Cellular senescence: putting the paradoxes in perspective

Immunity, Inflammation, and Cancer

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Cellular senescence: when bad things happen to good cells

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Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

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Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

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Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

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BRAFE600-associated senescence-like cell cycle arrest of human naevi

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Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans

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Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

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Senescence of activated stellate cells limits liver fibrosis

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Senescence of Activated Stellate Cells Limits Liver Fibrosis

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Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

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Chemokine signaling via the CXCR2 receptor reinforces senescence

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Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging

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Senescence in premalignant tumours

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Inflammatory networks during cellular senescence: causes and consequences.

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Molecular inflammation: Underpinnings of aging and age-related diseases

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Senescence in tumours: evidence from mice and humans

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Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

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p16INK4a induces an age-dependent decline in islet regenerative potential

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The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

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Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

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Oncogenic BRAF Induces Senescence and Apoptosis through Pathways Mediated by the Secreted Protein IGFBP7

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Age‐related intrinsic changes in human bone‐marrow‐derived mesenchymal stem cells and their differentiation to osteoblasts

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Formation of MacroH2A-Containing Senescence-Associated Heterochromatin Foci and Senescence Driven by ASF1a and HIRA

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DNA damage response and cellular senescence in tissues of aging mice

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Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence

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Accumulation of senescent cells in Mitotic tissue of aging primates

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DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion

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Hallmarks of senescence in carcinogenesis and cancer therapy

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Senescent Human Fibroblasts Increase the Early Growth of Xenograft Tumors via Matrix Metalloproteinase Secretion

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A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen.

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Human cell senescence as a DNA damage response

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Two faces of p53: aging and tumor suppression

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The role of chondrocyte senescence in osteoarthritis

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Senescence in human intervertebral discs

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Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

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The p16<SUP>INK4a</SUP>-RB pathway : molecular link between cellular senescence and tumor suppression

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Cellular senescence and cancer treatment

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Cellular senescence in vivo: Its relevance in ageing and cardiovascular disease

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SASP reflects senescence

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Senescence and the healing rates of venous ulcers

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Cellular senescence in the pathogenesis of benign prostatic hyperplasia

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Stem Cells, Their Niches and the Systemic Environment: An Aging Network

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Caveolin-1 Regulates the Antagonistic Pleiotropic Properties of Cellular Senescence through a Novel Mdm2/p53-Mediated Pathway

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Senescence and functional failure in hematopoietic stem cells

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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

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Cellular senescence: a link between cancer and age-related degenerative disease?

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Nuclear morphology is a deep learning biomarker of cellular senescence

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Endoplasmic reticulum calcium release through ITPR2 channels leads to mitochondrial calcium accumulation and senescence

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Glucocorticoids suppress selected components of the senescence‐associated secretory phenotype

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B Cell Immunosenescence

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Oxidative stress, cellular senescence and ageing

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MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition

Kovatcheva, M., Liu, D. D., Dickson, M. A., Klein, M. E., O’Connor, R., Wilder, F. O., Socci, N. D., Tap, W. D., Schwartz, G. K., Singer, S., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.3364 · Cited by 142 · see citing works

The Conundrum of Genetic “Drivers” in Benign Conditions

Kato, S., Lippman, S. M., Flaherty, K. T., & Kurzrock, R. (2016) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djw036 · Cited by 147 · see citing works

Molecular links between cellular senescence, longevity and age-related diseases – a systems biology perspective

Tăcutu, R., Budovsky, A., Yanai, H., & Fraifeld, V. E. (2011) · Aging · doi:10.18632/aging.100413 · Cited by 143 · see citing works

Colorimetric Detection of Senescence-Associated β Galactosidase

Itahana, K., Itahana, Y., & Dimri, G. P. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-239-1_8 · Cited by 137 · see citing works

The functional role of reactive stroma in benign prostatic hyperplasia

Schauer, I. G., & Rowley, D. R. (2011) · Differentiation · doi:10.1016/j.diff.2011.05.007 · Cited by 135 · see citing works

MicroRNA-34a Induces Vascular Smooth Muscle Cells Senescence by SIRT1 Downregulation and Promotes the Expression of Age-Associated Pro-inflammatory Secretory Factors

Badi, I., Burba, I., Ruggeri, C., Zeni, F., Bertolotti, M., Scopece, A., Pompilio, G., & Raucci, A. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu180 · Cited by 134 · see citing works

Sex Hormones and Anticancer Immunity

Özdemir, B. C., & Dotto, G. P. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-0137 · Cited by 132 · see citing works

Cellular senescence in aging and osteoarthritis

Toh, W. S., Brittberg, M., Farr, J., Foldager, C. B., Gomoll, A. H., Hui, J. H. P., Richardson, J. B., Roberts, S., & Spector, M. (2016) · Acta Orthopaedica · doi:10.1080/17453674.2016.1235087 · Cited by 130 · see citing works

Vascular endothelial cells senescence is associated with NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation via reactive oxygen species (ROS)/thioredoxin-interacting protein (TXNIP) pathway

Yin, Y., Zhou, Z., Liu, W., Chang, Q., Sun, G., & Dai, Y. (2017) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2017.01.001 · Cited by 130 · see citing works

Thymic Involution Perturbs Negative Selection Leading to Autoreactive T Cells That Induce Chronic Inflammation

Coder, B., Wang, H., Ruan, L., & Su, D. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500082 · Cited by 128 · see citing works

Epithelial innate immunity mediates tubular cell senescence after kidney injury

Jin, H., Zhang, Y., Ding, Q. J., Wang, S., Rastogi, P., Dai, D., Lu, D., Purvis, M., Cao, C., Wang, A. Y., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.125490 · Cited by 128 · see citing works

Evidence of oxidative stress-induced senescence in mature, post-mature and pathological human placentas

Cindrova-Davies, T., Fogarty, N. M. E., Jones, C. J. P., Kingdom, J., & Burton, G. J. (2018) · Placenta · doi:10.1016/j.placenta.2018.06.307 · Cited by 127 · see citing works

Senescence-Associated Secretory Phenotype and Its Possible Role in Chronic Obstructive Pulmonary Disease

Kumar, M., Seeger, W., & Voswinckel, R. (2014) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2013-0382ps · Cited by 129 · see citing works

The Link Between Inflammaging and Degenerative Joint Diseases

Rezuş, E., Cardoneanu, A., Burlui, A., Luca, A., Codreanu, C., Tamba, B.-I., Stanciu, G. D., Dima, N., Badescu, C. M., & Rezuș, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030614 · Cited by 120 · see citing works

Of Flies, Mice, and Men: Evolutionarily Conserved Tissue Damage Responses and Aging

Neves, J., Demaria, M., Campisi, J., & Jasper, H. (2015) · Developmental Cell · doi:10.1016/j.devcel.2014.11.028 · Cited by 116 · see citing works

Systemic DNA damage responses in aging and diseases

Ribezzo, F., Shiloh, Y., & Schumacher, B. (2016) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.12.005 · Cited by 116 · see citing works

Chronic low‐grade inflammation in heart failure with preserved ejection fraction

Mesquita, T., Lin, Y., & Ibrahim, A. G.-E. (2021) · Aging Cell · doi:10.1111/acel.13453 · Cited by 117 · see citing works

Ataxia-telangiectasia (A-T): An emerging dimension of premature ageing

Shiloh, Y., & Lederman, H. M. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.05.002 · Cited by 113 · see citing works

From lymphopoiesis to plasma cells differentiation, the age-related modifications of B cell compartment are influenced by “inflamm-ageing”

Bulati, M., Caruso, C., & Colonna‐Romano, G. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.04.001 · Cited by 113 · see citing works

MicroRNA-34a: the bad guy in age-related vascular diseases

Raucci, A., Macrì, F., Castiglione, S., Badi, I., Vinci, M. C., & Zuccolo, E. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03979-4 · Cited by 114 · see citing works

miR-34a Inhibits Lung Fibrosis by Inducing Lung Fibroblast Senescence

Cui, H., Ge, J., Xie, N., Banerjee, S., Zhou, Y., Antony, V. B., Thannickal, V. J., & Liu, G. (2017) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2016-0163oc · Cited by 104 · see citing works

How “reversible” is telomeric aging?

Epel, E. (2012) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-12-0370 · Cited by 103 · see citing works

Transgelins, cytoskeletal proteins implicated in different aspects of cancer development

Dvořáková, M., Nenutil, R., & Bouchal, P. (2014) · Expert Review of Proteomics · doi:10.1586/14789450.2014.860358 · Cited by 104 · see citing works

Navitoclax (ABT263) reduces inflammation and promotes chondrogenic phenotype by clearing senescent osteoarthritic chondrocytes in osteoarthritis

Yang, H., Chen, C., Chen, H., Duan, X., Li, J., Zhou, Y., Zeng, W., & Yang, L. (2020) · Aging · doi:10.18632/aging.103177 · Cited by 105 · see citing works

Targeting aurora kinases limits tumour growth through DNA damage‐mediated senescence and blockade of NF‐κB impairs this drug‐induced senescence

Liu, Y., Hawkins, O. E., Su, Y., Vilgelm, A. E., Sobolik, T., Thu, Y. M., Kantrow, S. M., Splittgerber, R. C., Short, S. P., Amiri, K. I., et al. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201201378 · Cited by 100 · see citing works

Molecular pathways of senescence regulate placental structure and function

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MyD88 and its divergent toll in carcinogenesis

Salcedo, R., Cataisson, C., Hasan, U. A., Yuspa, S. H., & Trinchieri, G. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.03.008 · Cited by 95 · see citing works

ATRX is a regulator of therapy induced senescence in human cells

Kovatcheva, M., Liao, W., Klein, M. E., Robine, N., Geiger, H., Crago, A. M., Dickson, M. A., Tap, W. D., Singer, S., & Koff, A. (2017) · Nature Communications · doi:10.1038/s41467-017-00540-5 · Cited by 89 · see citing works

Early Vascular Ageing and Cellular Senescence in Chronic Kidney Disease

Dai, L., Qureshi, A. R., Witasp, A., Lindholm, B., & Stenvinkel, P. (2019) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2019.06.015 · Cited by 94 · see citing works

Aging and radiation: bad companions

Hernández, L., Terradas, M., Camps, J., Martı́n, M., Tusell, L., & Genescà, A. (2015) · Aging Cell · doi:10.1111/acel.12306 · Cited by 89 · see citing works

Amyloid β protein aggravates neuronal senescence and cognitive deficits in 5XFAD mouse model of Alzheimer’s disease.

Wei, Z., Chen, X.-C., Song, Y., Pan, X.-D., Dai, X.-M., Zhang, J., Cui, X.-L., Wu, X.-L., & Zhu, Y.-G. (2016) · Chinese Medical Journal · doi:10.4103/0366-6999.186646 · Cited by 89 · see citing works

Cellular Senescence in Intervertebral Disc Aging and Degeneration

Patil, P. R., Niedernhofer, L. J., Robbins, P. D., Lee, J., Sowa, G., & Vo, N. N. (2018) · Current Molecular Biology Reports · doi:10.1007/s40610-018-0108-8 · Cited by 88 · see citing works

Senescent B cells in aging and age-related diseases: Their role in the regulation of antibody responses

Frasca, D. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2017.07.002 · Cited by 82 · see citing works

Metabolic requirements of human pro-inflammatory B cells in aging and obesity

Frasca, D., Diaz, A., Romero, M., Thaller, S. R., & Blomberg, B. B. (2019) · PLoS ONE · doi:10.1371/journal.pone.0219545 · Cited by 86 · see citing works

Metformin and the ATM DNA damage response (DDR): Accelerating the onset of stress-induced senescence to boost protection against cancer

Menéndez, J. A., Cufí, S., Oliveras‐Ferraros, C., Martı́n-Castillo, B., Joven, J., Vellón, L., & Vázquez‐Martín, A. (2011) · Aging · doi:10.18632/aging.100407 · Cited by 84 · see citing works

Impairing the radioresistance of cancer cells by hydrogenated nanodiamonds.

Grall, R., Girard, H., Saad, L., Petit, T., Gesset, C., Combis-Schlumberger, M., Paget, V., Delic, J., Arnault, J., & Chevillard, S. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.05.034 · Cited by 71 · see citing works

Response of Human Prostate Cancer Cells and Tumors to Combining PARP Inhibition with Ionizing Radiation

Barreto-Andrade, J. C., Efimova, E. V., Mauceri, H. J., Beckett, M. A., Sutton, H. G., Darga, T. E., Vokes, E. E., Posner, M. C., Kron, S. J., & Weichselbaum, R. R. (2011) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-11-0061 · Cited by 81 · see citing works

Integrated Multi-Omics for Novel Aging Biomarkers and Antiaging Targets

Wu, L., Xie, X., Liang, T., Ma, J., Yang, L., Yang, J., Li, L., Xi, Y., Li, H., Zhang, J., et al. (2021) · Biomolecules · doi:10.3390/biom12010039 · Cited by 82 · see citing works

Age-related bone diseases: Role of inflammaging

Bi, J., Zhang, C., Lu, C., Mo, C., Zeng, J., Yao, M., Jia, B., Liu, Z., Yuan, P., & Xu, S. (2024) · Journal of Autoimmunity · doi:10.1016/j.jaut.2024.103169 · Cited by 83 · see citing works

Cellular Senescence in Lung Fibrosis

Hernández‐González, F., Faner, R., Rojas, M. M., Agustí, A. G. N., Serrano, M., & Sellarés, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22137012 · Cited by 78 · see citing works

Is cellular senescence an example of antagonistic pleiotropy?

Giaimo, S., & di Fagagna, F. D. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00807.x · Cited by 77 · see citing works

Characterization of DNA damage-induced cellular senescence by ionizing radiation in endothelial cells

Kim, K. S., Kim, J. E., Choi, K. J., Bae, S., & Kim, D. H. (2013) · International Journal of Radiation Biology · doi:10.3109/09553002.2014.859763 · Cited by 76 · see citing works

Unresolved inflammation: ‘immune tsunami’ or erosion of integrity in immune-privileged and immune-responsive tissues and acute and chronic inflammatory diseases or cancer

Khatami, M. (2011) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2011.592826 · Cited by 75 · see citing works

Aging, Cell Senescence, the Pathogenesis and Targeted Therapies of Osteoarthritis

Zhang, X.-X., He, S.-H., Liang, X., Li, W., Li, T.-F., & Li, D.-F. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.728100 · Cited by 80 · see citing works

Extracellular vesicles extracted from young donor serum attenuate inflammaging via partially rejuvenating aged T‐cell immunotolerance

Wang, W., Wang, L., Ruan, L., Oh, J., Dong, X., Zhuge, Q., & Su, D. (2018) · The FASEB Journal · doi:10.1096/fj.201800059r · Cited by 73 · see citing works

Systemic Levels of Interleukin-6 Correlate With Progression Rate of Geographic Atrophy Secondary to Age-Related Macular Degeneration

Nielsen, M. K., Subhi, Y., Molbech, C. R., Falk, M. K., Nissen, M. H., & Sørensen, T. L. (2019) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.18-25878 · Cited by 77 · see citing works

The power of proteomics to monitor senescence-associated secretory phenotypes and beyond: toward clinical applications

Basisty, N., Kale, A., Patel, S., Campisi, J., & Schilling, B. (2020) · Expert Review of Proteomics · doi:10.1080/14789450.2020.1766976 · Cited by 69 · see citing works

YAP1‐LATS2 feedback loop dictates senescent or malignant cell fate to maintain tissue homeostasis

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Sunitinib induces cellular senescence via p53/ D ec1 activation in renal cell carcinoma cells

Zhu, Y., Xu, L., Zhang, J., Hu, X., Liu, Y., Yin, H., Lv, T., Zhang, H., Liu, L., An, H., et al. (2013) · Cancer Science · doi:10.1111/cas.12176 · Cited by 73 · see citing works

Markers of cellular senescence.

Carnero, A. (2013) · Methods in Molecular Biology · doi:10.1007/978-1-62703-239-1_4 · Cited by 68 · see citing works

Senescence in Chronic Obstructive Pulmonary Disease

Tuder, R. M., Kern, J. A., & Miller, Y. E. (2012) · Proceedings of the American Thoracic Society · doi:10.1513/pats.201201-012ms · Cited by 69 · see citing works

Identification of microRNA-mRNA functional interactions in UVB-induced senescence of human diploid fibroblasts

Greussing, R., Hackl, M., Charoentong, P., Pauck, A., Monteforte, R., Cavinato, M. S., Hofer, E., Scheideler, M., Neuhaus, M., Mičutková, L., et al. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-224 · Cited by 71 · see citing works

Nutrition and ageing: knowledge, gaps and research priorities

Mathers, J. C. (2013) · Proceedings of The Nutrition Society · doi:10.1017/s0029665112003023 · Cited by 69 · see citing works

Wound duration and healing rates: Cause or effect?

Bosanquet, D. C., & Harding, K. G. (2014) · Wound Repair and Regeneration · doi:10.1111/wrr.12149 · Cited by 69 · see citing works

Extracellular vesicles from mesenchymal stromal cells: Therapeutic perspectives for targeting senescence in osteoarthritis

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A Possible New Mechanism in the Pathophysiology of Polycystic Ovary Syndrome (PCOS): The Discovery That Leukocyte Telomere Length Is Strongly Associated With PCOS

Li, Q., Du, J., Feng, R., Xu, Y., Wang, H., Sang, Q., Xing, Q., Zhao, X., Li, J., He, L., et al. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3685 · Cited by 66 · see citing works

All's well that ends well: why large species have short telomeres

Risques, R. A., & Promislow, D. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0448 · Cited by 66 · see citing works

Four faces of cellular senescence

Rodier, F., & Campisi, J. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201009094 · Cited by 2,016 · see citing works

Cellular Senescence and Tumor Promotion

Demaria, M. (2020) · Springer eBooks · doi:10.1007/978-3-319-57415-8_79 · Cited by 3 · see citing works

Tumour suppressors and cellular senescence

Chan, A. S. L., Mowla, S. N., Arora, P., & Jat, P. (2014) · IUBMB Life · doi:10.1002/iub.1335 · Cited by 17 · see citing works

Cellular senescence: a double‐edged sword in the fight against cancer

Ohtani, N., Takahashi, A., Mann, D. J., & Hara, E. (2012) · Experimental Dermatology · doi:10.1111/j.1600-0625.2012.01493.x · Cited by 57 · see citing works

Cellular senescence and tumor suppression

Adams, P. D. (2010)