10LBA Interim phase 2 results of study CO-1686-008: A phase 1/2 study of the irreversible, mutant selective, EGFR inhibitor rociletinib (CO-1686) in patients with advanced non small cell lung cancer
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Third-generation EGFR-TKIs are designed to specifically inhibit mutant EGFR (19del-EGFR, L858R-EGFR and/or T790M+EGFR), sparing the WT receptor.
“These agents are designed to specifically inhibit mutant EGFR (ie, 19del-EGFR, L858R-EGFR and/or T790M+EGFR), sparing the WT receptor.14–18”
From Mechanisms of resistance to EGFR-targeted drugs: lung cancer (2016) · cites this paper as [16]
The T790M mutation was observed in approximately 50% of cases in which biopsy was obtained at relapse following gefitinib or erlotinib treatment in patients with exon 19 deletion or L858R EGFR mutation.
“The presence of the T790M mutation was observed in approximately 50% of the cases in which biopsy was obtained at the time of relapse following gefitinib or erlotinib treatment in patients with the exon 19 deletion or the L858R EGFR mutation.”
From Mechanisms of resistance to EGFR-targeted drugs: lung cancer (2016) · cites this paper as [16]
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Mechanisms of resistance to EGFR-targeted drugs: lung cancer
Morgillo, F., Della Corte, C. M., Fasano, M., & Ciardiello, F. (2016) · ESMO Open · doi:10.1136/esmoopen-2016-000060 · Cited by 476 · see citing works
Treatment approaches for EGFR-inhibitor-resistant patients with non-small-cell lung cancer
Tan, C., Gilligan, D., & Pacey, S. (2015) · The Lancet Oncology · doi:10.1016/s1470-2045(15)00246-6 · Cited by 390 · see citing works
Califano, R., Morgillo, F., de Mello, R. A., & Mountzios, G. (2015) · PubMed Central · doi:10.3978/j.issn.2305-5839.2015.03.44 · Cited by 13 · see citing works
“For the modified H-score system, three staining intensity levels (scored from 0 to 3) are considered and a total score ranging from 0 to 300 is provided; cases are classified as negative (score 0-50), weakly positive [51-100], moderately positive [101-200], or strongly positive [201-300] (54).”
Background10-year long-term survival of a metastaticEGFR-mutated nonsmall cell lung cancer patient
Kempf, E., Planchard, D., Chevalier, T. L., & Soria, J. (2015) · European Respiratory Journal · doi:10.1183/09031936.00017315 · Cited by 12 · see citing works
Self-citation(E)-3-(dimethylamino)-1-(1H-indol-3-yl)prop-2-en-1-one
Zou, W.-S., Jiang, L., Jia, S., et al. (2018) · International Conference on Biological Sciences and Technology (BST) · doi:10.2991/bst-17.2018.38 · Cited by 1 · see citing works
“Such as N-(2-((2-(dimethylamino) ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amin o)phenyl)acrylamide(1),N-(3-((2-((4-(4-acetylpiperazin-1-yl)-2-methoxyphenyl)amin o)-5-(trifluoromethyl)pyrimidin-4-yl)oxy)phenyl)acrylamide(2)[6-7],N-(3-((5-chloro2-((2-methoxy-4-(4-methylpiperazin-1-yl)p…”
- Authors
- Soria, J., Sequist, L. V., Goldman, J. W., Wakelee, H. A., Gadgeel, S. M., Varga, A., Yu, H. A., Solomon, B. J., Ou, S. H., Papadimitrakopoulou, V., Oxnard, G. R., Horn, L., Dziadziuszko, R., Chao, B., Spira, A. I., Liu, S., Mekhail, T., Matheny, S., Litten, J., & Camidge, R. D.
- ORCID
- Venue
- European Journal of Cancer
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 50
- Pages
- 199
- ISSN
- 0959-8049 (ISSN-L)
- OpenAlex
- W2151554357
- Cited by
- 5
- References
- 0
- Citations by year
- 2018: 1 · 2016: 1 · 2015: 3
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Cancer (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
- Health Sciences › Medicine › Oncology › HER2/EGFR in Cancer Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Diagnosis and Treatment
- Keywords
- rociletinib, EGFR inhibitors, mutant EGFR, advanced non-small cell lung cancer, irreversible EGFR inhibitors
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