Cellular senescence as a tumor-suppressor mechanism

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218 · cited 1×

Atmospheric carbon dioxide concentrations over the past 60 million years

Pearson, P. N., & Palmer, M. R. (2000) · Nature · doi:10.1038/35021000 · Cited by 1,771

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

Jacobs, J. J. L., Kieboom, K., Marino, S., DePinho, R. A., & van Lohuizen, M. (1999) · Nature · doi:10.1038/16476 · Cited by 1,580

Telomere states and cell fates

Blackburn, E. H. (2000) · Nature · doi:10.1038/35040500 · Cited by 1,395

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

Lin, A. W., Barradas, M., Stone, J. C., van Aelst, L., Serrano, M., & Lowe, S. W. (1998) · Genes & Development · doi:10.1101/gad.12.19.3008 · Cited by 945

Senescence of human fibroblasts induced by oncogenic Raf

Zhu, J., Woods, D., McMahon, M., & Bishop, J. M. (1998) · Genes & Development · doi:10.1101/gad.12.19.2997 · Cited by 826

Microarray analysis of replicative senescence

Shelton, D. N., Chang, E., Whittier, P. S., Choi, D., & Funk, W. D. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80420-5 · Cited by 764

Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence

Ohtani, N., Zebedee, Z., Huot, T. J. G., Stinson, J. A., Sugimoto, M., Ohashi, Y., Sharrocks, A. D., Peters, G., & Hara, E. (2001) · Nature · doi:10.1038/35059131 · Cited by 654

Replicative Senescence: Implications for in Vivo Aging and Tumor Suppression

Smith, J. R., & Pereira-Smith, O. M. (1996) · Science · doi:10.1126/science.273.5271.63 · Cited by 547

PML is induced by oncogenic ras and promotes premature senescence

Ferbeyre, G., de Stanchina, E., Querido, E., Baptiste, N., Prives, C., & Lowe, S. W. (2000) · Genes & Development · doi:10.1101/gad.14.16.2015 · Cited by 536

Regulation of a Senescence Checkpoint Response by the E2F1 Transcription Factor and p14 ARF Tumor Suppressor

Dimri, G. P., Itahana, K., Acosta, M., & Campisi, J. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.1.273-285.2000 · Cited by 401

Tumor suppressors and oncogenes in cellular senescence

Bringold, F., & Serrano, M. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00083-8 · Cited by 379

Untitled work

(2000) · PubMed · Cited by 371

Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19ARF) and is amplified in a subset of human breast cancers

Jacobs, J. J. L., Keblusek, P., Robanus-Maandag, E., Kristel, P., Lingbeek, M., Nederlof, P. M., van Welsem, T., van de Vijver, M. J., Koh, E. Y., Daley, G. Q., et al. (2000) · Nature Genetics · doi:10.1038/81583 · Cited by 368

Regulation of cellular senescence by p53

Itahana, K., Dimri, G., & Campisi, J. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.02228.x · Cited by 365

Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts.

McConnell, B. B., Starborg, M., Brookes, S., & Peters, G. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70137-x · Cited by 314

Genes involved in senescence and immortalization

Lundberg, A. S., Hahn, W. C., Gupta, P., & Weinberg, R. A. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00155-1 · Cited by 313

Uncoupling the Senescent Phenotype from Telomere Shortening in Hydrogen Peroxide-Treated Fibroblasts

Chen, Q. M., Prowse, K. R., Tu, V. C., Purdom, S., & Linskens, M. H. K. (2001) · Experimental Cell Research · doi:10.1006/excr.2001.5182 · Cited by 186

Radiation-Induced Senescence-like Growth Arrest Requires TP53 Function but not Telomere Shortening

Suzuki, K., Mori, I., Nakayama, Y., Miyakoda, M., Kodama, S., & Watanabe, M. (2001) · Radiation Research · doi:10.1667/0033-7587(2001)155[0248:rislga]2.0.co;2 · Cited by 177

Expression of catalytically active telomerase does not prevent premature senescence caused by overexpression of oncogenic Ha-Ras in normal human fibroblasts.

Wei, S., Wei, S., & Sedivy, J. M. (1999) · PubMed · Cited by 166

Stress-induced secretion of growth inhibitors: a novel tumor suppressor function of p53

Komarova, E. A., Diatchenko, L. B., Rokhlin, O. W., Hill, J. E., Wang, Z. J., Krivokrysenko, V. I., Feinstein, E., & Gudkov, A. V. (1998) · Oncogene · doi:10.1038/sj.onc.1202303 · Cited by 140

Mouse models in tumor suppression

Ghebranious, N., & Donehower, L. A. (1998) · Oncogene · doi:10.1038/sj.onc.1202573 · Cited by 103

Reducing mammary cancer risk through premature stem cell senescence

Boulanger, C. A., & Smith, G. H. (2001) · Oncogene · doi:10.1038/sj.onc.1204312 · Cited by 93

mdm2: a bridge over the two tumour suppressors, p53 and Rb

Yap, D., Hsieh, J.-K., Chan, F., & Lü, X. (1999) · Oncogene · doi:10.1038/sj.onc.1202954 · Cited by 93

ASPB10 insulin induction of increased mitogenic responses and phenotypic changes in human breast epithelial cells: Evidence for enhanced interactions with the insulin-like growth factor-I receptor

Milazzo, G., Sciacca, L., Papa, V., Goldfine, I. D., & Vigneri, R. (1997) · Molecular Carcinogenesis · doi:10.1002/(sici)1098-2744(199701)18:1 · Cited by 87

Creation of psoriatic plaques: the ultimate tumor suppressor pathway.: A new model for an ancient T‐cell‐mediated skin disease. Viewpoint

Nickoloff, B. J. (2001) · Journal of Cutaneous Pathology · doi:10.1034/j.1600-0560.2001.280201.x · Cited by 78 · cited 1×

DNA Methyltransferase Inhibition in Normal Human Fibroblasts Induces a p21-dependent Cell Cycle Withdrawal

Young, J. I., & Smith, J. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009470200 · Cited by 74

Two Posttranscriptional Pathways That Regulate p21Cip1/Waf1/Sdi1Are Identified by HPV16-E6 Interaction and Correlate with Life Span and Cellular Senescence

Burkhart, B., Alcorta, D. A., Chiao, C., Isaacs, J. S., & Barrett, J. C. (1999) · Experimental Cell Research · doi:10.1006/excr.1998.4345 · Cited by 36

Cellular senescence: when bad things happen to good cells

Campisi, J., & d'Adda di Fagagna, F. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2233 · Cited by 4,441

A DNA damage checkpoint response in telomere-initiated senescence

Fagagna, F. D. D., Reaper, P. M., Clay-Farrace, L., Fiegler, H., Carr, P., von Zglinicki, T., Saretzki, G., Carter, N. P., & Jackson, S. P. (2003) · Nature · doi:10.1038/nature02118 · Cited by 2,917

Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

Campisi, J. (2005) · Cell · doi:10.1016/j.cell.2005.02.003 · Cited by 2,379

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

Narita, M., Nuñez, S., Heard, E., Narita, M., Lin, A. W., Hearn, S. A., Spector, D. L., Hannon, G. J., & Lowe, S. W. (2003) · Cell · doi:10.1016/s0092-8674(03)00401-x · Cited by 2,278

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

Chen, Z., Trotman, L. C., Shaffer, D., Lin, H.-K., Dotan, Z. A., Niki, M., Koutcher, J. A., Scher, H. I., Ludwig, T., Gerald, W., et al. (2005) · Nature · doi:10.1038/nature03918 · Cited by 1,993

Untitled work

(2000) · PubMed · Cited by 371

Cellular senescence and tumor suppression

Adams, P. D. (2010)

Cellular senescence: putting the paradoxes in perspective

Campisi, J. (2011) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.10.005 · Cited by 368

Unraveling the nexus between cellular senescence and malignant transformation: a paradigm shift in cancer research

Song, X., Liu, X.-Y., Guo, Q., Xu, H., & Cao, L. (2024) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2024.0157 · Cited by 4

Une re-vue de la sénescence cellulaire

Bischof, O., Dejean, A., & Pineau, P. (2009) · médecine/sciences · doi:10.1051/medsci/2009252153 · Cited by 30