Glutamine antagonists in chemotherapy

Livingston, R.B.; Venditti, J.M.; Cooney, D.A.; Carter, S.K.

doi:10.1016/s1054-3589(08)60594-3

Cited by 60Amino Acid Enzymes and MetabolismCancer Research and TreatmentsBiochemical and Molecular Research

Glutamine antagonists in chemotherapy

Livingston, R.B., Venditti, J.M., Cooney, D.A., Carter, S.K.·1971·Advances in Pharmacology

DOI 10.1016/s1054-3589(08)60594-3

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Clinical trials using glutamine analogues were abandoned due to lack of efficacy and/or severe toxicity, likely because the drugs were relatively non-specific and affected many glutamine-utilizing enzymes.
“Clinical trials using glutamine analogues to treat cancers were initiated decades ago, but these trials were abandoned due to lack of efficacy and/or severe patient toxicity (Livingston et al., 1970; O’Dwyer et al., 1984). The absence of a therapeutic window for these studies can likely be attributed to fact that these drugs were relatively non-specific and a panoply of glutamine utilizing enzymes”
From Targeting Metabolism for Cancer Therapy (2017) · cites this paper as Livingston et al., 1970

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Authors: Livingston, R. B., Venditti, J. M., Cooney, D. A., & Carter, S. K.
Affiliations: National Institutes of Health (US)
Venue: Advances in Pharmacology
Publisher: Elsevier
Published: 1971
Volume: 8
Pages: 57-120
ISSN: 1054-3589 (ISSN-L)
DOI: 10.1016/s1054-3589(08)60594-3
OpenAlex: W1438529674
Cited by: 60
References: 75
Citations by year: 2026: 1 · 2025: 4 · 2024: 1 · 2023: 4 · 2022: 2 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 1 · 2014: 1 · 2013: 2
FWCI: 2.36
Type: book chapter
Language: en
Open access: closed
Locations: Advances in pharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Cancer Research and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
Keywords: glutamine antagonist, L-asparaginase, azaserine, glutaminase, combination chemotherapy, anticancer agents, Escherichia coli asparaginase
MeSH terms: Adult, Aminobutyrates, Animals, Asparaginase, Azaserine, Azo Compounds, Child, Diazooxonorleucine, Drug Combinations, Drug Interactions, Glutaminase, Glutamine, Glutamate-Ammonia Ligase, Humans, Hydroxylysine, Leukemia, Leukemia L1210, Liver, Methionine Sulfoximine, Neoplasms, RNA, Transfer, Mice, Rats

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Glutamine antagonists in chemotherapy

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