Isomer-specific effects of conjugated linoleic acid (CLA) on adiposity and lipid metabolism
Abstract
Isomers of conjugated linoleic acid (CLA), unsaturated fatty acids found in ruminant meats and dairy products, have been shown to reduce adiposity and alter lipid metabolism in animal, human, and cell culture studies. In particular, dietary CLA decreases body fat and increases lean body mass in certain rodents, chickens, and pigs, depending on the isomer, dose, and duration of treatment. However, the effects of CLA on human adiposity are conflicting because these studies have used different mixtures and levels of CLA isomers and diverse subject populations. Potential antiobesity mechanisms of CLA include decreased preadipocyte proliferation and differentiation into mature adipocytes, decreased fatty acid and triglyceride synthesis, and increased energy expenditure, lipolysis, and fatty acid oxidation. This review will address the current research on CLA's effects on human and animal adiposity and lipid metabolism as well as potential mechanism(s) responsible for CLA's antiobesity properties.
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Conjugated linoleic acid (cLA) is present in extra virgin olive oil (EVOO).
“The presence of cLA in EVOO [39], [40] was determined by selective derivatization with 4-phenyl-1,2,4- triazoline-3,5-dione (PTAD) and product analysis by HPLC-MS/MS (Figure S2) (30).”
From Olives and olive oil are sources of electrophilic fatty acid nitroalkenes (2014) · cites this paper as [40]
Both mammalian and enterosalivary microbiome enzymes can synthesize conjugated diene fatty acids in humans both de novo and by desaturation of monoenoic fatty acid substrates.
“In addition, both mammalian and enterosalivary microbiome enzymes can synthesize conjugated diene fatty acids in humans both de novo and by desaturation of monoenoic fatty acid substrates [39], [40].”
From Olives and olive oil are sources of electrophilic fatty acid nitroalkenes (2014) · cites this paper as [40]
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References 87 · Cited by 219
- Authors
- Evans, M. E., Brown, J. M., & McIntosh, M. K.
- Affiliations
- Emory University (US)
- University of North Carolina at Greensboro (US)
- Corresponding author
- McIntosh, Michael K
- ORCID
- Evans, Mary E
- Venue
- The Journal of Nutritional Biochemistry
- Publisher
- Elsevier BV
- Published
- 2002-09
- Volume
- 13
- Issue
- 9
- Pages
- 508-516
- ISSN
- 0955-2863 (ISSN-L)
- OpenAlex
- W2012063330
- Cited by
- 219
- References
- 87
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 3 · 2022: 1 · 2020: 5 · 2019: 5 · 2017: 7 · 2016: 9 · 2015: 7 · 2014: 10 · 2013: 14 · 2012: 7
- FWCI
- 12.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Nutritional Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R00HL096166)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- conjugated linoleic acid, CLA isomers, adiposity, lipid metabolism, preadipocyte differentiation, adipocyte proliferation, triglyceride synthesis, lipolysis, fatty acid oxidation, energy expenditure, fat mass, ruminant products, dietary fatty acids
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