Cited by 333Metabolism, Diabetes, and CancerGlycogen Storage Diseases and MyoclonusCardiac electrophysiology and arrhythmias

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A Novel Domain in AMP-Activated Protein Kinase Causes Glycogen Storage Bodies Similar to Those Seen in Hereditary Cardiac Arrhythmias

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Hudson, Emma R., Pan, David A., James, John, Lucocq, John M., Hawley, Simon A., Green, Kevin A., Baba, Otto, Terashima, Tatsuo, Hardie, D.Grahame·2003·Current Biology

DOI 10.1016/s0960-9822(03)00249-5

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Abstract

The AMP-activated protein kinase (AMPK) is an alphabetagamma heterotrimer that is activated by low cellular energy status and affects a switch away from energy-requiring processes and toward catabolism. While it is primarily regulated by AMP and ATP, high muscle glycogen has also been shown to repress its activation. Mutations in the gamma2 and gamma3 subunit isoforms lead to arrhythmias associated with abnormal glycogen storage in human heart and elevated glycogen in pig muscle, respectively. A putative glycogen binding domain (GBD) has now been identified in the beta subunits. Coexpression of truncated beta subunits lacking the GBD with alpha and gamma subunits yielded complexes that were active and normally regulated. However, coexpression of alpha and gamma with full-length beta caused accumulation of AMPK in large cytoplasmic inclusions that could be counterstained with anti-glycogen or anti-glycogen synthase antibodies. These inclusions were not affected by mutations that increased or abolished the kinase activity and were not observed by using truncated beta subunits lacking the GBD. Our results suggest that the GBD binds glycogen and can lead to abnormal glycogen-containing inclusions when the kinase is overexpressed. These may be related to the abnormal glycogen storage bodies seen in heart disease patients with gamma2 mutations.

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Authors: Hudson, E. R., Pan, D. A., James, J., Lucocq, J. M., Hawley, S. A., Green, K. A., Baba, O., Terashima, T., & Hardie, D. G.
Affiliations: University of Dundee (GB)
Tokyo Medical and Dental University (JP)
Corresponding author: Hardie, D.Grahame
ORCID: Hudson, Emma R.
Pan, David A.
Lucocq, John M.
Green, Kevin A.
Baba, Otto
Hardie, D.Grahame
Venue: Current Biology
Publisher: Elsevier BV
Published: 2003-05
Volume: 13
Issue: 10
Pages: 861-866
ISSN: 0960-9822 (ISSN-L)
DOI: 10.1016/s0960-9822(03)00249-5
OpenAlex: W2154405414
Cited by: 332
References: 28
Citations by year: 2026: 4 · 2025: 4 · 2024: 6 · 2023: 4 · 2022: 10 · 2021: 11 · 2020: 8 · 2019: 10 · 2018: 13 · 2017: 10 · 2016: 12 · 2015: 17 · 2014: 16 · 2013: 16 · 2012: 20
FWCI: 7.75
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3730 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Current Biology (publishedVersion)
PubMed (publishedVersion)
Discovery Research Portal (University of Dundee) (publishedVersion)
Funders: Tenovus
European Commission
Wellcome Trust (QLG1-CT-2001-01488)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Glycogen Storage Diseases and Myoclonus
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords: AMPK, glycogen synthase, protein inclusions, energy homeostasis, kinase overexpression
MeSH terms: Arrhythmias, Cardiac, Inclusion Bodies, Glycogen, Glycogen Synthase, Humans, Multienzyme Complexes, Precipitin Tests, Recombinant Fusion Proteins, Protein Serine-Threonine Kinases, Sequence Deletion, Protein Structure, Tertiary, Protein Subunits, Cell Line, Tumor, AMP-Activated Protein Kinases

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A Novel Domain in AMP-Activated Protein Kinase Causes Glycogen Storage Bodies Similar to Those Seen in Hereditary Cardiac Arrhythmias

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