Cited by 188Sarcoma Diagnosis and TreatmentBone Tumor Diagnosis and TreatmentsCardiac tumors and thrombi

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Osteosarcoma over the age of forty

Grimer, R.J, Cannon, S.R, Taminiau, A.M, Bielack, S, Kempf-Bielack, B, Windhager, R, Dominkus, M, Saeter, G, Bauer, H, Meller, I, Szendroi, M, Folleras, G, San-Julian, M, van der Eijken, J·2003·European Journal of Cancer

DOI 10.1016/s0959-8049(02)00478-1

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Abstract

The European Musculo Skeletal Oncology Society (EMSOS) has carried out a retrospective review of patients over the age of 40 years with osteosarcoma. 481 patients from 12 centres or multicentric groups were included. 42 patients had osteosarcoma arising in Paget's disease, median survival was 9 months. Patients with axial or metastatic tumours also did badly whilst 41 patients with radiation-induced osteosarcoma had a prognosis paralleling conventional osteosarcoma matched for patient age and site of the tumour. 238 patients had high grade non-metastatic osteosarcoma and had a survival of 46% at 5 years. Older patients had less chemotherapy and fared worse. Osteosarcoma in the elderly is a curable condition and warrants intensive treatment with chemotherapy and surgical resection.

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Authors: Grimer, R. J., Cannon, S. R., Taminiau, A. M., Bielack, S., Kempf-Bielack, B., Windhager, R., Dominkus, M., Saeter, G., Bauer, H., Meller, I., Szendroi, M., Folleras, G., San-Julian, M., & van der Eijken, J.
Affiliations: Royal Orthopaedic Hospital (GB)
Royal National Orthopaedic Hospital (GB)
Leiden University Medical Center (NL)
University Hospital Münster (DE)
University of Graz (AT)
University of Vienna (AT)
Karolinska University Hospital (SE)
Tel Aviv Sourasky Medical Center (IL)
Corresponding author: Grimer, R.J
ORCID: Grimer, R.J
Windhager, R
Venue: European Journal of Cancer
Publisher: Elsevier BV
Published: 2003-01
Volume: 39
Issue: 2
Pages: 157-163
ISSN: 0959-8049 (ISSN-L)
DOI: 10.1016/s0959-8049(02)00478-1
OpenAlex: W2052299135
Cited by: 188
References: 25
Citations by year: 2026: 2 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 8 · 2021: 13 · 2020: 10 · 2019: 11 · 2018: 10 · 2017: 7 · 2016: 9 · 2015: 11 · 2014: 13 · 2013: 7 · 2012: 6
FWCI: 2.73
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: European Journal of Cancer (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Sarcoma Diagnosis and Treatment
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone Tumor Diagnosis and Treatments
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac tumors and thrombi
Keywords: osteosarcoma, elderly patients, Paget's disease, radiation-induced osteosarcoma, metastatic osteosarcoma, survival, chemotherapy, surgical resection, prognosis
MeSH terms: Adult, Aged, Aged, 80 and over, Bone Neoplasms, Female, Humans, Male, Middle Aged, Neoplasm Metastasis, Neoplasms, Radiation-Induced, Osteitis Deformans, Prognosis, Retrospective Studies, Osteosarcoma, Survival Analysis, Age Distribution, Sex Distribution

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