Clinical aspects and pathogenesis of Candida infection

Weig, M

doi:10.1016/s0966-842x(98)01407-3

Cited by 58Antifungal resistance and susceptibilityFungal Infections and StudiesYeasts and Rust Fungi Studies

Clinical aspects and pathogenesis of Candida infection

Weig, M·1998·Trends in Microbiology

DOI 10.1016/s0966-842x(98)01407-3

Open this paper in CoChat — free account

Integrity signals

Registry

Crossref · 10.1016/s0966-842x(98)01407-3

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Alterations in host immune response or microbiota or environment can stimulate the growth of C. albicans, causing thrush, vaginal yeast infections, diaper rash, and serious infections in immunocompromised individuals.
“Unfortunately, alterations in the host immune response or its microbiota or changes in the environment can stimulate the growth of C. albicans, a phenomenon that can cause thrush, vaginal yeast infections, diaper rash, and even more serious infections especially in immunocompromised individuals [82].”
From Antimicrobial Properties of Antidepressants and Antipsychotics—Possibilities and Implications (2021) · cites this paper as [82]
Candida infections are especially serious in immunocompromised individuals and in healthy people with implanted medical devices.
“Candida infections are especially serious in immunocompromised individuals (such as those with AIDS or those undergoing anticancer or immunosuppression therapies) and healthy people with implanted medical devices (96, 201).”
From Candida albicans Biofilms and Human Disease (2015) · cites this paper as [201]

Still being checked.

Sorted by citations

Candida albicans Biofilms and Human Disease
Nobile, C. J., & Johnson, A. D. (2015) · Annual Review of Microbiology · doi:10.1146/annurev-micro-091014-104330 · Cited by 1,057 · see citing works
Development and regulation of single- and multi-species Candida albicans biofilms
Lohse, M. B., Gulati, M., Johnson, A. D., & Nobile, C. J. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.107 · Cited by 643 · see citing works
NRG1, a repressor of filamentous growth in C.albicans, is down‐regulated during filament induction
Braun, B. R., Kadosh, D., & Johnson, A. D. (2001) · The EMBO Journal · doi:10.1093/emboj/20.17.4753 · Cited by 345 · see citing works
Induction of theCandida albicansFilamentous Growth Program by Relief of Transcriptional Repression: A Genome-wide Analysis
Kadosh, D., & Johnson, A. D. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-01-0073 · Cited by 285 · see citing works
UME6 , a Novel Filament-specific Regulator of Candida albicans Hyphal Extension and Virulence
Banerjee, M., Thompson, D. S., Lazzell, A., Carlisle, P. L., Pierce, C., Monteagudo, C., López-Ribot, J. L., & Kadosh, D. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-11-1110 · Cited by 243 · see citing works
Coevolution of Morphology and Virulence in Candida Species
Childers, D. S., Carlisle, P. L., & Kadosh, D. (2011) · Eukaryotic Cell · doi:10.1128/ec.05085-11 · Cited by 227 · see citing works
Expression levels of a filament-specific transcriptional regulator are sufficient to determine Candida albicans morphology and virulence
Carlisle, P. L., Banerjee, M., Lazzell, A., Monteagudo, C., López-Ribot, J. L., & Kadosh, D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804061106 · Cited by 215 · see citing works
A sticky situation: Untangling the transcriptional network controlling biofilm development in Candida albicans
Fox, E. P., & Nobile, C. J. (2012) · Transcription · doi:10.4161/trns.22281 · Cited by 114 · see citing works
Expression of UME6 , a Key Regulator of Candida albicans Hyphal Development, Enhances Biofilm Formation via Hgc1- and Sun41-Dependent Mechanisms
Banerjee, M., Uppuluri, P., Zhao, X. R., Carlisle, P. L., Vipulanandan, G., Villar, C. C., López-Ribot, J. L., & Kadosh, D. (2013) · Eukaryotic Cell · doi:10.1128/ec.00163-12 · Cited by 88 · see citing works
Global Identification of Biofilm-Specific Proteolysis in Candida albicans
Winter, M. B., Salcedo, E. C., Lohse, M. B., Hartooni, N., Gulati, M., Sánchez, H., Takagi, J., Hube, B., Andes, D. R., Johnson, A. D., et al. (2016) · mBio · doi:10.1128/mbio.01514-16 · Cited by 89 · see citing works
Candida albicans Ume6, a Filament-Specific Transcriptional Regulator, Directs Hyphal Growth via a Pathway Involving Hgc1 Cyclin-Related Protein
Carlisle, P. L., & Kadosh, D. (2010) · Eukaryotic Cell · doi:10.1128/ec.00046-10 · Cited by 69 · see citing works
Regulatory mechanisms controlling morphology and pathogenesis in Candida albicans
Kadosh, D. (2019) · Current Opinion in Microbiology · doi:10.1016/j.mib.2019.04.005 · Cited by 64 · see citing works
Comparative Evolution of Morphological Regulatory Functions in Candida Species
Lackey, E., Vipulanandan, G., Childers, D. S., & Kadosh, D. (2013) · Eukaryotic Cell · doi:10.1128/ec.00164-13 · Cited by 61 · see citing works
Secretion of serine peptidase by a clinical strain ofCandida albicans: influence of growth conditions and cleavage of human serum proteins and extracellular matrix components
dos Santos, A. L. S., de Carvalho, I. M., Silva, B. A., Portela, M. B., Alviano, C. S., & Soares, R. M. D. A. (2006) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2005.00023.x · Cited by 59 · see citing works
A Re-Evaluation of the Relationship between Morphology and Pathogenicity in Candida Species
Kadosh, D., & Mundodi, V. (2020) · Journal of Fungi · doi:10.3390/jof6010013 · Cited by 59 · see citing works
Antimicrobial Properties of Antidepressants and Antipsychotics—Possibilities and Implications
Caldara, M., & Marmiroli, N. (2021) · Pharmaceuticals · doi:10.3390/ph14090915 · Cited by 54 · see citing works
Protein kinase A and fungal virulence
Fuller, K. K., & Rhodes, J. C. (2012) · Virulence · doi:10.4161/viru.19396 · Cited by 53 · see citing works
A 5′ UTR ‐mediated translational efficiency mechanism inhibits the C andida albicans morphological transition
Childers, D. S., Mundodi, V., Banerjee, M., & Kadosh, D. (2014) · Molecular Microbiology · doi:10.1111/mmi.12576 · Cited by 45 · see citing works
A GAS-like gene family in the pathogenic fungus Candida glabrata The EMBL accession numbers for the sequences reported in this paper are AJ302061 for CgGAS1, AJ302062 for CgGAS2 and AJ302063 for CgGAS3.
Weig, M., Haynes, K., Rogers, T. R., Kurzai, O., Frosch, M., & Mühlschlegel, F. A. (2001) · Microbiology · doi:10.1099/00221287-147-8-2007 · Cited by 46 · see citing works
Self-citation
Heterogeneity of metallo and serine extracellular proteinases in oral clinical isolates ofCandida albicansin HIV-positive and healthy children from Rio de Janeiro, Brazil
Costa, E. M. M. D. B., dos Santos, A. L. S., Cardoso, A. S., Portela, M. B., Abreu, C. M., Alviano, C. S., Hagler, A. N., & Soares, R. M. D. A. (2003) · FEMS Immunology & Medical Microbiology · doi:10.1016/s0928-8244(03)00145-7 · Cited by 40 · see citing works
Control of Candida albicans morphology and pathogenicity by post-transcriptional mechanisms
Kadosh, D. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2294-y · Cited by 40 · see citing works
Enhanced antifungal activity of voriconazole-loaded nanostructured lipid carriers against Candida albicans with a dimorphic switching model
Tian, B., Yan, Q., Wang, J., Ding, C., & Sai, S. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s145695 · Cited by 36 · see citing works
Candidaspecies fail to produce the immunosuppressive secondary metabolite gliotoxinin vitro
Kupfahl, C., Ruppert, T., Dietz, A., Geginat, G., & Hof, H. (2007) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2007.00256.x · Cited by 34 · see citing works
Candida guilliermondiiisolated from HIV-infected human secretes a 50 kDa serine proteinase that cleaves a broad spectrum of proteinaceous substrates
Santos, A. L. S., & Soares, R. M. D. A. (2005) · FEMS Immunology & Medical Microbiology · doi:10.1016/j.femsim.2004.06.022 · Cited by 34 · see citing works
Identification of yeasts in public hospital primary care patients with or without clinical vaginitis
Erdem, H., Çetin, M., Timuroğlu, T., Çetin, A., Yanar, O., & Pahsa, A. (2003) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1046/j.0004-8666.2003.00089.x · Cited by 33 · see citing works
Novel silver(I) complexes of coumarin oxyacetate ligands and their phenanthroline adducts: Biological activity, structural and spectroscopic characterisation
Mujahid, M., Trendafilova, N. S., Kia, A. F.-A., Rosair, G. M., Kavanagh, K. A., Devereux, M. M., Walsh, M., McClean, S., Creaven, B. S., & Georgieva, I. (2016) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2016.07.010 · Cited by 29 · see citing works
Filamentation Is Associated with Reduced Pathogenicity of Multiple Non- albicans Candida Species
Banerjee, M., Lazzell, A. L., Romo, J. A., Lopez-Ribot, J. L., & Kadosh, D. (2019) · mSphere · doi:10.1128/msphere.00656-19 · Cited by 29 · see citing works
Global translational landscape of the Candida albicans morphological transition
Mundodi, V., Choudhary, S., Smith, A. D., & Kadosh, D. (2020) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkaa043 · Cited by 24 · see citing works
Ssn6 has dual roles in Candida albicans filament development through the interaction with Rpd31
Lee, J., Oh, J., Ku, M., Kim, J., Lee, J., & Kang, S. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.01.011 · Cited by 27 · see citing works
Epigenetic determinants of phenotypic plasticity in Candida albicans
Rai, L. S., Singha, R., Brahma, P., & Sanyal, K. (2017) · Fungal Biology Reviews · doi:10.1016/j.fbr.2017.07.002 · Cited by 24 · see citing works
Investigation of Extracellular Phospholipase and Proteinase Activities of Candida Species Isolated from Individuals Denture Wearers and Genotypic Distribution of Candida albicans Strains
Günyar, Ö. A. (2011) · Current Microbiology · doi:10.1007/s00284-010-9858-0 · Cited by 23 · see citing works
Fungal Disease in Britain and the United States 1850–2000
Homei, A., & Worboys, M. (2013) · Palgrave Macmillan UK eBooks · doi:10.1057/9781137377029 · Cited by 21 · see citing works
Effect of Antifungal Treatment in a Diet-Based Murine Model of Disseminated Candidiasis Acquired via the Gastrointestinal Tract
Kadosh, D., Najvar, L. K., Bocanegra, R. A., Olivo, M., Kirkpatrick, W. R., Wiederhold, N. P., & Patterson, T. F. (2016) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01144-16 · Cited by 21 · see citing works
Unraveling How Candida albicans Forms Sexual Biofilms
Perry, A. M., Hernday, A. D., & Nobile, C. J. (2020) · Journal of Fungi · doi:10.3390/jof6010014 · Cited by 17 · see citing works
Synergistic Antifungal Activity of Synthetic Peptides and Antifungal Drugs against Candida albicans and C. parapsilosis Biofilms
Bezerra, L. P., Freitas, C. D. T., Silva, A. F. B., Amaral, J. L., Neto, N. A. S., Silva, R. G. G., Parra, A. L. C., Goldman, G. H., Oliveira, J. T. A., Mesquita, F. P., et al. (2022) · Antibiotics · doi:10.3390/antibiotics11050553 · Cited by 17 · see citing works
Novel 4,6-Disubstituted s-Triazin-2-yl Amino Acid Derivatives as Promising Antifungal Agents
Alhameed, R. A., Almarhoon, Z. M., Sholkamy, E. N., Khan, S. A., Ul‐Haq, Z., Sharma, A., de la Torre, B. G., Alberício, F., & El‐Faham, A. (2020) · Journal of Fungi · doi:10.3390/jof6040237 · Cited by 15 · see citing works
Peptidase profiles from non-albicans Candidaspp. isolated from the blood of a patient with chronic myeloid leukemia and another with sickle cell disease
de Melo, A. C. N., Dornelas-Ribeiro, M., de Souza, E. P., Macrae, A., Fracalanzza, S. E. L., & Vermelho, A. B. (2007) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2007.00269.x · Cited by 15 · see citing works
Expression levels and subcellular localization of Bcy1p in Candida albicans mutant strains devoid of one BCY1 allele results in a defective morphogenetic behavior
Giacometti, R., Souto, G., Silberstein, S., Giasson, L., Cantore, M. L., & Passeron, S. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2005.11.016 · Cited by 15 · see citing works
Ppg1, a PP2A-Type Protein Phosphatase, Controls Filament Extension and Virulence in Candida albicans
Bataineh, M. T. A., Lazzell, A. L., Lopez-Ribot, J. L., & Kadosh, D. (2014) · Eukaryotic Cell · doi:10.1128/ec.00199-14 · Cited by 16 · see citing works
Tpd3‐Pph21 phosphatase plays a direct role in Sep7 dephosphorylation in Candida albicans
Liu, Q., Han, Q., Wang, N., Yao, G., Zeng, G., Wang, Y., Huang, Z., Sang, J., & Wang, Y. (2016) · Molecular Microbiology · doi:10.1111/mmi.13376 · Cited by 14 · see citing works
Network Analysis Guided Designing of Multi-Targeted Anti-Fungal Agents: Synthesis and Biological Evaluation
Singh, M., Verma, H., Bhandu, P., Kumar, M., Narendra, G., Choudhary, S., Singh, P. K., & Silakari, O. (2022) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2022.134128 · Cited by 13 · see citing works
A possible CD1a Langerhans cell–mast cell interaction in chronic hyperplastic candidosis
Ali, A., Rautemaa‐Richardson, R., Hietanen, J. H. P., Beklen, A., & Konttinen, Y. T. (2007) · Journal of Oral Pathology and Medicine · doi:10.1111/j.1600-0714.2007.00527.x · Cited by 12 · see citing works
The Antifungal Potential of Ozonated Extra-Virgin Olive Oil Against Candida albicans: Mechanisms and Efficacy
Augello, S., Cameli, V., Montanari, A., Tacconi, S., Uccelletti, D., Dini, L., & Schifano, E. (2024) · Biomolecules · doi:10.3390/biom14111472 · Cited by 12 · see citing works
Secreted aspartate proteinases, a virulence factor ofCandida spp.: Occurrence among clinical isolates
Hamal, P., Dostál, J., Raclavský, V., Krylová, M., Pichová, I., & Hrušková‐Heidingsfeldová, O. (2004) · Folia Microbiologica · doi:10.1007/bf02931614 · Cited by 11 · see citing works
Evaluation of antifungal activity of different homoeopathic mother tinctures against Candida albicans
Gupta, P. K., Prajapati, S., Sharma, M., Kumar, M., Dwivedi, B. K., & Arya, B. (2017) · Indian Journal of Research in Homoeopathy · doi:10.4103/ijrh.ijrh_31_17 · Cited by 9 · see citing works
Factores de virulencia en Candida sp
Rivera, L. E. C., Ramos, A. P., & Desgarennes, C. P. (2005) · Cited by 10 · see citing works
Genome-wide translational response of Candida albicans to fluconazole treatment
Choudhary, S., Mundodi, V., Smith, A. D., & Kadosh, D. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.02572-23 · Cited by 8 · see citing works
Effect of antifungal agents on protein composition of Candida albicans studied by capillary electrophoresis and chip technology
Kustos, I., Nyúl, A., Lóránd, T., Kocsis, B., & Kilár, F. (2006) · Journal of Biochemical and Biophysical Methods · doi:10.1016/j.jbbm.2006.02.002 · Cited by 8 · see citing works
Ribosome profiling reveals differences in global translational vs transcriptional gene expression changes during early Candida albicans biofilm formation
Mundodi, V., Choudhary, S., Smith, A. D., & Kadosh, D. (2025) · Microbiology Spectrum · doi:10.1128/spectrum.02195-24 · Cited by 7 · see citing works
Antifungal activity of ruthenium (II) complex combined with fluconazole against drug-resistant Candida albicans in vitro and its anti-invasive infection in vivo
Xu, Z.-C., Ma, X.-R., Zhang, L., Chen, H., Qing, D.-M., Li, R., Ye, R., & Wang, R. (2024) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2024.112522 · Cited by 4 · see citing works
Science, Technology and Medicine in Modern History
Homei, A., & Worboys, M. (2013) · Directory of Open access Books (OAPEN Foundation) · Cited by 2 · see citing works
Candidalysin: From Mechanism of Action to Biomarker Development and Therapeutic Response
Chen, Y., Li, Q., Zhang, T., & Liu, N. (2020) · Innovations in Digital Health Diagnostics and Biomarkers · doi:10.36401/iddb-20-02 · Cited by 2 · see citing works
Nanotherapeutics of Phytoantioxidants for Microbial Infections
Bhushan, R., Upadhyay, S., & Rudrapal, M. (2022) · Wiley eBooks · doi:10.1002/9781119811794.ch14 · Cited by 2 · see citing works
Utilização de um meio cromogênico e da técnica de semi-nested PCR para identificação de espécies de Cândida
Oliveira, N. D. C., Rampazzo, ‪. D. C. P., Minari, M. C., Corrêa, P. R. C., Carneiro, M., Svidzinski, T. I. E., Maia, L. F., & Yamada‐Ogatta, S. F. (2006) · Semina Ciências Biológicas e da Saúde · doi:10.5433/1679-0367.2006v27n2p125 · Cited by 1 · see citing works
Exploring the fungal wall proteome by mass spectrometry
Yin, Q. Y. (2008) · UvA-DARE (University of Amsterdam) · Cited by 1 · see citing works
Comparison Between Phenotypic Characterization and Semi-Nested PCR for the Identification of Candida Species in Clinical Isolates
Sadeghi-Nejad, B., Samarbafzadeh, A., & Salehi, Z. (2015) · Jundishapur Journal of Natural Pharmaceutical Products · doi:10.17795/jjnpp-17391
Utilization of experimental design and surface response methodology to study the influence of glucose and ammonium sulphate in the chlamydosporulation of Candida albicans FMT123-05
Joatilde, de Souza, O. V. B., Talhari, C. C., Reinel, D., & Talhari, S. (2010) · Journal of Yeast and Fungal Research · doi:10.5897/jyfr.9000054
Identifizierung, Klonierung und Sequenzierung der 1,3-ß-D-Glucan-Synthetase bei der humanpathogenen Hefespezies Candida glabrata
Fakultät, M. (2003)

Authors: Weig, M.
Affiliations: University of Würzburg (DE)
Corresponding author: Weig, M
ORCID: Weig, M
Venue: Trends in Microbiology
Publisher: Elsevier BV
Published: 1998-12-01
Volume: 6
Issue: 12
Pages: 468-470
ISSN: 0966-842X (ISSN-L)
DOI: 10.1016/s0966-842x(98)01407-3
OpenAlex: W2057750664
Semantic Scholar: 83609f5a554d24efab2359061e14f714741f3fbe
Cited by: 58
References: 0
Citations by year: 2025: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 5 · 2019: 2 · 2017: 4 · 2016: 5 · 2015: 3 · 2014: 2 · 2013: 3 · 2012: 3
FWCI: 0.50
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Microbiology (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft
Universität Hamburg
Centre Hospitalier Universitaire Vaudois
Julius-Maximilians-Universität Würzburg
Università degli Studi di Perugia
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
Keywords: candidiasis, pathogenesis, clinical aspects, eukaryotic pathogens
MeSH terms: Candidiasis, Drug Resistance, Microbial, Humans, Polymorphism, Genetic, Gene Expression Regulation, Fungal

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Clinical aspects and pathogenesis of Candida infection

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks