Similarities between the Hedgehog and Wnt signaling pathways

Hedgehog signaling in animal development: paradigms and principlesPreprint

Ingham, P. W., & McMahon, A. P. (2001) · Genes & Development · doi:10.1101/gad.938601 · Cited by 3,025

Control of β-Catenin Phosphorylation/Degradation by a Dual-Kinase Mechanism

Liu, C., Li, Y., Semënov, M. V., Han, C., Baeg, G., Tan, Y., Zhang, Z., Lin, X., & He, X. (2002) · Cell · doi:10.1016/s0092-8674(02)00685-2 · Cited by 2,152

Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

Rubinfeld, B., Albert, I., Porfiri, E., Fiol, C. J., Munemitsu, S. M., & Polakis, P. G. (1996) · Science · doi:10.1126/science.272.5264.1023 · Cited by 1,420

The Hedgehog and Wnt signalling pathways in cancer

Taipale, J., & Beachy, P. A. (2001) · Nature · doi:10.1038/35077219 · Cited by 1,394

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK‐3β and β‐catenin and promotes GSK‐3β‐dependent phosphorylation of β‐catenin

Ikeda, S., Kishida, S., Yamamoto, H., Murai, H., Koyama, S., & Kikuchi, A. (1998) · The EMBO Journal · doi:10.1093/emboj/17.5.1371 · Cited by 1,248

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

Stone, D. M., Hynes, M., Armanini, M. P., Swanson, T. A., Gu, Q., Johnson, R. L., Scott, M. P., Pennica, D., Goddard, A. D., PHILLIPS, H. S., et al. (1996) · Nature · doi:10.1038/384129a0 · Cited by 1,104

Kremen proteins are Dickkopf receptors that regulate Wnt/β-catenin signalling

Mao, B., Wu, W., Davidson, G., Marhold, J., Li, M., Mechler, B. M., Delius, H., Hoppe, D., Stannek, P., Walter, C., et al. (2002) · Nature · doi:10.1038/nature756 · Cited by 1,038

The SCFbeta -TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in Ikappa Balpha and beta -catenin and stimulates Ikappa Balpha ubiquitination in vitroPreprint

Winston, J. T., Strack, P. R., Beer‐Romero, P., Chu, C. Y., Elledge, S. J., & Harper, J. W. (1999) · Genes & Development · doi:10.1101/gad.13.3.270 · Cited by 964

arrow encodes an LDL-receptor-related protein essential for Wingless signalling

Wehrli, M., Dougan, S. T., Caldwell, K. A., O’Keefe, L. V., Schwartz, S. L., Vaizel-Ohayon, D., Schejter, E. D., Tomlinson, A., & DiNardo, S. (2000) · Nature · doi:10.1038/35035110 · Cited by 871

Signaling cross-talk between TGF-β/BMP and other pathways

Guo, X., & Wang, X. (2008) · Cell Research · doi:10.1038/cr.2008.302 · Cited by 1,077

The Hedgehog Response Network: Sensors, Switches, and Routers

Lum, L., & Beachy, P. A. (2004) · Science · doi:10.1126/science.1098020 · Cited by 833

Communicating with Hedgehogs

Hooper, J. E., & Scott, M. P. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1622 · Cited by 806

The role of Notch in tumorigenesis: oncogene or tumour suppressor?

Radtke, F., & Raj, K. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1186 · Cited by 803

The casein kinase 1 family: participation in multiple cellular processes in eukaryotes

Knippschild, U., Gocht, A., Wolff, S., Huber, N., Löhler, J., & Stöter, M. (2005) · Cellular Signalling · doi:10.1016/j.cellsig.2004.12.011 · Cited by 601

TGF-β/BMP signaling and other molecular events: regulation of osteoblastogenesis and bone formation

Rahman, M. S., Akhtar, N., Jamil, H. M., Banik, R. S., & Asaduzzaman, S. M. (2015) · Bone Research · doi:10.1038/boneres.2015.5 · Cited by 596

Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes

Jope, R. S. (2003) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(03)00206-2 · Cited by 511

Hedgehog beyond medulloblastoma and basal cell carcinoma

Teglund, S., & Toftgård, R. (2010) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2010.01.003 · Cited by 437

Hedgehog Signaling Pathway is a New Therapeutic Target for Patients with Breast Cancer

Kubo, M., Nakamura, M., Tasaki, A., Yamanaka, N., Nakashima, H., Nomura, M., Kuroki, S., & Katano, M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0416 · Cited by 421

TCF-4 Mediates Cell Type-specific Regulation of Proglucagon Gene Expression by β-Catenin and Glycogen Synthase Kinase-3β

Yi, F., Brubaker, P. L., & Jin, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411487200 · Cited by 417

Glycogen synthase kinase 3: A key regulator of cellular fate

Forde, J. E., & Dale, T. C. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7045-7 · Cited by 385

Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates.Preprint

Chen, M.-H., Li, Y.-J., Kawakami, T., Xu, S.-M., & Chuang, P.-T. (2004) · Genes & Development · doi:10.1101/gad.1185804 · Cited by 407

Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface

Nusse, R. (2003) · Development · doi:10.1242/dev.00821 · Cited by 334

Wnt signaling pathways in biology and disease: mechanisms and therapeutic advances

Chen, X., Chu, Q., Shi, Q., Zeng, Y., Lu, J., & Li, J. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02142-w · Cited by 347

Medulloblastoma: signalling a change in treatment

Gilbertson, R. J. (2004) · The Lancet Oncology · doi:10.1016/s1470-2045(04)01424-x · Cited by 297

Hedgehog signaling plays a conserved role in inhibiting fat formation

Suh, J. M., Gao, X., McKay, J., McKay, R. M., Salo, Z., & Graff, J. M. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2005.11.012 · Cited by 279

Posttranslational Regulation of Drosophila PERIOD Protein by Protein Phosphatase 2A

Sathyanarayanan, S., Zheng, X., Xiao, R., & Sehgal, A. (2004) · Cell · doi:10.1016/s0092-8674(04)00128-x · Cited by 271

CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signalingPreprint

Price, M. A. (2006) · Genes & Development · doi:10.1101/gad.1394306 · Cited by 257

SAGA: a subgraph matching tool for biological graphs

Tian, Y., McEachin, R. C., Santos, C., States, D. J., & Patel, J. M. (2006) · Bioinformatics · doi:10.1093/bioinformatics/btl571 · Cited by 255

Wnt signalling and the control of cellular metabolism

Sethi, J. K., & Vidal‐Puig, A. (2010) · Biochemical Journal · doi:10.1042/bj20091866 · Cited by 254

A Hedgehog-Induced BTB Protein Modulates Hedgehog Signaling by Degrading Ci/Gli Transcription Factor

Zhang, Q. H., Zhang, L., Wang, B., Ou, C.-Y., Chien, C., & Jiang, J. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.05.004 · Cited by 230

Wnt and beyond Wnt: Multiple mechanisms control the transcriptional property of β-catenin

Jin, T., Fantus, I. G., & Sun, J. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2008.04.014 · Cited by 215

Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation

Liao, X., Siu, M. K. Y., Au, C. W. H., Wong, E. S. Y., Chan, H. Y., Ip, P. P. C., Ngan, H., & Cheung, A. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn230 · Cited by 201

Mechanism and evolution of cytosolic Hedgehog signal transduction

Wilson, C. W., & Chuang, P. (2010) · Development · doi:10.1242/dev.045021 · Cited by 208

A molecular fingerprint for medulloblastoma.

Lee, Y., Miller, H. L., Jensen, P., Hernán, R., Connelly, M., Wetmore, C., Zindy, F., Roussel, M. F., Curran, T., Gilbertson, R. J., et al. (2003) · PubMed · Cited by 192

A Conserved Docking Motif for CK1 Binding Controls the Nuclear Localization of NFAT1

Okamura, H., García‐Rodríguez, C., Martinson, H. M., Qin, J., Virshup, D. M., & Rao, A. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.10.4184-4195.2004 · Cited by 195

Hedgehog-Regulated Costal2-Kinase Complexes Control Phosphorylation and Proteolytic Processing of Cubitus Interruptus

Zhang, W., Zhao, Y., Tong, C., Wang, G., Wang, B., Jia, J., & Jiang, J. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.01.001 · Cited by 186

Smad7-Induced β-Catenin Degradation Alters Epidermal Appendage Development

Han, G., Li, A. G., Liang, Y.-Y., Owens, P., He, W., Lu, S., Yoshimatsu, Y., Wang, D., ten Dijke, P., Lin, X., et al. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.06.014 · Cited by 163

Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction

Apionishev, S., Katanayeva, N., Marks, S. A., Kalderon, D., & Tomlinson, A. (2004) · Nature Cell Biology · doi:10.1038/ncb1210 · Cited by 162

Behavioural manipulation in a grasshopper harbouring hairworm: a proteomics approach

Biron, D. G., Marché, L., Ponton, F., Loxdale, H. D., Galéotti, N., RENAULT, L., Joly, C., & Frédéric Thomas, A. (2005) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2005.3213 · Cited by 155

Inactive Wnt/β‐catenin pathway in conventional high‐grade osteosarcoma

Cai, Y., Mohseny, A. B., Karperien, M., Hogendoorn, P. C. W., Zhou, G., & Cleton-Jansen, A. (2009) · The Journal of Pathology · doi:10.1002/path.2628 · Cited by 158

Embryonic origins of mammalian hematopoiesis

Baron, M. H. (2003) · Experimental Hematology · doi:10.1016/j.exphem.2003.08.019 · Cited by 153

Wnt Signaling Stimulates Transcriptional Outcome of the Hedgehog Pathway by Stabilizing GLI1 mRNA

Noubissi, F. K., Goswami, S., Sanek, N. A., Kawakami, K., Minamoto, T., Moser, A. R., Grinblat, Y., & Spiegelman, V. S. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1500 · Cited by 135

Casein kinase 1α: biological mechanisms and theranostic potential

Jiang, S., Zhang, M., Sun, J., & Yang, X. (2018) · Cell Communication and Signaling · doi:10.1186/s12964-018-0236-z · Cited by 130

The role of nutraceuticals in the regulation of Wnt and Hedgehog signaling in cancer

Sarkar, F. H., Li, Y., Wang, Z. P., & Kong, D. (2010) · Cancer and Metastasis Reviews · doi:10.1007/s10555-010-9233-4 · Cited by 127

Basal Cell Carcinoma and Its Development

Mancuso, M., Pazzaglia, S., Tanori, M., Hahn, H., Merola, P., Rebessi, S., Atkinson, M. J., Majo, V. D., Covelli, V., & Saran, A. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2460 · Cited by 125

The Hedgehog Signalling Pathway in the Gastrointestinal Tract: Implications for Development, Homeostasis, and Disease

Lees, C. W., Howie, S., Sartor, R. B., & Satsangi, J. J. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.05.010 · Cited by 120

The Role of the Casein Kinase 1 (CK1) Family in Different Signaling Pathways Linked to Cancer Development

Knippschild, U., Wolff, S., Giamas, G., Brockschmidt, C., Wittau, M., Würl, P., Eismann, T., & Stöter, M. (2005) · Oncology Research and Treatment · doi:10.1159/000087137 · Cited by 114

Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation

Ambegaokar, S. S., & Jackson, G. R. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr432 · Cited by 113

Hedgehog–Gli signaling in brain tumors: stem cells and paradevelopmental programs in cancer

Altaba, A. R. I. (2003) · Cancer Letters · doi:10.1016/s0304-3835(03)00451-8 · Cited by 107

Sonic hedgehog signaling regulates Gli3 processing, mesenchymal proliferation, and differentiation during mouse lung organogenesis

Li, Y., Zhang, H., Choi, S. C., Litingtung, Y., & Chiang, C. C. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.03.009 · Cited by 108

Sonic hedgehog induces transcription-independent cytoskeletal rearrangement and migration regulated by arachidonate metabolites

Bijlsma, M. F., Borensztajn, K., Roelink, H., Peppelenbosch, M. P., & Spek, C. A. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.08.011 · Cited by 105

The Hedgehog signaling pathway plays an essential role in maintaining the CD44+CD24-/low subpopulation and the side population of breast cancer cells.

Tanaka, H., Nakamura, M., Kameda, C., Kubo, M., Sato, N., Kuroki, S., Tanaka, M., & Katano, M. (2009) · PubMed · Cited by 100

Hedgehog signaling pathway as a therapeutic target in various types of cancer

Onishi, H., & Katano, M. (2011) · Cancer Science · doi:10.1111/j.1349-7006.2011.02010.x · Cited by 99

Targeting the crosstalks of Wnt pathway with Hedgehog and Notch for cancer therapy

Chatterjee, S., & Sil, P. C. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.02.027 · Cited by 91

Segmenting the fly embryo: logical analysis of the role of the Segment Polarity cross-regulatory module

Sánchez, L., Chaouiya, C., & Thieffry, D. (2008) · The International Journal of Developmental Biology · doi:10.1387/ijdb.072439ls · Cited by 94

TCF7L2 genetic defect and type 2 diabetes

Cauchi, S., & Froguel, P. (2008) · Current Diabetes Reports · doi:10.1007/s11892-008-0026-x · Cited by 91

Failure of a medulloblastoma-derived mutant of SUFU to suppress WNT signaling

Taylor, M. D., Zhang, X., Liu, L., Hui, C., Mainprize, T. G., Scherer, S. W., Wainwright, B. J., Hogg, D., & Rutka, J. T. (2004) · Oncogene · doi:10.1038/sj.onc.1207605 · Cited by 88

Pharmacological Activation of mGlu4 Metabotropic Glutamate Receptors Inhibits the Growth of Medulloblastomas

Iacovelli, L., Arcella, A., Battaglia, G., Pazzaglia, S., Aronica, E., Spinsanti, P., Caruso, A., Smaele, E. D., Saran, A., Gulino, A., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2285-06.2006 · Cited by 78

Structural insight into small molecule action on Frizzleds

Kozielewicz, P., Turku, A., Bowin, C.-F., Petersen, J., Valnohová, J., Cañizal, M. C. A., Ono, Y., Inoue, A., Hoffmann, C., & Schulte, G. (2020) · Nature Communications · doi:10.1038/s41467-019-14149-3 · Cited by 78

Two Sides of the Same Coin: Wnt Signaling in Neurodegeneration and Neuro-Oncology

Caricasole, A., Bakker, A. C., Copani, A., Nicoletti, F., Gaviraghi, G., & Terstappen, G. C. (2005) · Bioscience Reports · doi:10.1007/s10540-005-2893-6 · Cited by 76

Targeting the Hedgehog signaling pathway for cancer therapy

Li, Y., Maitah, M. Y., Ahmad, A., Kong, D., Bao, B., & Sarkar, F. H. (2012) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2011.617367 · Cited by 75

Sending mixed signals: Cilia-dependent signaling during development and disease

Elliott, K. H., & Brugmann, S. A. (2018) · Developmental Biology · doi:10.1016/j.ydbio.2018.03.007 · Cited by 74

Next Stop, the Twilight Zone: Hedgehog Network Regulation of Mammary Gland Development

Lewis, M. T., & Veltmaat, J. M. (2004) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/b:jomg.0000037160.24731.35 · Cited by 71

SPOP suppresses tumorigenesis by regulating Hedgehog/Gli2 signaling pathway in gastric cancer

Zeng, C., Wang, Y., Lu, Q., Chen, J., Zhang, J., Liu, T., Lv, N., & Luo, S. (2014) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/preaccept-1585232004128170 · Cited by 71

Hedgehog Signal Transduction: Signal Integration and Cross Talk in Development and Cancer

Galdo, N. A. R., Lu, K., & Emerson, C. P. (2006) · Cell Cycle · doi:10.4161/cc.5.15.3130 · Cited by 70

Lipid Modification of Secreted Signaling Proteins

Miura, G. I., & Treisman, J. E. (2006) · Cell Cycle · doi:10.4161/cc.5.11.2804 · Cited by 66

mTORC1-Mediated Inhibition of 4EBP1 Is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma

Wu, C., Hou, S., Orr, B. A., Kuo, B., Youn, Y. H., Ong, T., Roth, F., Eberhart, C. G., Robinson, G. W., Solecki, D. J., et al. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.10.011 · Cited by 59

Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells

Stöter, M., Bamberger, A., Aslan, B., Kurth, M., Speidel, D., Löning, T., Frank, H., Kaufmann, P., Löhler, J., Henne‐Bruns, D., et al. (2005) · Oncogene · doi:10.1038/sj.onc.1208941 · Cited by 61

Functional Studies of Shaggy/Glycogen Synthase Kinase 3 Phosphorylation Sites in Drosophila melanogaster

Papadopoulou, D., Bianchi, M. W., & Bourouis, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.11.4909-4919.2004 · Cited by 60

Aberrant activation of hedgehog signaling pathway contributes to endometrial carcinogenesis through β-catenin

Liao, X., Siu, M. K. Y., Au, C. W., Chan, Q. K. Y., Chan, H. Y., Wong, E. S., Ip, P. P. C., Ngan, H., & Cheung, A. (2009) · Modern Pathology · doi:10.1038/modpathol.2009.45 · Cited by 58

Structural Architecture and Functional Evolution of Wnts

Bazán, J. F., Janda, C. Y., & García, K. C. (2012) · Developmental Cell · doi:10.1016/j.devcel.2012.07.011 · Cited by 56

Unexpected Hedgehog–Wnt interactions in epithelial differentiation

Watt, F. M. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.10.008 · Cited by 56

The role of Parafibromin/Hyrax as a nuclear Gli/Ci-interacting protein in Hedgehog target gene control

Mosimann, C., Hausmann, G., & Basler, K. (2009) · Mechanisms of Development · doi:10.1016/j.mod.2009.02.002 · Cited by 55

Crossing the line between activation and repression

Ma, J. (2004) · Trends in Genetics · doi:10.1016/j.tig.2004.11.004 · Cited by 55

SOX9 inhibits β-TrCP-mediated protein degradation to promote nuclear GLI1 expression and cancer stem cell properties

Deng, W., Vanderbilt, D. B., Lin, C., Martin, K. H., Brundage, K. M., & Ruppert, J. M. (2015) · Journal of Cell Science · doi:10.1242/jcs.162164 · Cited by 53

The Hedgehog pathway is a possible therapeutic target for patients with estrogen receptor-negative breast cancer.

Kameda, C., Tanaka, H., Yamasaki, A., Nakamura, M., Koga, K., Sato, N., Kubo, M., Kuroki, S., Tanaka, M., & Katano, M. (2009) · PubMed · Cited by 53

Antagonism between Hedgehog and Wnt signaling pathways regulates tumorigenicity (Review)

Ding, M., & Wang, X. (2017) · Oncology Letters · doi:10.3892/ol.2017.7030 · Cited by 55

The Mammalian Family of Katanin Microtubule-Severing Enzymes

Lynn, N. A., Martinez, E. M., Nguyen, H. T., & Torres, J. Z. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.692040 · Cited by 52

The sonic hedgehog-GLI1 signaling pathway in brain tumor development

Shahi, M. H., REY, J. A., & Castresana, J. S. (2012) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2012.720975 · Cited by 49

Wnt, Hedgehog and Junctional Armadillo/β-Catenin Establish Planar Polarity in the Drosophila Embryo

Colosimo, P. F., & Tolwinski, N. S. (2006) · PLoS ONE · doi:10.1371/journal.pone.0000009 · Cited by 45

Norcantharidin, Derivative of Cantharidin, for Cancer Stem Cells

Hsieh, C.-H., Chao, K. S. C., Liao, H., & Chen, Y.-J. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/838651 · Cited by 44

Roles of WNT, NOTCH, and Hedgehog signaling in the differentiation and function of innate and innate-like lymphocytes

Kling, J. C., & Blumenthal, A. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.1mr0616-272r · Cited by 36

Pyrvinium pamoate attenuates non-alcoholic steatohepatitis: Insight on hedgehog/Gli and Wnt/β-catenin signaling crosstalk

El-Derany, M. O., & El‐Demerdash, E. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.113942 · Cited by 36

A new role for an old kinase: CK2 and the circadian clock

Blau, J. (2003) · Nature Neuroscience · doi:10.1038/nn0303-208 · Cited by 36

Anabolic Agents and the Bone Morphogenetic Protein Pathway

Garrett, I. R. (2007) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(06)78004-8 · Cited by 35

Longitudinal axon guidance

Stoeckli, E. T. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.01.008 · Cited by 34

Genome-wide identification of phospho-regulators of Wnt signaling inDrosophila

Swarup, S., Pradhan‐Sundd, T., & Verheyen, E. M. (2015) · Development · doi:10.1242/dev.116715 · Cited by 33

Loss of Mpzl3 Function Causes Various Skin Abnormalities and Greatly Reduced Adipose Depots

Leiva, A. G., Chen, A. L., Devarajan, P., Chen, Z., Damanpour, S., Hall, J. A., Bianco, A. C., Li, J., Badiavas, E. V., Zaias, J., et al. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.94 · Cited by 31

Enhanced nuclear factor-kappa B-associated Wnt-1 expression in hepatitis B- and C-related hepatocarcinogenesis: identification by functional proteomics

Lee, T.-H., Tai, D., Cheng, C.-J., Sun, C.-S., Lin, C., Sheu, M.-J., Lee, W.-P., Peng, C., Wang, A. H. ‐., & Tsai, S. (2005) · Journal of Biomedical Science · doi:10.1007/s11373-005-9030-1 · Cited by 31

Lithium and an EPAC-specific inhibitor ESI-09 synergistically suppress pancreatic cancer cell proliferation and survival

Wang, X., Luo, C., Cheng, X., & Lü, M. (2017) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmx045 · Cited by 33

Hedgehog Signaling: Costal-2 Bridges the Transduction Gap

Kalderon, D. (2004) · Current Biology · doi:10.1016/j.cub.2003.12.047 · Cited by 31

Anti-apoptotic role of the sonic hedgehog signaling pathway in the proliferation of ameloblastoma

KANDA, S., Mitsuyasu, T., Nakao, Y., Kawano, S., GOTO, Y., Matsubara, R., & Nakamura, S. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.2010 · Cited by 30

Targeting androgen-independent pathways: new chances for patients with prostate cancer?

Cattrini, C., Zanardi, E., Vallome, G., Cavo, A., Cerbone, L., Meglio, A. D., Fabbroni, C., Latocca, M. M., Rizzo, F., Messina, C. G. M., et al. (2017) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2017.08.009 · Cited by 30

Secreted cell signaling molecules in axon guidance

Yoshikawa, S., & Thomas, J. B. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.01.005 · Cited by 28

Regulation of FGF-2, FGF-18 and Transcription Factor Activity by Perlecan in the Maturational Development of Transitional Rudiment and Growth Plate Cartilages and in the Maintenance of Permanent Cartilage Homeostasis

Hayes, A. J., Whitelock, J. M., & Melrose, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23041934 · Cited by 27

Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination

Li, T., Fan, J., Blanco‐Sánchez, B., Γιαγτζόγλου, Ν., Lin, G., Yamamoto, S., Jaiswal, M., Chen, K., Zhang, J., Wei, W., et al. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006054 · Cited by 25

Conditional cell reprogramming involves non-canonical β-catenin activation and mTOR-mediated inactivation of Akt

Suprynowicz, F. A., Kamonjoh, C. M., Krawczyk, E., Agarwal, S., Wellstein, A., Agboke, F. A., Choudhury, S., Liu, X., & Schlegel, R. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180897 · Cited by 22

Mutual Zonated Interactions of Wnt and Hh Signaling Are Orchestrating the Metabolism of the Adult Liver in Mice and Human

Kolbe, E., Aleithe, S., Rennert, C., Spormann, L., Ott, F., Meierhofer, D., Gajowski, R., Stöpel, C., Hoehme, S., Kücken, M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.104 · Cited by 22

MODELLING VASCULAR MORPHOGENESIS: CURRENT VIEWS ON BLOOD VESSELS DEVELOPMENT

Herrero, M. A., Köhn‐Luque, A., & Pérez-Pomares, J. M. (2009) · Mathematical Models and Methods in Applied Sciences · doi:10.1142/s021820250900384x · Cited by 20

Structure, function and disease relevance of Wnt inhibitory factor 1, a secreted protein controlling the Wnt and hedgehog pathways

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Elevated β-arrestin1 expression correlated with risk stratification in acute lymphoblastic leukemia

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Targeting glioma stem cells via the Hedgehog signaling pathway

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Signaling Pathways in Cancer

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The Hedgehog signalling pathways in human pathology

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Important concepts of mechanical regulation of bone formation and growth

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GLI2 but not GLI1/GLI3 plays a central role in the induction of malignant phenotype of gallbladder cancer

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Summary

Nusse, R. (2014)

CK1 in Developmental Signaling

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Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface

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Genome-wide identification of phospho-regulators of Wnt signaling inDrosophila

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