CoChat
Sign Up
Cited by 120

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Telomerase: biochemical considerations for enzyme and substrate

Kelleher, Colleen, Teixeira, M.Teresa, Förstemann, Klaus, Lingner, Joachim·2002·Trends in Biochemical Sciences
DOI 10.1016/s0968-0004(02)02206-5
Open this paper in CoChat — free account

Abstract

Telomerase extends chromosome ends by iterative reverse transcription of its RNA template. Following the addition of each telomeric repeat, the RNA template and the telomeric substrate reset their relative position in the active site provided by the telomerase reverse transcriptase (TERT). This step might require the formation of guanine-rich secondary structures in the nascent product. Results from numerous studies begin to delineate TERT sub-domains that orchestrate these events and support the model of cooperative action between distinct active sites within telomerase multimers. Natural telomere substrates are protein-DNA complexes that show an asymmetry between the two ends of a chromosome, possibly reflecting their differential mode of replication.

Overview

Integrity signals

Registry

Crossref · 10.1016/s0968-0004(02)02206-5

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 2 references

Research works printed but not linked: 72

  1. Nakamura, 1998, Reversing time – origin of telomerase, Cell, 92, 587, 10.1016/S0092-8674(00)81123-X · DOI
  2. Aisner, 2002, Telomerase regulation: not just flipping the switch, Curr. Opin. Genet. Dev., 12, 80, 10.1016/S0959-437X(01)00268-4 · DOI
  3. Blackburn, 2001, Switching and signaling at the telomere, Cell, 106, 661, 10.1016/S0092-8674(01)00492-5 · DOI
  4. Evans, 2000, Positive and negative regulation of telomerase access to the telomere, J. Cell Sci., 113, 3357, 10.1242/jcs.113.19.3357 · DOI
  5. Dubrana, 2001, Turning telomeres off and on, Curr. Opin. Cell Biol., 13, 281, 10.1016/S0955-0674(00)00210-6 · DOI
  6. Collins, 1999, Ciliate telomerase biochemistry, Annu. Rev. Biochem., 68, 187, 10.1146/annurev.biochem.68.1.187 · DOI
  7. Hammond, 1998, Euplotes telomerase – evidence for limited base-pairing during primer elongation and dGTP as an effector of translocation, Biochemistry, 37, 5162, 10.1021/bi972988o · DOI
  8. Hardy, 2001, Requirements for the dGTP-dependent repeat addition processivity of recombinant Tetrahymena telomerase, J. Biol. Chem., 276, 4863, 10.1074/jbc.M005158200 · DOI
  9. Prescott, 1997, Functionally interacting telomerase RNAs in the yeast telomerase complex, Genes Dev., 11, 2790, 10.1101/gad.11.21.2790 · DOI
  10. Forstemann, 2001, Molecular basis for telomere repeat divergence in budding yeast, Mol. Cell. Biol., 21, 7277, 10.1128/MCB.21.21.7277-7286.2001 · DOI
  11. Tzfati, 2000, Template boundary in a yeast telomerase specified by RNA structure, Science, 288, 863, 10.1126/science.288.5467.863 · DOI
  12. Lai, 2002, Template boundary definition in Tetrahymena telomerase, Genes Dev., 16, 415, 10.1101/gad.962602 · DOI
  13. Shippen-Lentz, 1990, Functional evidence for an RNA template in telomerase, Science, 247, 546, 10.1126/science.1689074 · DOI
  14. Zahler, 1991, Inhibition of telomerase by G-quartet DNA structures, Nature, 350, 718, 10.1038/350718a0 · DOI
  15. Jarstfer, 2002, Effects of nucleotide analogues on telomerase processivity: evidence for product-assisted translocation, Biochemistry, 41, 151, 10.1021/bi011649z · DOI
  16. Fletcher, 1996, Human telomerase inhibition by 7-deaza-2′-deoxypurine nucleoside triphosphates, Biochemistry, 35, 15611, 10.1021/bi961228v · DOI
  17. Wang, 1997, De novo telomere addition by Tetrahymena telomerase in vitro, EMBO J., 16, 866, 10.1093/emboj/16.4.866 · DOI
  18. Ware, 2000, Three telomerases with completely non-telomeric template replacements are catalytically active, EMBO J., 19, 3119, 10.1093/emboj/19.12.3119 · DOI
  19. Chen, 2000, Secondary structure of vertebrate telomerase RNA, Cell, 100, 503, 10.1016/S0092-8674(00)80687-X · DOI · Paper page
  20. O'Reilly, 1999, Telomerases, Curr. Opin. Struct. Biol., 9, 56, 10.1016/S0959-440X(99)80008-6 · DOI
  21. Peng, 2001, Analysis of telomerase processivity: mechanistic similarity to HIV-1 reverse transcriptase and role in telomere maintenance, Mol. Cell, 7, 1201, 10.1016/S1097-2765(01)00268-4 · DOI
  22. Bosoy, 2001, Functional analysis of conserved residues in the putative ‘finger’ domain of telomerase reverse transcriptase, J. Biol. Chem., 276, 46305, 10.1074/jbc.M108168200 · DOI
  23. Miller, 2000, Template definition by Tetrahymena telomerase reverse transcriptase, EMBO J., 19, 4412, 10.1093/emboj/19.16.4412 · DOI
  24. Beattie, 2000, Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding, Mol. Biol. Cell, 11, 3329, 10.1091/mbc.11.10.3329 · DOI
  25. Bachand, 2001, Functional regions of human telomerase reverse transcriptase and human telomerase RNA required for telomerase activity and RNA-protein interactions, Mol. Cell. Biol., 21, 1888, 10.1128/MCB.21.5.1888-1897.2001 · DOI
  26. Lai, 2001, RNA binding domain of telomerase reverse transcriptase, Mol. Cell. Biol., 21, 990, 10.1128/MCB.21.4.990-1000.2001 · DOI
  27. Armbruster, 2001, N-terminal domains of the human telomerase catalytic subunit required for enzyme activity in vivo, Mol. Cell. Biol., 21, 7775, 10.1128/MCB.21.22.7775-7786.2001 · DOI
  28. Bryan, 2000, Telomerase RNA bound by protein motifs specific to telomerase reverse transcriptase, Mol. Cell, 6, 493, 10.1016/S1097-2765(00)00048-4 · DOI
  29. Friedman, 1999, Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants, Genes Dev., 13, 2863, 10.1101/gad.13.21.2863 · DOI
  30. Mitchell, 2000, Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase, Mol. Cell, 6, 361, 10.1016/S1097-2765(00)00036-8 · DOI
  31. Xia, 1996, Reduced telomere length in ataxia-telangiectasia fibroblasts, Mutat. Res., 364, 1, 10.1016/0921-8777(96)00015-8 · DOI
  32. Counter, 1998, Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization, Proc. Natl. Acad. Sci. U. S. A., 95, 14723, 10.1073/pnas.95.25.14723 · DOI · Paper page
  33. Banik, 2002, C-terminal regions of the human telomerase catalytic subunit essential for in vivo enzyme activity, Mol. Cell. Biol., 22, 6234, 10.1128/MCB.22.17.6234-6246.2002 · DOI
  34. Beattie, 2001, Functional multimerization of the human telomerase reverse transcriptase, Mol. Cell. Biol., 21, 6151, 10.1128/MCB.21.18.6151-6160.2001 · DOI
  35. Lingner, 1996, Purification of telomerase from Euplotes aediculatus: requirement of a primer 3′ overhang, Proc. Natl. Acad. Sci. U. S. A., 93, 10712, 10.1073/pnas.93.20.10712 · DOI
  36. Wenz, 2001, Human telomerase contains two cooperating telomerase RNA molecules, EMBO J., 20, 3526, 10.1093/emboj/20.13.3526 · DOI
  37. Arai, 2002, Two independent regions of human telomerase reverse transcriptase are important for its oligomerization and telomerase activity, J. Biol. Chem., 277, 8538, 10.1074/jbc.M111068200 · DOI
  38. Collins, 1993, Tetrahymena telomerase catalyzes nucleolytic cleavage and nonprocessive elongation, Genes Dev., 7, 1364, 10.1101/gad.7.7b.1364 · DOI
  39. Lee, 1993, Sequence-specific DNA primer effects on telomerase polymerization activity, Mol. Cell. Biol., 13, 6586, 10.1128/MCB.13.10.6586 · DOI
  40. Hammond, 1997, The anchor site of telomerase from Euplotes aediculatus revealed by photo-cross-linking to single- and double-stranded DNA primers, Mol. Cell. Biol., 17, 296, 10.1128/MCB.17.1.296 · DOI
  41. Ohki, 2001, In vitro reconstitution of the end replication problem, Mol. Cell. Biol., 21, 5753, 10.1128/MCB.21.17.5753-5766.2001 · DOI
  42. Klobutcher, 1981, All gene-sized DNA molecules in four species of hypotrichs have the same terminal sequence and an unusual 3′ terminus, Proc. Natl. Acad. Sci. U. S. A., 78, 3015, 10.1073/pnas.78.5.3015 · DOI
  43. Munoz-Jordan, 2001, t-loops at trypanosome telomeres, EMBO J., 20, 579, 10.1093/emboj/20.3.579 · DOI
  44. Wellinger, 1993, Saccharomyces telomeres acquire single-strand TG1-3 tails late in S phase, Cell, 72, 51, 10.1016/0092-8674(93)90049-V · DOI
  45. Wellinger, 1996, Evidence for a new step in telomere maintenance, Cell, 85, 423, 10.1016/S0092-8674(00)81120-4 · DOI
  46. Makarov, 1997, Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening, Cell, 88, 657, 10.1016/S0092-8674(00)81908-X · DOI
  47. Wright, 1997, Normal human chromosomes have long G-rich telomeric overhangs at one end, Genes Dev., 11, 2810, 10.1101/gad.11.21.2801 · DOI
  48. Huffman, 2000, Telomere shortening is proportional to the size of the G-rich telomeric 3′-overhang, J. Biol. Chem., 275, 19719, 10.1074/jbc.M002843200 · DOI
  49. Riha, 2000, Analysis of the G-overhang structures on plant telomeres: evidence for two distinct telomere architectures, Plant J., 23, 633, 10.1046/j.1365-313x.2000.00831.x · DOI
  50. Maringele, 2002, EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70Delta mutants, Genes Dev., 16, 1919, 10.1101/gad.225102 · DOI
  51. Bailey, 2001, Strand-specific postreplicative processing of mammalian telomeres, Science, 293, 2462, 10.1126/science.1062560 · DOI
  52. Lingner, 1995, Telomerase and DNA end replication: no longer a lagging strand problem?, Science, 269, 1533, 10.1126/science.7545310 · DOI
  53. Forstemann, 2000, Telomerase-dependent repeat divergence at the 3′ ends of yeast telomeres, Nucleic Acids Res., 28, 2690, 10.1093/nar/28.14.2690 · DOI
  54. Marcand, 2000, Cell cycle restriction of telomere elongation, Curr. Biol., 10, 487, 10.1016/S0960-9822(00)00450-4 · DOI · Paper page
  55. Ray, 2002, Interactions between telomerase and primase physically link the telomere and chromosome replication machinery, Mol. Cell. Biol., 22, 5859, 10.1128/MCB.22.16.5859-5868.2002 · DOI
  56. Qi, 2000, The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase-associated Est1 protein, Genes Dev., 14, 1777, 10.1101/gad.14.14.1777 · DOI
  57. Evans, 1999, Est1 and Cdc13 as comediators of telomerase access, Science, 286, 117, 10.1126/science.286.5437.117 · DOI
  58. Pennock, 2001, Cdc13 delivers separate complexes to the telomere for end protection and replication, Cell, 104, 387, 10.1016/S0092-8674(01)00226-4 · DOI
  59. Lustig, 2001, Cdc13 subcomplexes regulate multiple telomere functions, Nat. Struct. Biol., 8, 297, 10.1038/86157 · DOI
  60. Taggart, 2002, Est1p as a cell cycle-regulated activator of telomere-bound telomerase, Science, 297, 1023, 10.1126/science.1074968 · DOI
  61. Nakamura, 1997, Telomerase catalytic subunit homologs from fission yeast and human, Science, 277, 955, 10.1126/science.277.5328.955 · DOI · Paper page
  62. Weinrich, 1997, Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT, Nat. Genet., 17, 498, 10.1038/ng1297-498 · DOI · Paper page
  63. Harrington, 1997, Human telomerase contains evolutionarily conserved catalytic and structural subunits, Genes Dev., 11, 3109, 10.1101/gad.11.23.3109 · DOI · Paper page
  64. Nakayama, 1998, Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas, Nat. Genet., 18, 65, 10.1038/ng0198-65 · DOI · Paper page
  65. Xia, 2000, Identification of functionally important domains in the N-terminal region of telomerase reverse transcriptase, Mol. Cell. Biol., 20, 5196, 10.1128/MCB.20.14.5196-5207.2000 · DOI
  66. Moriarty, 2002, Functional multimerization of human telomerase requires an RNA interaction domain in the N terminus of the catalytic subunit, Mol. Cell. Biol., 22, 1253, 10.1128/MCB.22.4.1253-1265.2002 · DOI
  67. Holt, 1999, Functional requirement of p23 and Hsp90 in telomerase complexes, Genes Dev., 13, 817, 10.1101/gad.13.7.817 · DOI
  68. Kharbanda, S. et al. (2000) Regulation of the hTERT telomerase catalytic subunit by the c-Abl tyrosine kinase, Curr. Biol. 10, 568–575 · DOI
  69. Seimiya, 2000, Involvement of 14-3-3 proteins in nuclear localization of telomerase, EMBO J., 19, 2652, 10.1093/emboj/19.11.2652 · DOI
  70. Bryan, 1998, Telomerase reverse transcriptase genes identified in Tetrahymena thermophila and Oxythricha trifallax, Proc. Natl. Acad. Sci. U. S. A., 95, 8479, 10.1073/pnas.95.15.8479 · DOI
  71. Collins, 1998, The reverse transcriptase component of the Tetrahymena telomerase ribonucleoprotein complex, Proc. Natl. Acad. Sci. U. S. A., 95, 8485, 10.1073/pnas.95.15.8485 · DOI
  72. Bryan, 2000, A mutant of Tetrahymena telomerase reverse transcriptase with increased processivity, J. Biol. Chem., 275, 24199, 10.1074/jbc.M003246200 · DOI

Cited by

See all 120

Metadata

Authors
Kelleher, C., Teixeira, M. T., Förstemann, K., & Lingner, J.
Venue
Trends in Biochemical Sciences
Publisher
Elsevier BV
Published
2002-11
Volume
27
Issue
11
Pages
572-579
ISSN
0968-0004
DOI
10.1016/s0968-0004(02)02206-5
Cited by
120
References
2
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Telomerase: biochemical considerations for enzyme and substrate. https://app.cochat.ai/papers/10.1016/s0968-0004(02)02206-5
The paper
Kelleher, C., Teixeira, M. T., Förstemann, K., & Lingner, J. (2002). Telomerase: biochemical considerations for enzyme and substrate. Trends in Biochemical Sciences. https://doi.org/10.1016/s0968-0004(02)02206-5