Nuclear factor of activated T cells 1 (NFAT1)-induced permissive chromatin modification facilitates nuclear factor-κB (NF-κB)-mediated interleukin-9 (IL-9) transactivation
Open accessAbstract
IL-9 regulates diverse inflammatory immune responses. Although the functional importance of IL-9 has been investigated in various pathophysiological conditions, molecular mechanisms by which TCR stimulation induced IL-9 gene expression are still unclear. In this study, we investigated the functional importance of the NFAT1 and NF-κB (p65) in IL-9 gene transcription in CD4(+) T cells. In vivo binding of NFAT1 and NF-κB (p65) to the IL-9 promoter was observed. NFAT1 binding induced a transcriptionally active chromatin configuration at the IL-9 promoter locus, whereas NF-κB (p65) binding transactivated the IL-9 promoter. Mouse deficient in NFAT1 shows a significant down-regulation of IL-9 expression that resulted from an inaccessible chromatin configuration at the IL-9 promoter. In parallel, knockdown of NF-κB (p65) also resulted in reduced IL-9 expression. In this process, NFAT1 plays a pivotal role as a core protein that creates an accessible platform for the assembly of transcription activators. The presence of NFAT1 correlates with recruitment of NF-κB (p65), p300, and active histone markers on the IL-9 promoter, resulting in a transcriptionally competent promoter. NFAT1 deficiency significantly reduced the recruitment of the above activation complex to the IL-9 promoter. In summary, our data suggest that functional cooperation of NFAT1 and NF-κB synergistically enhances IL-9 transcription in CD4(+) T cells.
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Gcn5-dependent histone acetylation probably increases binding of T cell receptor-induced factors such as NF-κB or NFAT that matter for Il9 expression after antigen receptor stimulation, or may help general transcription factors including RNA polymerase II.
“Gcn5-dependent histone acetylation likely increases binding of T cell receptor-induced factors such as NF-κB or NFAT that are important for Il9 gene expression following antigen receptor stimulation (27) or may facilitate the function of general transcription factors including RNA polymerase II (49).”
From Gcn5 Is Required for PU.1-Dependent IL-9 Induction in Th9 Cells (2012) · cites this paper as [27]
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Cites
THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
Baldwin, A. S. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.649 · Cited by 5,882 · see citing works
Function and Activation of NF-kappaB in the Immune System
Baeuerle, P. A., & Henkel, T. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.001041 · Cited by 4,745 · see citing works
VISTA: computational tools for comparative genomics
Frazer, K. A., Pachter, L. S., Poliakov, A., Rubin, E. M., & Dubchak, I. L. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh458 · Cited by 2,791 · see citing works
TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function
Rao, A., Luo, C. H., & Hogan, P. G. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.707 · Cited by 2,592 · see citing works
Signal transduction by lymphocyte antigen receptors
Weiss, A., & Littman, D. R. (1994) · Cell · doi:10.1016/0092-8674(94)90334-4 · Cited by 2,088 · see citing works
Transcriptional regulation by calcium, calcineurin, and NFAT
Hogan, P. G., Chen, L., Nardone, J., & Rao, A. (2003) · Genes & Development · doi:10.1101/gad.1102703 · Cited by 1,991 · see citing works
IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells
Korn, T., Bettelli, E., Gao, W., Awasthi, A., Jäger, A., Strom, T. B., Oukka, M., & Kuchroo, V. K. (2007) · Nature · doi:10.1038/nature05970 · Cited by 1,841 · see citing works
NFAT proteins: key regulators of T-cell development and function
Macián, F. (2005) · Nature reviews. Immunology · doi:10.1038/nri1632 · Cited by 1,575 · see citing works
Plasticity of CD4+ T Cell Lineage Differentiation
Zhou, L., Chong, M. M. W., & Littman, D. R. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.001 · Cited by 1,551 · see citing works
IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis
Komiyama, Y., Nakae, S., Matsuki, T., Nambu, A., Ishigame, H., Kakuta, S., Sudo, K., & Iwakura, Y. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.1.566 · Cited by 1,536 · see citing works
Veldhoen, M., Uyttenhove, C., van Snick, J., Helmby, H., Westendorf, A., Buer, J., Martin, B., Wilhelm, C., & Stockinger, B. (2008) · Nature Immunology · doi:10.1038/ni.1659 · Cited by 1,213 · see citing works
ALTERATION OF NUCLEOSOME STRUCTURE AS A MECHANISM OF TRANSCRIPTIONAL REGULATION
Workman, J. L., & Kingston, R. E. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.545 · Cited by 1,129 · see citing works
Dardalhon, V., Awasthi, A., Kwon, H., Galileos, G., Gao, W., Sobel, R. A., Mitsdoerffer, M., Strom, T. B., Elyaman, W., Ho, I.-C., et al. (2008) · Nature Immunology · doi:10.1038/ni.1677 · Cited by 1,122 · see citing works
p300/CBP proteins: HATs for transcriptional bridges and scaffolds
Chan, H. M., & La Thangue, N. B. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.13.2363 · Cited by 1,092 · see citing works
Sutton, C. E., Brereton, C. F., Keogh, B., Mills, K. H. G., & Lavelle, E. C. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060285 · Cited by 1,009 · see citing works
Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF‐κB
Chen, L., Mu, Y., & Greene, W. C. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf660 · Cited by 827 · see citing works
CREB-binding protein/p300 are transcriptional coactivators of p65
Gerritsen, M. E., Williams, A. J., Neish, A. S., Moore, S., Shi, Y., & Collins, T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.2927 · Cited by 811 · see citing works
Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer
Tone, Y., Furuuchi, K., Kojima, Y., Tykocinski, M. L., Greene, M. I., & Tone, M. (2008) · Nature Immunology · doi:10.1038/ni1549 · Cited by 807 · see citing works
Partners in transcription: NFAT and AP-1
Macián, F., López‐Rodríguez, C., & Rao, A. (2001) · Oncogene · doi:10.1038/sj.onc.1204386 · Cited by 766 · see citing works
Transforming Growth Factor‐β: Major Role in Regulation of Extracellular Matrix
ROBERTS, A. B., HEINE, U. I., FLANDERS, K. C., & SPORN, M. B. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb17931.x · Cited by 696 · see citing works
Transcriptional Mechanisms Underlying Lymphocyte Tolerance
Macián, F., Garcia-Cozar, F. J., Im, S., Horton, H. F., Byrne, M. C., & Rao, A. (2002) · Cell · doi:10.1016/s0092-8674(02)00767-5 · Cited by 687 · see citing works
Self-citationT CELL ANTIGEN RECEPTOR SIGNAL TRANSDUCTION PATHWAYS
Cantrell, D. A. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.259 · Cited by 673 · see citing works
Chang, H.-C., Sehra, S., Goswami, R., Yao, W., Yu, Q., Stritesky, G. L., Jabeen, R., McKinley, C., Ahyi, A.-N., Han, L., et al. (2010) · Nature Immunology · doi:10.1038/ni.1867 · Cited by 577 · see citing works
Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells
Staudt, V., Bothur, E., Klein, M., Lingnau, K., Reuter, S., Grebe, N., Gerlitzki, B., Hoffmann, M., Ulges, A., Taube, C., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.07.014 · Cited by 554 · see citing works
Elyaman, W., Bradshaw, E. M., Uyttenhove, C., Dardalhon, V., Awasthi, A., Imitola, J., Bettelli, E., Oukka, M., van Snick, J., Renauld, J.-C., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812530106 · Cited by 498 · see citing works
Interaction of NF-κB and NFAT with the Interferon-γ Promoter
Sica, A., Dorman, L., Viggiano, V., Cippitelli, M., Ghosh, P., Rice, N. R., & Young, H. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.48.30412 · Cited by 430 · see citing works
IL-9 as a mediator of Th17-driven inflammatory disease
Nowak, E. C., Weaver, C. T., Turner, H., Begum-Haque, S., Becher, B., Schreiner, B., Coyle, A. J., Kasper, L. H., & Noelle, R. J. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20090246 · Cited by 393 · see citing works
Rengarajan, J., Mowen, K. A., McBride, K. D., Smith, E. D., Singh, H., & Glimcher, L. H. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011128 · Cited by 332 · see citing works
Townsend, M. J., Fallon, P. G., Matthews, D. J., Smith, P., Jolin, H. E., & McKenzie, A. N. J. (2000) · Immunity · doi:10.1016/s1074-7613(00)00056-x · Cited by 328 · see citing works
FusionDB: a database for in-depth analysis of prokaryotic gene fusion events
Suhre, K. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkh053 · Cited by 326 · see citing works
Uyttenhove, C., Simpson, R. J., & Snick, J. V. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.18.6934 · Cited by 305 · see citing works
Cellular sources and immune functions of interleukin-9
Noelle, R. J., & Nowak, E. C. (2010) · Nature reviews. Immunology · doi:10.1038/nri2848 · Cited by 301 · see citing works
Hültner, L., Druez, C., Moeller, J., Uyttenhove, C., Schmitt, E., Rüde, E., Dormer, P. G., & Snick, J. V. (1990) · European Journal of Immunology · doi:10.1002/eji.1830200632 · Cited by 301 · see citing works
Transcriptional Regulation in Eukaryotes: Concepts, Strategies and Techniques
Carey, M., & Smale, S. T. (2000) · Cited by 253 · see citing works
STAT6-dependent regulation of Th9 development
Goswami, R., Jabeen, R., Yagi, R., Pham, D., Zhu, J., Goenka, S., & Kaplan, M. H. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102840 · Cited by 240 · see citing works
Na, S.-Y., Lee, S., Han, S., Choi, H., Im, S., & Lee, J. W. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.18.10831 · Cited by 235 · see citing works
Self-citationActivation of NF-κB by HTLV-I and implications for cell transformation
Sun, S., & Yamaoka, S. (2005) · Oncogene · doi:10.1038/sj.onc.1208969 · Cited by 232 · see citing works
NFAT pulls the strings during CD4+ T helper cell effector functions
Hermann-Kleiter, N., & Baier, G. (2010) · Blood · doi:10.1182/blood-2009-10-233585 · Cited by 218 · see citing works
Activation and Deactivation of Gene Expression by Ca2+/Calcineurin-NFAT-mediated Signaling
Im, S., & Rao, A. (2004) · Molecules and Cells · doi:10.1016/s1016-8478(23)13074-3 · Cited by 211 · see citing works
Self-citationRel Induces Interferon Regulatory Factor 4 (IRF-4) Expression in Lymphocytes
Grumont, R. J., & Gerondakis, S. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.8.1281 · Cited by 198 · see citing works
García‐Rodríguez, C., & Rao, A. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.12.2031 · Cited by 195 · see citing works
Eller, K., Wolf, D. G. F., Huber, J., Metz, M., Mayer, G. J., McKenzie, A. N. J., Maurer, M., Rosenkranz, A. R., & Wolf, A. M. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001183 · Cited by 182 · see citing works
Gessner, A., Blum, H., & Röllinghoff, M. (1993) · Immunobiology · doi:10.1016/s0171-2985(11)80414-6 · Cited by 165 · see citing works
Expression cloning of the murine and human interleukin 9 receptor cDNAs.
Renauld, J., Druez, C., Kermouni, A., et al. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5690 · Cited by 152 · see citing works
Stassen, M., Müller, C., Arnold, M., Hültner, L., Klein‐Hessling, S., Neudörfl, C., Reineke, T., Serfling, E., & Schmitt, E. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.7.4391 · Cited by 143 · see citing works
Regulation of human Th9 differentiation by type I interferons and IL‐21
Wong, M. T., Ye, J. J., Alonso, M. N., Landrigan, A., Cheung, R. K., Engleman, E. G., & Utz, P. J. (2010) · Immunology and Cell Biology · doi:10.1038/icb.2010.53 · Cited by 136 · see citing works
Coactivators and Corepressors of NF-κB in IκBα Gene Promoter
Gao, Z., Chiao, P. J., Zhang, X., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500754200 · Cited by 132 · see citing works
Koenig, A. O., Linhart, T., Schlengemann, K., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.10.045 · Cited by 131 · see citing works
NFAT1 Enhances HIV-1 Gene Expression in Primary Human CD4 T Cells
Cron, R. Q., Bartz, S. R., Clausell, A., Bort, S. J., Klebanoff, S. J., & Lewis, D. B. (2000) · Clinical Immunology · doi:10.1006/clim.1999.4831 · Cited by 124 · see citing works
Li, H., Nourbakhsh, B., Ćirić, B., Zhang, G., & Rostami, A. M. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000986 · Cited by 124 · see citing works
c-Rel Is Required for Chromatin Remodeling Across the IL-2 Gene Promoter
Rao, S., Gerondakis, S., Woltring, D., & Shannon, M. F. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.7.3724 · Cited by 115 · see citing works
Lerner, L. R., Henriksen, M. A., Zhang, X., & Darnell, J. E., Jr. (2003) · Genes & Development · doi:10.1101/gad.1135003 · Cited by 115 · see citing works
Induction of the CTLA-4 Gene in Human Lymphocytes Is Dependent on NFAT Binding the Proximal Promoter
Gibson, H. M., Hedgcock, C. J., Aufiero, B. M., Wilson, A. J., Hafner, M. S., Tsokos, G. C., & Wong, H. K. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.3831 · Cited by 112 · see citing works
Interleukin-9 and its receptor: involvement in mast cell differentiation and T cell oncogenesis
Renauld, J., Kermouni, A., Vink, A., Louahed, J., & Snick, J. V. (1995) · Journal of Leukocyte Biology · doi:10.1002/jlb.57.3.353 · Cited by 112 · see citing works
Steenwinckel, V., Louahed, J., Lemaire, M. M., Sommereyns, C., Warnier, G., McKenzie, A., Brombacher, F., Van Snick, J., & Renauld, J.-C. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0801941 · Cited by 109 · see citing works
Chromatin-level Regulation of the IL10 Gene in T Cells
Im, S.-H., Hueber, A., Monticelli, S., Kang, K.-H., & Rao, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401722200 · Cited by 103 · see citing works
Self-citationHauber, H.-P., Bergeron, C., & Hamid, Q. (2004) · International Archives of Allergy and Immunology · doi:10.1159/000078384 · Cited by 90 · see citing works
Demoulin, J., Roost, E. V., Stevens, M., Groner, B., & Renauld, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.36.25855 · Cited by 90 · see citing works
Kaminski, B. A., Kadereit, S., Miller, R. E., et al. (2003) · Blood · doi:10.1182/blood-2003-05-1732 · Cited by 90 · see citing works
McCaffrey, P. G., Jain, J., Jamieson, C., Sen, R., & Rao, A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)46027-9 · Cited by 88 · see citing works
Suppression of neutrophil accumulation in mice by cutaneous application of geranium essential oil.
Maruyama, N., Sekimoto, Y., Ishibashi, H., Inouye, S., Oshima, H., Yamaguchi, H., & Abe, S. (2005) · Journal of Inflammation · doi:10.1186/1476-9255-2-1 · Cited by 87 · see citing works
IL9 leads to airway inflammation by inducing IL13 expression in airway epithelial cells
Temann, U.-A., Laouar, Y., Eynon, E. E., Homer, R., & Flavell, R. A. (2006) · International Immunology · doi:10.1093/intimm/dxl117 · Cited by 86 · see citing works
Regulating Il9 transcription in T helper cells
Perumal, N. B., & Kaplan, M. H. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.01.006 · Cited by 85 · see citing works
Lee, C., Kang, K., So, J., Kwon, H., Son, J.-S., Song, M., Sahoo, A., Yi, H.-J., Hwang, K.-C., Matsuyama, T., et al. (2008) · Molecular Immunology · doi:10.1016/j.molimm.2008.07.037 · Cited by 84 · see citing works
Self-citationJohnson, B. V., Bert, A. G., Ryan, G. R., Condina, A., & Cockerill, P. N. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.18.7914-7930.2004 · Cited by 83 · see citing works
Tsytsykova, A. V., Rajsbaum, R., Falvo, J. V., Ligeiro, F., Neely, S. R., & Goldfeld, A. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708210104 · Cited by 81 · see citing works
NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression
Mehta, D. S., Wurster, A. L., Weinmann, A. S., & Grusby, M. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409512102 · Cited by 81 · see citing works
Xu, L., Han, C. L., Lim, K., & Wu, T. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1445 · Cited by 80 · see citing works
Reduced NFAT1 Protein Expression in Human Umbilical Cord Blood T Lymphocytes
Kadereit, S., Mohammad, S. F., Miller, R. E., et al. (1999) · Blood · doi:10.1182/blood.v94.9.3101 · Cited by 76 · see citing works
Redundant expression but selective utilization of nuclear factor of activated T cells family members
Timmerman, L., Healy, J. I., Ho, S. N., et al. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.6.2735 · Cited by 68 · see citing works
IL-4-independent regulation of in vivo IL-9 expression
Monteyne, P., Renauld, J., Broeck, J. V., Dunne, D. W., Brombacher, F., & Coutelier, J. P. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.6.2616 · Cited by 57 · see citing works
IL‐9 is a Th17‐derived cytokine that limits pathogenic activity in organ‐specific autoimmune disease
Stephens, G. L., Swerdlow, B., Benjamin, E., Coyle, A. J., Humbles, A. A., Kolbeck, R., & Fung, M. S. C. (2011) · European Journal of Immunology · doi:10.1002/eji.201040879 · Cited by 55 · see citing works
Stat6 and c-Jun Mediate Th2 Cell-Specific IL-24 Gene Expression
Sahoo, A., Lee, C., Jash, A., Son, J.-S., Kim, G.-C., Kwon, H., So, J., & Im, S. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002620 · Cited by 48 · see citing works
Self-citationCakouros, D., Cockerill, P. N., Bert, A. G., Mital, R., Roberts, D., & Shannon, M. F. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.1.302 · Cited by 36 · see citing works
Multiple Transcription Factors Are Required for Activation of Human Interleukin 9 Gene in T Cells
Zhu, Y. X., Kang, L. Y., Luo, W., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.26.15815 · Cited by 30 · see citing works
Refaat, A., Zhou, Y., Suzuki, S., Takasaki, I., Koizumi, K., Yamaoka, S., Tabuchi, Y., Saiki, I., & Sakurai, H. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.200907 · Cited by 29 · see citing works
NFAT and IRF Proteins Regulate Transcription of the Anti-HIV Gene, APOBEC3G
Farrow, M. A., Kim, E., Wolinsky, S. M., & Sheehy, A. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.154377 · Cited by 25 · see citing works
Dexamethasone inhibits IL-9 production by human T cells.
Holz, L. E., Jakobsen, K. P., Snick, J. V., Cormont, F., & Sewell, W. A. (2005) · Journal of Inflammation · doi:10.1186/1476-9255-2-3 · Cited by 18 · see citing works
Ishihara, S., & Schwartz, R. H. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003173 · Cited by 18 · see citing works
Interleukin 9 and its Receptor
Yang, Y. (1998) · Elsevier eBooks · doi:10.1006/rwei.1999.0375 · Cited by 15 · see citing works
Interleukin-9 and T cell subsets
Nowak, E. C., & Noelle, R. J. (2009) · Cell Cycle · doi:10.4161/cc.8.23.10069 · Cited by 8 · see citing works
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- Elyaman, W., Bradshaw, E. M., Uyttenhove, C., Dardalhon, V., Awasthi, A., Imitola, J., Bettelli, E., Oukka, M., van Snick, J., Renauld, J. C., Kuchroo, V. K., and Khoury, S. J. (2009) IL-9 induces differentiation of TH17 cells and enhances function of FoxP3 ϩ natural regulatory T cells. Proc. Natl. Acad. Sci. U.S.A. 106, 12885-12890
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Kim, I.-K., Kim, B.-S., Koh, C.-H., Seok, J.-W., Park, J.-S., Shin, K.-S., Bae, E.-A., Lee, G.-E., Jeon, H., Cho, J., et al. (2015) · Nature Medicine · doi:10.1038/nm.3922 · Cited by 167 · see citing works
Gcn5 Is Required for PU.1-Dependent IL-9 Induction in Th9 Cells
Goswami, R., & Kaplan, M. H. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201496 · Cited by 97 · see citing works
“1 or IRF4 binding to Il9, Gcn5-dependent histone acetylation likely increases binding of TCR-induced factors such as NF-kB or NFAT that are important for Il9 gene expression after Ag receptor stimulation (27) or may facilitate the function of general transcription factors including RNA polymerase II (49).”
BackgroundThe DNA-binding inhibitor Id3 regulates IL-9 production in CD4+ T cells
Nakatsukasa, H., Zhang, D., Maruyama, T., Chen, H., Cui, K., Ishikawa, M., Deng, L., Zanvit, P., Tu, E., Jin, W., et al. (2015) · Nature Immunology · doi:10.1038/ni.3252 · Cited by 80 · see citing works
- Authors
- Jash, A., Sahoo, A., Kim, G.-C., Chae, C.-S., Hwang, J.-S., Kim, J.-E., & Im, S.-H.
- Affiliations
- Gwangju Institute of Science and Technology (KR)
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Im, Sin-Hyeog
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 287
- Issue
- 19
- Pages
- 15445-15457
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC3346086
- OpenAlex
- W1987528629
- Cited by
- 75
- References
- 81
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 1 · 2023: 5 · 2022: 6 · 2021: 7 · 2020: 7 · 2019: 4 · 2018: 7 · 2017: 7 · 2016: 9 · 2015: 4 · 2014: 2 · 2013: 3 · 2012: 4
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Research Foundation (2011-0028529)
- Gwangju Institute of Science and Technology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- NFAT1, NF-κB p65, IL-9, chromatin accessibility, CD4+ T cells, T cell receptor stimulation, transcription factor cooperation, P300, histone modifications
- MeSH terms
- Animals, Base Sequence, Binding Sites, Cells, Cultured, Chromatin, Humans, Mice, Inbred C57BL, Molecular Sequence Data, Mutation, Promoter Regions, Genetic, Protein Binding, Sequence Homology, Nucleic Acid, Immunoblotting, CD4-Positive T-Lymphocytes, Transcriptional Activation, Interleukin-9, Mice, Knockout, RNA Interference, Chromatin Immunoprecipitation, NFATC Transcription Factors, Mice, Transcription Factor RelA, HEK293 Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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