In vitro and in vivo mineralization of Nafion membrane used for implantable glucose sensors
Abstract
The effects of the biological environment on the perfluorosulfonated ionomer Nafion membrane were investigated. Nafion membranes thermally annealed at 120 degrees C and kept in culture medium or implanted subcutaneously in rats showed extensive cracking after 4 weeks. In membranes annealed at 150 degrees C, cracking was reduced, but not eliminated. Deposits of calcium phosphates in the membrane were identified. These deposits appeared to be responsible for the cracking of the membranes, but the precise mechanism was unclear. The permeability to glucose of Nafion membranes annealed at 120 degrees C increased at 1 week and then decreased during the 3 following weeks. However, the cracking, protein adhesion, and mineralization of the membranes made the results difficult to interpret. This study revealed that mineralization of Nafion occurs in the biological environment, resulting in cracking and changes in permeability. Modifications to prevent the mineralization of Nafion are necessary to make it suitable for use in the implantable glucose sensor.
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The breakdown of Nafion membranes was likely caused by mineralization.
“Later studies by Mercado and Moussy demonstrated that this breakdown was likely caused by mineralization of the membrane.135”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [135]
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References 24 · Cited by 73
- Authors
- Mercado, R. C., & Moussy, F.
- Affiliations
- UConn Health (US)
- Corresponding author
- Moussy, F.
- Venue
- Biosensors and Bioelectronics
- Publisher
- Elsevier BV
- Published
- 1998-02
- Volume
- 13
- Issue
- 2
- Pages
- 133-145
- ISSN
- 0956-5663 (ISSN-L)
- OpenAlex
- W2059849140
- Cited by
- 73
- References
- 24
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 4 · 2013: 3 · 2012: 5
- FWCI
- 6.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biosensors and Bioelectronics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Fuel Cells and Related Materials
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Physical Sciences › Chemical Engineering › Bioengineering › Analytical Chemistry and Sensors
- Keywords
- Nafion membrane, perfluorosulfonated ionomer, mineralization, calcium phosphate deposits, implantable glucose sensor, membrane cracking, annealing, glucose permeability, protein adhesion, subcutaneous implantation, biocompatibility
- MeSH terms
- Animals, Glucose, Male, Membranes, Artificial, Minerals, Biosensing Techniques, Rats, Sprague-Dawley, Rats
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