Effects of panax ginseng extract on lipid metabolism in humans
Abstract
The purpose of this study was to examine the effects of Panax ginseng extract (PGE) on lipid metabolism in humans by measuring cholesterol, malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT). Serum total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL) and plasma MDA levels were decreased by administration of PGE for 8 weeks (6g per day), however, high density lipoprotein (HDL) was increased. Those results suggest that hypolipidemic effect of PGE is associated with a decrease in TC, TG, LDL, MDA levels and an increase in HDL. These findings support scientific claims that ginseng has the hypolipidemic potential. Administration of PGE increased SOD and CAT activities while decreased MDA level indicating that antioxidant potential of PGE might induce hypolipidemic effect as one of action mechanism.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The intake of Panax ginseng extract is not associated with serious side effects.
“The intake of Panax ginseng extract is not associated with serious side effects [21,32,33,34,35,36,37,38,39,40,41].”
From Plant Adaptogens—History and Future Perspectives (2021) · cites this paper as [32]
Cites
Aebi, H. (1984) · Methods in Enzymology · doi:10.1016/s0076-6879(84)05016-3 · Cited by 25,696 · see citing works
Enzymatic determination of total serum cholesterol.
Allain, C. C., Poon, L. S., Chan, C. S. G., Richmond, W., & Fu, P. C. (1974) · Clinical Chemistry · doi:10.1093/clinchem/20.4.470 · Cited by 9,845 · see citing works
Cholesterol determination in high-density lipoproteins separated by three different methods.
Lopes-Virella, M. F., Stone, P., Ellis, S. G., & Colwell, J. A. (1977) · Clinical Chemistry · doi:10.1093/clinchem/23.5.882 · Cited by 1,841 · see citing works
Prasad, K. (1999) · Circulation · doi:10.1161/01.cir.99.10.1355 · Cited by 290 · see citing works
Nebot, C., Moutet, M., Huet, P., Xu, J., Yadan, J., & Chaudière, J. (1993) · Analytical Biochemistry · doi:10.1006/abio.1993.1521 · Cited by 269 · see citing works
The Determination of Triglycerides in Plasma and Tissues
Sardesai, V. M., & Manning, J. A. (1968) · Clinical Chemistry · doi:10.1093/clinchem/14.2.156 · Cited by 209 · see citing works
Evaluation of the Ergogenic Properties of Ginseng
Bahrke, M. S., & Morgan, W. P. (1994) · Sports Medicine · doi:10.2165/00007256-199418040-00003 · Cited by 143 · see citing works
Determination of malondialdehyde by ion-pairing high-performance liquid chromatography
Bull, A. W., & Marnett, L. J. (1985) · Analytical Biochemistry · doi:10.1016/0003-2697(85)90506-8 · Cited by 121 · see citing works
Lipoprotein lipase activation by red Ginseng saponins in hyperlipidemia model animals
Inoue, M., Wu, C. Z., Dou, D., Chen, Y. J., & Ogihara, Y. (1999) · Phytomedicine · doi:10.1016/s0944-7113(99)80018-x · Cited by 57 · see citing works
STUDY OF THE HYPOLIPIDEMIC PROPERTIES OF PECTIN, GARLIC AND GINSENG IN HYPERCHOLESTEROLEMIC RABBITS
Ismail, M. F., Gad, M. Z., & Hamdy, M. A. (1999) · Pharmacological Research · doi:10.1006/phrs.1998.0421 · Cited by 53 · see citing works
Nutritional ergogenics in athletics
Williams, M. H. (1995) · Journal of Sports Sciences · doi:10.1080/02640419508732279 · Cited by 48 · see citing works
Suppression of avian hepatic cholesterogenesis by dietary ginseng
Muwalla, M. M., & Abuirmeileh, N. M. (1990) · The Journal of Nutritional Biochemistry · doi:10.1016/0955-2863(90)90034-i · Cited by 31 · see citing works
Lauridsen, S. T., & Mortensen, A. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(98)00234-2 · Cited by 30 · see citing works
Jorge, P. A. R., Neyra, L. C., Ozaki, M. R., & de Almeida, E. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(98)00137-3 · Cited by 19 · see citing works
Effect of aerobic exercise and ginsenosides on lipid metabolism in diet-induced hyperlipidemia mice.
Yang, Y., Wu, T., He, K., et al. (1999) · PubMed · Cited by 19 · see citing works
Taurine Reduces Atherosclerotic Lesion Development in Apolipoprotein E-Deficient Mine
Kondo, Y., Murakami, S., Oda, H., et al. (2002) · Advances in experimental medicine and biology · doi:10.1007/0-306-46838-7_21 · Cited by 17 · see citing works
Hyperlipemia-improving effects of ginsenoside-Rb2 in cholesterol-fed rats.
Yokozawa, T., Kobayashi, T., KAWAI, A., et al. (1985) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.33.722 · Cited by 11 · see citing works
김성수 (2002) · Journal of Ginseng Research · doi:10.5142/jgr.2002.26.2.067 · Cited by 8 · see citing works
김성수 (2002) · Journal of Ginseng Research · doi:10.5142/jgr.2002.26.2.059 · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Plant Adaptogens—History and Future Perspectives
Todorova, V., Ivanov, K., Delattre, C., Nalbantova, V., Karcheva-Bahchevanska, D., & Ivanova, S. (2021) · Nutrients · doi:10.3390/nu13082861 · Cited by 121 · see citing works
Todorova, V., Ivanov, K., & Ivanova, S. (2021) · Plants · doi:10.3390/plants11010064 · Cited by 56 · see citing works
- Authors
- Kim, S.
- Affiliations
- Purdue University West Lafayette (US)
- Corresponding author
- Kim, S
- ORCID
- Kim, S
- Venue
- Pharmacological Research
- Publisher
- Elsevier BV
- Published
- 2003-11
- Volume
- 48
- Issue
- 5
- Pages
- 511-513
- ISSN
- 1043-6618 (ISSN-L)
- OpenAlex
- W2033320316
- Cited by
- 188
- References
- 19
- Citations by year
- 2025: 3 · 2024: 10 · 2023: 4 · 2022: 10 · 2021: 15 · 2020: 11 · 2019: 8 · 2018: 7 · 2017: 6 · 2016: 12 · 2015: 5 · 2014: 10 · 2013: 19 · 2012: 11
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacological Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ginseng Biological Effects and Applications
- Health Sciences › Medicine › Surgery › Natural Products and Biological Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
- Keywords
- Panax ginseng extract, lipid metabolism, hypolipidemic effect, serum cholesterol, triglycerides, LDL cholesterol, HDL cholesterol, malondialdehyde, lipid peroxidation, superoxide dismutase, catalase, antioxidant activity, ginseng
- MeSH terms
- Adult, Antioxidants, Catalase, Cholesterol, Erythrocytes, Panax, Humans, Cholesterol, HDL, Lipoproteins, LDL, Male, Malondialdehyde, Plant Extracts, Superoxide Dismutase, Triglycerides, Lipid Metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
