The Otx family
Abstract
Otx1 and Otx2, the murine homologs of the Drosophila orthodenticle gene, play a remarkable role in specification and regionalization of forebrain and midbrain. Recently, genetic approaches have indicated that OTD, OTX1 and OTX2 have retained reciprocal functional equivalence in evolution, whereas their regulatory control has been remarkably modified. This suggests that during the evolution of the vertebrate brain, regulatory changes modulating the transcriptional and translational control of pre-existing gene functions might have favored the establishment of new morphogenetic pathways.
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Otx1 is necessary for normal corticogenesis.
“Otx1, murine homolog of the Drosophila transcription factor orthodenticle, is necessary for normal corticogenesis (Simeone et al. 2002), and may represent another putative target for miR-103.”
From A microRNA array reveals extensive regulation of microRNAs during brain development (2003) · cites this paper as Simeone et al. 2002
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A microRNA array reveals extensive regulation of microRNAs during brain development
KRICHEVSKY, A. M., KING, K. S., DONAHUE, C. P., KHRAPKO, K., & KOSIK, K. S. (2003) · RNA · doi:10.1261/rna.5980303 · Cited by 1,040 · see citing works
- Authors
- Simeone, A., Puelles, E., & Acampora, D.
- Venue
- Current Opinion in Genetics & Development
- Publisher
- Elsevier BV
- Published
- 2002-08
- Volume
- 12
- Issue
- 4
- Pages
- 409-415
- ISSN
- 0959-437X
- Cited by
- 108
- References
- 0
- Language
- en
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