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Cited by 2,199Sarcoma Diagnosis and TreatmentBone Tumor Diagnosis and TreatmentsGlobal Cancer Incidence and Screening

Osteosarcoma incidence and survival rates from 1973 to 2004: Data from the Surveillance, Epidemiology, and End Results Program

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Mirabello, Lisa, Troisi, Rebecca J., Savage, Sharon A.·2009·Cancer
DOI 10.1002/cncr.24121PMC PMC2813207
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Abstract

BACKGROUND: Osteosarcoma, which is the most common primary bone tumor, occurs most frequently in adolescents, but there is a second incidence peak among individuals aged >60 years. Most osteosarcoma epidemiology studies have been embedded in large analyses of all bone tumors or focused on cases occurring in adolescence. Detailed descriptions of osteosarcoma incidence and survival with direct comparisons among patients of all ages and ethnicities are not available. METHODS: Frequency, incidence, and survival rates for 3482 patients with osteosarcoma from the National Cancer Institute's population‐based Surveillance, Epidemiology, and End Results (SEER) Program between 1973 and 2004 were investigated by age (ages 0‐24 years, 25‐59 years, and 60 to ≥85 years), race, sex, pathology subtype, stage, and anatomic site. RESULTS: There were large differences in incidence and survival rates by age. There was a high percentage of osteosarcoma with Paget disease and osteosarcoma as a second or later cancer among the elderly. There was a high percentage of osteosarcoma among patients with Paget disease and osteosarcoma as a second or later cancer among the elderly. Tumor site differences among age groups were noted. Survival rates varied by anatomic site and disease stage and did not improve significantly from 1984 to 2004. CONCLUSIONS: This comprehensive, population‐based description of osteosarcoma, identified important differences in incidence, survival, pathologic subtype, and anatomic site among age groups, and quantified the impact of osteosarcoma in patients with Paget disease or as a second cancer on incidence and mortality rates. These findings may have implications in understanding osteosarcoma biology and epidemiology. Cancer 2009. © 2009 American Cancer Society.

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  • Osteosarcoma is the most common primary malignant tumour of bone.

    “Osteosarcoma is the most common primary malignant tumour of the bone.”

    From Osteosarcoma (2022) · cites this paper as [1]

  • Higher rates of osteosarcoma have been observed in African American children and young adults in the USA than in white individuals.

    “higher rates of osteosarcoma have been observed in African American children and young adults in the USA than in white individuals 1 .”

    From Osteosarcoma (2022) · cites this paper as [1]

  • Osteosarcoma incidence is bimodal, with peaks around 18 and 60 years of age.

    “Osteosarcoma incidence is bimodal, peaking at 18 and 60 years of age”

    From Osteosarcoma (2022) · cites this paper as [1]

  • Osteosarcoma incidence has a primary peak in adolescents and young adults and a second smaller peak in the seventh and eighth decades of life.

    “Osteosarcoma incidence has a bimodal age distribution with a primary peak in adolescents and young adults and a second, smaller peak in the seventh and eighth decade of life 1”

    From Osteosarcoma (2022) · cites this paper as [1]

  • In the USA, osteosarcoma accounts for less than 1% of all new cancer diagnoses, with about 1,000 new cases per year, half occurring in children and adolescents.

    “In the USA, osteosarcoma accounts for <1% of all new cancer diagnoses with ~1,000 new cases diagnosed per year, half of these cases occurring in children and adolescents 1 .”

    From Osteosarcoma (2022) · cites this paper as [1]

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2 of the 52 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

  1. [9]Dorfman HA Czerniak B Bone Tumors St. Louis Mosby 1997
  2. [36]Kramárová E Stiller CA The international classification of childhood cancer Int J Cancer 1996 68 759 65 8980180
  3. [49]Aegerter E Kirkpatrick JA Orthopedic disease 4 Philadelphia Saunders 1975

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Authors
Mirabello, L., Troisi, R. J., & Savage, S. A.
Affiliations
National Institutes of Health (US)
Corresponding author
Savage, Sharon A.
ORCID
Venue
Cancer
Publisher
Wiley
Published
2009-02-05
Volume
115
Issue
7
Pages
1531-1543
ISSN
  • 0008-543X (ISSN-L)
  • 1097-0142
DOI
10.1002/cncr.24121
PMC
PMC2813207
OpenAlex
W1988325237
Cited by
2,199
References
52
Citations by year
2026: 114 · 2025: 138 · 2024: 166 · 2023: 167 · 2022: 161 · 2021: 194 · 2020: 201 · 2019: 162 · 2018: 172 · 2017: 142 · 2016: 151 · 2015: 129 · 2014: 106 · 2013: 72 · 2012: 52
FWCI
33.68
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Cancer (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Cancer Institute (Z01CP010142)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
  • Health Sciences › Medicine › Rheumatology › Bone Tumor Diagnosis and Treatments
  • Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
Keywords
osteosarcoma, incidence, survival rate, age differences, Paget disease, secondary malignancies, elderly patients, disease stage, SEER, bone tumors, mortality trends
MeSH terms
Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Bone Neoplasms, Child, Child, Preschool, Ethnicity, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Osteosarcoma, Sex Factors, Survival Rate, SEER Program

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