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Cited by 113Hemoglobin structure and functionBlood transfusion and managementBiomedical and Chemical Research

The DOI matches its Crossref record; 48 of the 49 references it cites were found in a registry or an index.

The physiology of oxygen transport

Habler, Oliver P, Messmer, Konrad F.W·1997·Transfusion Science
DOI 10.1016/s0955-3886(97)00041-6
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Abstract

Adequate organ function requires adequate provision of cells with oxygen (O2). The driving force for O2-diffusion from ambient air to its site of consumption in cell mitochondria is the oxygen partial pressure (pO2) gradient along this pathway. After uptake in the lungs, O2 transport in blood is achieved (1) through binding to haemoglobin and (2) through physical dissolution in plasma. While the sum of O2 in these two transport states defines total oxygen content of blood, the delivery of O2 to different organs is determined by cardiac output and arterial O2 content, being the product of both parameters. In the case of anaemia, intravascular volume and cardiac compensatory mechanisms determine the degree of O2 content reduction allowable prior tissue hypoxia and lactacidosis occur. When intravascular volume is preserved (e.g. normovolemic dilutional anaemia), reductions in O2 content are tolerated to a much higher degree than in hypovolemic anaemia (e.g. haemorrhagic shock).

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Cites

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Citations

Cites

Research works printed but not linked: 10

  1. Braunitzer, 1963, Molekulare Struktur der Hämoglobine, Nova Acta Acad Caesar Leop Carol, 26, 471
  2. Messmer, 1969, The use of colloidal solutions for extreme haemodilution, Bibl Haematol, 33, 261
  3. Van Woerkens, 1992, Profound haemodilution: what is the critical level of haemodilution at which oxygen delivery-dependent oxygen consumption starts in an anesthetized human?, Anesth Analg, 75, 818
  4. Klövekorn, 1974, Akute präoperative Hämodilution: eine Möglichkeit zur autologen Bluttransfusion, Chirurg, 45, 452
  5. Messmer, 1972, Circulatory significance of haemodilution: rheological changes and limitations, Adv Microcirc, 4, 1
  6. Sunder-Plassmann, 1975, Acute normovolemic haemodilution, Bibl Haematol, 41, 44
  7. Brückner, 1990, Blood rheology and systematic oxygen transport, Clin Hemorheol, 10, 383
  8. Kleen, 1996, Effects of haemodilution on gastric regional perfusion and intramucosal pH, Am J Physiol, 271, H1849
  9. Oberhauser, 1996, Isovolämische Hämodilution (IHD) zur Einsparung von Fremdbluttransfusionen: Effektivität bei grossen gynäkologischen Eingriffen, Infusionsther Transfusionsmed, 23, 15
  10. Spahn, 1996, Haemodilution tolerance in patients with coronary artery disease, Anesth Analg, 82, 687

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Metadata

Authors
Habler, O. P., & Messmer, K. F. W.
Affiliations
  • Institut für Chirurgische Forschung (DE)
  • Ludwig-Maximilians-Universität München (DE)
Corresponding author
Habler, Oliver P
Venue
Transfusion Science
Publisher
Elsevier BV
Published
1997-09
Volume
18
Issue
3
Pages
425-435
ISSN
0955-3886 (ISSN-L)
DOI
10.1016/s0955-3886(97)00041-6
OpenAlex
W2085056517
Cited by
113
References
49
Citations by year
2026: 2 · 2025: 6 · 2024: 6 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 6 · 2019: 7 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 4 · 2013: 6 · 2012: 3
FWCI
0.12
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Transfusion Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
  • Health Sciences › Medicine › Hematology › Blood transfusion and management
  • Health Sciences › Medicine › Physiology (medical) › Biomedical and Chemical Research
Keywords
oxygen transport, oxygen partial pressure gradient, cardiac output, arterial oxygen content, tissue hypoxia, anemia, hemorrhagic shock, lactacidosis, oxygen delivery
MeSH terms
Anemia, Biological Transport, Cells, Hemoglobins, Humans, Lung, Oxygen, Oxygen Consumption, Pulmonary Alveoli

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