Catheter-type sensor for potentiometric monitoring of oxygen, pH and carbon dioxide
Abstract
The fabrication and analytical performance of a catheter-type electrode suitable for potentiometric monitoring of PO2, pH and PCO2 in flowing blood is described. The catheter electrode is based on impregnating a single segment of dual-lumen gas permeable silicone rubber tubing with the proton ionophore tridodecylamine to impart H+ permselectivity to both inner and outer walls of the tubing. One lumen is filled with an unbuffered bicarbonate solution and the other lumen is filled with a strong buffer. By inserting Ag/AgCl reference electrode wires in each lumen and a cobalt electrode in the buffered lumen, simultaneous potentiometric detection of PO2, pH and PCO2 is achieved. The response of cobalt electrode to PO2 arises from a steady-state mixed potential owing to slow oxidation of cobalt and simultaneous reduction of oxygen on the surface of the cobalt electrode. The response towards PCO2 is completely analogous to the response mechanism of a conventional Severinghaus PCO2 sensor (i.e., change in pH of the bicarbonate solution). Continuous measurements of PO2, pH and PCO2 during 4-5 h blood pump studies using the catheter electrodes correlate well with conventional bench-top blood gas analyzer (PO2: r2 = 0.992; pH: r2 = 0.940; PCO2: r2 = 0.993.
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NO releasing intravascular glucose, pH, and CO2 sensors using diazeniumdiolated NO donors demonstrated much improved electrochemical responses over corresponding control sensors.
“Similar to oxygen sensors, NO releasing intravascular glucose,271–275 pH,275,276 and CO2275,277 sensors using diazeniumdiolated NO donors have also been tested, demonstrating much improved electrochemical responses over the corresponding control sensors.”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [275]
Cites
Clinical Application of Blood Gases.
Cole, P. (1983) · Annals of Internal Medicine · doi:10.7326/0003-4819-99-2-289_4 · Cited by 164 · see citing works
Potentiometric gas sensing electrodes
Ross, J. W., Riseman, J. H., & Krueger, J. (1973) · Pure and Applied Chemistry · doi:10.1351/pac197336040473 · Cited by 162 · see citing works
Do optical sensors really measure pH?
Janata, J. (1987) · Analytical Chemistry · doi:10.1021/ac00136a019 · Cited by 130 · see citing works
Mixed Potential Response Mechanism of Cobalt Electrodes toward Inorganic Phosphate
Meruva, R. K., & Meyerhoff, M. E. (1996) · Analytical Chemistry · doi:10.1021/ac951086v · Cited by 120 · see citing works
Self-citationEspadas-Torre, C., & Meyerhoff, M. E. (1995) · Analytical Chemistry · doi:10.1021/ac00114a003 · Cited by 117 · see citing works
Self-citationOptical triple sensor for measuring pH, oxygen and carbon dioxide
Weigl, B. H., Holobar, A., Trettnak, W., et al. (1994) · Journal of Biotechnology · doi:10.1016/0168-1656(94)90175-9 · Cited by 95 · see citing works
MEASUREMENTS OF BLOOD GASES: Po2 AND Pco2*
Severinghaus, J. W. (1968) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1968.tb20345.x · Cited by 85 · see citing works
Performance of an in-vivo, continuous blood-gas monitor with disposable probe.
Miller, W. W., Yafuso, M., Yan, C. F., et al. (1987) · Clinical Chemistry · doi:10.1093/clinchem/33.9.1538 · Cited by 74 · see citing works
CLINICAL APPLICATION OF BLOOD GASES
Chinard, F. P. (1989) · CHEST Journal · doi:10.1016/s0012-3692(16)35100-5 · Cited by 62 · see citing works
Iglehart, M. L., Buck, R. P., & Pungor, E. (1988) · Analytical Chemistry · doi:10.1021/ac00155a003 · Cited by 56 · see citing works
Telting‐Diaz, M., Collison, M. E., & Meyerhoff, M. E. (1994) · Analytical Chemistry · doi:10.1021/ac00076a025 · Cited by 45 · see citing works
Self-citationPotentiometric combination ion-carbon dioxide sensors for in vitro and in vivo blood measurements
Collison, M. E., Aebli, G. V., Petty, J., et al. (1989) · Analytical Chemistry · doi:10.1021/ac00196a010 · Cited by 39 · see citing works
In vivo probes: Problems and perspectives
Thompson, M. E., & Vandenberg, E. T. (1986) · Clinical Biochemistry · doi:10.1016/s0009-9120(86)80037-6 · Cited by 21 · see citing works
Potentiometric oxygen sensor based on mixed potential of cobalt wire electrode
Meruva, R. K., & Meyerhoff, M. E. (1997) · Analytica Chimica Acta · doi:10.1016/s0003-2670(96)00570-3 · Cited by 20 · see citing works
Self-citationClinical Arterial Blood Gas Analysis
Lane, E. E., & Jf, W. (1987) · Cited by 18 · see citing works
Problems with the gas-calibrated PCO2 electrode
Bateman, N. T., Musch, T. I., Smith, C. A., et al. (1980) · Respiration Physiology · doi:10.1016/0034-5687(80)90054-7 · Cited by 17 · see citing works
Simplified procedure for forming polymer-based ion-selective electrodes
Fogt, E. J., Cahalan, P. T., Jevne, A. H., et al. (1985) · Analytical Chemistry · doi:10.1021/ac00283a044 · Cited by 16 · see citing works
Potentiometric oxygen sensing with copper films: Response mechanism and analytical implications
Meruva, R. K., & Meyerhoff, M. E. (1995) · Electroanalysis · doi:10.1002/elan.1140071105 · Cited by 16 · see citing works
Self-citationEffects of catalyst on the electrical properties of silicone rubber
Yokoyama, T., Kinjo, N., & Mukai, J. (1984) · Journal of Applied Polymer Science · doi:10.1002/app.1984.070290604 · Cited by 9 · see citing works
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Wo, Y., Brisbois, E. J., Bartlett, R. H., & Meyerhoff, M. E. (2016) · Biomaterials Science · doi:10.1039/c6bm00271d · Cited by 251 · see citing works
Self-citationRivera, K. R., Yokus, M. A., Erb, P. D., Pozdin, V. A., & Daniele, M. (2019) · The Analyst · doi:10.1039/c8an02201a · Cited by 57 · see citing works
- Authors
- Meruva, R. K., & Meyerhoff, M. E.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Meyerhoff, Mark E.
- ORCID
- Meyerhoff, Mark E.
- Venue
- Biosensors and Bioelectronics
- Publisher
- Elsevier BV
- Published
- 1998-02
- Volume
- 13
- Issue
- 2
- Pages
- 201-212
- ISSN
- 0956-5663 (ISSN-L)
- OpenAlex
- W2010718741
- Cited by
- 64
- References
- 19
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 1 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 6 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biosensors and Bioelectronics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01gm028882-20)
- National Institute of General Medical Sciences (GM 28882)
- Topics
- Physical Sciences › Chemical Engineering › Bioengineering › Analytical Chemistry and Sensors
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Keywords
- oxygen partial pressure, blood pH, partial pressure of CO2, cobalt electrodes, mixed potential, blood pump, blood gas analysis
- MeSH terms
- Animals, Blood Gas Analysis, Carbon Dioxide, Catheterization, Humans, Hydrogen-Ion Concentration, Oxygen, Biosensing Techniques
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