The DOI matches its Crossref record; 23 of the 24 references it cites were found in a registry or an index.
How Taxol® stabilises microtubule structure
Open accessAbstract
The structure of tubulin shows paclitaxel (Taxol(R)) binding to a pocket in beta tubulin on the microtubule's inner surface, which counteracts the effects of GTP hydrolysis occurring on the other side of the monomer.
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“The binding of paclitaxel counters the conformational effect of GTP-hydrolysis on microtubules, stabilizing microtubules against depolymerization.69,70”
From Electronic energy migration in microtubules (2023) · cites this paper as [70]
Citations
Cites
MICROTUBULE POLYMERIZATION DYNAMICS
Desai, A. B., & Mitchison, T. J. (1997) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.13.1.83 · Cited by 2,660
Structure of the αβ tubulin dimer by electron crystallography
Nogales, E., Wolf, S., & Downing, K. (1998) · Nature · doi:10.1038/34465 · Cited by 1,623
High-Resolution Model of the Microtubule
Nogales, E., Whittaker, M., Milligan, R. A., & Downing, K. H. (1999) · Cell · doi:10.1016/s0092-8674(00)80961-7 · Cited by 1,200
Crystal structure of the bacterial cell-division protein FtsZ
Löwe, J., & Amos, L. (1998) · Nature · doi:10.1038/34472 · Cited by 920
Self-citationTubulin and FtsZ form a distinct family of GTPases
Nogales, E., Downing, K. H., Amos, L., & L�we, J. (1998) · Nature Structural Biology · doi:10.1038/nsb0698-451 · Cited by 614
Self-citationGuanine nucleotide-dependent assembly of FtsZ into filaments
Mukherjee, A. K., & Lutkenhaus, J. (1994) · Journal of Bacteriology · doi:10.1128/jb.176.9.2754-2758.1994 · Cited by 379
Rigidity of microtubules is increased by stabilizing agents.
Mickey, B., & Howard, J. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.130.4.909 · Cited by 333
Kurachi, M., Hoshi, M., & Tashiro, H. (1995) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.970300306 · Cited by 279
Tubulin and microtubule structure
Downing, K. H., & Nogales, E. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80082-3 · Cited by 273
Analysis of microtubule rigidity using hydrodynamic flow and thermal fluctuations.
Venier, P., Maggs, A. C., Carlier, M., & Pantaloni, D. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36840-0 · Cited by 259
Cited by
Sorted by citations
Refined structure of αβ-tubulin at 3.5 Å resolution 1 1Edited by I. A. Wilson
Löwe, J., Li, H., Downing, K. H., & Nogales, E. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.5077 · Cited by 1,169
Self-citationStructural Insights into Microtubule Function
Nogales, E. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.277 · Cited by 796
Alushin, G. M., Lander, G. C., Kellogg, E. H., Zhang, R., Baker, D., & Nogales, E. (2014) · Cell · doi:10.1016/j.cell.2014.03.053 · Cited by 696
Medicinal Plants: Their Use in Anticancer Treatment.
Greenwell, M., & Rahman, P. K. S. M. (2015) · International Journal of Pharmaceutical Sciences and Research · doi:10.13040/ijpsr.0975-8232.6(10).4103-12 · Cited by 656
An Inhibitor of FtsZ with Potent and Selective Anti-Staphylococcal Activity
Haydon, D. J., Stokes, N. R., Ure, R., Galbraith, G., Bennett, J. M., Brown, D. R., Baker, P. J., Barynin, V. V., Rice, D. W., Sedelnikova, S. E., et al. (2008) · Science · doi:10.1126/science.1159961 · Cited by 452
Metadata
- Authors
- Amos, L. A., & Löwe, J.
- Affiliations
- MRC Laboratory of Molecular Biology (GB)
- Venue
- Chemistry & Biology
- Publisher
- Elsevier BV
- Published
- 1999-03
- Volume
- 6
- Issue
- 3
- Pages
- R65-R69
- ISSN
- 1074-5521 (ISSN-L)
- OpenAlex
- W2025691233
- Cited by
- 248
- References
- 24
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 1 · 2023: 10 · 2022: 10 · 2021: 4 · 2020: 4 · 2019: 7 · 2018: 9 · 2017: 15 · 2016: 9 · 2015: 13 · 2014: 16 · 2013: 10 · 2012: 11
- FWCI
- 2.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Chemistry & Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
- Physical Sciences › Chemistry › Organic Chemistry › Heterocyclic Compound Synthesis and Bioactivity
- Keywords
- paclitaxel, microtubule stabilization, beta-tubulin, GTP hydrolysis, microtubule dynamics, drug binding sites
- MeSH terms
- Amino Acid Sequence, Animals, Antineoplastic Agents, Phytogenic, Humans, Microtubules, Molecular Sequence Data, Protein Conformation, Paclitaxel
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