The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Similarities between the Hedgehog and Wnt signaling pathways
Abstract
Hedgehog and Wnt proteins are signaling molecules that direct many aspects of metazoan development through signal transduction pathways that are just beginning to be understood. Recently, the common use of glycogen synthase kinase 3 and casein kinase 1 has been added to a growing list of straightforward similarities between Hedgehog and Wnt signaling pathways. These kinases silence both pathways by labeling a key transcription factor (Cubitus interruptus) or co-activator (beta-catenin) for proteolysis, and it is possible that reversal of these phosphorylation events is, in each case, central to pathway activation. This review compares the two pathways to explore whether our more extensive knowledge of Wnt pathways can be of predictive value for investigating Hedgehog signaling.
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“there is much cross-talk with the Wnt pathway through GSK-3β and casein kinase I (115–118)”
From Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation (2011) · cites this paper as [118]
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1 retracted
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The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
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arrow encodes an LDL-receptor-related protein essential for Wingless signalling
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The Hedgehog Response Network: Sensors, Switches, and Routers
Lum, L., & Beachy, P. A. (2004) · Science · doi:10.1126/science.1098020 · Cited by 833
Hooper, J. E., & Scott, M. P. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1622 · Cited by 806
The role of Notch in tumorigenesis: oncogene or tumour suppressor?
Radtke, F., & Raj, K. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1186 · Cited by 803
The casein kinase 1 family: participation in multiple cellular processes in eukaryotes
Knippschild, U., Gocht, A., Wolff, S., Huber, N., Löhler, J., & Stöter, M. (2005) · Cellular Signalling · doi:10.1016/j.cellsig.2004.12.011 · Cited by 601
Metadata
- Authors
- Kalderon, D.
- Affiliations
- Columbia University (US)
- Corresponding author
- Kalderon, Daniel
- ORCID
- Kalderon, Daniel
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2002-11
- Volume
- 12
- Issue
- 11
- Pages
- 523-531
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W2038585541
- Cited by
- 141
- References
- 74
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 7 · 2016: 2 · 2015: 4 · 2014: 5 · 2013: 3 · 2012: 4
- FWCI
- 1.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Keywords
- Hedgehog signaling, Wnt signaling, glycogen synthase kinase-3, casein kinase 1, Cubitus interruptus, β-catenin, protein phosphorylation, proteolysis, transcriptional coactivator, signal transduction, developmental signaling
- MeSH terms
- Animals, Cytoskeletal Proteins, Drosophila, Proto-Oncogene Proteins, Signal Transduction, Trans-Activators, Drosophila Proteins, Zebrafish Proteins, Wnt Proteins, beta Catenin, Hedgehog Proteins
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