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Cited by 4Polymer Surface Interaction StudiesBlood transfusion and managementMechanical Circulatory Support Devices

Biocompatibility in transfusion medicine

NYDEGGER, U·1996·Transfusion Science
DOI 10.1016/s0955-3886(96)90081-8
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Abstract

The first measurable event upon interaction of artificial surfaces with blood is adsorption of proteins within seconds or minutes. At a later stage, blood cells interact with the surfaces through the initially deposited protein layer. The chemical composition of the surface is only one criterion for differential deposition of various plasma proteins, with molecular motion (polymer chain ends, loops and their flexibility), and topography (roughness, porosity) of the surface decisively influencing the interactions as well. Initially incompatible surfaces, which may be dangerous to the patient, may be rendered compatible by physicochemical surface modifications. Modern methods to estimate biocompatibility have become so sensitive that they may detect biological modifications of the blood after contact with a surface, which has no consequence for the patient. In these cases it is often difficult to decide whether a material should be classified as biocompatible or non-biocompatible. This paper discusses some methods that we have used for the study of biocompatibility of extracorporeal circuitry. It seems to us that minute signs of laboratory evidence for bioincompatibility should not preclude usage of the material in a clinical setting.

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Crossref · 10.1016/s0955-3886(96)90081-8

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14 of 14 references verified0 citation errors · 0 not checkable

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  • Super-hydrophobic polymer surfaces with water contact angles above 150°, low surface energy, and self-cleaning properties resist microbial cell adhesion in short-term applications.

    “Super-hydrophobic polymer surfaces, such as very smooth silicone, polyurethane, polytetrafluoroethylene (PTFE), poly(vinyl chloride) (PVC), and polyethylene (PE), that have water contact angles larger than 150°, low surface energy,55,56 as well as unique water repellent57 and self-cleaning abilities,56 are known to have resistance to microbial cell adhesion during short-term applications.58”

    From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [58]

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Authors
NYDEGGER, U.
Affiliations
Swiss Red Cross (CH)
Corresponding author
NYDEGGER, U
ORCID
NYDEGGER, U
Venue
Transfusion Science
Publisher
Elsevier BV
Published
1996-12
Volume
17
Issue
4
Pages
481-488
ISSN
0955-3886 (ISSN-L)
DOI
10.1016/s0955-3886(96)90081-8
OpenAlex
W1975010661
Cited by
4
References
14
Citations by year
2016: 1 · 2014: 1 · 2013: 1
FWCI
0.00
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Transfusion Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
  • Health Sciences › Medicine › Biochemistry › Blood transfusion and management
  • Physical Sciences › Engineering › Biomedical Engineering › Mechanical Circulatory Support Devices
Keywords
biocompatibility, hemocompatibility, protein adsorption, plasma proteins, surface topography, surface roughness, surface modification, transfusion medicine
MeSH terms
Biocompatible Materials, Blood Transfusion, Humans

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