Detection and structural characterization of ras oncoprotein-inhibitors complexes by electrospray mass spectrometry

Refined crystal structure of the triphosphate conformation of H‐ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis.

PAI, E. F., Krengel, U., Petsko, G. A., Goody, R. S., Kabsch, W., & Wittinghofer, A. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07409.x · Cited by 1,074 · see citing works

The Cellular Functions of Small GTP-Binding Proteins

Hall, A. (1990) · Science · doi:10.1126/science.2116664 · Cited by 866 · see citing works

ras GTPase activating protein: Signal transmitter and signal terminator

McCormick, F. (1989) · Cell · doi:10.1016/0092-8674(89)90976-8 · Cited by 607 · see citing works

Detection of noncovalent receptor-ligand complexes by mass spectrometry

Ganem, B., Li, Y., & Henion, J. (1991) · Journal of the American Chemical Society · doi:10.1021/ja00016a069 · Cited by 464 · see citing works

Observation of noncovalent enzyme-substrate and enzyme-product complexes by ion-spray mass spectrometry

Ganem, B., Li, Y. T., & Henion, J. D. (1991) · Journal of the American Chemical Society · doi:10.1021/ja00020a085 · Cited by 331 · see citing works

ras oncogenes: their role in neoplasia

Barbacid, M. (1990) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1990.tb01848.x · Cited by 242 · see citing works

Observation of a small oligonucleotide duplex by electrospray ionization mass spectrometry

Light‐Wahl, K. J., Springer, D. L., Winger, B. E., Edmonds, C. G., Camp, D., Thrall, B. D., & Smith, R. D. (1993) · Journal of the American Chemical Society · doi:10.1021/ja00055a070 · Cited by 158 · see citing works

Direct observation of a ternary complex between the dimeric enzyme HIV-1 protease and a substrate-based inhibitor

Baca, M., & Kent, S. B. H. (1992) · Journal of the American Chemical Society · doi:10.1021/ja00036a066 · Cited by 146 · see citing works

Ras oncoprotein inhibitors: The discovery of potent, ras nucleotide exchange inhibitors and the structural determination of a drug-protein complex

Taveras, A. G., Remiszewski, S., Doll, R. J., Cesarz, D., Huang, E. C., Kirschmeier, P. T., Pramanik, B. N., Snow, M. E., Wang, Y.-S., del Rosario, J., et al. (1997) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(96)00202-7 · Cited by 123 · see citing works

Mass spectrometric detection of the noncovalent GDP-bound conformational state of the human H-ras protein

Ganguly, A. K., Pramanik, B. N., Tsarbopoulos, A., Covey, T. R., Huang, E. C., & Fuhrman, S. A. (1992) · Journal of the American Chemical Society · doi:10.1021/ja00042a046 · Cited by 100 · see citing works

Application of electrospray mass spectrometry in probing protein-protein and protein-ligand noncovalent interactions

Huang, E. C., Pramanik, B. N., Tsarbopoulos, A., Reichert, P., Ganguly, A. K., Trotta, P. P., Nagabhushan, T. L., & Covey, T. R. (1993) · Journal of the American Society for Mass Spectrometry · doi:10.1016/1044-0305(93)85026-t · Cited by 58 · see citing works

A mass spectrometry method for mapping the interface topography of interacting proteins, illustrated by the melittin-calmodulin system

Steiner, R. F., Albaugh, S., Fenselau, C., Murphy, C. M., & Vestling, M. M. (1991) · Analytical Biochemistry · doi:10.1016/0003-2697(91)90127-f · Cited by 42 · see citing works

Studies of the Ras-GDP and Ras-GTP noncovalent complexes by electrospray mass spectrometry

Ganguly, A. K., Pramanik, B. N., Huang, E. C., Tsarbopoulos, A., GIRIJAVALLABHAN, V. M., & Liberles, S. D. (1993) · Tetrahedron · doi:10.1016/s0040-4020(01)88022-4 · Cited by 26 · see citing works

Structural analysis of the CHO‐derived interleukin‐4 by liquid‐chromatography/electrospray ionization mass spectrometry

Tsarbopoulos, A., Pramanik, B. N., Nagabhushan, T. L., & Covey, T. R. (1995) · Journal of Mass Spectrometry · doi:10.1002/jms.1190301217 · Cited by 18 · see citing works

Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design

Ostrem, J. M. L., & Shokat, K. M. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.139 · Cited by 641 · see citing works

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

Maurer, T., Garrenton, L. S., Oh, A., Pitts, K., Anderson, D. J., Skelton, N. J., Fauber, B. P., Pan, B., Malek, S., Stokoe, D., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116510109 · Cited by 618 · see citing works

Mass Spectrometry

Burlingame, A. L., Boyd, R. K., & Gaskell, S. J. (1998) · Analytical Chemistry · doi:10.1021/a1980023+ · Cited by 148 · see citing works

Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C

Weiss, A., Lorthiois, E., Barys, L., Beyer, K. S., Bomio-Confaglia, C., Burks, H., Chen, X., Cui, X., de Kanter, R., Dharmarajan, L., et al. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-22-0158 · Cited by 150 · see citing works

Ras inhibition via direct Ras binding—is there a path forward?

Wang, W., Fang, G., & Rudolph, J. (2012) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2012.07.082 · Cited by 104 · see citing works

Direct Modulation of Small GTPase Activity and Function

Cromm, P. M., Spiegel, J., Grossmann, T. N., & Waldmann, H. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201504357 · Cited by 78 · see citing works

Inhibitors of Ras–SOS Interactions

Lu, S., Jang, H., Zhang, J., & Nussinov, R. (2016) · ChemMedChem · doi:10.1002/cmdc.201500481 · Cited by 72 · see citing works

Inhibition of Ras–effector interactions by cyclic peptides

Wú, X., Upadhyaya, P., Villalona-Calero, M. A., Briesewitz, R., & Pei, D. (2012) · MedChemComm · doi:10.1039/c2md20329d · Cited by 69 · see citing works

Evaluation of complexation of metal-mediated DNA-binding drugs to oligonucleotides via electrospray ionization mass spectrometry

Reyzer, M. L. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.21.e103 · Cited by 69 · see citing works

Progress in targeting RAS with small molecule drugs

McCormick, F. P. (2019) · Biochemical Journal · doi:10.1042/bcj20170441 · Cited by 63 · see citing works

Overcoming Resistance to Drugs Targeting KRAS Mutation

Jiao, D., & Yang, S. (2020) · The Innovation · doi:10.1016/j.xinn.2020.100035 · Cited by 61 · see citing works

Design, Synthesis and Biological Evaluation of Sugar‐Derived Ras Inhibitors

Peri, F., Airoldi, C., Colombo, S., Martegani, E., van Neuren, A. S., Stein, M., Marinzi, C., & Nicotra, F. (2005) · ChemBioChem · doi:10.1002/cbic.200400420 · Cited by 41 · see citing works

Selective cytotoxicity of a bicyclic Ras inhibitor in cancer cells expressing K-RasG13D

Palmioli, A., Sacco, E., Airoldi, C., Nicolantonio, F. D., D’Urzo, A., Shirasawa, S., Sasazuki, T., Domizio, A. D., GIOIA, L. D., Martegani, E., et al. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.06.069 · Cited by 33 · see citing works

The centaurin γ-1 GTPase-like domain functions as an NTPase

Soundararajan, M., Yang, X., Elkins, J. M., Sobott, F., & Doyle, D. (2007) · Biochemical Journal · doi:10.1042/bj20060555 · Cited by 29 · see citing works

Glycyrrhetinic acid binds to the conserved P-loop region and interferes with the interaction of RAS-effector proteins

Zhang, Y., Wang, Z., Ma, X., Yang, S., Hu, X., Tao, J., Hou, Y., & Bai, G. (2018) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2018.11.002 · Cited by 25 · see citing works

Direct GDP-KRAS G12C inhibitors and mechanisms of resistance: the tip of the iceberg

Rosen, J. C., Sacher, A. G., & Tsao, M. (2023) · Therapeutic Advances in Medical Oncology · doi:10.1177/17588359231160141 · Cited by 22 · see citing works

Targeting KRAS-mutant non-small cell lung cancer: challenges and opportunities

Zhang, J., Park, D., Shin, D. M., & Deng, X. (2015) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmv118 · Cited by 19 · see citing works

A novel terpenoid class for prevention and treatment of KRAS‐driven cancers: Comprehensive analysis using in situ, in vitro, and in vivo model systems

Ganaie, A. A., Siddique, H. R., SHEIKH, I. A., Parray, A., Wang, L., Panyam, J., Villalta, P. W., Deng, Y., Konety, B. R., & Saleem, M. (2020) · Molecular Carcinogenesis · doi:10.1002/mc.23200 · Cited by 17 · see citing works

Binding of Nucleotides to Guanylate Kinase, p21 , and Nucleoside-diphosphate Kinase Studied by Nano-electrospray Mass Spectrometry

Prinz, H., Lavie, A., Scheidig, A. J., Spangenberg, O., & Konrad, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.50.35337 · Cited by 17 · see citing works

Therapeutic Targeting the Allosteric Cysteinome of RAS and Kinase Families

Li, L., Meyer, C., Zhou, Z.-W., Elmezayen, A., & Westover, K. (2022) · Journal of Molecular Biology · doi:10.1016/j.jmb.2022.167626 · Cited by 14 · see citing works

Determination of micelle mass by electrospray ionization mass spectrometry

Nohara, D., Kajiura, T., & Takeda, K. (2005) · Journal of Mass Spectrometry · doi:10.1002/jms.818 · Cited by 14 · see citing works

Direkte Modulation von Aktivität und Funktion kleiner GTPasen

Cromm, P. M., Spiegel, J., Grossmann, T. N., & Waldmann, H. (2015) · Angewandte Chemie · doi:10.1002/ange.201504357 · Cited by 9 · see citing works

NMR Study to Identify a Ligand-Binding Pocket in Ras

Maurer, T., & Wang, W. (2013) · The Enzymes · doi:10.1016/b978-0-12-416749-0.00002-6 · Cited by 9 · see citing works

Structure-Activity Studies on Arylamides and Arysulfonamides Ras Inhibitors

Colombo, S., Palmioli, A., Airoldi, C., Tisi, R., Fantinato, S., Olivieri, S., GIOIA, L. D., Martegani, E., & Peri, F. (2010) · Current Cancer Drug Targets · doi:10.2174/156800910791054185 · Cited by 9 · see citing works

A New Dawn for Targeted Cancer Therapy: Small Molecule Covalent Binding Inhibitor Targeting K-Ras (G12C)

Li, N., Liu, C., Zhang, W., & Rao, G. (2023) · Current Medicinal Chemistry · doi:10.2174/0109298673258913231019113814 · Cited by 7 · see citing works

Spiclomazine displays a preferential anti-tumor activity in mutant KRas-driven pancreatic cancer

Guo, X., Zhao, W., Liu, Z., & Wang, J. (2018) · Oncotarget · doi:10.18632/oncotarget.24025 · Cited by 7 · see citing works

Sugar-Based Inhibitors of Ras Activation

Domizio, A. D., & Peri, F. (2013) · The Enzymes · doi:10.1016/b978-0-12-416749-0.00005-1 · Cited by 2 · see citing works

Screening and rank ordering of reversible mechanism‐based inhibitors of Hepatitis C virus NS3 protease using electrospray ionization mass spectrometry

Liu, Y., Ramanathan, L., Malcolm, B. A., Njoroge, G. F., Chan, T., & Pramanik, B. N. (2011) · Journal of Mass Spectrometry · doi:10.1002/jms.1948 · Cited by 2 · see citing works

Promising Molecular Targets for Design of Antitumor Drugs Based on Ras Protein Signaling Cascades

Klochkov, S. G., Евгеньевна, Н. М., & Aleksandrova, Y. R. (2020) · Russian Journal of Bioorganic Chemistry · doi:10.1134/s1068162020050118 · Cited by 2 · see citing works

Estudio funcional de Sos1 y Sos2 in vivo e in vitro en la regulación de procesos fisiológicos y tumorales: las proteínas Sos como dianas terapéuticas en cáncer

Liceras-Boillos, P. (2017) · doi:10.14201/gredos.137078

Mechanism of Action and Metabolism of Antineoplastic and Chemopreventive Agents

(2002) · CRC Press eBooks · doi:10.1201/9781420042696.ch5

BindingDB Entry 50042134: Ras inhibition via direct Ras binding--is there a path forward?

BindingDB (2013) · UC San Diego · doi:10.7270/q2rr20jz

Studies of the Ras-GDP and Ras-GTP noncovalent complexes by electrospray mass spectrometry

Ganguly, A. K., Pramanik, B. N., Huang, E. C., Tsarbopoulos, A., GIRIJAVALLABHAN, V. M., & Liberles, S. D. (1993) · Tetrahedron · doi:10.1016/s0040-4020(01)88022-4 · Cited by 26 · see citing works

Ras oncoprotein inhibitors: The discovery of potent, ras nucleotide exchange inhibitors and the structural determination of a drug-protein complex

Taveras, A. G., Remiszewski, S., Doll, R. J., Cesarz, D., Huang, E. C., Kirschmeier, P. T., Pramanik, B. N., Snow, M. E., Wang, Y.-S., del Rosario, J., et al. (1997) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(96)00202-7 · Cited by 123 · see citing works

Electrospray ionization mass spectrometry for the study of non-covalent complexes: an emerging technology

Pramanik, B. N., Bartner, P. L., Mirza, U. A., Liu, Y., & Ganguly, A. K. (1998) · Journal of Mass Spectrometry · doi:10.1002/(sici)1096-9888(1998100)33:10 · Cited by 167 · see citing works

Detection of molecular ions of non-covalent complexes of Ras-GDP and Ras-GppNp by MALDI-TOF mass spectrometry

Akashi, S., Shirouzu, M., Yokoyama, S., Takio, K., 明石知子, 白水, 美., 茂之, 横., & 擴士, 瀧. (1996)

Detection of Molecular Ions of Non-Covalent Complexes of RasGDP and RasGppNp by MALDI-TOFMS.

Akashi, S., Shirouzu, M., Yokoyama, S., & Takio, K. (1996) · Journal of the Mass Spectrometry Society of Japan · doi:10.5702/massspec.44.269 · Cited by 4 · see citing works