Cited by 161Cancer, Hypoxia, and MetabolismMetal-Catalyzed Oxygenation MechanismsHeterocyclic Compound Synthesis and Bioactivity

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2-Oxoglutarate analogue inhibitors of hif prolyl hydroxylase

Mole, David R, Schlemminger, Imre, McNeill, Luke A, Hewitson, Kirsty S, Pugh, Christopher W, Ratcliffe, Peter J, Schofield, Christopher J·2003·Bioorganic & Medicinal Chemistry Letters

DOI 10.1016/s0960-894x(03)00539-0

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Abstract

Hydroxylation of hypoxia-inducible factor, a nuclear transcription factor, is catalysed by iron and 2-oxoglutarate dependent hydroxylases. Various analogues of the 2-oxoglutarate cosubstrate were synthesised and shown to inhibit the activity of human hypoxia-inducible factor-1alpha prolyl hydroxylases in cell-free extracts.

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BindingDB Entry 50037819: A novel series of imidazo[1,2-a]pyridine derivatives as HIF-1alpha prolyl hydroxylase inhibitors.
BindingDB (2012) · UC San Diego · doi:10.7270/q2ms3tkt
BindingDB Entry 50021279: Synthesis of (aryloxyacetylamino)-isonicotinic/nicotinic acid analogues as potent hypoxia-inducible factor (HIF)-1alpha inhibitors.
BindingDB (2009) · UC San Diego · doi:10.7270/q2pr7vqt
BindingDB Entry 50037808: Design and synthesis of substituted pyridine derivatives as HIF-1alpha prolyl hydroxylase inhibitors.
BindingDB (2012) · UC San Diego · doi:10.7270/q21z4579
BindingDB Entry 5782: Dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1α prolyl hydroxylases-1, -2, and -3 with altered selectivity.
BindingDB (2013) · UC San Diego · doi:10.7270/q2b27sxp
BindingDB Entry 50030611: 2-Oxoglutarate analogue inhibitors of prolyl hydroxylase domain 2.
BindingDB (2010) · UC San Diego · doi:10.7270/q24f1qsq
BindingDB Entry 50030901: Using NMR solvent water relaxation to investigate metalloenzyme-ligand binding interactions.
BindingDB (2010) · UC San Diego · doi:10.7270/q2jd4wwn
BindingDB Entry 50037809: Structure-based design, synthesis, and SAR evaluation of a new series of 8-hydroxyquinolines as HIF-1alpha prolyl hydroxylase inhibitors.
BindingDB (2012) · UC San Diego · doi:10.7270/q2x63nrx
BindingDB Entry 50042786: Structural basis for inhibition of the fat mass and obesity associated protein (FTO).
BindingDB (2013) · UC San Diego · doi:10.7270/q21v5gbq
BindingDB Entry 50015984: Discovery of Novel Pyrazole-Based KDM5B Inhibitor
BindingDB (2023) · UC San Diego · doi:10.7270/q2gx4gjr
BindingDB Entry 50033517: HIF-1a inhibitors: synthesis and biological evaluation of novel moracin O and P analogues.
BindingDB (2012) · UC San Diego · doi:10.7270/q2wd40xf
BindingDB Entry 50026481: Discovery of novel hydroxy-thiazoles as HIF-alpha prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluation.
BindingDB (2010) · UC San Diego · doi:10.7270/q2xw4jm5
BindingDB Entry 50041898: Benzimidazole-2-pyrazole HIF Prolyl 4-Hydroxylase Inhibitors as Oral Erythropoietin Secretagogues.
BindingDB (2013) · UC San Diego · doi:10.7270/q28053vf
BindingDB Entry 50042359: Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors.
BindingDB (2013) · UC San Diego · doi:10.7270/q26q1zjv
BindingDB Entry 50031078: Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches.
BindingDB (2010) · UC San Diego · doi:10.7270/q2959hpq
BindingDB Entry 50018355: Targeting histone demethylase KDM5B for cancer treatment.
BindingDB (2024) · UC San Diego · doi:10.7270/q2nk3k7p
BindingDB Entry 5995: Selective Small Molecule Probes for the Hypoxia Inducible Factor (HIF) Prolyl Hydroxylases.
BindingDB (2014) · UC San Diego · doi:10.7270/q29z93hf

Authors: Mole, D. R., Schlemminger, I., McNeill, L. A., Hewitson, K. S., Pugh, C. W., Ratcliffe, P. J., & Schofield, C. J.
Affiliations: Centre for Human Genetics (GB)
University of Oxford (GB)
Corresponding author: Schofield, Christopher J
ORCID: Mole, David R
Pugh, Christopher W
Ratcliffe, Peter J
Schofield, Christopher J
Venue: Bioorganic & Medicinal Chemistry Letters
Publisher: Elsevier BV
Published: 2003-08
Volume: 13
Issue: 16
Pages: 2677-2680
ISSN: 0960-894X (ISSN-L)
DOI: 10.1016/s0960-894x(03)00539-0
OpenAlex: W2007522021
Cited by: 145
References: 28
Citations by year: 2025: 1 · 2024: 2 · 2023: 5 · 2022: 6 · 2021: 3 · 2020: 9 · 2019: 6 · 2018: 7 · 2017: 7 · 2016: 8 · 2015: 3 · 2014: 5 · 2013: 6 · 2012: 10
FWCI: 2.60
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Bioorganic & Medicinal Chemistry Letters (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust
Deutscher Akademischer Austauschdienst
Medical Research Council
Biotechnology and Biological Sciences Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Catalyzed Oxygenation Mechanisms
Physical Sciences › Chemistry › Organic Chemistry › Heterocyclic Compound Synthesis and Bioactivity
Keywords: prolyl hydroxylase inhibitors, hypoxia-inducible factor-1α, HIF-1α hydroxylation, enzyme inhibition, hypoxia
MeSH terms: Catalysis, Cell-Free System, Enzyme Inhibitors, Humans, Iron, Iron Chelating Agents, Isoenzymes, Ketoglutaric Acids, Procollagen-Proline Dioxygenase, Transcription Factors, Molecular Structure, Hypoxia-Inducible Factor 1, alpha Subunit

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2-Oxoglutarate analogue inhibitors of hif prolyl hydroxylase

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