Combined photodynamic therapy and hyperbaric oxygenation in carcinoma of the esophagus and the esophago-gastric junction✩
Open accessAbstract
OBJECTIVES: The photochemical reaction of photodynamic therapy (PDT) depends on the presence of molecular oxygen. Due to anoxic regions in tumor tissue and vascular shutdown during PDT the efficiency is limited. Therefore, the use of hyperbaric oxygen which increases the oxygen in tumor tissue, as well as the amount of singlet oxygen, may enhance the efficiency of PDT. PATIENTS AND METHODS: After diagnostic work-up, photosensitization was carried out with a hematoporphyrin-derivate 2 mg/kg BW 48 h prior to PDT. The light dose was calculated as 300 J/cm fiber tip. Thirty-one patients were treated by PDT alone and 44 patients received PDT under hyperbaric oxygen at a level of two absolute atmospheric pressure. RESULTS: Improvement regarding stenosis-diameter could be obtained in both treatment arms with no significant difference (P=0.82). The dysphagia-score and tumor-length also decreased in both groups and showed a significant difference in favour of the PDT/HBO-group (P=0. 0064 and P=0.0002, respectively). The median overall survival for the PDT-group was 7 months and for the PDT/HBO-group 12 months (P=0. 0098). CONCLUSION: According to this prospective non-randomized study, combined PDT/HBO represents a new approach in the treatment of esophageal and cardia cancer which appears to have enhanced the efficiency of PDT.
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Hjelde and colleagues demonstrated that hyperoxia did not affect the degree of toxicity of photodynamic therapy relative to normoxic conditions in vitro, in contrast to other experimental and clinical studies.
“Hjelde and colleagues investigated the effect of oxygen tension on photodynamic therapy toxicity in an established cell line. 435 The authors demonstrated that hyperoxia did not affect the degree of toxicity of photodynamic therapy relative to normoxic conditions in vitro, in contrast to other experimental and clinical studies. 436 , 437 , 438”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [437]
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Oxygen therapy in cancer treatment: progress & promisesPreprint
Rai, D. (2022) · doi:10.22541/au.165888617.79233708/v1
- Authors
- Maier, A., Tomaselli, F., Anegg, U., Rehak, P., Fell, B., Luznik, S., Pinter, H., & Smolle-Jüttner, F. M.
- Affiliations
- Medical University of Graz (AT)
- Venue
- European Journal of Cardio-Thoracic Surgery
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-12
- Volume
- 18
- Issue
- 6
- Pages
- 649-655
- ISSN
- 1010-7940 (ISSN-L)
- 1873-734X
- OpenAlex
- W2025223499
- Cited by
- 54
- References
- 31
- Citations by year
- 2024: 1 · 2023: 4 · 2022: 6 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 1 · 2015: 4 · 2014: 3 · 2013: 1 · 2012: 2
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Cardio-Thoracic Surgery (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Health Sciences › Medicine › Surgery › Esophageal Cancer Research and Treatment
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- photodynamic therapy, hyperbaric oxygen therapy, esophageal cancer, gastroesophageal junction cancer, hematoporphyrin derivative, photosensitizers, tumor hypoxia, stenosis, dysphagia, overall survival, combination therapy
- MeSH terms
- Aged, Aged, 80 and over, Carcinoma, Combined Modality Therapy, Esophageal Neoplasms, Esophagogastric Junction, Female, Humans, Hyperbaric Oxygenation, Male, Middle Aged, Photochemotherapy, Prospective Studies, Proportional Hazards Models, Statistics, Nonparametric
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