The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Calmodulin Is a Limiting Factor in the Cell
Abstract
The total intracellular concentration of calmodulin (CaM) in the cell appears to be significantly below the total concentration of its targets, making it a limiting factor in their regulation. In this review we discuss the ways in which this is likely to impact signaling. A key conclusion is that competition for a limiting pool of CaM enables cross-talk between CaM-dependent signaling pathways.
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“Activation is also curtailed by insufficient cellular free CaM for all its binding proteins, since a significant fraction of CaM is membrane bound and not available in the cytosol, and the relatively low affinity of unphosphorylated CaMKII for the free Ca2+/CaM (95).”
From Synaptic memory and CaMKII (2023) · cites this paper as [95]
Citations
Cites
Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.
Bredt, D. S., & Snyder, S. H. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.2.682 · Cited by 3,308
TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function
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Range of Messenger Action of Calcium Ion and Inositol 1,4,5-Trisphosphate
Allbritton, N. L., Meyer, T., & Stryer, L. (1992) · Science · doi:10.1126/science.1465619 · Cited by 1,146
Calmodulin supports both inactivation and facilitation of L-type calcium channels
Zühlke, R. D., Pitt, G. S., Deisseroth, K. A., Tsien, R. W., & REUTER, H. (1999) · Nature · doi:10.1038/20200 · Cited by 899
Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons
Deisseroth, K. A., Heist, E. K., & Tsien, R. W. (1998) · Nature · doi:10.1038/32448 · Cited by 656
Calmodulin is a subunit of nitric oxide synthase from macrophages.
Cho, H. J., Xie, Q. W., Calaycay, J. R., Mumford, R. A., Swiderek, K. M., Lee, T. D., & Nathan, C. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.176.2.599 · Cited by 635
Structure of the gating domain of a Ca2+-activated K+ channel complexed with Ca2+/calmodulin
Schumacher, M. A., Rivard, A. F., Bächinger, H. P., & Adelman, J. P. (2001) · Nature · doi:10.1038/35074145 · Cited by 604
Ca2+/calmodulin binds to and modulates P/Q-type calcium channels
Lee, A., Wong, S. T., Gallagher, D., Li, B., Storm, D. R., Scheuer, T., & Catterall, W. A. (1999) · Nature · doi:10.1038/20194 · Cited by 480
(1982) · Elsevier eBooks · doi:10.1016/c2013-0-07290-8 · Cited by 418
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Plasma membrane phosphoinositide organization by protein electrostatics
McLaughlin, S., & Murray, D. (2005) · Nature · doi:10.1038/nature04398 · Cited by 868
Greenwald, E. C., Mehta, S., & Zhang, J. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00333 · Cited by 502
Organization and Ca2+Regulation of Adenylyl Cyclases in cAMP Microdomains
Willoughby, D., & Cooper, D. M. F. (2007) · Physiological Reviews · doi:10.1152/physrev.00049.2006 · Cited by 466
Ca2+/Calmodulin-dependent Protein Kinases
Swulius, M. T., & Waxham, M. N. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8086-2 · Cited by 411
Unified Mechanisms of Ca2+ Regulation across the Ca2+ Channel Family
Liang, H., DeMaria, C. D., Erickson, M. G., Mori, M. X., Alseikhan, B. A., & Yue, D. T. (2003) · Neuron · doi:10.1016/s0896-6273(03)00560-9 · Cited by 306
Metadata
- Authors
- Persechini, A.
- Affiliations
- University of Missouri–Kansas City (US)
- Corresponding author
- Persechini, A
- ORCID
- Persechini, A
- Venue
- Trends in Cardiovascular Medicine
- Publisher
- Elsevier BV
- Published
- 2002-01
- Volume
- 12
- Issue
- 1
- Pages
- 32-37
- ISSN
- 1050-1738 (ISSN-L)
- OpenAlex
- W1976471735
- Cited by
- 148
- References
- 40
- Citations by year
- 2026: 2 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 3 · 2020: 6 · 2019: 7 · 2018: 3 · 2017: 4 · 2016: 5 · 2015: 7 · 2014: 6 · 2013: 3 · 2012: 2
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Cardiovascular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01dk053863-04)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK53863)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
- Keywords
- calmodulin, intracellular calcium signaling, signaling crosstalk, calcium-dependent signaling
- MeSH terms
- Calcium, Calmodulin, Humans, Protein Binding, Protein Processing, Post-Translational, Biosensing Techniques, Signal Transduction
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