AMPA amd NMDA receptors: similarities and differences in their synaptic distribution
Abstract
Recent technical developments, including antigen-retrieval and electron microscopic immunogold methods, are making it possible to determine some of the basic principles governing the subcellular distribution of ionotropic glutamate receptors. Distinct AMPA and NMDA receptor subtypes are selectively targeted to functionally different synapses of a single cell, resulting in an input-selective fine-tuning and regulation of the postsynaptic responses. The amount, density and variability of AMPA receptors at a given glutamatergic synapse is governed by both pre- and postsynaptic factors, resulting in functionally distinct glutamatergic connections that display characteristic patterns of receptor expression.
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Live-cell imaging techniques like FRAP and single molecule tracking changed the view that glutamate receptors are restricted to synapses.
“Whereas reports based on static EM suggested that glutamate receptors are restricted to synapses (Nusser, 2000), live-cell imaging techniques like FRAP and single molecule tracking changed this view radically (Richards et al., 2004; Triller and Choquet, 2005).”
From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Nusser, 2000
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References 46 · Cited by 108
- Authors
- Nusser, Z.
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2000-06
- Volume
- 10
- Issue
- 3
- Pages
- 337-341
- ISSN
- 0959-4388 (ISSN-L)
- OpenAlex
- W2069124425
- Cited by
- 108
- References
- 46
- Citations by year
- 2026: 2 · 2025: 3 · 2023: 1 · 2022: 5 · 2021: 3 · 2020: 4 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 4 · 2014: 3 · 2013: 2 · 2012: 5
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- AMPA receptors, NMDA receptor, ionotropic glutamate receptors, subcellular localization, synaptic targeting, glutamatergic synapses, postsynaptic regulation, receptor density, synaptic plasticity
- MeSH terms
- Animals, Neurons, Synapses, Receptors, N-Methyl-D-Aspartate, Receptors, AMPA
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