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Reliability and validity of the Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index in Italian patients with osteoarthritis of the knee
Open accessAbstract
Objective The Western Ontario and McMaster Universities (WOMAC) Osteoarthritis (OA) Index is a tested questionnaire to assess symptoms and physical functional disability in patients with OA of the knee and the hip. We adapted the WOMAC for the Italian language and tested its metric properties in 304 patients with symptomatic OA of the knee.Methods Three hundred and four consecutive patients, attending 29 rheumatologic outpatient clinic in northern, central, and southern Italy, were asked to answer two disease-specific questionnaires (WOMAC and Lequesne algofunctional index) and one generic instrument (Medical Outcomes Study SF-36 Health Survey-MOS SF-36). A sample of 258 patients was readministered the WOMAC 7-10 days after the first visit and the structured interview, which also assessed demographic and other characteristics. Internal consistency was assessed using Cronbach's alpha, reliability using intraclass correlation coefficients (ICCs), and construct and discriminant validity using Spearman's correlations, Wilcoxon rank sum test, and Kruskal-Wallis test.Results All WOMAC subscales (pain, stiffness, and physical function) were internally consistent with Cronbach's coefficient alpha of 0.91, 0.81, and 0.84, respectively. Test-retest reliability was satisfactory with ICCs of 0.86, 0.68, and 0.89, respectively. In comparison with the SF-36, the expected correlations were found when comparing items measuring similar constructs, supporting the concepts of convergent construct validity. Very high correlations were also obtained between WOMAC scores and Lequesne OA algofunctional index. WOMAC physical function, but not WOMAC stiffness and pain subscales, was weakly associated with radiological OA severity (P=0.03). Also, WOMAC pain score was inversely correlated (P=0.01) with years of formal education. Examination of discriminant validity showed that the scores on the WOMAC and SF-36 followed hypothesized patterns: the WOMAC discriminated better among subjects with varying severity of knee problems, whereas the SF-36 discriminated better among subjects with varying levels of self-reported health status and comorbidity.Conclusion The Italian version of WOMAC is a reliable and valid instrument for evaluating the severity of OA of the knee, with metric properties in agreement with the original, widely used version.
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“The Italian translation of the WOMAC showed adequate internal consistency, test-retest reliability, and construct validity.25”
From Acceptance and commitment therapy for prevention of chronic pain after total knee arthroplasty. (2026) · cites this paper as [25]
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“Construct validity For construct validation [13], it was hypothesized a priori the HAAS would achieve moderate to high correlations with: (a) disability, the Italian version of Western Ontario and McMaster University index (WOMAC) for THA [14] and the Italian version of the Knee injury and Osteoarthritis Outcome Scale…”
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“moderate clinically important difference (moderate CID) and really important difference (RID) for improvement in VAS and SF-36 pain as changes corresponding to 10, 20 and 50 mm improvement on patient global assessment (anchor). A cut-off of 10 mm for defining MCID is consistent with a similar cut-off used in previous…”
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“The following Patient-reported Outcome Measures (PROMs) were used: Western Ontario & McMaster Uni-versities Osteoarthritis (WOMAC) [29], Knee Injury and Osteoarthritis Outcome Score (KOOS), International Knee Documentation Committee (IKDC) subjective score, visual analogue scale (VAS), TEGNER…”
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“Knee pain was categorized into four groups based on the WOMAC pain score: no pain (score = 0), mild pain (0 score 4), moderate pain (score ≥ 4), and severe pain (score ≥ 8) 13,35,36 .”
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“The patients were assessed according to the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score (11) at baseline (T0) and after 2 months (T2).”
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“Secondary outcomes were: appendicular muscle strength assessed by hand grip strength test (HGS) [37] using the Jamar hydraulic hand dynamometer (Sammons Preston, Rolyon, Bolingbrook, IL, USA); the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) to assess pain, joint stiffness and function [38];…”
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“The WOMAC questionnaire is a self-administered disease-specific validated outcome measure, and it was used to assess pain, stiffness, and physical function disability in patients suffering from knee and hip osteoarthritis [23].”
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“25,26 The SF-36 is a widely used health-related quality of life questionnaire that measures various aspects of physical and mental health.”
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“or may not be symptomatic, and the associated radiographs are either normal or abnormal.(3) To date, the management strategies for OA have been directed at symptoms, primarily pain.”
Cementless total hip arthroplasty in the treatment after acetabular fractures
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Targeting Neuroinflammation in Osteoarthritis with Intra-Articular Adelmidrol
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“Ranges of the WOMAC scores were: pain (0–50); stiffness (0–20), and functional limitation (0–170) [74].”
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“All WOMAC subscales (pain, stiffness, and physical function) have satisfactory test-retest reliability with ICCs of 0.86, 0.68, and 0.89 ( Nakarmi, Haq & Vaidya, 2019 ; Salaffi et al., 2003 ).”
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“The WOMAC test–retest reliability was satisfactory with ICCs of 0.86, 0.68 and 0.89, respectively (Salaffi et al. 2003).”
MethodInfluentialWu, Y., Li, T., Lee, K.-C., Lam, K. H. S., Chang, C.-Y., Chang, C.-K., & Chen, L. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11113241 · Cited by 18
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“All WOMAC subscales (pain, stiffness, and physical function) were internally consistent with Cronbach’s coefficient alpha of 0.91, 0.81, and 0.84, respectively (Salaffi et al., 2003).”
MethodInfluentialExploring the efficacy of low-level laser therapy and exercise for knee osteoarthritis
Kholvadia, A., Constantinou, D., & Gradidge, P. J.-L. (2019) · South African Journal of Sports Medicine · doi:10.17159/2078-516x/2019/v31i1a6058 · Cited by 16
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“Data considered for quantitative analysis consisted of the hip-knee-ankle (HKA) angle, the Western Ontario and McMaster Universities (WOMAC) questionnaire [12, 13] to assess pain, physical function disability and stiffness, and the Knee Society Score (KSS) [14, 15] to rate patient’s knee and functional abilities.”
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Trovato, B., Petrigna, L., Sortino, M., Roggio, F., & Musumeci, G. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e14136 · Cited by 16
Evaluation of the effect of D-002, a mixture of beeswax alcohols, on osteoarthritis symptoms
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“function scores are highly correlated [41].”
Bhatia, A., Goni, V. G., Chopra, S., Singh, B., & Katare, O. P. (2020) · Contemporary Clinical Trials Communications · doi:10.1016/j.conctc.2020.100664 · Cited by 15
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“The WOMAC consists of 24 items, rated on a five point Likert scale, and divided into 3 sub-scales [23,24]:”
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“In this study, the WOMAC scale was used to evaluate the functional status of lower extremities suffering from KOA by assessing 17 functional ADLs, five pain-related activities, and two stiffness categories [30].”
MethodAladraii, A. A., Allehaibi, L., Fattani, A. A., Alkhudairy, T. A., Margan, A. M. A., Al‐Dubai, S. A. R., Mohammed, A. A., Mohorjy, D. K., & Alqarni, A. S. (2024) · Saudi Journal of Medicine and Medical Sciences · doi:10.4103/sjmms.sjmms_237_23 · Cited by 12
“[9,10] The current study found better functional outcome in the medial parapatellar compared with the subvastus approach at 3 and 6 months, which is in contrast with the findings of previous studies that have reported that the subvastus approach has a significantly better functional outcome in the…”
ResultCeballos‐Laita, L., Jiménez‐del‐Barrio, S., Marín-Zurdo, J., Moreno-Calvo, A., Marín, J., Albarova‐Corral, I., & Estébanez-de-Miguel, E. (2022) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2022.101667 · Cited by 12
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“a sitting or lying position, standing, bending, walking, getting in and out of a car, shopping, putting on or taking off socks, lying in bed, getting in or out of a bath, sitting and heavy and light household duties [20,21].”
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“The WOMAC is a measure of symptoms and physical impairment originally designed for patients presenting with osteoarthritis (OA) of the hip or knee [11] by evaluating five pain-related activities, two stiffness categories, and 17 functional activities [11,12].”
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“…changes from baseline to the study conclusion in patient-reported pain at rest and during movement, clinically measured range of motion, and overall patient-reported WOMAC scores [20]-including its three subscales assessing pain, stiffness, and physical function [20]-in the HA and Glc + CS groups.”
BackgroundInfluentialKiafzezi, D., Stamati, A., Karagiannis, T., Goulis, D. G., & Christoforidis, A. (2024) · Calcified Tissue International · doi:10.1007/s00223-024-01250-z · Cited by 10
“It includes three subscales: pain, stiffness, and physical function, and the scores from each subscale are then combined to provide an overall assessment of the individual's condition [54].”
Salaffi, F., Carotti, M., Farah, S., Ciccullo, C., Gigante, A. P., Bandinelli, F., & Carlo, M. D. (2025) · Journal of Personalized Medicine · doi:10.3390/jpm15010022 · Cited by 10
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“WOMAC is a widely used, reliable, valid, and responsive measure of treatment outcomes in patients with OA of the knee (16, 17).”
MethodVenditto, T. (2017) · Muscles Ligaments and Tendons Journal · doi:10.11138/mltj/2017.7.2.331 · Cited by 10
Kon, E., Altadonna, G., Filardo, G., Matteo, B. D., & Marcacci, M. (2014) · Springer eBooks · doi:10.1007/978-3-642-34746-7_120 · Cited by 10
“telephone, computer based, and touchscreen administration are all suitable ways of completing the test [25–28], which has also been adapted in more than 60 languages [29–36].”
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Effect of an Innovative Biofeedback Insole on Patient Rehabilitation after Total Knee Arthroplasty
Castellarin, G., Merlini, M., Bettinelli, G., Riso, R., Bori, E., & Innocenti, B. (2022) · Applied Sciences · doi:10.3390/app12052456 · Cited by 9
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Cross-Culturally Adapted Versions of Patient Reported Outcome Measures for the Lower Extremity
Zhang, Y., Ren, J., Zang, Y., Guo, W., Disantis, A. E., & Martin, R. L. (2023) · International Journal of Sports Physical Therapy · doi:10.26603/001c.74528 · Cited by 9
Rizvi, M. R., Sharma, A., Hasan, S., Ahmad, F., Asad, M. R., Iqbal, A., & Alghadir, A. H. (2023) · Scientific Reports · doi:10.1038/s41598-023-45908-4 · Cited by 9
“The WOMAC is a self-administered validated questionnaire used for the assessment of hip and knee OA 15 .”
MethodBhatia, A. M., & Bhatia, S. S. (2023) · Journal of Orthopaedics · doi:10.1016/j.jor.2023.03.009 · Cited by 9
Punzi, L., & Ramonda, R. (2005) · Aging Clinical and Experimental Research · doi:10.1007/bf03324606 · Cited by 9
Ippolito, M., Spurio, G., Compagno, V., Rizzo, A., Simone, M. D., Corsale, A. M., Mazzola, G., Giarratano, A., Meraviglia, S., Cortegiani, A., et al. (2022) · British Journal of Pain · doi:10.1177/20494637221134169 · Cited by 8
Klenow, T. D., Kahle, J. T., Fedel, F. J., Ropp, J., & Highsmith, M. J. (2017) · JPO Journal of Prosthetics and Orthotics · doi:10.1097/jpo.0000000000000135 · Cited by 8
Role of geniculate artery embolization in the treatment of knee pain secondary to osteoarthritis
Shaker, M., Mahmoud, M. S. S., Nassar, W. A. M., ElShimy, A. M. S., & Nasser, H. M. (2023) · The Egyptian Journal of Radiology and Nuclear Medicine · doi:10.1186/s43055-023-00984-4 · Cited by 8
Postoperative scores for robot-assisted and conventional total knee arthroplasty: A meta-analysis
Ward, G. H., & Montalbano, M. J. (2023) · Journal of Clinical Orthopaedics and Trauma · doi:10.1016/j.jcot.2023.102189 · Cited by 8
Prevalence and Characteristics of Knee Osteoarthritis Among the General Public in Saudi Arabia
Bashekah, K. A., Zagzoug, M. E., Banaja, A. W., Alghamdi, A. A., Mishiming, O. S., Jan, M. A., Kemawi, O. A., Alharbi, B. A., Althagafi, A. A., & Aljifri, S. M. (2023) · Cureus · doi:10.7759/cureus.47666 · Cited by 8
“Other studies in Italy [39], Germany [40], and Turkey [41] showed similar results to the Moroccan study.”
ResultKhuman, P. R., Chavda, D., Surbala, L., & Bhatt, U. (2018) · Physiotherapy - The Journal of Indian Association of Physiotherapists · doi:10.4103/pjiap.pjiap_21_17 · Cited by 8
Translation, validation and cross‐cultural adaptation of the Nepali version of WOMAC® LK 3.1
Nakarmi, S., Haq, S. A., & Vaidya, B. (2019) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.13690 · Cited by 8
Nannoni, G., Volterrani, G., Mattarocci, A., Minoretti, P., & Emanuele, E. (2020) · Drug Discoveries & Therapeutics · doi:10.5582/ddt.2020.03034 · Cited by 8
Ayhan, F. F., Çoban, A. D., Karasu, A. U., Karaoğlan, B., Çınar, E., Eyigör, S., Uzun, Ö., Borman, P., Vural, S. P., Yaman, A., et al. (2024) · Turkish Journal of Physical Medicine and Rehabilitation · doi:10.5606/tftrd.2024.13735 · Cited by 8
Galluccio, F., D’Angela, D., Polistena, B., Porta, F., Barskova, T., Tofani, L., Spandonaro, F., & Matucci‐Cerinic, M. (2021) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x21994024 · Cited by 7
Effects of extracorporeal shockwave therapy for mild knee osteoarthritis: A pilot study
Choi, I. J., Jeon, J. H., Choi, W.-H., & Yang, H.-E. (2023) · Medicine · doi:10.1097/md.0000000000036117 · Cited by 7
“[10] This WOMAC index consists of 24 items divided into 3 subscales that evaluate pain, stiffness, and function.”
Cissus QuadrangularisReduces Joint Pain in Exercise-Trained Men: A Pilot Study
Bloomer, R. J., Farney, T. M., McCarthy, C. G., & Lee, S.-R. (2013) · The Physician and Sportsmedicine · doi:10.3810/psm.2013.09.2021 · Cited by 7
Belo, J. N., Bierma‐Zeinstra, S., Terwee, C. B., Heintjes, E. M., & Koes, B. W. (2008) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2008.02.006 · Cited by 7
“An example is the validation of the WOMAC in an Italian population [ 33 ].”
MethodOnigbinde, A. T., Owolabi, R. A., Kamil, L., Isaac, S. O., & Ibikunle, A. F. (2018) · Hong Kong Physiotherapy Journal · doi:10.1142/s1013702518500075 · Cited by 7
“Physical function was assessed using the WOMAC OS Questionnaire.(18) The physical function subscale was used to assess functional abilities of patients in this study.”
MethodHow to Manage Metallosis: A Retrospective Cohort Analysis after Revision Hip Surgery
Bruschetta, A., Palco, M., Fenga, D., Giuca, G., Holzer, L. A., Alito, A., Cacciola, G., Meo, F. D., & Cavaliere, P. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12144809 · Cited by 6
Balance confidence and associated factors among patients with knee osteoarthritis
John, J. N., Ugwu, C. O., John, D. O., Okezue, O. C., Mgbeojedo, U. G., & Onuorah, O. C. (2024) · Journal of Bodywork and Movement Therapies · doi:10.1016/j.jbmt.2024.05.009 · Cited by 6
Silveira, J., Oliveira, D. S., Martins, A. C., Costa, L. M. S. F., Neto, F. L. M., Ferreira‐Gomes, J., & Vaz, C. (2024) · ARP Rheumatology · doi:10.63032/sdvb2224 · Cited by 6
Thigh muscle features in female patients with severe knee osteoarthritis: a cross-sectional study
Liu, T., Xie, H., Yan, S., Zeng, J., & Zhang, K. (2025) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-025-08361-0 · Cited by 6
“The WOMAC score, widely utilized for assessing the primary symptoms of KOA in daily living, serves as a critical tool for evaluating the severity and progression of the disease [77].”
Park, J., & Herron, C. (2021) · Alternative and Complementary Therapies · doi:10.1089/act.2021.29326.jpa · Cited by 6
Landrino, M., Alberio, R. L., Clemente, A., & Grassi, F. A. (2022) · Orthopedic Reviews · doi:10.52965/001c.37889 · Cited by 6
Early results with a bicruciate-retaining total knee arthroplasty: a match-paired study
Biazzo, A., D’Ambrosi, R., Staals, E. L., Masia, F., Izzo, V., & Verde, F. (2020) · European Journal of Orthopaedic Surgery & Traumatology · doi:10.1007/s00590-020-02834-9 · Cited by 6
Dadalto, T. V., de Souza, C. P., & da Silva, E. B. (2013) · Fisioterapia em Movimento · doi:10.1590/s0103-51502013000400007 · Cited by 6
Monticone, M., Ambrosini, E., Secci, C., Rocca, B., Ferrante, S., & Capone, A. (2016) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/phm.0000000000000609 · Cited by 6
“We used the adapted Italian version.(15) At the end of treatment, we also evaluated the global perceived effect (GPE) using the question: “Overall, how much did the treatment you received help your hip problem?”; the GPE was determined using a 7-level Likert scale with 2 improvement levels (helped a lot = 1, helped =…”
MethodCOMPARING QUALITY OF LIFE AMONG PEOPLE WITH DIFFERENT PATTERNS AND SEVERITIES OF KNEE OSTEOARTHRITIS
Tangtrakulwanich, B., Chongsuvivatwong, V., & Geater, A. F. (2006) · Journal of Musculoskeletal Research · doi:10.1142/s0218957706001650 · Cited by 6
Adhya, B., Singh, A., Kumari, P., Saini, S. K., & Singh, B. (2021) · Journal of Postgraduate Medicine Education and Research · doi:10.5005/jp-journals-10028-1450 · Cited by 5
Song, J.-L., Ye, Z.-Q., Li, W., Chen, Z., Wang, X.-W., & Chen, W. (2025) · PLoS ONE · doi:10.1371/journal.pone.0319482 · Cited by 4
“The reliability of the WOMAC pain and physical function subscales in this study was high (ICC = 0.86 and 0.89, respectively) [26].”
Influential
Metadata
- Authors
- Salaffi, F., Leardini, G., Canesi, B., Mannoni, A., Fioravanti, A., Caporali, R., Lapadula, G., & Punzi, L.
- Affiliations
- Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT)
- Azienda Sanitaria di Firenze (IT)
- University of Siena (IT)
- University of Pavia (IT)
- Azienda Universitaria Ospedaliera Consorziale - Policlinico Bari (IT)
- University of Padua (IT)
- Corresponding author
- Salaffi, F
- Venue
- Osteoarthritis and Cartilage
- Publisher
- Elsevier BV
- Published
- 2003-08
- Volume
- 11
- Issue
- 8
- Pages
- 551-560
- ISSN
- 1063-4584 (ISSN-L)
- OpenAlex
- W2087139148
- Cited by
- 331
- References
- 71
- Citations by year
- 2026: 22 · 2025: 33 · 2024: 28 · 2023: 33 · 2022: 25 · 2021: 16 · 2020: 23 · 2019: 13 · 2018: 18 · 2017: 16 · 2016: 10 · 2015: 12 · 2014: 16 · 2013: 6 · 2012: 11
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Osteoarthritis and Cartilage (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- Topics
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Health Sciences › Medicine › Surgery › Total Knee Arthroplasty Outcomes
- Keywords
- knee osteoarthritis, questionnaire reliability, construct validity, test-retest reliability, SF-36, Lequesne algofunctional index, pain, stiffness, physical function, radiographic severity, educational attainment, health status, comorbidities, patient-reported outcomes, cross-cultural adaptation, Italy, North America
- MeSH terms
- Aged, Aged, 80 and over, Cross-Sectional Studies, Disability Evaluation, Female, Humans, Italy, Male, Middle Aged, Pain, Surveys and Questionnaires, Reproducibility of Results, Cohort Studies, Comorbidity, Muscle, Skeletal, Osteoarthritis, Knee
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