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The Potent Somatostatin Analogue Vapreotide Does Not Decrease Pancreas-Specific Complications After Elective Pancreatectomy: A Prospective, Multicenter, Double-Blinded, Randomized, Placebo-Controlled Trial
Abstract
BACKGROUND: Pancreatectomy can be complicated by pancreatic anastomotic leakage, causing major morbidity. STUDY DESIGN: Our aim was to determine if vapreotide, a potent long-acting somatostatin analogue, would decrease pancreas-related complications. This prospective, multicenter, randomized, double-blind, placebo-controlled trial involved 275 patients without preexisting chronic pancreatitis undergoing elective proximal, central, or distal pancreatectomy. Complications were defined by objective criteria before beginning the study. RESULTS: One hundred thirty-five patients received vapreotide; 140 patients received placebo. There were no statistically significant differences between vapreotide- and placebo-treated patients in either pancreas-related complications (30.4% versus 26.4%, respectively) or in other complications not directly related to the pancreas (40% versus 42%, respectively). CONCLUSIONS: The potent somatostatin analogue vapreotide does not appear to decrease postoperative complications after major pancreatectomy in patients without chronic pancreatitis.
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Cited by
Pasireotide for Postoperative Pancreatic Fistula
Allen, P. J., Gönen, M., Brennan, M. F., Bucknor, A. A., Robinson, L. M., Pappas, M. M., Carlucci, K. E., D'Angelica, M. I., DeMatteo, R. P., Kingham, T. P., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1313688 · Cited by 438
Surgery for Pancreatic Cancer: Recent Controversies and Current Practice
Wray, C. J., Ahmad, S. A., Matthews, J. B., & Lowy, A. M. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.03.035 · Cited by 259
Klek, S., Forbes, A., Gabe, S., Holst, M., Wanten, G., Irtun, Ø., Damink, S. O., Panisic-Sekeljic, M., Pelaez, R. B., Pironi, L., et al. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.04.009 · Cited by 180
Metadata
- Authors
- Sarr, M. G.
- Venue
- Journal of the American College of Surgeons
- Published
- 2003-04
- Volume
- 196
- Issue
- 4
- Pages
- 556-564
- ISSN
- 1072-7515 (ISSN-L)
- OpenAlex
- W2035476720
- Cited by
- 173
- References
- 0
- FWCI
- 4.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Potent Somatostatin Analogue Vapreotide Does Not Decrease Pancreas-Specific Complications After Elective Pancreatectomy: A Prospective, Multicenter, Double-Blinded, Randomized, Placebo-Controlled Trial. https://app.cochat.ai/papers/10.1016/s1072-7515(03)00104-2
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- Sarr, M. G. (2003). The Potent Somatostatin Analogue Vapreotide Does Not Decrease Pancreas-Specific Complications After Elective Pancreatectomy: A Prospective, Multicenter, Double-Blinded, Randomized, Placebo-Controlled Trial. Journal of the American College of Surgeons. https://doi.org/10.1016/s1072-7515(03)00104-2
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