The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
How enzymes adapt: lessons from directed evolution
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Citations
Cites
Rapid evolution of a protein in vitro by DNA shuffling
Stemmer, W. P. C. (1994) · Nature · doi:10.1038/370389a0 · Cited by 1,932
The Triplet State and Molecular Electronic Processes in Organic Molecules
Lower, S. K., & El-Sayed, M. A. (1966) · Chemical Reviews · doi:10.1021/cr60240a004 · Cited by 1,146
Randomization of genes by PCR mutagenesis.
Cadwell, R. C., & Joyce, G. F. (1992) · Genome Research · doi:10.1101/gr.2.1.28 · Cited by 1,068
Molecular spectroscopy of the triplet state
McGlynn, S. P., AZUMI, T., & Kinoshita, M. (1969) · Prentice Hall eBooks · Cited by 964
Molecular evolution by staggered extension process (StEP) in vitro recombination
Zhao, H., Giver, L., Shao, Z., Affholter, J. A., & Arnold, F. H. (1998) · Nature Biotechnology · doi:10.1038/nbt0398-258 · Cited by 757
Self-citationThe stability of proteins in extreme environments
Jaenicke, R., & Böhm, G. (1998) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(98)80094-8 · Cited by 743
Adjustment of conformational flexibility is a key event in the thermal adaptation of proteins
Závodszky, P., Kardos, J., Svingor, Á., & Petsko, G. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7406 · Cited by 526
Directed evolution of a thermostable esterase
Giver, L., Gershenson, A., Freskgard, P.-O., & Arnold, F. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.12809 · Cited by 517
Self-citationDirected evolution converts subtilisin E into a functional equivalent of thermitase
Zhao, H., & Arnold, F. H. (1999) · Protein Engineering, Design and Selection · doi:10.1093/protein/12.1.47 · Cited by 317
Self-citationEngineering an enzyme to resist boiling
van den Burg, B., Vriend, G., Veltman, O. R., Venema, G., & Eijsink, V. G. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2056 · Cited by 293
Cited by
Choreographing an enzyme's dance
Villali, J., & Kern, D. (2010) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2010.08.007 · Cited by 98
Nadar, S. S., & Rathod, V. K. (2019) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2018.12.015 · Cited by 73
Metadata
- Authors
- Arnold, F. H., Wintrode, P. L., Miyazaki, K., & Gershenson, A.
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2001-02
- Volume
- 26
- Issue
- 2
- Pages
- 100-106
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W2156470306
- Cited by
- 389
- References
- 25
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- closed
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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- CoChat. (2026). Citation check: How enzymes adapt: lessons from directed evolution. https://app.cochat.ai/papers/10.1016/s0968-0004(00)01755-2
- The paper
- Arnold, F. H., Wintrode, P. L., Miyazaki, K., & Gershenson, A. (2001). How enzymes adapt: lessons from directed evolution. Trends in Biochemical Sciences. https://doi.org/10.1016/s0968-0004(00)01755-2
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
