Cited by 113Hemoglobin structure and functionBlood transfusion and managementBiomedical and Chemical Research

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The physiology of oxygen transport

Habler, Oliver P, Messmer, Konrad F.W·1997·Transfusion Science

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Abstract

Adequate organ function requires adequate provision of cells with oxygen (O2). The driving force for O2-diffusion from ambient air to its site of consumption in cell mitochondria is the oxygen partial pressure (pO2) gradient along this pathway. After uptake in the lungs, O2 transport in blood is achieved (1) through binding to haemoglobin and (2) through physical dissolution in plasma. While the sum of O2 in these two transport states defines total oxygen content of blood, the delivery of O2 to different organs is determined by cardiac output and arterial O2 content, being the product of both parameters. In the case of anaemia, intravascular volume and cardiac compensatory mechanisms determine the degree of O2 content reduction allowable prior tissue hypoxia and lactacidosis occur. When intravascular volume is preserved (e.g. normovolemic dilutional anaemia), reductions in O2 content are tolerated to a much higher degree than in hypovolemic anaemia (e.g. haemorrhagic shock).

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Authors: Habler, O. P., & Messmer, K. F. W.
Affiliations: Institut für Chirurgische Forschung (DE)
Ludwig-Maximilians-Universität München (DE)
Corresponding author: Habler, Oliver P
Venue: Transfusion Science
Publisher: Elsevier BV
Published: 1997-09
Volume: 18
Issue: 3
Pages: 425-435
ISSN: 0955-3886 (ISSN-L)
DOI: 10.1016/s0955-3886(97)00041-6
OpenAlex: W2085056517
Cited by: 113
References: 49
Citations by year: 2026: 2 · 2025: 6 · 2024: 6 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 6 · 2019: 7 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 4 · 2013: 6 · 2012: 3
FWCI: 0.12
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Transfusion Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
Health Sciences › Medicine › Hematology › Blood transfusion and management
Health Sciences › Medicine › Physiology (medical) › Biomedical and Chemical Research
Keywords: oxygen transport, oxygen partial pressure gradient, cardiac output, arterial oxygen content, tissue hypoxia, anemia, hemorrhagic shock, lactacidosis, oxygen delivery
MeSH terms: Anemia, Biological Transport, Cells, Hemoglobins, Humans, Lung, Oxygen, Oxygen Consumption, Pulmonary Alveoli

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