizes human hepatocarcinoma to ionizing radiation by blocking autophagy and cell cycle arrest resulting in senescence

Ramesh, G., Das, S., & Rao, B. S. S. (2020) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.13354 · Cited by 23 · see citing works

Essential role of hyperacetylated microtubules in innate immunity escape orchestrated by the EBV-encoded BHRF1 protein

Glon, D., Vilmen, G., Perdiz, D., Hernández, E., Beauclair, G., Quignon, F., Berlioz‐Torrent, C., Maréchal, V., Poüs, C., Lussignol, M., et al. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010371 · Cited by 23 · see citing works

Small heat shock proteins mediate cell-autonomous and -nonautonomous protection in a Drosophila model for environmental-stress-induced degeneration

Kawasaki, F., Koonce, N. L., Guo, L., Fatima, S., Qiu, C., Moon, M. T., Zheng, Y., & Ordway, R. W. (2016) · Disease Models & Mechanisms · doi:10.1242/dmm.026385 · Cited by 23 · see citing works

Human GABARAP can restore autophagosome biogenesis in aC. elegans lgg-1mutant

Jenzer, C., Manil-Ségalen, M., Lefebvre, C., Largeau, C., Glatigny, A., & Legouis, R. (2014) · Autophagy · doi:10.4161/auto.29745 · Cited by 22 · see citing works

Selective autophagy receptor Joka2 co-localizes with cytoskeleton in plant cells

Zientara‐Rytter, K., & Sirko, A. (2014) · Plant Signaling & Behavior · doi:10.4161/psb.28523 · Cited by 22 · see citing works

Targeting bortezomib-induced aggresome formation using vinorelbine enhances the cytotoxic effect along with ER stress loading in breast cancer cell lines

Miyahara, K., Kazama, H., Kokuba, H., KOMATSU, S., Hirota, A., Takemura, J., Hirasawa, K., Moriya, S., Abe, A., Hiramoto, M., et al. (2016) · International Journal of Oncology · doi:10.3892/ijo.2016.3673 · Cited by 22 · see citing works

Host cell autophagy promotes BK virus infection

Bouley, S. J., Maginnis, M. S., Derdowski, A., Gee, G. V., O’Hara, B. A., Nelson, C. D. S., Bara, A. M., Atwood, W. J., & Dugan, A. S. (2014) · Virology · doi:10.1016/j.virol.2014.03.009 · Cited by 20 · see citing works

Proprotein convertase 7 (PCSK7) reduces apoA‐V levels

Ashraf, Y., Duval, S., Sachan, V., Essalmani, R., Susan‐Resiga, D., Roubtsova, A., Hamelin, J., Gerhardy, S., Kirchhofer, D., Tagliabracci, V. S., et al. (2020) · FEBS Journal · doi:10.1111/febs.15212 · Cited by 20 · see citing works

hnRNPK modulates selective quality-control autophagy by downregulating the expression of HDAC6 in 293�cells

Li, Z., Liu, X., Ma, J., Zhang, T., Gao, X., & Liu, L. (2018) · International Journal of Oncology · doi:10.3892/ijo.2018.4517 · Cited by 20 · see citing works

Harnessing Nanochaperone‐Mediated Autophagy for Selective Clearance of Pathogenic Tau Protein in Alzheimer's Disease

Xu, L., Wu, X., Zhao, S., Hu, H., Wang, S., Zhang, Y., Chen, J., Zhang, X., Zhao, Y., Ma, R., et al. (2024) · Advanced Materials · doi:10.1002/adma.202313869 · Cited by 21 · see citing works

Deoxynivalenol induces structural alterations in epidermoid carcinoma cells A431 and impairs the response to biomechanical stimulation

Favero, G. D., Woelflingseder, L., Janker, L., Neuditschko, B., Seriani, S., Gallina, P., Sbaizero, O., Gerner, C., & Marko, D. (2018) · Scientific Reports · doi:10.1038/s41598-018-29728-5 · Cited by 20 · see citing works

Combined EGFR and ROCK Inhibition in Triple-negative Breast Cancer Leads to Cell Death Via Impaired Autophagic Flux

Rontogianni, S., Iskit, S., van Doorn, S., Peeper, D. S., & Altelaar, M. A. F. (2019) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra119.001800 · Cited by 19 · see citing works

Microtubules Facilitate Autophagosome Formation and Fusion of Autophagosomes with Endosomes

Köchl, R., Hu, X. W., Chan, E. Y. W., & Tooze, S. A. (2005) · Traffic · doi:10.1111/j.1600-0854.2005.00368.x · Cited by 436 · see citing works

Microtubules Support Production of Starvation-induced Autophagosomes but Not Their Targeting and Fusion with Lysosomes

Fass, E., Shvets, E., Degani, I., Hirschberg, K., & Elazar, Z. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607031200 · Cited by 286 · see citing works

Starvation-induced Hyperacetylation of Tubulin Is Required for the Stimulation of Autophagy by Nutrient Deprivation

Geeraert, C., Ratier, A., Pfisterer, S. G., Perdiz, D., Cantaloube, I., Rouault, A., Pattingre, S., Proikas‐Cezanne, T., Codogno, P., & Poüs, C. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.091553 · Cited by 204 · see citing works

Role of microtubules and kinesin-1 in autophagic survey

Geeraert, C., & Poüs, C. (2010) · OpenGrey (Institut de l'Information Scientifique et Technique)

MK‐STYX Impacts Autophagy and Microtubule Dynamics

Mattei, A. M., Christian, P., & Hinton, S. D. (2019) · The FASEB Journal · doi:10.1096/fasebj.2019.33.1_supplement.645.1