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How Taxol® stabilises microtubule structure
Open accessAbstract
The structure of tubulin shows paclitaxel (Taxol(R)) binding to a pocket in beta tubulin on the microtubule's inner surface, which counteracts the effects of GTP hydrolysis occurring on the other side of the monomer.
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“The binding of paclitaxel counters the conformational effect of GTP-hydrolysis on microtubules, stabilizing microtubules against depolymerization.69,70”
From Electronic energy migration in microtubules (2023) · cites this paper as [70]
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Metadata
- Authors
- Amos, L. A., & Löwe, J.
- Affiliations
- MRC Laboratory of Molecular Biology (GB)
- Venue
- Chemistry & Biology
- Publisher
- Elsevier BV
- Published
- 1999-03
- Volume
- 6
- Issue
- 3
- Pages
- R65-R69
- ISSN
- 1074-5521 (ISSN-L)
- OpenAlex
- W2025691233
- Cited by
- 248
- References
- 24
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 1 · 2023: 10 · 2022: 10 · 2021: 4 · 2020: 4 · 2019: 7 · 2018: 9 · 2017: 15 · 2016: 9 · 2015: 13 · 2014: 16 · 2013: 10 · 2012: 11
- FWCI
- 2.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Chemistry & Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
- Physical Sciences › Chemistry › Organic Chemistry › Heterocyclic Compound Synthesis and Bioactivity
- Keywords
- paclitaxel, microtubule stabilization, beta-tubulin, GTP hydrolysis, microtubule dynamics, drug binding sites
- MeSH terms
- Amino Acid Sequence, Animals, Antineoplastic Agents, Phytogenic, Humans, Microtubules, Molecular Sequence Data, Protein Conformation, Paclitaxel
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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