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Calmodulin Is a Limiting Factor in the Cell
Abstract
The total intracellular concentration of calmodulin (CaM) in the cell appears to be significantly below the total concentration of its targets, making it a limiting factor in their regulation. In this review we discuss the ways in which this is likely to impact signaling. A key conclusion is that competition for a limiting pool of CaM enables cross-talk between CaM-dependent signaling pathways.
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“Activation is also curtailed by insufficient cellular free CaM for all its binding proteins, since a significant fraction of CaM is membrane bound and not available in the cytosol, and the relatively low affinity of unphosphorylated CaMKII for the free Ca2+/CaM (95).”
From Synaptic memory and CaMKII (2023) · cites this paper as [95]
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Metadata
- Authors
- Persechini, A.
- Affiliations
- University of Missouri–Kansas City (US)
- Corresponding author
- Persechini, A
- ORCID
- Persechini, A
- Venue
- Trends in Cardiovascular Medicine
- Publisher
- Elsevier BV
- Published
- 2002-01
- Volume
- 12
- Issue
- 1
- Pages
- 32-37
- ISSN
- 1050-1738 (ISSN-L)
- OpenAlex
- W1976471735
- Cited by
- 148
- References
- 40
- Citations by year
- 2026: 2 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 3 · 2020: 6 · 2019: 7 · 2018: 3 · 2017: 4 · 2016: 5 · 2015: 7 · 2014: 6 · 2013: 3 · 2012: 2
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Cardiovascular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01dk053863-04)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK53863)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
- Keywords
- calmodulin, intracellular calcium signaling, signaling crosstalk, calcium-dependent signaling
- MeSH terms
- Calcium, Calmodulin, Humans, Protein Binding, Protein Processing, Post-Translational, Biosensing Techniques, Signal Transduction
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