Positron emission tomography radioligands for dopamine transporters and studies in human and nonhuman primates
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At therapeutic doses, methylphenidate blocks 60% to 70% of striatal dopamine transporters.
“At therapeutic doses, methylphenidate blocks 60% to 70% of striatal dopamine transporters (DAT) (13)”
From Effects of stimulants on brain function in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis (2014) · cites this paper as [13]
Methylphenidate's key mechanism of action is blockade of over 50% of striatal DAT, leading to increased striatal dopamine release.
“The explorative analysis at a more lenient threshold revealed an additional increase in right putamen activation, in line with the key mechanism of action of methylphenidate of the blockade of over 50% of striatal DAT, leading to increased striatal dopamine release (13).”
From Effects of stimulants on brain function in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis (2014) · cites this paper as [13]
Cites
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Self-citationRelationship between psychostimulant-induced "high" and dopamine transporter occupancy.
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- Authors
- Volkow, N. D., Fowler, J. S., Ding, Y.-S., Wang, G.-J., & Gatley, S. J.
- Affiliations
- State University of New York (US)
- Brookhaven National Laboratory (US)
- ORCID
- Volkow, N.D.
- Venue
- Advances in Pharmacology
- Publisher
- Elsevier
- Published
- 1997
- Volume
- 42
- Pages
- 211-214
- ISSN
- 1054-3589 (ISSN-L)
- OpenAlex
- W1561875607
- Cited by
- 26
- References
- 6
- Citations by year
- 2019: 2 · 2018: 1 · 2017: 1 · 2015: 2 · 2013: 3 · 2012: 1
- FWCI
- 1.30
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Advances in pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Energy
- National Institutes of Health (5r01da009490-08)
- National Institute on Drug Abuse (DA 09490-01, DA-06891, DA-06278, R01DA006278, R01DA006891)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiopharmaceutical Chemistry and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Keywords
- dopamine transporter, PET radiotracer, cocaine, methylphenidate, psychostimulants, non-human primates, baboon brain, radioligand kinetics
- MeSH terms
- Animals, Brain, Carbon Radioisotopes, Carrier Proteins, Cocaine, Dopamine, Humans, Membrane Glycoproteins, Methylphenidate, Nerve Tissue Proteins, Parkinson Disease, Primates, Radioligand Assay, Reference Values, Tomography, Emission-Computed, Dopamine Uptake Inhibitors, Radiopharmaceuticals, Substance-Related Disorders, Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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